1. Establishment of allergen-specific IgE transgenic mice as animal models of allergy
Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H. and Karasuyama, H.: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int. Immunol. 11: 987-994, 1999. (PubMed)
2. Chronic allergic inflammation mediated by basophils independently of T cells and mast cells
Sato, E., Hirahara, K., Wada, Y., Yoshitomi, T., Azuma, T., Matsuoka, K., Kubo, Taya, C., Yonekawa, H., Karasuyama, H. and Shiraishi, A.: Chronic inflammation in skin can be induced in IgE transgenic mice by a single challenge of multivalent antigen. J. Allergy Clin. Immunol. 111: 143-148, 2003. (PubMed)
Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., and Karasuyama, H.: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23: 191-202, 2005. (PubMed)
Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 110: 913-920, 2007. (PubMed)
Kojima, T., Obata, K., Mukai, K., Sato, S., Takai , T. , Minegishi, Y., and Karasuyama, H .: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J. Immunol. 179: 7093-7100, 2007 (PubMed).
Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H .: Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis. Immunity 2008 ( doi:10.1016/j.immuni.2008.02.008, published online on March 13, 2008 ) (PubMed).
3. Regulation of the high affinity receptor IgE (FceRI) expression on the cell surface
Kubo, S., Matsuoka, K., Taya, C., Kitamura, F., Takai, T., Yonekawa, H. and Karasuyama, H.: Drastic up-regulation of high affinity IgE receptor on mast cells is induced by IgE binding through stabilization and accumulation of the receptor on the cell surface. J. Immunol. 167: 3427-34, 2001. (PubMed)
Kubo, S., Nakayama, T., Matsuoka, K., Yonekawa, H., Karasuyama, H.: Long-term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J. Immunol. 170: 775-780, 2003. (PubMed)
Kubota, T., Mukai, K., Minegishi, Y., and Karasuyama, H.: Different stabilities of the structurally-related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their α chains. J. Immunol. 176: 7008-7014, 2006. (PubMed)