top > Div. of Biofunctional Molecules > Dept. of Applied Functional Molecules

  • Div. of Biomedical Materials
  • Div. of Biofunctional Restoration
  • Div. of Medical Devices
  • Div. of Biomolecular Chemistry
  • Medical and Dental Device Technology Incubation Center
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Member

A.Kishida Prof
Y.Kadoma Senior Assoc Prof
A.Ohsaki Assist Prof
T.Kimura Assist Prof
K.Kojima Eng Official

Research Theme

  1. Development of a novel tissues with a high reliance for regenerative medicine (Bioscaffold)
    A novel technology was researchd for preparing the acellular tissue without using any detergent.
  2. Development of a molecular assembly using ultra-high pressure technology
    The molecular assembly was obtained by static ultra-high pressure (10,000atm). Using this technology, synthetic gene vector is being.
  3. Development of high-performance adhesive resins (Adhesion promoting polymers for precious metals)
    Highly efficient adhesive monomers for precious metals are being developed to obtain stable bonding between resins and precious metals in the oral cavity.
  4. Drug discovery from tropical resources
    We found new agents such as anti-Helicobacter pylori, anti-cancer, anti-Alzheimer disease from tropical resources.

Publications

  1. M.Okada, S.Yasuda, T.Kimura, M.Iwasaki, S.Ito, A.Kishida, T.Furuzono, Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities, J.Biomed. Mater.Res. Part A 76A(1): 95-101, 2006
  2. C.Yoshikawa, A.Goto, Y.Tsujii, T.Fukuda, T.Kimura, K.Yamamoto, A.Kishida, Protein Repellency of Well-Defined，Concentrated Poly(2-hydroxyethyl methacrylate) Brushes by the Size-Exclusion Effect, Macromolecules 39(6): 2284-2290, 2006
  3. K. Nam, T. Kimura, A. Kishida, Influence of Cross-linking on Physiocochemical and Biological Properties of Collagen-Phospholipid Polymer Hybrid Gel, Transactions of the Materials Research Society of Japan, 31(3): 735-738, 2006
  4. K. Nam, T. Kimura, A. Kishida, Preparation and cheracterization of cross-linked collagen-phospholid polymer hybrid gel" Biomaterials 28(1): 1-8, 2007, Online published Sep 7, 2006
  5. T. Kimura, K. Nam, S. Mutsuo, H. Yoshizawa, M. Okada, T. Furuzono, T. Fujisato, A.Kishida, Gene Transfection Using Inorganic Particle/PVA/DNA Complexes Prepared by Ultra High Pressure Technology, Molecular Therapy 13(Suppl 1): S75-75, 2006
  6. T. Fujisato, M. Yin, K. Minatoya, K Niwaya, A. Kishida, T. Nakatani, S. Kitamura, Host cell infiltration to tranplanted acellular allografts in porcine model, Tissue Eng, 12(4): 1077-1077, 2006
  7. T. Kimura, S. Iwai, T. Moritan, K. Nam, S. Mutsuo, H. Yoshizawa, M. Okada, T. Furuzono, T. Fujisato, A. Kishida, Preparation of PVA/DNA hydrogels via hydrogen bonds with ultra high pressurization and controlled release of DNA from the hydrogels for gene delivery, J. Artif. Organs, in press
  8. T. Kimura, S. Funamoto, A. Kishida, Gene transfection on the tissue engineered bone decellularized by ultra high hydrostatic pressurization, Controlled Release Society Newsletter, to be submitted
  9. Inatsu S, Ohsaki A, Nagata K. Idebelone acts against growth of Helicobacter pylori by inhibiting its respiration. Antimicrobial Agents and Chemother 2006:50: 2237-9.
  10. Isobe T, Doe M, Morimoto Y, Nagata K, Ohsaki A. The anti-Helicobacter pylori flavones in Brazilian plant, Hyptis fasciculate, and the activity of methoxyflavones. Biol Pharm Bull 2006: 29:1039-41.
  11. Kagata T, Saito S, Shigemori H, Ohsaki A, Ishiyama H, Kubota T, Kobayashi J. Paratunamides A-D, New Oxindole Alkaloids from Cinnamodendron axillare. J Nat Prod 2006:69:1517-21.
  12. Ohsaki A, Yokoyama R, Miyatake H.; Fukuyama, Y. Two Diterpene Rhamnosides, Mimosasides B and C, from Mimosa hostilis. Chem Pharm Bull, 54:1728-9. 2006

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