1. Bio-functionalization of metals with electrochemical surface modification
Bio-functionalization of metals is investigated with surface treatment techniques such as molecule immobilization and anodic oxidation. These surface treatments make it possible to inhibit protein adsorption, platelet adhesion and biofilm formation, and to enhance wear resistance and hard-tissue compatibility.
2. Development of novel alloys and porous composites for biomedical applications
Novel alloy systems for biomedical applications are designed from the viewpoints of mechanical properties and biocompatibility. Co-Cr-Mo alloys having high strength and ductility for dental applications are developed. The porous alloys having low Young’s modulus are obtained with selective laser melting technique.
3. Development of Zr-based alloys for minimizing MRI artifacts
Zr-based alloys with low magnetic susceptibility, high strength and corrosion resistance are investigated for minimizing MRI artifacts by controlling their microstructure and constituent phase for aneurysm clips, artificial joints, and dental implants, etc.
4. Effort to minimalize metal allergy
Countermeasure techniques for metal ion release from metallic biomaterials which causes metal allergy are investigated. Novel reagents of patch testing for the detection of sensitization to metal ions are developed.