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Hajime Karasuyama

1972 - 1978 Tokyo Medical and Dental University School of Medicine MD. 1978.

1978 - 1980 Internship at Tsukuba University Hospital

1980 - 1984 Postgraduate, Department of Immunology, Faculty of Medicine,
         University of Tokyo PhD. 1984.

1984 - 1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland

1987 - 1990 Research Associate, Department of Immunology, Faculty of Medicine,
         University of Tokyo

1990 - 1995 Scientific member, Basel Institute for Immunology, Basel, Switzerland

1995 - 2000 Head, Department of Immunology,
         The Tokyo Metropolitan Institute of Medical Science

2000 - present Professor, Department of Immune Regulation
           Tokyo Medical and Dental University, Graduate School

Main publications

Karasuyama, H., Wada, T., Yoshikawa, S., and Obata, K.: Emerging roles of basophils in protective immunity against parasites. Trends Immunol . 32: 125-130, 2011. (PubMed)

Karasuyama, H., Mukai, K., Obata, K., Tsujimura, Y., and Wada, T.: Nonredundant roles of basophils in immunity. Annu. Rev. Immunol . 29: 45-69, 2011. (PubMed)

Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., Nonoyama, S., Karasuyama, H ., and Minegishi, Y.: Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med . 208: 235-249, 2011. (PubMed)

Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., Kawano, Y., Minegishi, Y., Yokozeki, H., Watanabe, N., and Karasuyama, H.: Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest . 120: 2867-2875, 2010. (PubMed).

Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I., and Karasuyama, H .: Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med . 206: 1291-1301, 2009. (PubMed).

Karasuyama, H., Mukai, K., Tsujimura, Y. and Obata, K.: Newly-discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol . 9: 9-13, 2009. (PubMed).

Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H .: Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis. Immunity 28: 581-589, 2008 (PubMed).

Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H .: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448: 1058-1062, 2007 (PubMed).

Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, T., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H., D., Renner, E., D., Jansson, A., Belohradsky, B., H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., and Karasuyama, H.: Human Tyk2 deficiency reveals requisite roles of Tyk2 in multiple cytokine signals involved in innate and acquired immunity.Immunity 25: 745-755, 2006(PubMed)

Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., and Karasuyama, H.: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23: 191-202, 2005 (PubMed)

Toyama-Sorimachi, N., Tsujimura, Y., Maruya,M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K. and Karasuyama, H.: Ly49Q, a novel member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. Proc. Natl. Acad. Sci. USA. 101: 1016-1021, 2004 (PubMed)

Saijo, K., Schmedt, C., Su, I-h., Karasuyama, H., Lowell, C.A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A.: Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development. Nature Immunol. 4: 274-279, 2003. (PubMed)

Kubo, S., Matsuoka, K., Taya, C., Kitamura, F., Takai, T., Yonekawa, H. and Karasuyama, H.: Drastic up-regulation of high affinity IgE receptor on mast cells is induced by IgE binding through stabilization and accumulation of the receptor on the cell surface. J. Immunol. 167: 3427-34, 2001. (PubMed)

Toyama-Sorimachi, N., Taguchi, Y., Yagita, H., Kitamura, F., Kawasaki, A., Koyasu, S. and Karasuyama, H.: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J. Immunol. 166: 3771-9, 2001. (PubMed)

Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Immunoglobulin b signaling regulates locus accessibility for ordered Ig gene rearrangements. J. Exp. Med. 191: 1333-1340, 2000. (PubMed)

Matsuoka, K., Taya, C., Kubo, S., Toyama-Sorimachi, N., Kitamura, F., Ra, C., Yonekawa, H. and Karasuyama, H.: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int. Immunol. 11: 987-994, 1999. (PubMed)

Tsuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Kuida, K., Fujimoto, J. and Karasuyama, H.: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human preB cell receptor. Blood 92: 4317-4324, 1998. (PubMed)

Kuida, K., Haydar, T. F., Kuan, C-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P. and Flavell, R. A.: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998. (PubMed)

Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H: The Iga/Igb heterodimer on m-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997. (PubMed)

Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E. and Karasuyama, H.: LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J. Biol. Chem. 272: 22679-22684, 1997. (PubMed)

Kuida, K., Zheng, T. S., Na, S., Kuan C., Yang, D., Karasuyama, H, Rakic, P. and Flavell, R. A.: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384: 368-372, 1996. (PubMed)

Karasuyama, H, Rolink, A. and Melchers, F.: Surrogate light chain in B cell development. Adv. Immunol. 63: 1-41, 1996. (PubMed)

Karasuyama, H, Rolink, A., Shinkai, Y., Young, F., Alt, F. W., and Melchers, F. : The expression of VpreB/l5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77: 133-143, 1994. (PubMed)

Karasuyama, H, Rolink, A., and Melchers, F.: A complex of glycoproteins is associated with VpreB/ l5 surrogate light chain on the surface of m heavy chain-negative early precursor B cell lines. J. Exp. Med. 178: 469-478, 1993. (PubMed)

Golumbek, P. T., Lazenby, A. J., Levitsky, H. I., Jaffee, L. H., Karasuyama, H., Baker, M. and Pardoll, D.: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254: 713-716, 1991. (PubMed)

Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y. and Melchers, F.: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells "in vitro" and "in vivo". EMBO J. 10: 327-336, 1991. (PubMed)

Karasuyama, H., Kudo, A. and Melchers, F.: The proteins encoded by the VpreB and l5 pre-B cell-specific genes can associate with each other and with m heavy chain. J. Exp. Med. 172: 969-972, 1990. (PubMed)

Fearon, E. R., Pardoll, D. M., Itaya, T., Golumbek, P., Levitsky, H. I., Simons, J. W., Karasuyama, H., Vogelstein, B. and Frost, P.: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an anti-tumor response. Cell 60: 397-403, 1990. (PubMed)

Tohyama, N., Karasuyama, H. and Tada, T.: Growth autonomy and tumorigenicity of interleukin-6 dependent cells transfected with IL-6 cDNA. J. Exp. Med. 171: 389-400, 1990. (PubMed)

Karasuyama, H., Tohyama, N. and Tada, T.: Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med. 169: 13-25, 1989. (PubMed)

Karasuyama, H., Rolink, A. and Melchers, F.: Recombinant interleukin 2 or 5, but not 3 or 4 induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts. J. Exp. Med. 167: 1377-1390, 1988. (PubMed)

Staerz, U. D., Karasuyama, H. and Garner, A. M.: Cytotoxic T lymphocytes against a soluble protein. Nature 329: 449-451, 1987. (PubMed)

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