研究業績 Publications
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Naoki Miyamoto, Miho Yoshimura, Yuji Okubo, Kayo Suzuki-Nagata, Takeshi Tsumuraya, Nobutoshi Ito, Ikuo Fujii. “Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters.” Bioorg. Med. Chem., 26, 1412–1417 (2018).
Naoko Matsubara, Akihiro Imamura, Tatsuya Yonemizu, Chizuru Akatsu, Hongrui Yang, Akiharu Ueki, Natsuki Watanabe, Hajjaj Abdu-Allah, Nobutaka Numoto, Hiromu Takematsu, Shinobu Kitazume, Thomas F. Tedder, Jamey D. Marth, Nobutoshi Ito, Hiromune Ando, Hideharu Ishida, Makoto Kiso and Takeshi Tsubata. “CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice” Front. Immunol., 9, 820 (2018).
Rocio Otero, Michiyasu Ishizawa, Nobutaka Numoto, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa, Antonio Mouriño, Makoto Makishima, and Sachiko Yamada. “25S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex” J. Med. Chem., 61, 6658–6673 (2018)
Teikichi Ikura, Naoya Tochio, Ryosuke Kawasaki, Mizuki Matsuzaki, Akihiro Narita, Mahito Kikumoto, Naoko Utsunomiya-Tate, Shin-ichi Tate, Nobutoshi Ito. “The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation” FEBS Lett., 592, 3082–3091 (2018)
Nobutaka Numoto, Narutoshi Kamiya, Gert-Jan Bekker, Yuri Yamagami, Satomi Inaba, Kentaro Ishii, Susumu Uchiyama, Fusako Kawai, Nobutoshi Ito, and Masayuki Oda. “Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle” Biochemistry, 57, 5289–5300 (2018)
Satomi Inaba, Nobutaka Numoto, Shuhei Ogawa, Hisayuki Morii, Teikichi Ikura, Ryo Abe, Nobutoshi Ito and Masayuki Oda. “Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.” J. Biol. Chem., 292, 1052–1060 (2017)
Manjiri R. Kulkarni, Nobutaka Numoto, Nobutoshi Ito, Yutaka Kuroda. “Modeling and experimental assessment of a buried Leu–Ile mutation in dengue envelope domain III” Biochem. Biophys. Res. Commun., 471, 163–168 (2016)
Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, and Masatoshi Hagiwara. “Selective inhibition of the kinase DYRK1A by targeting its folding process” Nature Commun., 7, 11391 (2016)
Ikura, T. & Ito, N. “Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids” Vitam. Horm., 100, 117-136 (2016)
Chizuru Akatsu, Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Ayse Konuskan Ucar, Mohammad Aslam, Shirly Phoon, Takahiro Adachi, Koji Furukawa, Nobutoshi Ito, and Takeshi Tsubata. “CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP” J. Exp. Med., 213, 2691-2706 (2016)
Tomomi Imamura, Kyota Fujita, Kazuhiko Tagawa, Teikichi Ikura, Xigui Chen, Hidenori Homma, Takuya Tamura, Ying Mao, Juliana Bosso Taniguchi, Kazumi Motoki, Makoto Nakabayashi, Nobutoshi Ito, Kazunori Yamada, Kentaro Tomii, Hideyuki Okano, Julia Kaye, Steven Finkbeiner & Hitoshi Okazawa. “Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.” Sci. Rep., 6, 33861 (2016)
Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, Takayoshi Okabe, Hirotatsu Kojima, Naoko Inoue, Yukiko Okuno, Masatsugu Denawa, Suguru Yoshida, Junichi Fukuhara, Kensuke Ninomiya, Teikichi Ikura, Toshio Furuya, Tetsuo Nagano, Kousuke Noda, Susumu Ishida, Takamitsu Hosoya, Nobutoshi Ito, Nagahisa Yoshimura, Masatoshi Hagiwara. “Identification of a dual inhibitor of SRPK1 and CK2 that attenuates pathological angiogenesis of macular degeneration in mice” Molecular Pharmacology, 88, 316-325 (2015).
So Masaki, Isao Kii, Yuto Sumida, Tomoe Kato-Sumida, Yasushi Ogawa, Nobutoshi Ito, Mitsuhiro Nakamura, Rie Sonamoto, Naoyuki Kataoka, Takamitsu Hosoya, Masatoshi Hagiwara. “Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis” Bioorganic & Medicinal Chemistry, 23, 4434-4441 (2015).
Manjiri R. Kulkarni, Monirul M. Islam, Nobutaka Numoto, Montasir Elahi, Mamunur R. Mahib, Nobutoshi Ito, Yutaka Kuroda. “Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants” Biochim. Biophys. Acta Protein Proteomics, 1854, 1438–1443 (2015)
Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C.M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mourińo, Hiroaki Tokiwa, Makoto Makishima, and Sachiko Yamada. “Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds” J. Med. Chem., 58, 9510−9521 (2015)
Yasuaki Anami, Yuta Sakamaki, Toshimasa Itoh, Yuka Inaba, Makoto Nakabayashi, Teikichi Ikura, Nobutoshi Ito, Keiko Yamamoto. “Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.” Bioorg. Med. Chem., 23, 7274−7281 (2015)
Takeru Kudo, Michiyasu Ishizawa, Kazuki Maekawa, Makoto Nakabayashi, Yusuke Watarai, Hikaru Uchida, Hiroaki Tokiwa, Teikichi Ikura, Nobutoshi Ito, Makoto Makishima, and Sachiko Yamada: Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor. J. Med. Chem., 57 (10), 4073–4087 (2014).
Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M. (2014) CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J. Clin. Invest., 124, 3479-3488 (2014).
東京医科歯科大学