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Porcherie, A., Mathieu, C., Peronet, R., Schneider, E., Claver, J., Commere, P-H., Kiefer-Biasizzo, H., Karasuyama, H ., Milon, G., Dy, M., Kinet, J-P., Louis, J., Blank, U., and Mecheri, S.: Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cereberal malaria. J. Exp. Med . 208: 2225-2236, 2011. (PubMed)

Yamagishi, H., Mochizuki, Y., Hamakubo, T., Obata, K., Ugajin, T., Sato, S., Kawano, Y., Minegishi, Y., and Karasuyama, H .: Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner. Biochem. Biophys. Res. Commun . 415: 709-713, 2011. (PubMed)

Karasuyama, H ., Obata, K., Wada, T., Tsujimura, Y., and Mukai, K.: Newly appreciated roles for basophils in allergy and protective immunity. Allergy 66: 1133-1141, 2011. (PubMed)

Nishikado, H., Mukai, K., Kawano, Y., Minegishi, Y., and Karasuyama, H .: NK cell-depleting anti-asialo GM1 Ab exhibits a lethal eoff-target' effect on basophils in vivo . J. Immunol . 186: 5766-5771, 2011. (PubMed)

Ishikawa, Y., Kobayashi, K., Yamamoto, M., Nakata, K., Takagawa, T., Funada, Y., Kotani, Y., Karasuyama, H ., Yoshida, M., and Nishimuar, Y.: Antigen-specific IgG ameliorates allergic airway inflammation via Fc receptor IIB on dendritic cells. Respir. Res . 12: 42, 2011. (PubMed)

Jonsson, F., Mancardi, D.A., Kita, Y., Karasuyama, H ., Iannascoli, B., Van Rooijen, N., Shimizu , T., Daeron, M, and Bruhns, P.: Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest . 121: 1484-1496, 2011. (PubMed)

Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., Nonoyama, S., Karasuyama, H ., and Minegishi, Y.: Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med . 208: 235-249, 2011. (PubMed)

Karasuyama, H., Wada, T., Yoshikawa, S., and Obata, K.: Emerging roles of basophils in protective immunity against parasites. Trends Immunol . 32: 125-130, 2011. (PubMed)

Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada, T.: Nonredundant roles of basophils in immunity. Annu. Rev. Immunol . 29: 45-69, 2011.@(PubMed)

Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., Kawano, Y., and Minegishi, Y.: Nonredundant roles for basophils in immediate- and delayed-onset allergic reactions. The Open Allergy Journal . 3: 73-80, 2010. (Online publication)

Torrero, M.N., Hubner, M.P., Larson, D., Karasuyama, H., and Mitre, E.: Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis . J. Immunol . 185: 7426-7434, 2010. (PubMed)

Ishikawa, R., Tsujimura, Y., Obata, K., Kawano, Y., Minegishi, Y., and Karasuyama, H.: IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen. Biochem. Biophys. Res. Commun . 402: 742-746, 2010. (PubMed).

Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., Kawano, Y., Minegishi, Y., Yokozeki, H., Watanabe, N., and Karasuyama, H.: Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest . 120: 2867-2875, 2010. (PubMed).

Karasuyama, H., Tsujimura Y., Obata, K., Mukai, K., and Minegishi Y.: Basophils and mast cells play distinct roles in acute and chronic allergic reactions. Environmental and genetic factors in allergy and clinical immunology . (Eds.: van Ree, R., Ring, J., and Marone, G) pp63-65, 2010.

Matsushima, Y., Kikkawa, Y., Takada, T, Matsuoka, K., Seki, Y., Yoshida, H., Minegishi, Y., Karasuyama, H ., and Yonekawa, H.: An atopic dermatitis-like skin disease with hyper-IgEemia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene. J. Immunol . 185: 2340-2349, 2010 (PubMed).

Anyan, W.K., Kumagai, T., Simogawara, R.F., Seki, T., Akao, N, Obata K., Kwansa-Bentum, B., Bosompem, K.M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.: Schistosoma eggs have a direct role in the induction of basophils capable of a high level of IL-4 production: Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo. Trop. Med. Health 38: 13-22, 2010.

Karasuyama, H ., Tsujimura, Y., Obata, K., and Mukai, K.: Role for basophils in systemic anaphylaxis. Chem. Immunol. Allergy . 95: 85-97, 2010. (PubMed).

Nakata, K., Kobayashi, K., Ishikawa, Y., Yamamoto, M., Funada, Y., Kotani, Y., Blumberg, R.S., Karasuyama, H., Yoshida, M., and Yoshihiro Nishimura.: The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner. Biochem. Biophys. Res. Commun . 395:238-243, 2010. (PubMed).

Ugajin, T., Kojima, T., Mukai, K., Obata K., Kawano, Y., Minegishi, Y., Eishi Y., Yokozeki, H., and Karasuyama, H.: Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. J. Leukoc. Biol . 86: 1417-1425, 2009. (PubMed).

Takai, T., and Karasuyama, H.: The study of allergy by Japanese researchers: a historical perspective. Int. Immunol . 21: 1311-1316, 2009. (PubMed).

Minegishi, Y.: Hyper-IgE syndrome. Curr. Opin. Immunol . 21: 487-492, 2009. (PubMed).

Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., and Karasuyama, H .: Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med . 206: 1291-1301, 2009. (PubMed).

Belkina N. V., Lie, Y., Hao J-J., Karasuyama, H. and Shaw, S.: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc. Natl. Acad. Sci. USA . 106: 4707-4712, 2009. (PubMed).

Mukai, K., Obata, K., Tsujimura, Y. and Karasuyama, H.: New insights into the roles for basophils in acute and chronic allergy. Allergol. Int . 58: 11-19, 2009. (PubMed).

Khodoun, M., Strait, R., Orekov, T., Hogan, S., Karasuyama, H ., Herbert, D. R., Kohl, J. and Finkelman, F. D. : Peanuts can contribute to anaphylactic shock by activating complement. J. Allergy Clin. Immunol . 58: 11-19, 2009. (PubMed).

Minegishi Y. and Karasuyama, H.: Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary human immunodeficiency . Int. Immunol. 21: 105-112, 2009. (PubMed).

Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T. and Taki, S.: Fc receptor g -chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4. Nat. Immunol. 10: 214-222, 2009. (PubMed).

Karasuyama, H., Mukai, K., Tsujimura, Y. and Obata, K.: Newly-discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol . 9: 9-13, 2009 (PubMed).

Yoshikawa, S., Kawano, Y., Minegishi, Y. and Karasuyama, H.: The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int. Immunol . 21: 43-52, 2009. (PubMed) .

Watanabe, M., Satoh, T., Yamamoto, Y., Kanai, Y., Karasuyama, H. and Yokozeki, H.: Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J. Immunol. 181: 5653-5659, 2008 (PubMed).

Takada, T., Shitara, H., Matsuoka, K., Kojima, E., Ishii, R., Kikkawa, Y., Karasuyama, H ., Kohno, K. and Yonekawa, H.: A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis. Transgenic Res . in press (PubMed).

Minegishi, Y. and Karasuyama, H .: Genetic origins of hyper-IgE syndrome. Curr. Allergy Asthma Rep . 8(5): 386-91, 2008 (PubMed).

Yasuda, T., Sanjo, H., Pages, G., Kawano, Y., Karasuyama, H ., Pouyssegur, J., Ogata, M. and Kurosaki, T. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28: 499-508, 2008 (PubMed).

Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H .: Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis. Immunity 28: 581-589, 2008 (PubMed).

Minegishi, Y. and Karasuyama, H.: Hyperimmunoglobulin E syndrome and tyrosine kinasae 2 deficiency. Curr. Opin. Allergy Clin Immunol . 7: 506?509, 2007 (PubMed).

Kojima, T., Obata, K., Mukai, K., Sato, S., Takai , T. , Minegishi, Y., and Karasuyama, H .: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J. Immunol. 179: 7093-7100, 2007 (PubMed).

Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H .: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448: 1058-1062, 2007 (PubMed).

Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110: 913-920, 2007. (PubMed)

Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, T., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H., D., Renner, E., D., Jansson, A., Belohradsky, B., H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., and Karasuyama, H.: Human Tyk2 deficiency reveals requisite roles of Tyk2 in multiple cytokine signals involved in innate and acquired immunity.Immunity 25: 745-755, 2006 (PubMed)

Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H ., Tashiro, S., Muto, A. and Igarashi, K.: Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J. Biol. Chem. 15; 281(50): 38226-38234, 2006 (PubMed)

Yamamoto, M., Hayashi, K., Nojima, T., Matsuzaki, Y., Kawano, Y., Karasuyama, H., Goitsuka, R., and Kitamura D.: BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces k gene rearrangement.Blood 108: 2703-2711, 2006 (PubMed)

Kawano, Y., Yoshikawa, S., Minegishi, Y., and Karasuyama, H.: PreB cell receptor assesses the quality of IgH chains and tunes the preB cell repertoire by delivering differential signals. J. Immunol. 177: 2242-2249, 2006 (PubMed)

Kubota, T., Mukai, K., Minegishi, Y., and Karasuyama, H.: Different stabilities of the structurally-related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their chains. J. Immunol. 176: 7008-7014, 2006 (PubMed)

Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., and Karasuyama, H.: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.Immunity 23: 191-202, 2005 (PubMed)

Jimi, E., Phillips, R. J., Rincon, M., Voll, R., Karasuyama, H., Flavell, R., and Ghosh, S.: Activation of NFk-B promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells.Int. Immunol. 17: 815-825, 2005 (PubMed)

Kawano, Y., Yoshikawa, S., Minegishi, Y., and Karasuyama, H.: Selection of stereotyped VH81X-mH chains via preB cell receptor early in ontogeny and their conservation in adults by marginal zone B cells.Int. Immunol. 17: 857-867, 2005 (PubMed)

Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H.: Inhibitory NK Receptor Ly49Q Is Expressed on Subsets of Dendritic Cells in a Cellular Maturation- and Cytokine Stimulation-Dependent Manner.J. Immunol. 174:4621-9, 2005 (PubMed)

Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi M.: Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration.J. Allergy Clin. Immunol. 115: 822-7, 2005 (PubMed)

Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y.: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.J. Exp. Med. 201: 333-9, 2005 (PubMed)

Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J.: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Immunology 112: 575-582, 2004 (PubMed)

Kiyokawa N, Sekino T, Matsui T, Takenouchi H, Mimori K, Tang WR, Matsui J, Taguchi T, Katagiri YU, Okita H, Matsuo Y, Karasuyama H, Fujimoto J.: Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod. Pathol. 17: 423-9, 2004 (PubMed)

Maezawa, Y., Nakajima, H., Seto, Y., Suto, A., Kumano, K., Kubo, S., Karasuyama, H., Saito, Y., Iwamoto, I.: IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin. Exp. Immunol. 135: 12-18, 2004 (PubMed)

Toyama-Sorimachi, N., Tsujimura, Y., Maruya,M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K. and Karasuyama, H.: Ly49Q, a novel member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.Proc. Natl. Acad. Sci. USA. 101: 1016-1021, 2004 (PubMed)

Terauchi, M., Koi, H., Hayano, C., Toyama-Sorimachi, N., Karasuyama, H., Yamanashi, Y., Aso, T. and Shirakata, M.: Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cyotomegalovirus infection. J. Virol. 77: 8187-8195, 2003 (PubMed)

Kawashima, I., Yoshida, Y., Taya, C., Shitara, H., Yonekawa, H., Karasuyama, H., Tada, N., Furukawa, K., Tai, T.: Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int. J. Oncol. 23: 381-388, 2003 (PubMed)

Maezawa, Y., Nakajima, H., Kumano, K., Kubo, S., Karasuyama, H., Iwamoto, I.: Role of IgE in Th2 cell-mediated allergic airway inflammation. Int. Arch. Allergy Immunol. 131 Suppl 1: 2-6, 2003 (PubMed)

Saijo, K., Schmedt, C., Su, I-h., Karasuyama, H., Lowell, C.A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A.: Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development. Nature Immunol. 4: 274-279, 2003 (PubMed)

Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, N., Watanabe, M. and Karasuyama, H.: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS lett. 537: 203-209, 2003. (PubMed)

Kubo, S., Nakayama, T., Matsuoka, K., Yonekawa, H., Karasuyama, H.: Long-term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J. Immunol. 170: 775-780, 2003. (PubMed)

Sato, E., Hirahara, K., Wada, Y., Yoshitomi, T., Azuma, T., Matsuoka, K., Kubo, Taya, C., Yonekawa, H., Karasuyama, H. and Shiraishi, A.: Chronic inflammation in skin can be induced in IgE transgenic mice by a single challenge of multivalent antigen. J. Allergy Clin. Immunol. 111: 143-148, 2003. (PubMed)

Taguchi, T., Kiyokawa, N., Mimori, K., Suzuki, T., Sekino, T., Nakajima, H., Saito, M., Katagiri, Y., Matsuo, N., Matsuo, Y., Karasuyama, H. and Fujimoto, J.: Pre-BCR-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J. Immunol. 170: 252-260, 2003.(PubMed)

Wang, J.-W., Howson, J. M., Ghansah, T., Desponts, C., Ninos, J. M., May, S. L., Nguyen, K. H. T., Toyama-Sorimachi, N. and Kerr, W. G.: Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science 295: 2094-2097, 2002. (PubMed)

Wang, Y-H., Stephan, R. P., Scheffold, A., Kunkel, D., Karasuyama, H., Radbruch, A. and Cooper M. D.: Differential surrogate light chain expression governs B cell differentiation. Blood 99:2 459-2467, 2002. (PubMed)

Stephan, R. P., Elgavish, E., Karasuyama, H., Kubagawa, H., Cooper, M. D.: Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice. J Immunol. 167: 3734-3739, 2001. (PubMed)

Kubo, S., Matsuoka, K., Taya, C., Kitamura, F., Takai, T., Yonekawa, H. and Karasuyama, H.: Drastic up-regulation of high affinity IgE receptor on mast cells is induced by IgE binding through stabilization and accumulation of the receptor on the cell surface. J. Immunol. 167: 3427-34, 2001. (PubMed)

Kinoshita, T., Nagata, K., Sorimachi, N., Karasuyama, H., Sekiguchi, T., Miyajima,A.: Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment. Exp. Hematol. 299: 1091-7, 2001. (PubMed)

Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A.: Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin. Exp. Immunol. 124: 461-464, 2001. (PubMed)

Kouro, T., Nagata, K., Takaki, S., Karasuyama, H. and Takatsu, K.: Bruton's tyrosine kinase (Btk) is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int. Immunol. 13: 485-493, 2001. (PubMed)

Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J. Immunol. 166: 3771-9, 2001. (PubMed)

Kohara, Y., Tanabe, K., Matsuoka, K., Kanda, N., Matsuda, H., Karasuyama, H. and Yonekawa, H.: A major determinant QTL responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on chromosome 9. Immunogenetics 53: 15-21, 2001. (PubMed)

Fujimoto T, Kawashima H, Tanaka T, Hirose M, Toyama-Sorimachi N, Matsuzawa Y, Miyasaka M.: CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int. Immunol. 13: 359-66, 2001. (PubMed)

Kubo, S. Matsuoka, K, Taya, C, Kitamura, F, Yonekawa, H. and Karasuyama, H.: IgE stabilizes its high affinity receptor (FceRI) on mast cells in vitro and ex vivo: The mechanism of IgE-mediated FceRI up-regulation and its physiological meaning. In Activating and inhibitory immunoglobulin-like receptors. Eds. Cooper M.D., Takai, T, Ravetch, J.V. Springer-Verlag Tokyo, pp183-188, 2001.

Maki, K., Nagata, K, Kitamura, F., Takemori, T. and Karasuyama, H.: The preBCR signaling through Igb regulates locus accessibility for ordered immunoglobulin gene rearrangements. In Activating and inhibitory immunoglobulin-like receptors: Eds. Cooper, M. D., Takai, T., Ravetch, J. V., Springer-Verlag, Tokyo, pp153-158, 2001.

Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Functional characterization of mouse CD94 by using a novel monoclonal antibody. In Activating and inhibitory immunoglobulin-like receptors. Eds. Cooper, M. D., Takai, T., Ravetch, J. V., Springer-Verlag, Tokyo, pp85-89, 2001.

Minegishi, Y., Conley, M.E. Negative selection at the pre-BCR checkpoint elicited by human m heavy chain with unusual CDR3 regions. Immunity 14, 631-641, 2001. (PubMed)

Wang, D., Boylin, E.C., Minegishi, Y., Wen, R., Smith, C.I., Ihle, J.N., Conley, M.E. Variations in the human phospholipase Cgamma2 gene in patients with B-cell defects of unknown etiology. Immunogenetics. 53, 550-556, 2001. (PubMed)

Rapalus L., Minegishi Y., Lavoie A., Cunningham-Rundles C., Conley M.E. Analysis of SWAP-70 as a Candidate Gene for Non-X-Linked Hyper IgM Syndrome and Common Variable Immunodeficiency. Clin. Immunol. 101: 270-275, 2001. (PubMed)

Ohnishi, K., Melchers, F., Karasuyama, H. and Shimizu, T.: The identification of a non-classical cadherin expressed during B cell development and its interaction with surrogate light chain. J. Biol. Chem. 275: 31134-44, 2000. (PubMed)

Ellinger-Ziegelbauer, H., Karasuyama, H.,Yamada, E., Tsujikawa, K., Todokoro, K. and Nishida, E.: Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells 5: 491-498, 2000. (PubMed)

Nagaoka, H., Takahashi, Y., Hayashi, R., Nakamura, T., Ishii, K., Matsuda, J., Ogura, A., Shirakata, Y., Karasuyama, H., Sudo, T., Nishikawa, S., Tsubata, T., Mizuochi, T., Asano, T., Sakano, H. and Takemori, T.: Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J. Exp. Med. 192: 171-182, 2000. (PubMed)

Nomura, K., Kanegane, H., Karasuyama, H., Tsukada, S., Agematsu, K., Murakami, G., Sakazume, S., Sako, M., Tanaka, R., Kuniya, Y., Komeno, T., Ishihara, S., Hayashi, K., Kishimoto, T. and Miyawaki, T.: Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood 96: 610-617, 2000. (PubMed)

Tagawa, K., Taya, C., Hayashi, Y., Nakagawa, M., Ono, Y., Fukuda, R., Karasuyama, H., Toyama-Sorimachi, N., Katsui, Y., Hata, S., Ishiura, S., Nonaka, I., Seyama, Y., Arahata, K., Yonekawa, H., Sorimachi, H. and Suzuki, K.: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum. Mol. Genet. 9: 1393-1402, 2000. (PubMed)

Donohoe, M. E., Beck-Engeser, G. B., Lonberg, N., Karasuyama, H., Riley, R. L., Jak, H-M., and Blomberg, B. B.: Transgenic human l5 rescues the murine l5 nullizygous phenotype. J. Immunol. 164: 5269-5276, 2000. (PubMed)

Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Immunoglobulin b signaling regulates locus accessibility for ordered Ig gene rearrangements. J. Exp. Med. 191: 1333-1340, 2000. (PubMed)

Nagata, K., Tsuji, T., Matsushima, K., Hanai, N. and Irimura, T.: Redistribution of P-Selectin conunter-ligands is prerequisite to superoxide anion production and release by human neutrophils. Int. Immunol. 12:487-492, 2000. (PubMed)

Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N. and Karasuyama, H.: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS lett. 468: 234-238, 2000. (PubMed)

Minegishi, Y., Lavoie, A., Cunningham-Rundles, C., Bedard, P.M., Hebert, J., Louise, C., Dan, K., Sedlak, D., Buckley, R.H., Fischer, A., Durandy, A., Conley, M.E. Mutations in AID in patients with Hyper IgM syndrome. Clin. Immunol. 97, 203-210, 2000.(PubMed)

Conley, M.E., Rohrer, J., Minegishi, Y. X-linked agammaglobulinemia. Clin. Rev. Allergy. Immunol. 19, 183-204, 2000. (PubMed)

Conley, M.E., Rohrer, J., Rapalus, L., Boylin, E., Minegishi, Y. Defects in B cell development: Comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse. Immunol. Rev. 178, 75-90, 2000. (PubMed)

Bosma, G. C., Chang, Y., Karasuyama, H. and Bosma, M. J.: Differential effect of an immunoglobulin m transgene on development of pre-B cells in fetal and adult scid mice. Proc. Natl. Acad. Sci. USA. 96: 11952-11957, 1999. (PubMed)

Miyazaki, T., Kato, I., Takeshita, S., Karasuyama, H. and Kudo, A.: l5 is required for rearrangement of the Ig k light chain gene in pro-B cell lines. Int. Immunol. 11: 1195-1202, 1999. (PubMed)

Rolink, A., Andersson, J., Ghia, P., Grawunder, U., Kalberer, C., Karasuyama, H., Oka, Y., ten Boekel, E., Winkler, T. H. and Melchers, F.: Molecular mechanisms guiding B cell development. In Primary immunodeficiency diseases (eds. Ochs, H. D., Smith, E. I. E. and Puck, J. M.) pp.56-65. Oxford University Press, New York, 1999.

Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H. and Karasuyama, H.: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int. Immunol. 11: 987-994, 1999. (PubMed)

Kuramochi, S., Matsuda, Y., Okamoto, M., Kitamura, F., Yonekawa, H. and Karasuyama, H.: Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase and comparative chromosomal mapping of the human, mouse and rat homologues. Immunogenetics 49: 369-375, 1999. (PubMed)

Ishiwatari-Hayasaka, H., Osawa, T., Fujimoto, T., Hirama, T., Toyama-Sorimachi, N. and Miyasaka, M. : Requirements for signal delivery through CD44.; Analysis using CD44-Fas chimeric proteins. J. Immunol. 163: 1258-1264, 1999. (PubMed)

Ye, S. K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I. L., Honjo, T. and Ikuta, K. : Induction of germline transcription in the TCRg locus by Stat5; implications for accessibility control by the IL-7 receptor. Immunity 11: 213-223, 1999. (PubMed)

Yoshida, H., Honda, K., Shinkura, R., Adachi, S., Nishikawa, S., Maki, K., Ikuta, K. and Nishikawa, S.I.: IL-7 receptor a+ CD3- cells in the embryonic intestine induces the organizing center of Peyers patches. Int. Immunol. 11: 643-655, 1999. (PubMed)

Abe, K., Matsuoka, K., Inoue, N., Taga, M. and Kato, T.: Messenger RNA of neuronal nitric oxide synthase is expressed and possibly functions in mouse oocytes and embryos during preimplantation development. Biomed. Res. 20: 61-65, 1999.

Yamaguchi, M., Machida, H., Korenaga, R., Toyama-Sorimachi, N., Ando, J., Miyasaka, M., Matsumoto, T., Nakano, H., Kumada, K., Takeda, M.: The effect of flow on the neutrophil-mediated Ca2+ responses in human vascular endothelial cells stimulated by endotoxin. Surg. Today 29: 966-969, 1999. (PubMed)

Rohrer, J., Minegishi, Y., Richter, D., Eguiguren, J., Conley, M.E. Unusual mutations in Btk: An insertion a duplication, an inversion, and four large deletions. Clin. Immunol. 90, 28-37, 1999. (PubMed)

Minegishi, Y., Hendershot, L. M., Conley, M. E. Novel mechanisms control the folding and assembly of l5/14.1 and VpreB to produce an intact surrogate light chain. Proc. Natl. Acad. Sci. USA. 96. 3041-3046. 1999. (PubMed)

Minegishi, Y., Coustan-Smith, E., Rapalus, L. Ersoy, F., Campana, D., Conley, M.E. Mutations in Iga (CD79a) result in a complete block in B-cell development. J. Clin. Invest. 104, 1115-1121, 1999. (PubMed)

Conley, M.E., Rapalus, L., Boylin, E.C., Rohrer, J., Minegishi, Y. Gene conversion events contribute to the polymorphic variation of the surrogate light chain gene l5/14.1. Clin. Immunol. 93, 162-167, 1999. (PubMed)

Minegishi, Y., Rohrer, J., Coustan-Smith, E., Lederman, H.M., Pappu, R., Campana, D., Chan, A.C., Conley, M.E. An essential role for BLNK in human B cell development. Science, 286, 1954-1957, 1999. (PubMed)

Minegishi, Y., Rohrer, J., Conley, M.E. Defects in B cell development-Recent progress in diagnosis and therapy. Curr. Opin. Pediatr. 11, 528-532, 1999.. (PubMed)

Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., Fujimoto, J. and Karasuyama, H.: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human preB cell receptor. Blood 92: 4317-4324, 1998. (PubMed)

Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M, Groudine, M. and Igarashi, K.: Identification of Bach2 as a B cell-specific partner for small Maf proteins that negatively regulates the immunoglobulin heavy chain gene 3 enhancer. EMBO J. 17: 5734-5743, 1998. (PubMed)

Kuida, K., Haydar, T. F., Kuan, C-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P. and Flavell, R. A.: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998. (PubMed)

Meffre, E., Papavasiliou, F., Cohen, P., de Bouteiller, O., Bell, D., Karasuyama, H., Schiff, C., Banchereau, J., Liu, Y. J. and Nussenzweig, M. C.: Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J. Exp. Med. 188: 765-772, 1998. (PubMed)

Karasuyama, H. and Takatsu, K.: B cell activation. In Encyclopedia of Immunology. 2nd Ed. (eds. Roitt, I. M. and Delves, P. J.) Academic Press, London. Vol. 1, pp349-352, 1998.

Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W. H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M. and Shimizu, T. : Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187: 1779-88, 1998. (PubMed)

Adachi, S., Yoshida, H., Honda, K., Maki, K., Saijo, K., Ikuta, K., Saito, T. and Nishikawa, S. I. : Essential role of IL-7 receptor a in the formation of Peyer's patch anlage. Int. Immunol. 10: 1-7, 1998. (PubMed)

Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F., Tsubio, H., Ando, J., Sakurai, T., Morii, N., Narumiya, S. and Miyasaka, M. : Analysis of Intracellular signal-transducing elements involved in transendothelial migration of lymphoma cells. Jpn. J. Cancer Res. 89: 571-577, 1998. (PubMed)

Tsuzuki, S., Toyama-Sorimachi, N., Kitamura, F. and Miyasaka, M. : FK506 (tacrolimus)inhibits wxtravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration. FEBS Lett. 430: 414-418, 1998. (PubMed)

Minegishi, Y., Coustan-Smith, E., Wang, Y.H., Cooper, M.D., Campana, D., Conley, M.E. Mutations in the human _5/14.1 gene result in B cell deficiency and agammaglobulinemia. J. Exp. Med. 187, 71-77, 1998. (PubMed)

Conley, M.E., Mathias, D., Treadaway, J., Minegishi, Y., Rohrer, J. Mutations in Btk in patients with presumed X-linked agammaglobulinemia. Am. J. Hum. Genet. 62, 1034-1043, 1998. (PubMed)

Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H.: The Iga/Igb heterodimer on m-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997. (PubMed)

Kuramochi, S. Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama, H.: LOK, a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. In Kinases and phosphatases in lymphocyte and neuronal signaling (eds. Yakura, H.) Springer-Verlag. pp354, 1997.

Koyama, M., Ishihara, K., Karasuyama, H., Cordell, J. L., Iwamoto, A., and Nakamura, T. CD79a/CD79b heterodimers are expressed on pro-B cell surfaces without associated m heavy chain. Int. Immunol. 9: 1767-1772, 1997. (PubMed)

Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama, H.: LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J. Biol. Chem. 272: 22679-22684, 1997. (PubMed)

Emoto, K., Toyama-Sorimachi, N., Karasuyama, H., Inoue, K. and Umeda M.: Exposure of phosphatidylethanolamine of the surface of apoptotic cells. Exp. Cell Research 232: 430-434, 1997. (PubMed)

Karasuyama, H., Nakamura, T., Nagata, K., Kuramochi, S., Kitamura, F. and Kuida, K.: The roles of preB cell receptor in early B cell development and its signal transduction. Immunol. Cell Biol. 75: 209-216, 1997. (PubMed)

Shimabukuro, K., Toyama-Sorimachi, N., Ozaki, Y., Goi, T., Furukawa, K., Miyasaka, M. and Aso, T.: The expression patterns of standard and variant CD44 molecules in normal uterine and cervical cancer. Gynecologic Oncology, 64: 26-34, 1997. (PubMed)

Nakagawara, A., Nakamura, Y., Ikeda, H., Hiwasa, T., Kuida, K., Su, M. S.-S., Zhao, H., Cnaan, A. and Sakiyama, S.: High levels of expression and nuclear localization of ICE and CPP32 in neuroblastomas regressing in vivo. Cancer Research, 57: 4578-4584, 1997. (PubMed)

Chin, Y. E., Kitagawa, M., Kuida, K. and Flavell, R. A. and Fu, X. Y.: Activation of STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol. 17: 5328-5337, 1997. (PubMed)

Toyama-Sorimachi, N., Kitamura, F., Habuchi, H., Tobita, Y., Kimata, K. and Miyasaka, M. : Widespread expression of chondroitin sulfate type serglycins with CD44 binding ability in hemopoietic cells. J. Biol. Chem. 272: 26714-26719, 1997. (PubMed)

Ohsugi, M., Kuramochi, S., Matsuda, S. and Yamamoto, T. : Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase which is specifically expressed in spermatocytes. J. Biol. Chem. 272: 33092-33099, 1997. (PubMed)

Kubo, S., Hasegawa, A., Hashimoto, K., Shimizu, C., Kubo, M., Tada, T. and Nakayama, T. : CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRVb11+. Immunolgy 92: 437-446, 1997. (PubMed)

Amling, M., Neff, L., Tanaka, S., Inoue, D., Kuida, K., Weir, E., Philbrick, W. M., Broadus, A. E. and Baron, R.: Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J. Cell Biol. 136: 205-213, 1997. (PubMed)

Ikeda, H., Nakamura, Y., Hiwasa, T., Sakiyama, S., Kuida, K., Su, M. S., Nakagawara, A.: Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis. Eur. J. Cancer 33: 2081-2083, 1997. (PubMed)

Fantuzzi, G., Ku, G., Harding, M. W., Livingston, D. J., Sipe, J. D., Kuida, K., Flavell, R. A., Dinarello, C. A.: Response to local inflammation of IL-1b-converting enzyme- deficient mice. J. Immunol. 158: 1818-1824, 1997. (PubMed)

Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R. A., Sato, V., Harding, M. W., Livingston, D. J. and Su, M. S.: Activation of interferon-g inducing factor mediated by interleukin-1b converting enzyme. Science 275: 206-209, 1997. (PubMed)

Yoshida, K., Minegishi, Y., Okawa, H., Yata, J., Tokoi, S., Kitagawa, T., Utagawa, T. Epstein-Barr virus-associated malignant lymphoma with macroamylasemia and monoclonal gammopathy in a patient with Wiskott-Aldrich syndrome. Pediatr. Hematol. Oncol. 14, 85-89, 1997. (PubMed)

Kuida, K., Zheng, T. S., Na, S., Kuan C., Yang, D., Karasuyama, H., Rakic, P. and Flavell, R. A.: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372, 1996. (PubMed)

Karasuyama, H., Rolink, A. and Melchers, F.: Surrogate light chain in B cell development. Adv. Immunol. 63: 1-41, 1996. (PubMed)

Eynon, E. E., Kuida, K., and Flavell, R. A. : Disruption of Cytokine Signaling in Lymphoid Development: Unique Contributions of the Common Cytokine Gamma Chain and the Jak3 Kinase. J. Interferon Cytokine Res. 16: 677-684, 1996. (PubMed)

Maki, K., Sunaga, S., Komagata, Y., Kodaira, Y., Mabuchi, A., Karasuyama, H., Yokomuro, K., Miyazaki, J. and Ikuta, K.: Interleukin 7 receptor-deficient mice lack gd T cells. Proc. Natl. Acad. Sci. USA. 93: 7172-7177, 1996. (PubMed)

Minegishi, Y., Akagi, K., Nishikawa, K., Okawa, H., Yata, J. Analysis of the CDR3 region of the rearranged IgH chain genes in patients with severe combined immunodeficiency and severe lymphopenia. J. Immunol. 156, 4666-4671, 1996. (PubMed)

Yel, L., Minegishi, Y., Coustan-Smith, E., Buckley, R. H., Trubel, H., Pachman, L. M., Kitchingman, G. R., Campana, D., Rohrer, J., Conley, M. E. Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. New Engl. J. Med. 335, 1486-1493, 1996. (PubMed)

Winkler, T. H., Rolink, A., Melchers, F. and Karasuyama, H.: Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur. J. Immunol. 25: 446-450. 1995. (PubMed)

Rolink, A., Andersson, J., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., ten Boeckel, E., Winkler, T. H., and Melchers, F.: B-cell development in mouse and man. The Immunologist 3: 125-151, 1995.

Rolink, A., Ghia, P., Grawunder, U., Haasner, D., Karasuyama, H., Kalberer, C., Winkler, T. and Melchers, F.: In- vitro analyses of mechanisms of B-cell development. Semin. Immunol. 7: 155-167, 1995. (PubMed)

Sawai, H., Yamasaki, N., Shigeta, M., Komori, S., Karasuyama, H., Koyama, K. and Isojima, S.: Direct production of the Fab fragment derived from the sperm immobilized antibody using polymerase chain reaction and cDNA expression vectors. Amer. J. Reprod. Immunol. 34: 26-34. 1995. (PubMed)

Melchers, F., Rolink, A., Grawunder, U., Winkler, T.H., Karasuyama, H., Ghia, P. and Andersson, J.: Positive and negative selection events during B lymphopoiesis. Curr. Opin. Immunol. 7: 214-227. 1995. (PubMed)

Suwa, H., Tanaka, T., Kitamura, F., Shiohara, T., Kuida, K., Miyasaka, M.: Dysregulated expression of the IL-2 receptor b-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice.: Int. Immunol. 7: 1441-1449, 1995. (PubMed)

Toyama-Sorimachi, N., Sorimachi, H., Tobita, Y., Kitamura, F., Yagita, H., Suzuki, K., Miyasaka, M.: A novel ligand for CD44 is serglycin, a hematopoietic cell lineage- specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J. Biol. Chem. 270: 7437-7444, 1995. (PubMed)

Ando, J., Tsuboi, H., Korenaga, R., Takada, Y., Toyama-Sorimachi, N., Miyasaka, M., Kamiya, A.: Down-regulation of vascular adhesion molecule-1 by fluid shear stress in cultured mouse endothelial cells. Ann. N. Y. Acad. Sci. 748: 148-156, 1995. (PubMed)

Minegishi, Y., Ishii, N., Maeda, H., Takagi, S., Tsuchida, M., Okawa, H., Sugamura, K., Yata J. Three novel mutations in the interleukin-2 receptor gamma chain gene in four unrelated patients with X-linked severe combined immunodeficiency. Hum. Genet. 96, 681-683, 1995. (PubMed)

Minegishi, Y., Ishii, N., Okawa, H., Sugamura, K., Yata, J. T cell reconstitution by haploidentical bone marrow transplantation does not restore the diversification of the Ig heavy chain gene in patients with X-linked SCID. Bone Marrow Transplant. 16, 801-806, 1995. (PubMed)

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