Naoki Miyamoto, Miho Yoshimura, Yuji Okubo, Kayo Suzuki-Nagata, Takeshi
Tsumuraya, Nobutoshi Ito, Ikuo Fujii. “Structural basis of the broad substrate
tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters.” Bioorg. Med. Chem., 26, 1412–1417 (2018).
Naoko Matsubara, Akihiro Imamura, Tatsuya Yonemizu, Chizuru Akatsu, Hongrui
Yang, Akiharu Ueki, Natsuki Watanabe, Hajjaj Abdu-Allah, Nobutaka Numoto,
Hiromu Takematsu, Shinobu Kitazume, Thomas F. Tedder, Jamey D. Marth, Nobutoshi
Ito, Hiromune Ando, Hideharu Ishida, Makoto Kiso and Takeshi Tsubata. “CD22-Binding
Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22
Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in
Mice” Front. Immunol., 9, 820 (2018).
Rocio Otero, Michiyasu Ishizawa, Nobutaka Numoto, Teikichi Ikura,
Nobutoshi Ito, Hiroaki Tokiwa, Antonio Mouriño, Makoto Makishima, and Sachiko
Yamada. “25S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3:
Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural
Analysis of Its Vitamin D Receptor Complex” J.
Med. Chem., 61, 6658–6673 (2018)
Teikichi Ikura, Naoya Tochio, Ryosuke Kawasaki, Mizuki Matsuzaki, Akihiro
Narita, Mahito Kikumoto, Naoko Utsunomiya-Tate, Shin-ichi Tate, Nobutoshi Ito.
“The trans isomer of Tau peptide is
prone to aggregate, and the WW domain of Pin1 drastically decreases its
aggregation” FEBS Lett., 592, 3082–3091 (2018)
Nobutaka Numoto, Narutoshi Kamiya, Gert-Jan Bekker, Yuri Yamagami, Satomi Inaba, Kentaro Ishii, Susumu Uchiyama, Fusako Kawai, Nobutoshi Ito, and Masayuki Oda. “Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle” Biochemistry, 57, 5289–5300 (2018)
Satomi Inaba, Nobutaka Numoto, Shuhei Ogawa, Hisayuki Morii, Teikichi Ikura, Ryo Abe, Nobutoshi Ito and Masayuki Oda. “Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.” J. Biol. Chem., 292, 1052–1060 (2017)
Manjiri R. Kulkarni, Nobutaka Numoto, Nobutoshi Ito, Yutaka Kuroda.
“Modeling and experimental assessment of a buried Leu–Ile mutation in dengue
envelope domain III” Biochem. Biophys.
Res. Commun., 471, 163–168 (2016)
Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno,
Suguru Yoshida, Tomoe Kato, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi
Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, and Masatoshi
Hagiwara. “Selective inhibition of the kinase DYRK1A by targeting its folding
process” Nature Commun., 7, 11391 (2016)
Ikura, T. & Ito, N. “Crystal Structure of the Vitamin D Receptor Ligand-Binding
Domain with Lithocholic Acids” Vitam. Horm., 100, 117-136 (2016)
Chizuru Akatsu, Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Ayse
Konuskan Ucar, Mohammad Aslam, Shirly Phoon, Takahiro Adachi, Koji Furukawa,
Nobutoshi Ito, and Takeshi Tsubata. “CD72 negatively regulates B lymphocyte
responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP” J. Exp. Med., 213, 2691-2706 (2016)
Tomomi Imamura, Kyota Fujita, Kazuhiko Tagawa, Teikichi Ikura, Xigui Chen, Hidenori Homma, Takuya Tamura, Ying Mao, Juliana Bosso Taniguchi, Kazumi Motoki, Makoto Nakabayashi, Nobutoshi Ito, Kazunori Yamada, Kentaro Tomii, Hideyuki Okano, Julia Kaye, Steven Finkbeiner & Hitoshi Okazawa. “Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.” Sci. Rep., 6, 33861 (2016)
Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu
Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi
Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano,
Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa
Yoshimura, Masatoshi Hagiwara. “Identification of a dual inhibitor of SRPK1 and
CK2 that attenuates pathological angiogenesis of macular degeneration in mice” Molecular Pharmacology, 88, 316-325 (2015).
So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa,
Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu
Hosoya, Masatoshi Hagiwara. “Design and synthesis of a potent inhibitor of
class 1 DYRK kinases as a suppressor of adipogenesis” Bioorganic & Medicinal Chemistry, 23, 4434-4441 (2015).
Manjiri R. Kulkarni, Monirul M. Islam, Nobutaka Numoto, Montasir Elahi, Mamunur R. Mahib, Nobutoshi Ito, Yutaka Kuroda. “Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants” Biochim. Biophys. Acta Protein Proteomics, 1854, 1438–1443 (2015)
Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C.M.
Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mourińo, Hiroaki Tokiwa, Makoto
Makishima, and Sachiko Yamada. “Synthesis, Biological Activities and X-ray
Crystal Structural Analysis of 25-Hydroxy-25(or
26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds” J. Med. Chem., 58, 9510−9521 (2015)
Yasuaki Anami, Yuta Sakamaki, Toshimasa Itoh, Yuka Inaba, Makoto
Nakabayashi, Teikichi Ikura, Nobutoshi Ito, Keiko Yamamoto. “Fine tuning of
agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length
of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.” Bioorg. Med. Chem., 23, 7274−7281 (2015)
Takeru Kudo, Michiyasu Ishizawa, Kazuki Maekawa, Makoto Nakabayashi,
Yusuke Watarai, Hikaru Uchida, Hiroaki Tokiwa, Teikichi Ikura, Nobutoshi Ito,
Makoto Makishima, and Sachiko Yamada: Combination of Triple Bond and Adamantane
Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D
Receptor. J. Med. Chem., 57 (10), 4073–4087 (2014).
Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M,
Tsubota T, Ito N, Hosoya T, Hagiwara M. (2014) CDK9 inhibitor FIT-039 prevents
replication of multiple DNA viruses. J.
Clin. Invest., 124, 3479-3488
(2014).