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| 1. |
Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M (2009) Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Nucleic Acids Res., 2009 Sep 3 [Epub ahead of print] |
| 2. |
Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara, M., Cooper DR. (2009) Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA. Endocrinology, 150, 2087-2097. |
| 3. |
Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. (2008) Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244. |
| 4. |
Ohno, G., Hagiwara, M. and Kuroyanagi, H. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes and Dev., 22,360-374. |
| 5. |
Kuroyanagi, H, Ohno, G., Mitani, S., and Hagiwara, M. (2007) Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol. Cell. Biol. 27, 8612-8621. |
| 6. |
Ideue T, Sasaki Y, Hagiwara M and Hirose T. (2007) Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes & Dev., 21, 1993-1998. |
| 7. |
Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S and Yoshida M (2007) A novel cell cycle inhibitor spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature Chem. Biol., 3, 576-583. |
| 8. |
Nojima,T., Hirose,T.,Kimura,H.,& Hagiwara,M. (2007) The interaction between cap-binding complex and REF is required for intronless mRNA export. J. Biol. Chem. 282,15645-15651. |
| 9. |
Aida, T., Konishi,A., Hagiwara,M., ＆ Hashimoto,K. (2007) Shortened Life-Spans of Biotech Pioneer Patents in Japan: A Lesson from the DNA Chip. Nature Biotech. 25, 533-535. |
| 10. |
Kimura, H., Takizawa N., Allemand, E., Hori, T., Iborra, F.J., Nozaki, N., Muraki, M., Hagiwara, M.., Krainer, A.R., Fukagawa, T., and Okawa, K. (2006) A novel histone-exchange factor, protein phosphatase 2Cg, mediates the exchange and dephosphorylation of H2A/H2B. J. Cell Biol. 175,389-400 |
| 11. |
Kuroyanagi, H., Kobayashi, T., Mitani, S., and Hagiwara, M. (2006) A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo. Nature Methods 3, 909-915 |
| 12. |
Wada, K., Howard, J.T., McConnell, P., Whitney, O., Lints, T., Rivas, M.V. Horita, H., Patterson, M.A., White, S.A., Scharff, C., Haesler, S., Zhao, S., Sakaguchi, H., Hagiwara, M., Shiraki, T., Hirozane-Kishikawa, T., Skene, P., Hayashizaki, Y., Carninci, P., and Jarvis, E.D. (2006) A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci USA. 103(41):15212-15217 |
| 13. |
Hirose T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M., and Steitz, J.A. (2006) A spliceosomal intron-binding protein, IBP160, links position-dependent assembly of intorn-encoded box C/C snoRNP to pre-mRNA splicing. Mol. Cell. 23(5):673-684 |
| 14. |
Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA and Hagiwara M (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 103(30):11329-11333 |
| 15. |
Ohki, N. and Hagiwara, M. (2005) Bio-Object, a stochastic simulator for post-transcriptional regulation. Bioinformatics 21, 2478-2487. |
| 16. |
Wada, K.,Sakaguchi, H.,Jarvis, E.,and Hagiwara, M. (2004) Differential expression of glutamate receptors in avian neural pathways for learned vocalization. J. Comp. Neurol. 476,44-64. |
| 17. |
Muraki, M., Ohkawara, B.,Hosoya, T., Onogi, H.,Koizumi, J.,Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M. and Hagiwara, M. (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J. Biol. Chem. 279, 24246-24254. |
| 18. |
Takano, M., Koyama, Y., Ito, H., Hoshino, S.,Onogi, H.,Hagiwara, M., Furukawa, K. and Horigome,T(2004) Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J. Biol. Chem. 279,13265-13271. |
| 19. |
Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H. & Hagiwara, M. (2004) TNFa-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells. Gene to Cells. 1,59-70 |
| 20. |
Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka,N., Amachi,T., Koizumi,J., Hagiwara, M. & Ueda,K (2003) Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear proteinCROP/Luc7A Biochem. Biophys. Res. Comm. 301,324-329. |
| 21. |
Suzuki,H.,Wu, JH,,Hossain, K.,Ohhata,T., Du, J., Akhand, AA., Hayakawa, A., Kimura,H., Hagiwara ,M., ＆Nakashima,I.(2003) Involvement of MKK6 in TCRa beta(int)CD69(lo):a target population for apoptotic cell death in thymocytes. FASEB J.17-1538-40 |
| 22. |
Katsu, R., Onogi, H., Wada, K., Kawaguchi, K. & Hagiwara, M. (2002) Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. J. Biol. Chem. 277, 44220-44228. |
| 23. |
Suzuki, T., Yamakuni , T., Hagiwara, M. , & Ichinose, H. (2002) Identification of ATF-2 as a Transcriptional Regulator for the Tyrosine Hydroxylase Gene. J. Biol. Chem. 277, 40768-40774. |
| 24. |
Kimura, Y., Corcoran, E.E., Eto K., Gengyo-Ando, K., Muramatsu, M., Kobayashi, R., Freedman, J.H., Mitani, S., Hagiwara, M., Means, A.R., & Tokumitsu H. (2002) A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 3, 962-966. |
| 25. |
Wada, K.,Inoue,K,& Hagiwara, M. (2002) Identification of methylated protein arginine N-methyltransferase 1,PRMT1 with a new expression cloning strategy. Biochem. Biophys. Acta. 1591,1-10. |
| 26. |
Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) A novel dual-specificity phosphatase SKRP1 interacts with the MAPKK MKK7 and inactivates the JNK MAPK pathway: Implication for the precise regulation of the particular MAPK pathway. J. Biol. Chem. 277, 23909-23918. |
| 27. |
Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) Scaffold role of a MAP linase phosphatase, SKRP1 for the JNK signaling pathway. J. Biol. Chem. 277, 23919-23926. |
| 28. |
Kamimoto, T., Zama, T., Aoki, R., Muro, Y. & Hagiwara, M. (2001) Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J. Biol. Chem. 276, 37520-37528. |
| 29. |
Kojima, T., Zama, T., Wada, K., Onogi, H. & Hagiwara, M. (2001) Cloning of Human PRP4 Reveals Interaction with Clk1. J. Biol. Chem. 276, 32247-32256. |
| 30. |
Osada, M., Inaba, R., Shinohara, H., Hagiwara, M., Nakamura, M. & Ikawa, Y. (2001) Regulatory Domain of Protein Stability of Human P51/TAP63, a P53 Homologue. Biochem. & Biophys. Res. Comm. 283, 1135-1141. |
| 31. |
Aratani, S., Fujii, R., Oishi, T., Fujita, H., Amano, T., Ohshima, T., Hagiwara, M., Fukamizu, A. & Nakajima, T. (2001) Dual roles of RNA helicase A on CREB-dependent transcription. Mol. Cell. Biol., 21, 4460-4469. |
| 32. |
Ueda, H.R., Hagiwara, M. & Kitano, H. (2001) Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J. Theoret. Biol. 210, 401-406. |
| 33. |
Kuroyanagi, H., Kimura, T., Wada, K., Hisamoto, N., Matsumoto, K. & Hagiwara, M. (2000) SPK-1, a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germ line development. Mech. Dev.. 99, 51-64. |
| 34. |
Muro,Y., Kamimoto,T., Tomita,Y., and Hagiwara, M., (2000) Spectrum of autoantibodies against a dynamin-related protein,dymple. Arthritis Rheumatism 43, 7, 1516-1519. |
| 35. |
Inoue, K., Mizuno, T., Wada, K. & Hagiwara, M. (2000) Novel RING finger proteins, Air1p and 2p interact with Hmtlp and inhibit the arginine methylation of Np13p. J. Biol. Chem. 275, 32793-32799. |
| 36. |
Usukura, J., Nishizawa, Y., Shimomura, A., Kobayashi, K., Nagatsu, T. & Hagiwara, M. (2000) Direct imaging of phosphorylation dependent congormational change and DNA binding of CREB by electron microscopy. Genes to Cells 5, 515-522. |
| 37. |
Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inoue, S., Hirose, K., Iino, M. & Hagiwara, M, (2000) A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol. 18, 313-316. |
| 38. |
Kawahara, K., Watanabe, S., Ohshima, T., Soejima, Y., Oishi, T., Aratani, S., Nakata, M., Shibata, M., Inoue, K., Amano, T., Fujii, R., Yanai, K., Hagiwara, M., Fukamizu, A., Maruyama, I. & Nakajima, T. (1999) Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells. Biochem. Biophys. Res. Comm. 266, 417-424. |
| 39. |
Sakaguchi, H., Wada, K., Maekawa, M., Watsuji, T. & Hagiwara, M, (1999) Song-induced phosphorylation of cAMP response element binding protein in the songbird brain. J. Neuroscience 19, 3973-3981. |
| 40. |
Koizumi, J., Okamoto, Y., Onogi, H., Mayeda, A., and Krainer, A. & Hagiwara, M, (1999) The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). J. Biol. Chem. 274, 11125-11131. |
| 41. |
Okamoto, Y., Onogi, H., Honda, R., Yasuda, H., Wakabayashi, T., Nimura, Y. & Hagiwara, M. (1998) cdc2 kinase-mediated phosphorylation of splicing factor SF2/ASF. Biochem. Biophys. Res. Comm. 249, 872-878 |
| 42. |
Yoshida, K., Imaki, J., Okamoto, Y., Iwakabe, H., Fujisawa, H., Matsuda, A., Nakanishi, S., Matsuda, H. & Hagiwara, M. (1998) CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells. Mol. Brain Res. 57, 241-247. |
| 43. |
Shimomura, A., Okamoto, Y., Hirata, Y., Kobayashi, M., Kawakami, K., Kiuchi, K., Wakabayashi, T. & Hagiwara, M. (1998) Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D Cells. J. Neurochem. 70, 1029-1034. |
| 44. |
Muro, Y., Ogawa, Y., Kato, Y. & Hagiwara, M. (1998) Autoantibody to thioredoxin reductase in an ovarian cancer patient. Biochem. Biophys. Res. Commun. 242, 267-271. |
| 45. |
Kuroyanagi, N., Onogi, H., Wakabayashi, T. & Hagiwara, M. (1998) Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem. Biophys. Res. Commun. 242, 357-364. |
| 46. |
Kamimoto, T., Nagai, Y., Onogi, H., Muro, Y., Wakabayashi, T. & Hagiwara, M. (1998) Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J. Biol. Chem. 273,1044-1051 |
| 47. |
Muro, Y., Kano, T., Sugiura, K. & Hagiwara, M. (1997) Low frequency of autoantibodies against Ki-67 antigen in Japanese patients with systemic autoimmune. J. Autoimmunity 10, 499-503. |
| 48. |
Nomoto, S., Watanabe, Y., Ninomiya-Tsuji, J., Yang, L.-X., Kiuchi, K., Hagiwara, M., Hidaka, H., Matsumoto, K. & Irie, K. (1997) Functional analyses of mammalian protein kinase kinase C Isozymes in budding yeast and mammalian fibroblasts. Genes to Cells 2, 601-614. |
| 49. |
Nagai, Y., Kojima, T., Muro, Y., Hachiya, T., Nishizawa, Y., Wakabayashi, T. & Hagiwara, M. (1997) Identification of a novel nuclear speckle-type protein, SPOP. FEBS Lett. 418, 23-26 |
| 50. |
Masunaga, R., Nagasaka, A., Nakai, A., Kotak, M., Sawai, Y., Oda, N., Mokuno, T., Shimazaki, K., Hayakawa, N., Kato, R., Hiran, E., Hagiwara, M., & Hidaka, H. (1997) Alteration of platelet aggregation in patients with thyroid disorders. Metabolism 46, 1128-1131. |
| 51. |
Watsuji, T., Okamoto, Y., Emi, N., Katsuoka, Y. & Hagiwara. M. (1997) Controlled gene expression with a reverse tetracycline regulated retroviral vector (RTRV) system. Biochem. Biophys. Res. Commun. 234, 769-773 |
| 52. |
Watanabe, Y., Takaetsu, G., Hagiwara, M., Irie, K. & Matsumoto, K. (1997) Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) Mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17, 2615-2623. |
| 53. |
Sugiura, K., Muro, Y., Nagai, Y. & Hagiwara, M. (1997) Expression cloning and intracellular localization of a human ZF5 homologue. Biochem. Biophys. Acta. 1352, 23-26 |
| 54. |
Muro, Y., Kamimoto, T. & Hagiwara, M. (1997) Anti-Mitosin antibodies in a patient with chronic graft-versus-host disease after allogenic bone marrow transplantation. Bone Marrow Transplantation 19, 951-953. |
| 55. |
Kobayashi, M., Shimomura, A., Hagiwara, M. & Kawakami, K. (1997) Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase a1 subunit gene promoter. Nucleic Acids Res. 25, 877-882. |
| 56. |
Okajima, T., Okuno, S., Fujisawa, H. & Hagiwara, M. (1996) Nuclear localization of Ca2+/Calmodulin-dependent protein kinase IV and calspermin. Bioimage 4, 117-128. |
| 57. |
Moriguchi, T., Toyoshima, F., Gotoh, Y., Iwamatsu, A., Irie, K., Mori, E., Kuroyanagi, N., Hagiwara, M., Matsumoto, K. & Nishida, E. (1996). Purification and identification of a major activator for p38 from osmotically shocked cells: Activation of MAPKK6 by osmotic shock, tumor necrosis factor-a and H2O2. J. Biol. Chem. 271, 26981-26988. |
| 58. |
Okada, H., Miyamura, K., Ito, T., Hagiwara, M., Wakabayashi, T., Mizuno, M., Colosi, P., Kurtzman, G. & Yoshida, J. (1996) Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Therapy 3, 957-964. |
| 59. |
Shimomura, A., Ogawa, Y., Fujisawa, H. & Hagiwara, M. (1996) Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. J. Biol. Chem. 271, 17957-17960. |
| 60. |
Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. & Hagiwara, M. (1996) A novel kinase cascade mediated by MAPKK6 and MKK3. J. Biol. Chem. 271, 13675-13679. |
| 61. |
Yasunami, M., Suzuki, K., Maruyama, H., Kawakami, H., Nagai, Y., Hagiwara, M. & Ohkubo, H. (1996) Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to NeuroD/BHF1. Biochem. Biophys. Res. Commun. 220, 754-758. |
| 62. |
Okada, H., Yoshida, J., Sokabe, M., Wakabayashi, T. & Hagiwara, M. (1996) Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int. J. Cancer. 66, 255-260 |
| 63. |
Yoshida, K., Imaki, J., Fujisawa, H., Harada, T., Ohki, K., Matsuda, H. and Hagiwara, M. (1996) Differential distribution of CaM kinases and induction of c-fos expression by flashing and sustained light in rat retinal cells. Invest. Ophthalmol. Vis. Sci. 37, 174-179. |
| 64. |
Harada, T., Imaki, J., Hagiwara, M., Ohki, K., Takamura, M., Ohashi, T., Matsuda, H. & Yoshida, K. (1995) Phosphorylation of CREB in rat retinal cells after focal retinal injury. Exp. Eye. Res. 61,769-772 |
| 65. |
Kano, T., Suzuki, Y., Shibuya, M., Kiuchi, K. & Hagiwara, M. (1995) Cocaine-induced CREB phosphorylation and c-fos expression were suppressed in parkinsonism model mice. NeuroReport 6, 2197-2200. |
| 66. |
Ohki, K., Yoshida, K., Hagiwara, M., Harada, T., Takamura, M., Ohashi, T., Matsuda, H. & Imaki, J. (1995) Nitric oxide induces c-fos gene expression via cyclic AMP response element binding protein (CREB) phosphorylation in rat retinal pigment epithelium. Brain Res. 696, 140-144. |
| 67. |
Yoshida, K., Imaki, J., Matsuda, H. & Hagiwara, M. (1995) Light-induced CREB phosphorylation and gene expression in rat retinal cells. J. Neurochem. 65,1499-1504. |
| 68. |
Okada, H., Yoshida, J., Seo, H., Wakabayashi, T., Sugita K. & Hagiwara, M. (1994). Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells. Cancer Immunol. Immunother. 39, 313-317. |
| 69. |
Alberts, A.S., Arias, J., Hagiwara, M., Montminy, R.M. & Feramisco, J.R. (1994) Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J. Biol. Chem. 269,7623-7630. |
| 70. |
Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, R.M. & Goodman, R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859. |
| 71. |
Nakamura, S., Wakusawa, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1993) Effects of isoquinoline sulphonamide compounds on multi-drug-resistant P388 cells. J. Pharmacol. 45, 268-273. |
| 72. |
Shimohama, S., Narita, M., Matsushima, H., Kimura, J., Kameyama, M., Hagiwara, M., Hidaka, H. & Taniguchi, T. (1993). Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer’s disease. Neurology 43, 1407-1413. |
| 73. |
Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., & Montminy, R. M. (1993) Stimulus-transcription coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Mol. Cell. Biol. 13, 4852-4859. |
| 74. |
Kawamoto, F., Fujioka, H., Murakami, R., Syafruddin, Hagiwara, M., Ishikawa, T. & Hidaka, H. (1993) The roles of Ca2+/calmodulin-andcGMP-dependent pathways in gametogenesis of a rodent malaria parasite, Plasmodium berghei. Eur. J. Cell. Biol. 60, 101-107. |
| 75. |
Matsushima, H., Shimohama, S., Yamaoka, Y., Kimura, J., Taniguchi, T., Hagiwara, M. & Hidaka, H. (1993) Alteration of human platelet protein kinase C with normal aging. Mech. Ageing Dev. 69,129-36. |
| 76. |
Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S. & Montminy, M. (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70, 105-13. |
| 77. |
Okazaki, K., Watanabe, M., Ando, Y., Hagiwara, M., Terasawa, M. & Hidaka, H. (1992) Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Biochem. Biophys. Res. Commun. 185,147-53. |
| 78. |
Goto, S., Kobayashi, M., Murate, T., Hotta, T., Hagiwara, M., Hoshino, T., Hidaka, H. & Saito, H. (1992). Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C. Thromb. Res. 68, 87-95. |
| 79. |
Usuda, N., Hagiwara, M., Kong, Y., Shimizu, T., Hidaka, H. & Nagata, T. (1992) Immunohistochemical locazilation of protein kinase C isozymes. Acta. Histochem. Cytochem. 25, 707-715. |
| 80. |
Wakusawa, S., Nakamura, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1992) Overcoming of vinblastine resistance by isoquinoline sulfonamide compounds in adriamycin-resistant leukemiacells. Mol. Pharmacol. 41, 1034-1038. |
| 81. |
Kato, M., Hagiwara, M. & Hidaka, H. (1992) Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA). Biochem. J. 281, 339-42. |
| 82. |
Iwamoto, T., Hagiwara, M., Hidaka, H., Isomura, T., Kioussis, D. & Nakashima, I. (1992) Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J. Biol. Chem. 267, 18644-18648. |
| 83. |
Uchida, C., Hagiwara, M. & Hidaka, H. (1991) Ca(2+)-independent, phospholipid-activated protein kinase in 3Y1 cells. Arch. Biochem. Biophys. 288, 421-426. |
| 84. |
Terasawa, M., Hagiwara, M., Hachiya, T., Kobayashi, R., Obata, S., Wakabayashi, T. & Hidaka, H. (1991) Identification and characterization of protein kinase C-related enzymes in frog retina. Arch. Biochem. Biophys. 287, 213-7. |
| 85. |
Hagiwara, M., Wakusawa, S., Miyamoto, K., & Hidaka, H. (1991). Obviation of drug resistance and affinity purification of P-glycoprotein by isoquinoline sulfonamides. Cancer Lett. 60, 103-7. |
| 86. |
Sumi, M., Kiuchi, K., Ishikawa, T., Ishii, A., Hagiwara, M., Nagatsu, T. & Hidaka, H. (1991). The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contentsin PC12h cells. Biochem. Biophys. Res. Commun. 181, 968-975. |
| 87. |
Shimizu, T., Usuda, N., Sugenoya, A., Masuda, H., Hagiwara, M., Hidaka, H., Nagata, T. & Iida, F. (1991) Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. Cell. Mol. Biol. 37, 813-821. |
| 88. |
Usuda, N., Kong, Y., Hagiwara, M., Uchida, C., Terasawa, M., Nagata, T. & Hidaka, H. (1991) Differential localization of proteikinase C isozymes in retinal neurons. J. Cell Biol. 112, 1241-1247. |
| 89. |
Kato, M., Hagiwara, M., Nimura, Y., Shionoya, S. & Hidaka, H. (1991). Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands. J Endocrinol. 131, 155-162. |
| 90. |
Koyama, Y., Fukaya, Y., Ueda, H., Hachiya, T., Hagiwara, M., Hidaka, H. & Marunouchi, T. (1990). Expression of protein kinase C isozyme in human Langerhans' cells. Acta. Derm. Venereol. Stockh. 70, 502-505. |
| 91. |
Koyama, Y., Hachiya, T., Hagiwara, M., Kobayashi, M., Ohashi, K., Hoshino, T., Hidaka, H. & Marunouchi, T. (1990). Expression of kinaseC isozyme in epidermal Langerhans cells of the mouse. J. Invest. Dermatol. 94, 677-680. |
| 92. |
Onoda, K., Hagiwara, M., Hachiya, T., Usuda, N., Nagata, T. & Hidaka, H. (1990) Different expression of protein kinase C isozymes inpancreatic islet cells. Endocrinology 126, 1235-40. |
| 93. |
Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue,T., Naito, K., Toshioka, T. & Hidaka, H. (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide, of PC12D pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272. |
| 94. |
Miyamoto, K., Wakusawa, S., Nakamura, S., Koshiura, R., Otsuka, K., Naito, K., Hagiwara, M. & Hidaka, H. (1990) Circumvention of multi-drug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87. Cancer Lett. 51, 37-42. |
| 95. |
Hachiya, T., Hagiwara, M. & Hidaka, H. (1990) Immunoaffinity purification of type I protein kinase C. Arch. Biochem. Biophys. 280, 358-361. |
| 96. |
Sumi, M., Hagiwara, M. & Hidaka, H. (1990) d-Indobufen inhibits collagen-induced intracellular calcium mobilization and inositol phosphates formation in human platelets. Thromb. Res. 59,319-326. |
| 97. |
Shimosawa, S., Hachiya, T., Hagiwara, M., Usuda, N., Sugita, K. & Hidaka, H. (1990) Type-specific expression of protein kinase C isozymes in CNS tumor cells. Neurosci. Lett. 108, 11-16. |
| 98. |
Hagiwara, M., Uchida, C., Usuda, N., Nagata, T., & Hidaka, H. (1990) Zeta-related protein kinase C in nuclei of nerve cells. Biochem. Biophys. Res. Commun. 168, 161-168. |
| 99. |
Hagiwara, M., Hachiya, T., Watanabe, M., Usuda, N., Iida, F., Tamai, K. & Hidaka, H. (1990) Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. Cancer Res. 50, 5515-5519. |
| 100. |
Hagiwara, M., Sumi, M., Usuda, N., Nagata, T. & Hidaka, H. (1990) Discrepancy of protein kinase C translocation and platelet aggregation-immunocytobiochemical evidence. Arch. Biochem. Biophys. 280, 201-5 |
| 101. |
Tokumitsu, H., Chijiwa, T., Hagiwara, M., Mizutani, A., Terasawa, M. & Hidaka, H. (1990). KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 265, 4315-4320 |
| 102. |
Watanabe, M., Hachiya, T., Hagiwara, M. & Hidaka, H. (1989) Identification of type III protein kinase C in bovine aortic tissue. Arch. Biochem. Biophys. 273, 165-169. |
| 103. |
Mamiya, S., Hagiwara, M., Ishikawa, T. & Hidaka, H. (1989) Specific inhibition of 40 K protein phosphorylation in platelet by a new antithrombotic agent, d-indobufen. Thromb. Res. 54, 447-456. |
| 104. |
Mamiya, S., Hagiwara, M., Inoue, S. & Hidaka, H. (1989) Thyroid hormones inhibit platelet function and myosin light chain kinase. J. Biol. Chem. 264, 8575-8279. |
| 105. |
Kariya, K., Kawahara, Y., Fukuzaki, H., Hagiwara, M., Hidaka, H., Fukumoto, Y. & Takai, Y. (1989). Two types of protein kinase C With different functions in cultured rabbit aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 161, 1020-1027. |
| 106. |
Tokumitsu, H., Hagiwara, M., Onoda, K. & Hidaka, H. (1989) Anti-gizzard MLCK monoclonal antibody MM13 inhibits superprecipitation and phosphorylation of bovine aortic smooth muscle actomyosin. J. Biochem. 106, 511-514. |
| 107. |
Chijiwa, T., Hagiwara, M. & Hidaka, H. (1989) A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethy1)-5-chloroisoquinoline-8-sulfonamide,and affinity purification of casein kinase C in neuroblastoma NBC-20 cell: dependence on 1,2-diacylglycerol content and free calcium. J Biol Chem. 264, 5267-5272. |
| 108. |
Fu, T., Okano, Y., Hagiwara, M., Hidaka, H. & Nozawa, Y. (1989) NCB-20 cell: dependence on 1,2-diacylglycerol content and free calcium. Biochem. Biophys. Res. Commun. 162, 1279-1286. |
| 109. |
Hagiwara, M., Tokumitsu, H., Onoda, K., Tanaka, T., Ito, M., Kato, N. & Hidaka, H. (1989) Monoclonal antibody assessment of tissue- and species- specific myosin light chain kinase isozymes. J. Biochem. 106, 71-75. |
| 110. |
Hagiwara, M., Mamiya, S. & Hidaka, H. (1989) Selective binding of L-thyroxine by myosin light chain kinase. J. Biol. Chem. 264, 40-44. |
| 111. |
Ishikawa, T., Chijiwa, T., Hagiwara, M., Mamiya, S. & Hidaka, H. (1989) Thyroid hormones directly interact with vascular smooth muscle strips. Mol. Pharmacol. 35, 760-765. |
| 112. |
Tanaka, T., Hagiwara, M., Hidaka, H., Nunoki, K., Ohta, H., Onoda, K., Ito, M., Ohkubo, S., Hiai, H. & Nishizuka, Y. (1989) Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line. Biochem. Biophys. Res. Commun. 164,1397-1401. |
| 113. |
Abougou, J. C., Hagiwara, M., Hachiya, T., Terasawa, M., Hidaka, H. & Hartshorne, D. J. (1989) Phosphorylation of caldesmon. FEBS Lett. 257, 408-410. |
| 114. |
Hagiwara, M., Mamiya, S., Ochiai, M. & Hidaka, H. (1988) Thyroid hormones inhibit the Ca2+ calmodulin-induced activation of myosin light chain kinase. Biochem. Biophys. Res. Commun. 152, 270-276. |
| 115. |
Hagiwara, M., Inagaki, M., Takahashi, J., Yoshida, T. & Hidaka, H. (1988) A fluorescent protein kinase C inhibitor: 1-(1-hydroxy-5-isoquinolinylsulfonyl) piperazine. Pharmacology 36, 365-370. |
| 116. |
Ishikawa, T., Chijiwa, T., Hagiwara, M., Mamiya, S., Saitoh, M. & Hidaka, H. (1988) ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol. Pharmacol. 33, 598-603. |
| 117. |
Hagiwara, M., Inagaki, M., Kanamura, K., Ohta, H. & Hidaka, H. (1988) Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C. J. Pharmacol. Exp. Ther. 244, 355-360. |
| 118. |
Kiuchi, K., Hagiwara, M., Hidaka, H. & Nagatsu, T. (1988) Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. Neurosci. Lett. 89, 209-215. |
| 119. |
Ito, T., Tanaka, T., Yoshida, T., Onoda, K., Ohta, H., Hagiwara, M., Itoh, Y., Ogura, M., Saito, H. & Hidaka, H. (1988) Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association. J. Cell Biol. 107, 929-937. |
| 120. |
Hagiwara, M., Ochiai, M., Owada, K., Tanaka, T. & Hidaka, H. (1988) Modulation of tyrosine phosphorylation of p36 and other substrates by the S-100 protein. J. Biol. Chem. 263, 6438-6441. |
| 121. |
Hagiwara, M., Inoue, S., Tanaka, T., Nunoki, K., Ito, M. & Hidaka, H. (1988) Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem. Pharmacol. 37, 2987-2992. |
| 122. |
Tanaka, T., Ishikawa, T., Hagiwara, M., Onoda, K., Itoh, H. & Hidaka, H. (1988) Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle. Pharmacology 36, 313-320. |
| 123. |
Hidaka, H., Tanaka, T., Onoda, K., Hagiwara, M., Watanabe, M., Ohta, H., Ito, Y., Tsurudome, M. & Yoshida, T. (1988). Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum. J. Biol. Chem. 263, 4523-4526. |
| 124. |
Watanabe, M., Hagiwara, M., Onoda, K. & Hidaka, H. (1988). Monoclonal antibody recognition of two subtype forms of protein kinase C in human platelets. Biochem. Biophys. Res. Commun. 152, 642-648. |
| 125. |
Hagiwara, M., Inagaki, M., Watanabe, M., Ito, M., Onoda, K., Tanaka, T. & Hidaka, H. (1987) Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinoline sulfonamide derivatives. Mol. Pharmacol. 32, 7-12. |
| 126. |
Hagiwara, M., Inagaki, M. & Hidaka, H. (1987) Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide to the active site of cAMP-dependent protein kinase. Mol. Pharmacol. 31, 523-528. |
| 127. |
Inagaki, M., Hagiwara, M., Saitoh, M. & Hidaka, H. (1986) Protein kinase C negatively modulated by phorbol ester. FEBS. Lett. 202, 277-281. |
| 128. |
Inagaki, M., Kawamoto, S., Itoh, H., Saitoh, M., Hagiwara, M., Takahashi, J. & Hidaka, H. (1986) Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol. Pharmacol. 29, 577-81. |
| 129. |
Hagiwara, M., Endo, T., Kanayama, T. & Hidaka, H. (1984) Effect of (3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J. Pharmacol. Exp. Ther. 228, 467-471. |
| 130. |
Hagiwara, M., Endo, T. & Hidaka, H. (1984) Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem. Pharmacol. 33, 453-457. |
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