Medical Research Institute Tokyo Medical and Dental University

News & Topics

topics: Job Opportunity: Faculty Position (Assistant Professor) Department of Medical Chemistry

topics: 20th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium(2022.11.28)

topics: WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway

topics: Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci

topics: Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma

topics: The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45－/－ immunodeficient B cells

topics: Dynamic stem cell selection safeguards the genomic integrity of the epidermis

topics: Polygenic risk scores are associated with radiographic progression in patients with rheumatoid arthritis

topics: A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation

topics: Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: Novel mouse models for GATORopathy

topics: Development of polysaccharide-based carriers that enhance antibody production to target molecules

topics: Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

topics: Placenta mediates the effect of maternal hypertension polygenic score on offspring birth weight: a study of birth cohort with fetal growth velocity data

topics: HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

topics: EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis

topics: A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes

topics: Integrative genome-wide analyses reveal the transcriptional aberrations in Japanese esophageal squamous cell carcinoma

topics: miR-766-5p targets super-enhancers by downregulating CBP and BRD4

topics: Hepta-Histidine Inhibits Tau Aggregation

topics: Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells

topics: Obesity accelerates hair thinning by stem cell-centric converging mechanisms

topics: m6A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis

topics: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis

topics: Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum

topics: Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma

topics: HERV-Derived Ervpb1 Is Conserved in Simiiformes, Exhibiting Expression in Hematopoietic Cell Lineages Including Macrophages

topics: Guidelines for International Joint Research Project FY2021 Medical Research Institute, Tokyo Medical and Dental University

topics: Label‐free quality control and identification of human keratinocyte stem cells by deep learning‐based automated cell tracking

topics: A missense variant in NUF2, a component of the kinetochore NDC80 complex, causes impaired chromosome segregation and aneuploidy associated with microcephaly and short stature

topics: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy

topics: Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles

topics: Suppression of MET signaling mediated by pitavastatin and capmatinib inhibits oral and esophageal cancer cell growth

topics: A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides

topics: Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment

topics: WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID

topics: A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice

topics: Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

topics: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon

topics: Generation of three-dimensional heart organoids

topics: RTL1 Gene a Likely Culprit Behind Temple and Kagami-Ogata Syndromes

topics: Increasing the Effectiveness of Cancer Treatments: Anti-PD-L1 Immunotherapy

topics: A new molecular guardian of intestinal stem cells

topics: Potential target identified for migraine therapy

topics: Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

topics: How Stress Affects Bone Marrow

topics: Glioma stem cell (GSC)‐derived autoschizis‐like products confer GSC niche properties involving M1‐like tumor‐associated macrophages

topics: miR-1293, a candidate for miRNA-based cancer therapeutics, simultaneously targets BRD4 and the DNA repair pathway

topics: How Cells Decide the Way They Want to Recycle Their Content

topics: Estradiol/GPER affects the integrity of mammary duct-like structures in vitro

topics: Timing of Brain Cell Death Uncovers a New Target for Alzheimer’s Treatment

topics: Development of anticancer drug with tumor-suppressive miR-634 as a drug seed for the nucleic acid therapeutics