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2017

4. Chen Z, Wang Y, Kuwana M, Xu X, Hu W, Feng X, Wang H, Kimura A, Sun L. HLA-DRB1*04:01 and *12:02 as genetic risk factors for the development of anti-MDA5 antibodies in patients with dermatomyositis. J Rheumatol, In Press

3. Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K. ELABELA-APJ axis protects from pressure overload heart failure and Angiotensin II-induced cardiac damage. Cardiovasc Res, Epub on Mar. 23, 2017. (doi: 10.1093/cvr/cvx061)

2. #Gregson, JM, #Freitag DF, Surendran P, Nathan O. Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P, Staley JR, Willeit P, Nielsen SF, Caslake M, Trompet S, Polfus LM, Kuulasmaa K, Kontto J, Perola M, Blankenberg S, Veronesi G, Gianfagna F, Männistö S, Kimura A, Reilly DF, Mijatovic V, Munroe PB, Ehret GB, Uria-Nickelsen P, Malarstig A, Dehghan A, Sasaoka T, Kato N, Yamada Y, Kee F, Müller-Nurasyid M, Ferrières J, Arveiler D, Salomaa V, Thompson SG, Jukema JW, Packard CJ, Majumder AAS, Alam DS, Deloukas P, Schunkert H, Samani NJ, Kathiresan S, Nordestgaard BG, #Saleheen D, #Howson JMM, #Angelantonio ED, #Butterworth AS, #Danesh J. Genetic invalidation of Lp-PLA2 as a therapeutic target: lessons for future cardiovascular trials. Eur J Prev Cardiol 24(5): 492-504, 2017. (#; equal contribution)

1.  Kikkawa E, Tanaka M, Naruse TK, Tsuda TT, Tsuda M, Murata K, Kimura A. Diversity of MHC class I alleles in Spheniscus humboldti. Immunogenetics 69(2): 113-124, 2017.

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2016

8.  Ishii H, Matsuoka S, Nomura T, Nakamura M, Shiino T, Sato Y, Iwata-Yoshikawa N, Hasegawa H, Mizuta K, Sakawaki H, Miura T, Koyanagi Y, Naruse TK, Kimura A, Matano T. Association of lymph-node antigens with lower Gag-specific central@memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model. Sci Rep 6: 30153, 2016.

7. Oikawa M, Sakamoto N, Kobayashi A, Suzuki A, Yoshihisa A. Yamaki T, Nakazato K, Suzuki H, Saitoh S, Kiko Y, Nakano H, Hayashi T, Kimura A, Takeishi Y. Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and Zebra body. BMC Cardiovasc Disord 16(1): 83, 2016.

6. Kawai H, Morimoto S, Takakuwa Y, Ueda A, Inada K, Sarai M, Arimura T, Mutoh T, Kimura A, Ozaki Y. Hypertrophic cardiomyopathy accompanied by spinocerebellar atrophy with a novel mutation in troponin I gene. Int Heart J 57(4): 507-510, 2016.

5. #Iseda S, #Takahashi N, #Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H. Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization. J Virol 90(14): 6276-6290, 2016. (#; equal contribution)

4.  Naruse TK, Sakurai D, Ohtani H, Sharma G, Sharma SK, Vajpayee M, Narinder KM, Kaur G, Kimura A. APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population. J Hum Genet 61(3): 263-265, 2016.

3.  Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J@37(18): 1469-1475, 2016.

2.  Kimura A. Molecular genetics and pathogenesis of cardiomyopathy. J Hum Genet 61(1): 41-50, 2016.

1. Tanaka T, Kimura A. Cardiovascular genetics. J Hum Genet 61(1): 1, 2016.

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2015

5.  Kikkawa E, Tsuda TT, Hosomichi K, Tsuda M, Inoko H, Kimura A, Naruse TK, Murata K. Molecular evolutionary analysis of seven species of penguins (order: Sphenisciformes) in MHC class I gene. [in Japanese] MHC 22(3): 156-163, 2015.

4.  Nomura T, Yamamoto H, Ishii H, Akari H, Naruse TK, Kimura A, Matano T. Broadening of virus-specific CD8+ T-cell responses is indicative of residual viral replication in aviremic SIV controllers. PLoS Pathog 11(11): e1005247, 2015.

3.   #Kadota C, #Arimura T, Hayashi T, Naruse TK, Kawai S, Kimura A. Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations. J Hum Genet 60 (10): 641-645, 2015 (#; equal contribution)

2.   Sakurai D, Iwatani Y, Ohtani H, Naruse TK, Terunuma H, Sugiura W, Kimura A. APOBEC3H polymorphisms associated with susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics 67(4): 253-257, 2015.

1.    Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N. A novel mutation in a-myosin heavy chain gene is associated with sick sinus syndrome. Circ Arrhythm Electrophysiol 8(2): 400-408, 2015.

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2014

10. Tanaka A, Yuasa S, Mearini G, Egashira T, Seki T, Kodaira M, Kusumoto D, Kuroda Y, Okata S, Suzuki T, Arimura T, Makino S, Kimura K, Kimura A, Furukawa T, Carrier L, Nobe K, Fukuda K. ET-1 induces myofibrillar disarray and contractile vector in hypertrophic cardiomyopathy-iPS cell-derived cardiomyocytes. J Am Heart Assoc 3(6): e001263, 2014.

9. Nomura T, Yamamoto H, Takahashi N, Naruse TK, Kimura A, Matano T. Identification of SIV Nef CD8 T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model. Biochem Biophys Res Commun 450(2): 942-947, 2014.

8. #Makita N, #Yagihara N, #Crotti L, #Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, Kääb S, Guichney P, Bhuiyan ZA, Shimizu W, Watanabe H, Chazin WJ, George AL. Novel calmodulin (CALM2) mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet 7(4): 466-474, 2014. (#; equal contribution)

 7. Okada S, Suzuki Y, Arimura T, Kimura A, Narumi H, Hasegawa S. A novel de novo mutation of b-cardiac myosin heavy chain gene found in a 12-year-old boy with hypertrophic cardiomyopathy. J Genet 93(2): 557-560, 2014.

6DNaruse TK, Akari H, Matano T, Kimura A. Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques. Immunogenetics 66(3):161-170, 2014.

5. #Katsuumi G, #Shimizu W, Watanabe H, Noda T, Nogami A, Ohkubo K, Makiyama T, Takehara N, Kawamura Y, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Makita N, Minamino T. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int J Cardiol 172(2): 519-522, 2014. (#; equal contribution)

4. Kimura A. Departure from the Hardy-Weinberg equilibrium. Gene 537(2): 357, 2014.

3. Nishio A, Noguchi Y, Sato T, Naruse TK, Kimura A, Takagi A, Kitamura K. A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss. Ann Hum Genet 78(2): 83-91, 2014.

2. #Pinós T, #Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A. The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age 36(2): 933-943, 2014. (#; equal contribution)

1. Iwamoto N, Takahashi N, Seki S, Nomura T, Yamamoto H, Inoue M, Shu T, Naruse TK, Kimura A, Matano T. Control of SIV replication by vaccine-induced Gag- and Vif-specific CD8+ T cells. J Virol 88(1): 425-433, 2014.

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2013

19. An J, Kimura A. IkBL mapped within the HLA region is a novel regulator of alternative splicing involved in the pathogenesis of immune-related diseases. MHC 20(3): 191-197, 2013.

18. #Ichihara S, #Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu MF, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M. Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet. 6(6): 569-578, 2013. (#; equal contribution)

17. Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K. Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest. 123(12): 5203-5211, 2013.

16. #Arimura T, #Takeya R, Ishikawa T, Yamano T, Matsuo A, Tatsumi T, Nomura T, Sumimoto H, Kimura A. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor SRF. Circ J 77(12): 2990-2996, 2013. (#; equal contribution)

15. An J, Nakajima T, Shibata H, Arimura T, Yasunami M, Kimura A. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene. J Autoimmun 47: 2533, 2013.

14. Nakane T, Nomura T, Shi S, Nakamura M, Naruse TK, Kimura A, Matano T, Yamamoto H. Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques. PLoS ONE 8(9): e73453, 2013.

13. #Sakurai D, #Zhao J, #Deng Y, Kelly JA, Brown EE, Harley JB, Bae SC, Alarcόn-Riquelme ME, Edberg JC, Kimberly RP, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcón GS, Kaufman KM, Vyse TJ, Jacob CO, Gaffney PM, Sivils KM, James JA, Kamen DL, Gilkeson GS, Niewold TB, Merrill JT, Scofield RH, Criswell LA, Stevens AM21, Boackle SA, Kim JH, Choi J, Pons-Estel BA, Freedman BI, Anaya JM, Martin J, Yu CY, Chang DM, Song YW, Langefeld CD, Chen W, Grossman JM, Cantor RM, Hahn BH, Tsao BP. Preferential Binding to Elk-1 by SLE-Associated IL10 risk allele up-regulates IL10 expression. PLoS Genetics 10, e1003870, 2013.

12. Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am J Hum Genet 93(2): 289-297. 2013.

11. Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F. Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein. Rheumatol 52(10): 1769-1774, 2013.

10.  Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenbu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa T, Nakano T, Yamane Y, Kuba K, Imai Y, Saito N, Bonne G, Kimura A. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc Res 99(3): 382-394, 2013.

9.  #Crocini C, #Arimura T, Reischmann S, Eder A, Braren I, Hansen A, Eschenhagen T, Kimura A, Carrier L, Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. Basic Res Cardiol 103(3): 349, 2013. (#; equal contribution)  

8.  #Nakayama EE, #Nakajima T, Kaur G, Miyama J, Terunuma H, Mehra NK, Kimura A, Shioda T. A naturally occurring single amino acid substitution in human TRIM5ƒż linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection. AIDS Res Hum Retroviruses 29(6): 919-924, 2013. (#; equal contribution)

7.  Chan K, Patel RS, Newcombe P, Nelsone CP, Qasim A, Epstein SE, Burnett S, Vaccarino V, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, Eddine N, Mokhtari NEE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Wittaker JC, Tang WHW, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards MA, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden - a collaborative meta-analysis. J Am Col Cardiol 61(9): 957-970, 2013.

6.  Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL,  Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcón GS, Vyse TJ, Pons-Estel BA, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarcόn-Riquelme ME. Brown EE, Tsao BP. MicroRNA-3148 modulates allelic expression of Toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genetics 9(2): e1003336, 2013.

5.  #Kashiwakura Y, #Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H. CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T cell apoptosis accompanied by downregulation of Bim. Immunology 139(1): 48-60, 2013 (#; equal contribution)

4.  Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T. A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques. PLoS ONE 8(1): e54300, 2013.

3.  Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J 77(4): 959-967, 2013.

2.  Sharma G, Ohtani H, Kaur G, Naruse TK, Sharma SK, Vajpayee M, Kimura A, Mehra NK. Status of TIM-1 exon 4 haplotypes and CD4+T cell counts in HIV-1 seroprevalent North Indians. Hum Immunol 74(2): 163-165, 2013.

1.  Kimura A, Ohtani H, Naruse TK, Nakajima T, Akari H, Mori K, Matano T. Evolutional medicine: an approach to identify the human genome diversity associated with HIV-1/AIDS. In Proceeding of the International Conference on Emerging Frontiers and Challenges in HIV/AIDS Research. (Bandivdekar A, Puri CP, eds.), pp11-23, Varum Enderprises, Mumbai, 2013.

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2012

15. Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice. EMBO J 31(23): 4428-4440, 2012.

14. #Ishikawa T, #Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol 5(6): 1098-1107, 2012.

13. Sato A, Sakamoto N, Ando K, Kaneshiro T, Uekita H, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Sato M, Tamagawa K, Arimura T, Kimura A, Takeishi Y. Dilated phase of hypertrophic cardiomyopathy caused by two different sarcomere mutations, treated with surgical left ventricular reconstruction and cardiac resynchronization therapy with a defibrillator. Intern Med 51(18): 2559-2564, 2012.

12. Xi Y, Ai T, De Lange E, Li Z, Wu G, Brunelli L, Kyle WB, Cheng J, Ackerman MJ, Kimura A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M: Loss-of-function of hNav1.5 by ZASP1-D117N associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol 5(5): 1017-1026, 2012.

11. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol 159(3): 238-240, 2012.

10. Ohtani H, Naruse TK, Iwasaki Y, Ishida T, Akari H, Matano T, Kimura A. Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates. Immunogenetics 64(9): 669-678., 2012.

9. Tabara Y, Kohara K, Miki T; Millennium Genome Project for Hypertension (Fujioka A, Hanada H, Hata A, Hirawa N, Hiura Y, Imai Y, Inoko H, Itoh N, Iwai N, Kulski JK, Kamide K, Kato N, Osaka TK, Kawamoto R, Kawano Y, Kimura A, Kita Y, Kohara K, Kokubo Y, Mano H, Mano S, Miki T, Miyata T, Mizuki N, Morisaki T, Nakamura Y, Nakao K, Nakayama T, Nakura J, Ogawa M, Ogihara T, Ohkubo T, Ohno S, Oka A, Okamura T, Saruta T, Sekine A, Shiwa T, Soma M, Sugano S, Tabara Y, Tajima A, Takahashi N, Takashima N, Takeuchi F, Tokunaga K, Tomoike H, Umemura S, Yamane T, Yanai K, Yasunami M, Yatsu K, Yoshida T, Tabara Y). Hunting for genes for hypertension: the Millennium Genome Project for Hypertension. Hypertension Res 2012; 35(6): 567-573.

8. Nomura T, Terahara K, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T. Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques. J Virol 86(12): 6481-6490, 2012

7. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Similarities and differences in genetic and clinical characteristics between early repolarization syndrome and Brugada syndrome. Circ Arrhythm Electrophysiol 5(2): e60-e61, 2012

6. #Purevjav E, #Arimura T, Augustin S, Huby A-C, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna W, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PMA, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA. Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet 21(9): 2039-2053, 2012. (#; equal contribution)

5. #Otsuka H, #Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A. Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy. Circ J 76(2): 453-461, 2012. (#; equal contribution)

4. Bertrand AT, Renou L, Papadopoulos A, Beuvin M, Lacène E, Massart C, Ottolenghi C, Decostre V, Maron S, Schlossarek S, Cattin ME, Carrier L, Malissen M, Arimura T, Bonne G. DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death. Hum Mol Genet 21(5): 1037-1048, 2012.

3. #Saito Y, #Naruse TK, Akari H, Matano T, Kimura A. Diversity of MHC class I haplotypes in cynomolgus macaques. Immunogentics 64(2): 131-141, 2012. (#; equal contribution)

2. Takaki A, Yamazaki A, Maekawa T, Shibata H, Hirayama K, Kimura A, Hirai H, Yasunami M. Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques. Immunogenetics 64(1): 15-29, 2012.

1. Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T. Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques. J Virol 86(2): 738-745, 2012.

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2011

12. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 4(6): 874-881, 2011.

11. Takahashi M, Chen Z, Watanabe K, Kobayashi H, Nakajima T, Kimura A, Izumi Y. Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese. Open Dent J. 5: 190-194, 2011.

10. Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A. Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance the sensitivity to apoptosis in cardiomyocytes. Hum Mutat. 32(12): 1481-1491, 2011.

9. Nakamura M, Takahara Y, Ishii H, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T, Matsuoka S. Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques. Microbiol Immunol. 55(11): 768-773, 2011.

8. Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL. Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy. Circ J. 75(11): 2654-2659, 2011.

7. Naruse TK, Okuda Y, Mori K, Akari H, Matano T, Kimura A. ULBP4/RAET1E is highly polymorphic in the Old World monkey. Immunogenetics 63(8): 501-509, 2011.

6. Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T. Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge. Biochem Biophys Res Commun. 408(4): 615-619, 2011.

5. Kimura A. Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy. Circ J. 75(7): 1756-1765, 2011.

4. Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A. A single nucleotide polymorphism in the 3f-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese. J Hum Genet. 56(7): 545-547, 2011.

3. Ohtani H, Nakajima T, Akari H, Ishida T, Kimura A. Molecular evolution of immunoglobulin superfamily genes in primates. Immunogenetics 63(7): 417-428, 2011

2. Yanagimachi M, Miyamae T, Naruto T, Hara T, Kikuchi M, Hara R, Imagawa T, Mori M. Kaneko T, Goto H, Morita S, Mizuki N, Kimura A, Yokota S. Association of HLA-A*02:06 and DRB1*09:01 with clinical subtypes of juvenile idiopathic arthritis. J Hum Genet. 56(3): 196-199, 2011.

1. Kimura A. Cardiomyopathy, sarcomeropathy and Z-diskopathy. In Genes and Cardiovascular Function. (Dhalla NS, Nagano M, Ostadal B, eds.), pp225-234, Springer, New York, 2011.

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2010

16. Li Z, Ai T, Samani K, Xi Y, Tzeng HP, Xie M, Taylor MD, Wu S, Ge S, Dong JW. Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M. A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circ Arrhythm Electrophysiol. 3(6): 646-656, 2010.

15. Shichi D, Arimura T, Ishikawa T, Kimura A. Heart-specific small subunit of myosin light chain phosphatase activates Rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1. J Biol Chem. 285(44): 33680-33690, 2010.

14. Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 56(18): 1493-1502, 2010.

13. Chen Z, Nakajima T, Tanabe N, Hinohara K, Sakao S, Kasahara Y, Tatsumi K, Inoue Y, Kimura A. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene. Hum Genet. 128(4): 443-452, 2010.

12. Sugimoto C, Watanabe S, Naruse T, Kajiwara E, Shiino T, Umano N, Ueda K, Sato H, Ohgimoto S, Hirsh V, Villinger F, Ansari AA, Kimura A, Miyazawa M, Suzuki Y, Yamamoto N, Nagai Y, Mori K. Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV. PLoS ONE 5(7): e11678, 2010.

11. Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A. Diversity of MHC class I genes in Burmese-origin rhesus macaque. Immunogenetics 62(9): 601-611, 2010.

10. Hitomi N, Kubo T, Kitaoka H, Hirota T, Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL. A frameshift deletion mutation in the cardiac myosin-binding protein C gene was associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. J Cardiol. 56(2): 189-196.

9. #Choi JO, #You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE. Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations. Clin Cardiol. 33(7): 430-438, 2010.  (#; equal contribution)

8. An J, Nakajima T, Kuba K, Kimura A. Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage. Hypertension Res. 33(8): 831-835, 2010.

7. Itaya S, Nakajima T, Kaur G, Terunuma H, Ohtani H, Mehra N, Kimura A. No evidence an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. J Infect Dis. 202(5): 815-816, 2010.

6. #Wichukchinda N, #Nakajima T, Saipradit N, Nakayama EE, Ohtani H, Rojanawiwat A, Pathipvanich P, Ariyoshi K, Sawanpanyalert P, Shioda T, Kimura A. TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand. AIDS 24(11): 1625-1631, 2010  (#; equal contribution)

5. Takahashi M, Kimura A. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Gravesf disease. J Hum Genet. 55(5): 323-326, 2010.

4. #Neely1 GG, #Kuba K, #Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 141(1): 142-153, 2010. (#; equal contribution)

3. Kimura A. Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond. J Hum Genet. 55(2): 81-90, 2010.

2. Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A. Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model. J Am Coll Cardiol. 55(14): 1503-1505, 2010.

1. Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K. A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Biochim Biophys Acta. 1800(1): 31-39, 2010.

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2009

21. Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J Biol Chem. 284(50): 35122-35133, 2009.

20. Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease. J Hum Genet. 54(11): 642646, 2009.

19. #Nakajima T, #Nakayama EE, Kaur G, Terunuma H, Mimaya J, Ohtani H, Mehra N, Shioda Y, Kimura A. Impact of novel TRIM5a variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS 23(16): 2091-2100, 2009. (#; equal contribution)

18. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Validation of the association between AGTRL1 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet. 54(9): 554-556, 2009.

17. Romphruk AV, Romphruk A, Naruse TK, Raroengjai S, Puapairoj C, Inoko H, Leelayuwat C. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in Northeastern Thais. Immunogenetics 61(9): 611-617, 2009.

16. Park YE, Hayashi YK, Bonne G, Arimura T, Noguchi S, Nonaka I, Nishino I. Autophagic degradation of nuclear components in mammalian cells. Autophagy 5(6): 795-804, 2009.

15. Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A. Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease. Hum Genet. 126(4): 539-547, 2009.

14. Kang EH, Yamaguchi T, Tajima A, Nakajima T, Tomoyasu Y, Watanabe M, Yamaguchi M, Park SB, Maki K, Inoue I. Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population. Arch Oral Biol. 54(6): 556-562, 2009.

13. Tomoyasu Y, Yamaguchi T, Tajima A, Nakajima T, Inoue I, Maki K. Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population. Am J Orthod Dentofacial Orthop. 136(4): 536-541, 2009.

12. Kano T, Mori T, Kimura A. Gender ratio distortion in abortuses and live births from patients with recurrent spontaneous abortion. Am J Reprod Immunol. 62(3): 125-127, 2009.

11. Nakajima T, Kimura A. Comparative genomics: insight into human health and disease. In The HLA Complex in Biology and Medicine: a resource book. (Mehra N, ed), pp566-589, Jaypee Brothers Medical Publishers (P) Ltd. New Delhi, 2009.

10. #Arimura T, #Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A. Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol. 54(4): 334-342, 2009. (#; equal contribution)

9. Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD1 -the gene encoding cardiac ankyrin repeat protein- is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 54(4): 325-333, 2009.

8. Kimura A. Does a gene polymorphism predisposing to the intermediate phenotype predict the risk of disease? Circ J. 73(6): 1016-1017, 2009.

7. #Arimura T, #Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 83(1): 80-88, 2009. (#; equal contribution)

6. Kikkawa EF, Tsuda TT, Sumiyama D, Naruse TK, Fukuda M, Kurita M, Wilson RP, LeMaho Y, Miller GD, Tsuda M, Murata K, Kulski JK, Inoko H. Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus). Immunogenetics 61(5): 341-352, 2009.

5. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. J Hum Genet. 54(4): 248-251, 2009.

4. Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse T, Kimura A. Complex divergence at a microsatellite marker C1_2_5 in lineage of HLA-Cw/-B haplotype. J Hum Genet. 54(4): 224-229, 2009.

3. #Ueda K, #Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A. Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 54(2): 115-121, 2009. (#; equal contribution)

2. #Kominami S, #Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. J Hum Genet. 54(2): 108-114, 2009. (#; equal contribution)

1. Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Hirasawa EA, Hattori N, Nishino I, Kimura A. Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy. Circ J. 73(1): 158-161, 2009.

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2008

9. Nakajima T, Kaur G, Mehra NK, Kimura A. HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5. Cytogenet Genome Res. 123(1-4): 156-160, 2008.

8. Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A. Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics 60(12): 727-735, 2008.

7. Nakajima T, Kimura A. Genetic factors which confer sensitivity to highly active antiretroviral therapy (HAART) in HIV-infected subjects: implication of a benefit of an earlier initiation of HAART in HIV therapy. Pharmacogenomics 9(9): 1347-1351, 2008.

6. #Takemoto Y, #Naruse TK, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Shams H, Davatchi F, Inoko H, Ohno S, Kimura A. Re-evaluation of heterogeneity in HLA-B*510101 associated with Behçetfs disease. Tissue Antigens 72(4): 347-353, 2008. (#; equal contribution)

5. Kimura A. Molecular etiology and pathogenesis of hereditary cardiomyopathy. Circ J. 72(Suppl A): A38-A48, 2008.

4. Tsukamoto T, Dohki S, Ueno T, Kawada M, Takeda A, Yasunami M, Naruse T, Kimura A, Takiguchi M, Matano T. Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope. AIDS 22(8): 993-994, 2008.

3. Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban J, Yasunami M, Park JE, Izumi T, Kimura A. Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations. J Hum Genet. 53(4): 357-359, 2008.

2. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Hohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakamura T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project. Hum Mol Genet. 17(4): 617-627, 2008.

1. Shichi D, Matsumori A, Naruse TK, Inoko H, Kimura A. HLA-DP beta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy. Int J Immunogenet. 35(1): 37-43, 2008.

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2007

24. Arimura T, Hayashi T, Kimura A. Molecular Etiology of Idiopathic Cardiomyopathy. Acta Myologica 26(3): 153-158, 2007.

23. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am J Physiol Heart Card Physiol. 293(6): H3396-H3403, 2007.

22. Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya J, Terunuma H, Kimura A. Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics 59(10): 793-798, 2007.

21. Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrabdt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenoviv V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 101(4): e32-e42, 2007.

20. Nakamura K, Katayama Y, Kusano KF, Haraoka K, Tani Y, Nagase S, Morita H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T. Anti-KCNH2 Antibody-induced long QT syndrome novel acquired form of long QT syndrome-. J Am Coll Cardiol. 50(18): 1808-1809, 2007.

19. #Arimura T, #Matsumoto Y, Okazaki O, Hayashi T, Takahashi M, Inagaki N, Hinohara K, Ashizawa N, Yano K, Kimura A. Structural analysis of obscurin gene in hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 362(2): 281-287, 2007. (#; equal contribution)

18. Chen Z, Takahashi M, Naruse T, Nakajima T, Chen YW, Inoue Y, Ishilkawa I, Iwai T, Kimura A. Synergistic contribution of CD14 and HLA loci to the susceptibility to Buerger disease. Hum Genet. 122(3-4): 367-372, 2007.

17. Kano T, Mori T, Furudono M, Tamura I, Ishikawa H, Watanabe H, Kikkawa E, Warita T, Kawada H, Onizuka M, Takahashi M, Maeda Y, Naruse T, Inoko H, Kimura A. HLA may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapy. Am J Reprod Immunol. 58(4): 383-387, 2007.

16. Knöll R, Postel R, Wang J, Kraetzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Dieter K, Gudrun K, Schaefer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nuemberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Hertog JD, van Eeden F, Peters P, Hasenfuss G, Chien KR, Bakkers J. Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells. Circulation 116(5): 515-525, 2007.

15. Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Nagata Y, Iesaka Y, Kimura A, Hiraoka M, Anzelevitch C. A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome. J Cardiovasc Electrophysiol. 18(9): 972-977, 2007.

14. Sakagami T, Jinnai N, Nakajima T, Sekigawa T, Hasegawa T, Suzuki E, Inoue I, Gejyo F. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet. 52(1):66-72, 2007.

13. Ben Yaou R, Toutain A, Arimura T, Demay L, Massart C, Peccate C, Muchir A, Llense S, Deburgrave N, Leturcq F, Litim KE, Rahmoun-Chiali N, Richard P, Babuty D, Recan-Budiartha D. Multitissular involvement in a family with LMNA and EMD mutations: Role of digenic mechanism? Neurology 68(22): 1883-1894, 2007.

12. Muchir A, Pavilidis P, Decostre V, Herron AJ, Arimura T, Bonne G, Worman JJ. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifess muscular dystrophy. J Clin Invest. 117(5): 1282-1293, 2007.

11. Minehisa Y, Watanabe H, Kosaka T, Kimura A, Ito H. Successful outcome in a pregnant woman with isolated noncompaction of the left ventricular myocardium. Intern Med. 46(6): 285-289, 2007.

10. Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Itoh-Satoh M, Bonne G, Schwartz K, Kimura A. Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy. Biochem Biophys Res Commun. 357(1): 162-167, 2007.

9. Maehata Y, Takamizawa S, Ozawa S, Izukuri K, Kato Y, Sato S, Lee MC, Kimura A, Hata R. Type III collagen is essential for growth acceleration of human osteoblastic cells by ascorbic acid 2-phosphate, a long-acting vitamin C derivative. Matrix Biol. 26(5): 371-81, 2007.

8. Sugimori C, Yamazaki H, Feng X, Mochizuki K, Kondo Y, Takami A, Chuhjo T, Kimura A, Teramura M, Mizoguchi H, Omine M, Nakao S. Roles of DRB1*1501 and DRB1*1502 in the pathogenesis of aplastic anemia. Exp Hematol. 35(1): 13-20, 2007.

7. Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, Kiyosawa K, Fukushima H, Bahram S, Inoko H, Kawa S. Two critical genes (HLA-DRB1 and ABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics 59(1): 45-52, 2007.

6. Nouchi T, Yasunami M, Mibu R, Yasunaga S, Itoh-Satoh M, Takahashi M, Tanaka S, Kuwano H, Kimura A. Somatic mutations leading to incomplete extinction of HLA class I were associated with replication error phenotype-positive corlorectal carcinoma. MHC 13(3): 187-197, 2007.

5. Yatsu K, Mizuki N, Hirata N, Oka A, Ito N, Yamane T, Ogawa M, Shiwa T, TabaraY, Ohno S, Soma M, Hata A, Nakano K, Ueshima H, Ogiwara T, Tomoike H, Miki T, Kimura A, Mano S, Kulski JK, Umemura S, Inoko H. High-resolution mapping for essential hypertension using microsatellite markers. Hypertension 49(3): 446-452, 2007.

4. Kimura A, Takahashi M, Choi BY, Bae SW, Hohta S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Naruse T, Izumi T, Park JE. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations. Tissue Antigens 69(3): 265-269, 2007.

3. Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T. Vaccine-based long-term stable control of simian-human immunodeficiency virus 89.6PD replication in rhesus macaques. J Gen Virol. 88(Pt2): 652-659, 2007.

2. Takahashi-Tanaka Y, Yasunami M, Naruse T, Hinohara K, Matano T, Mori K, Miysazawa M, Honda M, Yasutomi Y, Nagai Y, Kimura A. Reference strand-mediated conformation analysis (RSCA)-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci. Electrophoresis 28(6): 918-924, 2007.

1. Aizawa Y, Mitsuma W, Ikrar T, Komura S, Hanawa H, Miyaima S, Miyoshi F, Kobayashi Y, Chinushi M, Kimura A, Hiraoka M, Aizawa Y. Human cardiac ryanodine receptor mutations in ion channel disorders in Japan. Int J Cardiol. 116(2): 263-265, 2007.

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2006

8. Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, Kimura A. Direct determination of SNP haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases. Hum Immunol. 67(4-5):363-373, 2006.

7. Takahashi M, Yasunami M, Kubota S, Tamai H, Kimura A. HLA-DPB1*0202 is associated with a predictor of good prognosis of Graves disease in Japanese. Hum Immunol. 67(1-2): 47-52, 2006.

6. Inagaki N, Hayashi T, Arimura T, Koga Y, Takahashi M, Shibata H, Teraoka K, Chikamori T, Yamashina A, Kimura A. alpha B-crystallin mutation in dilated cardiomyopathy. Biochem Biophys Res Commun. 342(2): 379-386, 2006.

5. Shiina T, Ota M, Shimizu S, Katsuyama Y, Hashimoto N, Takasu M, Anzai T, Kulski JK, Kikkawa E, Naruse T, Kimura N, Yanagiya K, Watanabe A, Hosomichi K, Kohara S, Iwamoto C, Umehara Y, Meyer A, Wanner V, Sano K, Macquin C, Ikeo K, Tokunaga K, Gojobori T, Inoko H, Bahram S. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics 173(3):1555-1570, 2006.

4. Kimura A, Takahashi M, Shibata H, Kobayashi Y, Obuchi N, Ota M, Inoko H, Numano F, Yasunami M. Identification of HLA-linked susceptibility genes for Takayasu arteritis. In Immunobiology of the Human MHC vol. II (Hansen HA, Dupont B, eds.), pp325-329, IHWG Press, Seattle, 2006.

3. Yasunami M, Shibata H, Shao WS, Takahashi M, Hamaguchi K, Sakata T, Ota M, Inoko H, Kimura A. Mapping of three different IDDM-susceptibility loci within the HLA region. In Immunobiology of the Human MHC vol. II (Hansen HA, Dupont B, eds.), pp330-333, IHWG Press, Seattle, 2006.

2. Naruse TK, Ota M, Katsuyama Y, Kikkawa E, Shichi D, Kimura A, Matsumori A, Sasayama S, Inoko H. Susceptible gene mapping of hepatitis C virus positive cardiomyopathy within the HLA region. In Immunobiology of the Human MHC vol. II (Hansen HA, Dupont B, eds.), pp351-354, IHWG Press, Seattle, 2006.

1. Takahashi M, Yasunami M, Tamai H, Kimura A. HLA-A and DPB1 control the susceptibility and production of thyroid stimulatory antibodies, respectively, in Graves' disease. In Immunobiology of the Human MHC vol. II (Hansen HA, Dupont B, eds.), pp364-367, IHWG Press, Seattle, 2006.

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2005

9. Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, ArimuraT, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano K, Kimura A. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. J Muscle Res Cell Motil. 26: 367-374, 2005.

8. Munkanta M, Terunuma H, Takahashi M, Hanabusa H, Miura T, Ikeda S, Sakai M, Fujii T, Takahashi Y, Oka S, Matsuda J, Ishikawa M, Takashima Y, Mimaya J, Ito M, Kimura A, Yasumani M. HLA-B polymorphism in Japanese HIV-1infectedlong-term surviving hemophiliacs. Viral Immunol. 18: 500-505, 2005.

7. Shichi D, Kikkawa FE, Ota M, Katsuyama Y, Kimura A, Matsumori A, Kulsky JK, Naruse KT, Inoko H. The haplotype block,NFKBIL1-ATP6V1G2-BAT1-MICB-MICA,within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus associated dilated cardiomyopathy. Tissue Antigens 66: 200-208, 2005.

6. Kubo T, Kitaoka H, Okawa M, Matsumura Y, Hitomi N, Yamazaki N, Furuno T, Takata J, Nishinaga M, Kimura A, Doi YL. Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac myosin-binding protein C gene. J Am Coll Cardiol. 46: 1737-1743, 2005

5. Mori K, Sugimoto C, Ohgimoto S, Nakayama EE, Shinoda T, Kusagasa S, Takebe Y, Kano M, Matano T, Yuasa T, Kitagawa D, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, Yamamoto N, Suzuki Y, Nagai Y. Influence of glycosylation on the efficacy of an Env-based vaccine against SIVmac239 in a macaque AIDS model. J Virol. 79: 10386-10389, 2005.

4. Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Spontaneous T wave alterans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing. J Cardiovasc Electrophysiol. 16: 217-220, 2005.

3. Noguchi Y, Yashima T, Hatanaka A, Uzawa M, Yasunami M, Kimura A, Kitamura K. A mutation in WFS1 in a Japanese family with autosomal dominant low-frequency sensorineural hearing loss. Acta Oto-Laryngologica 125: 1189-1194, 2005.

2. Aizawa Y, Ueda K, Komura S, Washizuka T, Chinushi M, Inagaki N, Matsumoto Y, Hayashi T, Takahashi M, Nakano N, Yasunami M, Kimura A, Hiraoka M, Aizawa Y. A novel mutation in FKBP12.6 binding region of the human cardiac ryanodine receptor gene (R2401H) in Japanese patient with catecholaminergic polymorphic ventricular tachycardia. Int J Cardiol. 99(2): 343-345, 2005.

1. Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T. Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan. Eur Resp J. 25(1): 131-138, 2005.

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2004

12. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki, N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Knoll R, Hoshijima M, Chien KR, Kimura A. TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 44: 2192-2201, 2004.

11. Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M. Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation. J Mol Cell Cardiol. 37: 1205-1211, 2004.

10. Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M. Truncated KCNQ1mutant,A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking. FEBS Lett. 574: 145-150, 2004.

9. Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access. Mol Pharmacol. 66: 330-336, 2004.

8. Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H. Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes. Diabet Res Clin Pract. 66: 163-171, 2004.

7. Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A. Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. J Biol Chem. 279: 27194-27198, 2004.

6. Matano T, Kobayashi M, Igarashi H, Takeda A, Nakamura H, Kano M, Sugimoto C, Mori K, Iida A, Hirata T, Hasegawa M, Yuasa T, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, O'Connor DH, Watkins DI, Nagai Y. Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial, J Exp Med. 199: 1709-1718, 2004.

5. Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K. The role of a common TNNT2 polymorphism in cardiac hypertrophy. J Hum Genet. 49: 129-133, 2004.

4. Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. Tissue Antigens 63: 223-230, 2004.

3. Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K. 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene. Circ J. 68: 174-177, 2004.

2. Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohta S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A. A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C. J Biol Chem. 279: 6746-6752, 2004.

1. Hayashi T, Arimura T, Ueda K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A. Identification and functional analysis of acaveolon-3 mutation associated with familial hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 313: 178-184, 2004.

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2003

7. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H. Identification of IkBL as the second MHC-linked susceptibility locus for Rheumatoid Arthritis. Am J Hum Genet. 72: 303-312, 2003.

6. Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A. Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese. MHC 9: 163-169, 2003.

5. Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T. Association study of the CD14 polymorphism with myocardial infarction in Japanese populations. Jpn Heart J. 44: 613-622, 2003.

4. Yoshida Y, Takano Y, Sasaoka T, Izumi T, Kimura A. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions. Arter Thrombo Vasc Biol. 23: 783-788, 2003.

3. Kimura A, Hayashi T, Itoh-Satoh M, Arimura T, Lee WH, Lee SY, Park JE. Molecular etiology of idiopathic cardiomyopathy: Identification of novel disease genes for hypertrophic cardiomyopathy and dilated cardiomyopathy. In Cardiomyopathies and Heart Failure; Biomolecular, Infectious and Immune Mechanisms (ed. Matsumori A), pp415-428, Klumer Academic Publishers, Boston, 2003.

2. Kimura A, Itoh-Satoh M, Hayashi T, Takahashi M, Arimura T, Yasunami M, Lee SY, Hwang TH, Lee WH, Park JE. Mutational profiles and molecular pathogenesis of hypertrophic cardiomyopathy and dilated cardiomyopathy in Asian populations. In Frontiers in Cardiovascular Health (eds. Dhalla NS, Chockalingam A, Berkovitz HI, Singal PK),pp195-206, Klumer Academic Publishers, Boston, 2003.

1. Kurosaka D, Yoshida K, Yasuda J, Yokoyama T, Kingetu I, Yamaguchi N, Joh K, Matsushima M, Saito S, Yamada A. Arthritis-inhibiting effect of systemic administration of endostatin in passive murine collagen-induced arthritis. Ann Rheum Dis. 62: 677-679, 2003

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2002

13. Knoll R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111: 943-955, 2002.

12. Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M. Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy. J Clin Allergy Clin Immunol. 110:652-658, 2002.

11. Matsumori A, Furukawa Y, Hasegawa K, Sato Y, Nakagawa H, Morikawa Y, Miura K, Ohno Y, Inaba Y, Sasayama S, Fujiwara H, Hiroe M, Hori M, Imaizumi T, Inoko H, Izumi T, Kawai S, Kawana M, Kimura A, Kitabatake A, Kitamura S, Kitaura Y, Matsuzaki M, Nagai R, Ogawa S, Shimada T, Simotohno K, Takeda N, Takihara K, Tanaka M, Tei T, Toyo-oka T, Yamaguchi I, Yokoyama M, Yutani C. Epidemiologic and clinical characteristics of cardiomyopathies in Japan: Analysis by nationwide surveys. Circ J. 66: 323-336, 2002.

10. Kuroda N, Ohnishi Y, Kimura A, Yokoyama M. Clinical significance of T-wave alternans in hypertrophic cardiomyopathy. Circ J. 66: 457-462, 2002.

9. Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M. Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene. J@Hum Genet. 47: 330-332, 2002.

8. Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A. Implication of an overlapping Na channelopathy in an idiopathic ventricular fibrillation associated with a cardiac Na channel mutation. Cardiovasc Res. 53: 348-354, 2002.

7. Satoh-Itoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A. Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun. 291: 385-393, 2002.

6. Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S. Analysis of HLA in children with gelatin allergy. Tissue Antigens 59: 412-416, 2002.

5. Nemoto T, Hori H, Yoshimoto M, Seyama Y, Kubota S. Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression. Blood 15:1478-81, 2002.

4. Morimoto T, Aoyagi M, Tamaki M, Yoshino Y, Hori H, Duan L, Yano T, Shibata M, Ohno K, Hirakawa K, Yamaguchi N. Increased levels of tissue endostatin inhuman malignant gliomas. Clin Cancer Res. 8: 2933-2938, 2002.

3. Matsuno H, Yudoh K, Uzuki M, Nakazawa F, Sawai T, Yamaguchi N, Olsen BR, Kimura T. Treatment with the angiogenesis inhibitor endostatin: A novel therapy in rheumatoid arthritis. J Rheumatol. 29: 890-895, 2002.

2. Furumatsu T, Yamaguchi N, Nishida K, Kawai A, Kunisada T, Namba M, Inoue H, Ninomiya Y. Endostatin inhibits adhesion of endothelial cells to collagen IVIaƒż2ƒŔ1 integrin, a possible cause of prevention of chondrosarcoma growth. J Biochem (Tokyo). 131:619-26, 2002.

1. Akagi A, Tajima S, Ishibashi A, Matsubara Y, Takehana M, Kobayashi S, Yamaguchi N. Type XVI collagen is expressed in factor XIIIa+ monocyte-derived dermal dendrocytes and constitutes a potential substrate for factor XIIIa. J Invest Dermatol. 118: 267-274, 2002.

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2001

13. Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A. Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese. Tissue Antigens 57: 66-69, 2001.

12. Lee WH, Hwang TH, Kimura A, Park SW, Satoh M, Nishi H, Harada H, Toyama J, Park JE. Different expressivity of a ventricular essential light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy. Am Heart J. 141: 184-189, 2001.

11. Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A. Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit, J Biol Chem. 276: 6073-6082, 2001.

10. Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region. Genomics 71: 263-270, 2001.

9. Soejima T, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T. Isolation of novel heart-specific genes using the bodymap. Genomics 74: 115-120, 2001.

8. Kimura A, Itoh-Satoh M, Hayashi T, Takahashi M, Arimura T. Molecular etiology of idiopathic cardiomyopathy in Asian populations. J Cardiol. 37: S139-S146, 2001.

7. Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A. Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4. Tissue Antigens 57: 520-535, 2001.

6. Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, Na-Bangchang K, Kimura A, Aikawa M, Hirayama K. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais. Parasitol Int. 50: 235-239, 2001.

5. Matsuzoe D, Hideshima T, Iwasaki A, Yoneda S, Kawahara K, Shirakusa T, Kimura A. Glutathione S-transferase nu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers. Carcinogenesis 22: 1327-1330, 2001.

4. Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser andGly670Arg, are associated with myocardial infarction in Japanese. Ann NY Acad Sci. 947: 259-269, 2001

3. Fukuda Y, Hoshino S, Shintaku S, Tanaka I, Dohi K, Kimura A. HLA-DMB polymorphism in living-related kidney transplantation. Transpl Proc. 33: 3302-3308, 2001.

2. Tsuchiya K, Kimura A, Kondo M, Nishimura Y, Sasazuki T. Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis. Tissue Antigens 58: 395-401, 2001.

1. Ubalee R, Suzuki F, Kikuchi M, Tasanor O, Wattanagoon Y, Ruangweerayut IIR, Na-Bangchang K, Karbwang J, Kimura A, Ito K, Kanda T, Hirayama K. Strong association of a tumor necrosis factor-a promoter allele with cerebral malaria in Myanmar. Tissue Antigens 58: 407-410, 2001.

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2000

14. Kimura A: Molecular genetic aspects of hypertrophic cardiomyopathy in the Orientals. In The Hypertrophied Heart (Takeda N, Nagano M, Dhalla NS eds.), pp333-343,Klumer Academic Publishers, Boston,2000

13. Tajima S, Akagi A, Tanaka N, Ishibashi A, Kawada A, Yamaguchi N: Expression of type XVI collagen in cultured skin fibroblasts is related to cell growth arrest. FEBS Lett. 469: 1-4, 2000.

12. Sakaguchi M, Toda M, Ebihara T, Irie S, Hori H, Imai A, Yanagida M, Miyazawa H, Ohsuna H, Ikezawa Z, Inoue S: IgE antibody to fish gelatin (type I collagen)in patients with fish allergy. J Allergy Clin Immunol. 106:579-584, 2000.

11. Oda H, Iwata I, Yasunami M, Ohkubo H: Structure of the mouse NDRF gene and its regulation during neuronal differentiation of P19 cells. Mol. Brain Res. 77: 37-46, 2000.

10. Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A: Characterization of human nebulette gene: A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy. Hum Genet 107: 440-451, 2000.

9. Akai J, Kimura A, Hata R: Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen collagena2 chain (COL1A2)gene promoter. Connective Tissue 32: 259-265, 2000.

8. Aida K, Juarez S, Kikuchi M, Gil M, Ayau O, DeLopez MP, Kaneko S, Yanagi T, Obispo T, Velasquez E, Jianbing M, Matta V, Paz M, Kimura A, Itoh K, Tada I, Hirayama K: HLA-B35 andMICA-A5 synergistically enhanced the susceptibility to Chagas disease, Trypanozoma cruzi infection. MHC 7: 63-70, 2000.

7. Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, Nakazawa K, Kimura A, Hiraoka M: A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. FEBS Lett. 479: 29-34, 2000.

6. Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F: Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis. Int J Cardiol. 75: S105-S110, 2000.

5. Kamizono S, Hiromatsu Y, Seki N, Bednarczuk T, Matsumoto H, Kimura A, Itoh K: A polymorphism of the 5'flanking region of tumor necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin Endocrinol. 52: 759-764, 2000.

4. Hata R, Akai J, Kimura A, Ishikawa O, Kuwana M, Sinkai H: Association of functional microsatellites in the human type 1 collagen a2 chain (COL1A2) gene with systemic screlosis. Biochem Biophys Res Commun. 272:36-40, 2000.

3. Kamizono S, Yamada K, Seki N, Higuchi T, Kimura A, Nonaka K, Itoh K: Susceptible locus for obese type2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene. Tissue Antigens 55: 449-452, 2000.

2. Furuse M, Kimura A, Esaki M, Jo Y, Matsumoto T, Fujishima M: Polymorphism of the heat-shock protein gene HSP70-2 in ulcerative colitis. MHC 7:2-6, 2000.

1. Hamaguchi K, Kimura A, Seki N, Higuchi T, Yasunaga S, Takahashi M, Sasazuki T, Kusuda Y, Okeda T, Itoh K, Sakata T: Analysis of tumor necrosis factor-a promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese. Tissue Antigens 55: 10-15, 2000.

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1999

19. Matsuzoe D, Hideshima T, Kimura A, Inada K, Watanabe K, Akita Y, Kawahara K, Shirakusa T: p53 mutations predict non-small cell lung carcinoma response to radiotherapy. Cancer Lett. 135: 189-194, 1999.

18. Takahashi M, Kobayashi Y, Ichiki M, Ouchi H, Numano F, Kimura A:HLA-linked susceptibility and resistance to Buerger's disease in Japanese. MHC 5:7-12, 1999.

17. Matsuzoe D, Hideshima T, Ohshima K, Kawahara K, Shirakusa T, Kimura A: Discrimination of double primary lung cancer from intrapulmonary metastasis byp53 gene mutation. Br J Cancer. 79: 1549-1552, 1999.

16. Yoshitake S, Kimura A, Okada M, Yao T, Sasazuki T: HLA class II alleles in Japanese patients with inflammatory bowel disease. Tissue Antigens 53: 350-358, 1999.

15. Fukuma K, Marubayashi S, Okuda K, Yamada K, Kimura A, Dohi K: Effect of lazaroid U-74389G and methyl predonisolone on endotoxin-induced shock in mice. Surgery 125: 421-430, 1999.

14. Doi YL, Kitaoka H, Hitomi N, Satoh M, Kimura A: Clinical expression in patients with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutation. Circulation 100: 448-449, 1999.

13. Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A: Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with non-familial idiopathic dilated cardiomyopathy in Japanese. Biochem Biophys Res Commun. 261: 332-339, 1999.

12. Satoh M, Takahashi M, Sakamoto T, Hiroe M, Marumo F, Kimura A: Structural analysis of the titin gene in hypertrophic cardiomyopathy: Identification of a novel disease gene. Biochem Biophys Res Commun. 262: 411-417, 1999.

11. Yoshitake S, Okada M, Kimura A, Sasazuki T: Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobactor Pyroli related diseases. Eur J Gastroenterol Hepatol. 11: 875-880, 1999.

10. Seki N, Kamizono S, Yamada A, Matsumoto H, Niiya F, Kimura A, Tsuchiya K, Suzuki R, Date Y, Tomita T, Itoh K, Ochi T: Polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in patients with rheumatoid arthritis. Tissue Antigens 54: 194-197, 1999.

9. Akai J, Kimura A, Hata R: Tanscriptional regulation of the human type I collagen a2 (COL1A2) gene by the combination of two dinucleotide repeats. Gene 239: 65-73, 1999.

8. Djoulah S, Busson M, Sasazuki T, Maillere B, Yasunaga S, Kimura A, Charron D, Hors J: A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 andHLA-DQB1 pockets. Tissue Antigens 54: 341-148, 1999.

7. Date Y, Seki N, Kamizono S, Higuchi T, Miyata K, Ohkuni M, Tatsuzawa O, Yokota S, Joo K, Ueda K, Joo K, Kimura A, Itoh K, Kato H: Identification of genetic risk factor for systemic rheumatoid arthritis in the 5'-flanking region of the TNF-alpha gene and HLA genes. Arthr Rheumat. 42: 2577-2582, 1999

6. Wang LM, Kimura A, Satoh M, Mineshita S: HLA linked with leprosy in Southern China: HLA-linked resistance alleles to leprosy. Int J Lepr. 67: 403-408, 1999.

5. Sakaguchi M, Hori H, Ebihara T., Irie S, Yanagida M, Inouye S: Reactivity of the IgE in bovine gelatin-sensitive children to gelatins from various animals. Immunology 96: 286-290, 1999.

4. Sakaguchi M, Hori H, Hattori S, Irie S, Imai A, Yanagida M, Miyazawa H, Toda M, Inouye S: IgE reactivity to alpha1 and alpha2 chains of denatured bovine type I collagen in children with bovine gelatin allergy. J Allergy Clin Immunol. 104: 695-699, 1999.

3. Akagi A, Tajima S, Ishibashi A, Yamaguchi N, Nagai Y: Expression of type XVI collagen in human skin fibroblasts: enhanced expression in fibrotic skin diseases. J Invest Dermatol. 113: 246-250, 1999.

2. Yamaguchi N, Iwata S, Munakata Y, Ikushima H, Lee J F, Hosono O, Schlossman SF, Morimoto C: CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response. Int Immunol. 11: 417-426, 1999.

1. Yamaguchi N, Anand-Apte B, Lee M. Sasaki T, Fukai N, Shapiro R, Que I, LowikC, Timpl R, Olsen B R: Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J. 18: 4414-4423, 1999.

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1998

14. Ikeda M, Orimo H, Moriyama H, Yoshitaka T, Matsubara N, Mibu R, Tanaka N, Shimada T, Kimura A, Shimizu K: Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability. Cancer Res. 58:594-598, 1998.

13. Zeki K, Tanaka Y, Morimoto I, Nishimura Y, Kimura A, Yamashita U, Eto S: Induction of expression of MHC-class-II antigen on human thyroid carcinoma by wild-type p53. Int J Cancer 75: 391-395, 1998.

12. Akai J, Kimura A, Arai K, Uehara K, Hata R: Fine structural analysis of the unique 5' region of human COL1A2 gene containing two regions of di-nucleotide repeats adjacent to the transcriptional start site. Connective Tissue 30: 1-6, 1998.

11. Shirai T, Hattori S, Sakaguchi M, Inoue S, Kimura A, Ebihara T, Irie S, Nagai R, Hori H: The complete cDNA coding sequence for the bovine pro alpha 2(I) chain of type I procollagen. Matrix Biol. 17: 85-88, 1998.

10. Higuchi T, Seki N, Kamizono S, Yamada A, Kimura A, Kato H, Itoh K: Polymorphism of the 5'-flankingregion of human tumor necrosis factor (TNF)-alpha gene in Japanese. Tissue Antigens 51: 605-612, 1998.

9. Hata R, Akai J, Kimura A: Cell position dependent reciprocal feedback regulation of type I collagen gene expression in cultured human skin fibroblasts. Cell Biol Internat. 22: 85-191, 1998.

8. Kimura A, Kobayashi Y, Takahashi M, Ohbuhi N, Kitamura H, Satoh M, Nakamura T, Sasaoka T, Hiroi S, Aerbajinai W, Yasukochi Y, Numano F: MICA gene polymorphism in Takayasu arteritis and Buerger disease. Int J Cardiol. 66: S107-S113, 1998.

7. Kitamura H, Kobayashi Y, Kimura A, Numano F: Association of clinical manifestations with HLA-B alleles in Takayasu arteritis. Int J Cardiol. 66: S121-S126, 1998

6. Matsumori A, Ohashi N, Sasayama S, Eto T, Fujisawa H, Imaizumi T, Izumi T, Kawamura K, Kawana M, Kimura A, Kitabatake A, Matsuzaki M, Nagai R, Tanaka H, Hiroe M, Hori M, Inoko H, Seko Y, Sekiguchi M, Shimotohno T, Sugishita Y, Takeda N, Takihara K, Tanaka M, Tokuhisa T, Toyooka T, Yokoyama M: Hepatitis C virus infection and cardiomyopathies: A multicenter study in Japan. Jpn Circ J. 62: 389-391, 1998.

5. Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F: Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. N Engl J Med. 339:1177-1185, 1998.

4. Hwang T, Lee W, Kimura A, Satoh M, Nakamura T, Kim M, Choi S, Park J: Early expression of a malignant phenotype of familial hypertrophic cardiomyopathy associated with a Gly716Arg myosin heavy chain mutation in a Korean family. Am J Cardiol. 82: 1509-1513, 1998.

3. Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F, Kimura A, Kato H, Imaizumi T: Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy. Circ Res. 83: 594-601, 1998.

2. Nomura Y, Kitteringham N, Shia K, Goseki M, Kimura A, Mineshita S: Use of the highly sensitive PCR method to detect the herpes Simplex Virus type 1genome from Behchet disease patients. J Med Dent Sci. 45: 51-58, 1998.

1. Hata RFInsoluble extracellular matrix gives positional information to cells and regulates morphogenesis as a morphocreator. Connective Tissue 30: 285-289, 1998.

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1997

21. Kimura A, Harada H, Park J, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang T, Choo J, Chung K, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T: Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nature Genet. 16: 379-382, 1997.

20. Kimura A: Molecular genetics of hypertrophic cardiomyopathy in Japan. Internal Me.d 36: 152-154, 1997.

19. Macaubas C, Jin L, Hallmeyer J, Kimura A, Mignot E: The complex mutation pattern of a microsatellite. Genome Res. 7: 635-641, 1997.

18. Mignot E, Kimura A, Latterman A, Lin X, Yasunaga S, Rattazzi C, Jin L, Guilleminault C, Grumet FC, Dement WC, Underhill P: Extensive HLA class II studies in 58 non DRB1*15 (DR2) narcoleptic patients with cataplexy maps susceptibility to the coding region of DQA1*0102 and DQB1*0602 gene. Tissue Antigens 49: 329-341, 1997.

17. Munkhbat B, Sato T, Hagihara M, Tsuchida F, Sato K, Kimura A, Munkhtuvshin N, Tsuji K: Molecular analysis of HLA polymorphism in Khoton-Mongolians. Tissue Antigens 50: 124-134, 1997.

16. Ohdan H, Fukuda Y, Shintaku S, Miyata Y, Tashiro H, Hoshino S, Sumimoto R, Asahara T, Kimura A, Dohi K: Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation. Transplant Proc. 29: 925-927, 1997.

15. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Shintaku S, Ohdan H, Miyata H, Dohi K: Induction of donor-specific hyporeactivity in augmented microchimerism in rat liver transplantation followed by donor bone marrow. Transplant Proc. 29: 1196-1197, 1997.

14. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K: Correlation of high-level microchimerism with graft acceptance in rat liver transplantation. Transplant Proc. 29: 1230-1231, 1997.

13. Lin L, Jin L, Kimura A, Carrington M, Mignot E: DQ microsatellite association studies in three ethnic groups. Tissue Antigens 50: 507-520, 1997.

12. Ohsuzu F, Katsushika S, Akanuma M, Nakamura H, Harada H, Satoh M, Hiroi S, Kimura A: Hypertrophic obstructive cardiomyopathy due to a novel T-to-A transition at codon 624 in the b-myosin heavy chain (beta-MHC) gene possibly related to the sudden death. Int J Cardiol. 62: 203-209, 1997.

11. Tamamori M, Ito H, Hiroe M, Marumo F, Hata R: Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides. Cell Biol Int. 21: 175-180, 1997.

10. Fukuda K, Hori H, Utani A, Burbelo P, Yamada Y: Formation of recombinant triple-helical [alpha1(IV)]2alpha2(IV) collagen molecules in CHO cells. Biochem Biophys Res Commun. 231:178-182, 1997.

9. Saito F, Yamada H, Sunada Y, Hori H, Shimizu T, Matsumura K: Characterization of a 30 kDa peripheral nerve glycoprotein that binds laminin and heparin. J Biol Chem. 272: 26708-26713, 1997.

8. Mimata C, Kitaoka M, Nagahiro S, Iyama K, Hori H, Yoshioka H, Ushio Y: Differential distribution and expressions of collagens in the cerebral aneurysmal wall. Acta Neuropathol. 94: 197-206, 1997.

7. Bencova M, Benca J, Kimura A, Podoba J: Hashimoto's thyroiditis and HLA-DR/DQ haplotypes associated with control of disease resistance. In Immunogenetics: Advances and Education (Madrigal AJ, Bencova M, Middleton D, Charron D eds.), pp99-101, Kulwer Academic Publishers, Dordrecht,1997.

6. Bencova M, Kimura A, Yoshida M, Hoshino S, Porubska S, Buc M, Reznicek J, Sasazuki T: The role of HLA-DR, DQ, DP subregions compatibility in the induction of cytotoxic T lymphocytes in kidney transplantation from living donor. In Immunogenetics: Advances and Education (Madrigal AJ, Bencova M, Middleton D, Charron D eds.), pp153-158, Kulwer Academic Publishers, Dordrecht,1997.

5. Kimura A, Date Y, Yasunaga S, Sasazuki T: DNA typing of the HLA-A gene and its clinical application. In Genetic Diversity of HLA: Functional and Medical Implications, vol. II (Charron D ed.), pp330-332, EDK Press, Paris, 1997.

4. Yasunaga S, Kimura A, Sasazuki T: Comprehensive sequence analysis ofHLA-DQA1 and -DQB1 alleles and characterization of DRB-QAP-DQA1-DQB1 haplotypes. In Genetic Diversity of HLA: Functional and Medical Implications, vol. II (Charron D ed.), pp113-114, EDK Press, Paris, 1997.

3. Mignot E, Macaubas C, Jin L, Hallmayer J, Kimura A, Grumet FC: The natural history of a microsatellite located in the HLA-DQ region. In Genetic Diversity of HLA: Functional and Medical Implications, vol. II (Charron D ed.), pp121-124, EDK Press, Paris, 1997.

2. Hirayama K, Sulaiman LH, Kimura A, Joo OK, Kikuchi M, Samah MZA, Abdullah NH, Kojima S, Wah MJ: Anti-malarial HLA-B53 in Africa and common DNA type HLA-B*1513 in Malaysian aborigines share a C-terminal pocket of peptide binding groove. In Genetic Diversity of HLA: Functional and Medical Implications, vol. II (Charron D ed.), pp689-692, EDK Press, Paris, 1997.

1. Kojima N, Miura M, Matano Y, Imai K, Sato M, Senoo H, Hata R: Reversible regulation of hepatic stellate cell functions by three-dimensional structure of extracellular matrix. In Cells of the Hepatic Sinusoid, Vol.6 (Wisse E, Knook D L, Balabaud C, eds),107-109,Kupffer Cell Foundation, Leiden, 1997.

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1996

25. Yasunaga S, Kimura A, Hamaguchi K, Roenningen KS, Sasazuki T: Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 47: 37-48, 1996.

24. Date Y, Kimura A, Kato Y, Sasazuki T: DNA typing of HLA-A gene: population study and identification of four new alleles in Japanese. Tissue Antigens 47: 93-101, 1996.

23. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Ito H, Dohi K: Assessment of microchimerism in rat liver transplantation by polymerase chain reaction. Hepatology 23: 828-834, 1996.

22. Tamai H, Sudo T, Kimura A, Matsubayashi S, Kuma K, Nagataki S: Association between the DRB1*08032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease. Ann Internal Med. 124:490-494, 1996.

21. Kimura A, Kitamura H, Date Y, Numano F: Comprehensive analysis of HLA genes in Takayasu arteritis in Japan. Int J Cardiol. 54: S65-S73, 1996.

20. Aerbajinai W, Tsuchiya T, Kimura A, Yasukochi Y, Numano F: HLA class IIDNA typing in Buerger's disease. Int J Cardiol. 54: S197-S202, 1996.

19. Hori T, Kamikawaji N, Kimura A, Sone T, Komiyama N, Komiyama S, Sasazuki T: Japanese ceder polinosis and HLA-DP5. Tissue Antigens 47: 485-491, 1996.

18. Koyanagi T, Koga Y, Nishi H, Toshima H, Sasazuki T, Imaizumi T, Kimura A: DNA typing of HLA class II genes in Japanese patients with rheumatic heart disease. J Mol Cell Cardiol. 28: 1349-1353, 1996.

17. Fukuda Y, Kimura A, Hoshino S, Shintaku S, Sakaguchi T, Asahara T, Sakaki M, Sumimoto R, Tashiro H, Furukawa M, Ohdan H, Yoshida T, Dohi K: HLA-DR8 subtyping by polymerase chain reaction(PCR)- DNA conformation polymorphism(DCP) analysis: a simple and practical genotyping method. Hiroshima J Med Sci. 45: 85-92, 1996.

16. Muto M, Date Y, Ichimiya M, Mori K, Kamikawaji N, Kimura A, Sasazuki T, Asagami C: Significance of antibodies to streptococcal M protein in psoriatic arthritis and their association with HLA-A*0207. Tissue Antigens 48: 645-650, 1996.

15. Hirayama K, Samah MZA, Sulaiman LH, Kimura A, Joo OK, Kikuchi M, Abdullah NH, Kojima S, Wah MJ: Molecular analysis of HLA-B in the Malaysian aborigines. Tissue Antigens 48: 692-697, 1996.

14. Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E: Mutation rate varies among alleles at a microsatellite locus: phylogenic evidence. Proc Natl Acad Sci USA 93: 15285-15288, 1996.

13. Koga Y, Toshima H, Kimura A, Harada H, Koyanagi T, Nishi H, Nakata M, Imaizumi T: Clinical manifestations of hypertrophic cardiomyopathy with mutations in the cardiac b-myosin heavy chain and cardiac troponin T genes. J Cardiac Failure 2: S97-S103, 1996.

12. Mori K, Sasazuki T, Kimura A, Ito Y: HLA-DP antigens and poststrreptococcal acute glomerulonephritis in Japan. Acta Paediatrica 85: 916-918, 1996.

11. Shintaku S, Fukuda Y, Kimura A, Hoshino S, Asahara T, Dohi K: HLA-A and-B@genotyping in living related one haploidentical kidney transplantation. Jpn J Med Sci Biol. 49: 187-200, 1996.

10. Maruya E, Ishikawa Y, Lin L, Tokunaga K, Kimura A, Nita H, Yokoyama S, Saji H: Allele typing of HLA-A10 group by nested-PCR-low ionic strength single strand conformation polymorphism and a novel A26 allele (A26KY, A*2605). Hum Immunol. 50: 140-147, 1996.

9. Senoo H, Imai K, Sato M, Kojima N, Miura M, Hata R: Three-dimensional structure of extracellular matrix reversibly regulates morphology, proliferation and collagen metabolism of perisinusoidal stellate cells. Cell Biol Int. 20: 501-512, 1996.

8. Sasaki T, Hori H, Arai K, Hattori S, Nagai Y: Effects of a factor derived from polymorphonuclear leukocytes on the growth and collagen metabolism in normal and scleroderma skin fibroblast cultures. J Dermatol Sci. 11: 10-18, 1996.

7. Yamada H, Chiba A, Endo T, Kobata A, Anderson LVB, Hori H, Fukuta-Ohi H, Kanazawa I, Campbell KP, Shimizu T, Matsumura K: Characterization of dystroglycan-laminin interaction in peripheral nerve. J Neurochem. 66: 1518-1524, 1996.

6. Kobayashi T, Onoda N, Takagi T, Hori H, Hattori S, Nagai Y, TajimaS, Nishikawa T: Immunolocalizations of human gelatinase (type IV collagenase, MMP9)and TIMP (tissue inhibitor of metalloproteinases) in normal epidermis and some epidermal tumors. Arch Dermatol Res. 288: 239-244, 1996.

5. Yamada H, Denzer AJ, Hori H, Tanaka T, Anderson LVB, Fujita S, Fukuta-Ohi H, Shimizu T, Ruegg MA, Matsumura K: Dystroglycan is a dual receptor for agrinandlaminin-2 in Schwann cell membrane. J Biol Chem. 271:23418-23423, 1996.

4. Kobayashi T, Sakuraoka T, Hattori S, Hori H, Nagai Y, Tajima S, NishikawaT: Immunolocalization of human gelatinase (type IV collagenase, MMP-9) and tissue inhibitor of metalloproteinase 1 in Hailey-Hailey and Darier's diseases. Dermatol. 193: 110-114, 1996.

3. Kitaoka M, Iyama K, Ushijima T, Mimata C, Hori H, Abe N, Yoshioka H: Differential expressions of collagen types IV, III, and I during the development of invasive trophoblasts in rats. Dev Dynamics 207: 319-331,1996.

2. Mizuta T, Shimada H, Arai K, Hori H, Hattori S, Yamamoto K, Sakai T, Nagai Y: Characterization of monoclonal antibodies recognizing human merosin and their use in affinity purificaion of native merosin. Hybridoma 15: 373-378, 1996.

1. Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E: Tracking the evolutionary history of a microsatellite locus located in the HLA-DQA1/DQB1class II region: a phylogenic approach. In Current Topics on Molecular Evolution (Nei M, Takahata N eds.), pp79-87, Institute of Molecular Evolutionary Genetics, Mishima, 1996.

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1995

19. Kimura A, Nishi H, Harada H, Noguchi M, Ashizawa N, Koga Y, Yano K, Yazaki Y, Kitabatake A, Toshima H, Sasazuki T. Genetic analysis of hypertrophic cardiomyopathy in Japan. In Developmental Mechanisms of Heart Disease (Clark EB, Markwald RR, Takao A eds.) pp113-120, Futura Press, New York, 1995.

18. Kimura A, Harada H, Nishi H, Yasunaga S, Koyanagi T, Koga Y, Imaizumi T, Toshima H, Sasazuki T. Genetic approaches to identification of a novel responsible gene for hypertrophic cardiomyopathy. In Cardiac Development and Gene Regulation (Yazaki Y ed.), pp127-144, Excerpta Medica, Tokyo, 1995.

17. Ohsako N, Tamai H, Sudo T, Mukuta T, Tanaka H, Kuma K, Kimura A, Sasazuki T. Clinical characteristics of subacute thyroiditis classified according to Human Leukocyte Antigen typing. J Clin Endocrionol Metab. 80: 3653-3656, 1995.

16. Nakajima A, Matsuhashi N, Kodama T, Yazaki Y, Takazoe M, Kimura A. HLA-linked disease susceptibility gene and disease resistance gene in Crohn's disease. Gastroenterol. 109: 1462-1467, 1995.

15. Mignot E, Kimura A, Abbal M, Thorsby E, Lin X, Voros A, Macaubas C, Bouissou F, Sollid LM, Cambon-Thomsen A, Yasunaga S, Grumet FC. DQCAR microsatellite polymorphisms in three selected HLA Class II associated diseases. Tissue Antigens 46: 299-304, 1995.

14. Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, Albert ED. Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter. Tissue Antigens 45: 317-321, 1995.

13. Sudo T, Kamikawaji N, Kimura A, Date Y, Savoie CJ, Nakashima H, Furuichi E, Kuhara S, Sasazuki T. Differences in MHC-class I self-peptide repertoires among HLA-A2 subtypes. J Immunol. 155: 4749-4756, 1995.

12. Nakao M, Yamana H, Imai Y, Toh Y, Toh U, Kimura A, Yanoma S, Kakegawa T, Itoh K. HLA A2601-restricted cytotoxic T lymphocytes recognizing a peptide antigen expressed on squamous cell carcinoma. Cancer Res. 55: 4248-4252, 1995.

11. Nishi H, Koga Y, Koyanagi T, Harada H, Imaizumi T, Toshima H, Sasazuki T, Kimura A. DNA typing of HLA class II genes in Japanese patients with dilated cardiomyopathy. J Mol Cell Cardiol. 27: 2385-2392, 1995.

10. Nishi H, Kimura A, Harada H, Koga Y, Adachi K, Matsuyama K, Koyanagi T, Imaizumi T, Toshima H, Sasazuki T. A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy. Circulation 91: 2911-2915, 1995.

9. Petronzelli F, Kimura A, Ferrante P, Mazzilli MC. Polymorphism in the upstream regulatory region of DQA1 gene in the Italian population. Tissue Antigens 45: 258-263, 1995.

8. Kato M, Takazawa K, Kimura A, Rüegg JC, Amano K, Wang Y, Sasaki Y, Toyo-oka T. Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death. Lancet 345: 1247, 1995.

7. Mukai T, Kimura A, Ishibashi H, Sasazuki T, Sata M, Maruyama T, Sakai H, Niho Y. Association of HLA-DRB1*0803 and *1602 with the susceptibility to primary biliary cirrhosis. Intrenat Hepatol Commun. 3: 207-212, 1995.

6. Dong RP, Kamikawaji N, Toida N, Fujita Y, Kimura A, Sasazuki T. Characterization of T cell epitopes in streptococcal M12 protein restricted by HLA-DP9. J Immunol. 154: 4536-4545, 1995.

5. Fukuda Y, Kimura A, Hoshino S, Tashiro H, Furukawa M, Shintaku S, Hori H, Sasazuki T, Dohi K. Significance of the HLA-DQB1 matching in one-haplotype identical kidney transplant pairs and the matching analysis by the polymerase chain reaction (PCR)-heteroduplex-polymorphism method. Tissue Antigens 45: 49-56, 1995.

4. Macaubas C, Hallmayer J, Kalil J, Kimura A, Yasunaga S, Grumet FC, Mignot E. Extensive polymorphism of a (CA)n microsatellite located in the HLA-DQA1/DQB1 class II region. Hum Immunol. 42: 209-220, 1995.

3. Wan XL, Kimura A, Dong RP, Honda K, Tamai H, Sasazuki T. HLA-A and DRB4 genes in controlling the susceptibility to Hashimoto's thyroiditis. Hum Immunol. 42: 131-136, 1995.

2. Shintaku S, Kimura A, Fukuda Y, Date Y, Tashiro H, Hoshino S, Furukawa M, Sasazuki T, Dohi K. Polymerase chain reaction-based HLA-A genotyping and its application to matching in kidney transplantation. Transpl Proc. 27: 689-692, 1995.

1. Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K. Monitoring for engraftment of rat orthotopic liver transplantation by semiquantitative PCR. Transpl Proc. 27: 537-539, 1995.

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