● Onodera,T., J. C. Poe, T. F. Tedder
and Tsubata, T.
CD22 Regulates Time Course of Both B Cell Division and Antibody Response.
J.
Immunol.
(2008) 180: 907-913
●Adachi, T. and Tsubata, T.
FRET-based
Ca２＋ measurement in B lymphocyte by flow cytometry and confocal microscopy.
Biochem. Biophys. Res. Commun.
(2008) 142: 377-382
●Zhu, C., Fujimoto, M., Sato, M.,
Yanagisawa, T., Tsubata, T.
Novel
binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in
CD22 achtivated by B lymphocyte stimulation with antigen.
J.
Biol. Chem.
(2008) 283: 1653-1659
● Jie Yu, Sawada, T., Adachi, T.,
Xiaoming Gao., Takematsu, H., Kozutsumi, Y., Ishida, H., kiso, M. and Tsubata,T.
Synthetic
glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.
Biochem. Biophys. Res. Commun.
(2007) 360: 759-764
●Bin-Cheng Yan, Adachi, T., Tsubata,
T.
ER
stress is involved in B cell antigen receptor ligation-induced apoptosis.
Biochem. Biophys. Res. Commun. (2007) 365: 143-148
●Adachi, T., Wienands, J., Tsubata,
T., Kurosaki, T.
Interdomain
A is crucial for ITAM-dependent and ﾐindependent regulation of Syk.
Biochem. Biophys. Res. Commun.
(2007) 364: 111-117
●Sato, M., Adachi, T. and Tsubata,
T.
Augmentation
of signaling through BCR containing IgE but not that containing IgA due to lack
of CD22-mediated signal regulation.
J.
Immunol.
(2007) 178: 2901-2907
●Tsubata, T.
B
cell abnormality and systemic lupus erythematosus.
APLAR
J. Rheum. (2006)
9: 372-376
●Devi, S. S., Hagiyama, H., Adachi,
T., Miyasaka, N. and Tsubata, T.
The
tumor suppressor p53 is not required for antigen receptor-mediated apoptosis
of B lymphocytes.
Signal
Transduction. (2006)
6: 54-61.
●Akagawa, M., Ito, S., Toyoda, K.,
Ishii, Y., Tatsuda, E., Shibata, T., Kawai, Y., Ishino, K., Kishi, Y., Adachi,
T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T. and Uchida, K.
Bispecific
antibodies against modified protein and DNA with oxidized lipids.
Proc.
Natl. Acad. Sci. USA.
(2006) 103: 6160-5.
●Tsubata, T.
B
cell abnormality and autoimmune disorders.
Autoimmunity.
(2005)
38: 331-337.
●Nitschke,
L., and Tsubata, T.
Molecular
interactions regulate BCR signal inhibition by CD22 and CD72.
Trends immunol. (2004)
25:543-550.
●Kawamura, T., Kanai, T., Dohi, T., Uraushihara,
K., Totsuka, T., Iiyama, R., Taneda, C., Yamazaki, M., Nakamura, T., Higuchi,
T., Aiba, Y., Tsubata, T. and Watanabe, M.
Ectopic CD40 ligand expression on B cells trigger intestinal inflammation.
J. Immunol.(2004) 172:6388-6397.
● Hirai,
H., Adachi, T., and Tsubata, T.
Involvement of cell cycle progression in survaival signaling through CD40 in
B lymphocyte line WEHI-231.
Cell
Death Differ. (2004)
11:261-269
● Hokazono,
Y., Adachi, T., Wabl, M., Tada, N., Amagasa, T., and Tsubata, T.
Inhibitory co-receptors activated by antigens but not
by anti-immunoglobulin heavy chain antibodies install requirement of co-stimulation
through CD40 for survival and proliferation of B cells.
J. Immunol. (2003) 171: 1835-1843
●
Saijo, K., Schmedt, C., Su, I. H., Karasuyama, H., Lowell, C. A., Reth, M.,
Adachi, T., Patke, A., Santana, A., Tarakhovsky, A.
Essential role of Src-family protein tyrosine kinases
in NF-kB activation during B cell development.
Nat Immunol. (2003) 4 :274-279
● Suzuki,
A., Kaisho, T., Ohishi, M.,
Tsukio-Yamaguchi, M., Tsubata, T., Koni,P.A., Sasaki, T., Mak, T. W., and Nakano,
T.
Critical roles of Pten in B cell homeostasis and immunoglobulin
class switch recombination.
J.Exp.Med.(2003) 197:657-667
● Wakabayashi,
C., Adachi,T., Wienands,J., Tsubata,T.
A distinct signaling pathway
used by the IgG-containing B cell antigen receptor
Science.(2002) 298:2392-2395
抗体には、免疫応答の初期に産生されるIgM型（クラス）抗体、感染防御能の高いIgGクラスの抗体、消化管免疫に関係するIgAクラス,寄生虫感染やアレルギーに関係するIgEクラスがあります。今回の論文では、抗体産生細胞の活性化制御機構が抗体のクラスによって異なることを世界に先駆けて明らかにしました。この機構には膜型レクチン分子CD22/Siglec2が関与します。この機構を人為的に制御することができるようになれば、どのようなクラスの抗体が産生されるかを制御することが可能になります。
論文別冊はこちら
● Higuchi,
T., Aiba, Y., Nomura, T., Matsuda, J., Mochida, K., Suzuki, M., Kikutani, H.,
Honjo, T., Nishioka, K. and Tsubata T.
Cutting Edge: Ectopic expression of CD40 ligand on
B cells induces lupus-like autoimmune disease.
J. Immunol.(2002)
168:9-12.
●Tsubata,
T.
Molecular mechanisms for apoptosis induced by siganling
through the B cell antigen receptor.
Int. Rev. Immunol.(2001) vol20, no.6, 675-678,791-803.
●Adachi, T.,
Wienands, J., Wakabayashi, C., Yakura, H., Reth,
M. and Tsubata, T.
SHP-1 requires
inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation
of cellular substrates.
J. Biol. Chem.276:26648-26655
(2001) .
●Suzuki, A., Tsukio-Yamaguchi,
M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A.,
Higuchi, T., Fukumoto, M., Tsubata, T., Ohashi, P., Koyasu, S., Penninger, J.
M., Nakano, T. and Mak, T. W.
T cell-specific loss of
Pten leads to defects in central and peripheral tolerance.
Immunity 14: 523-534 (2001)
●Tsubata,
T., Wakabayashi, C. and Adachi, T.
Regulation of B cell antigen receptor signaling by CD72.
In
ﾒActivating and Inhibitory Immunoglobulin-like Receptorsﾓ(ed.
by Max D. Cooper, Toshiyuki Takai, and Jeffrey V. Ravetch) Sprnger-Verlag Tokyo
p. 123-128 (2001)
●Nagaoka, H.,
Takahashi, Y., Hayashi, R., Nakamura, T., Ishii, K., Matsuda,
J.-I., Ogura,
A., Shirakata, Y., Karasuyama, H., Sudo, T., Nishikawa, S.-I., Tsubata,
T., Mizuochi, T., Asano, T., Sakano, H., Takemori, T.
Ras mediates effector pathways responsible for pre-B cell survival, which
is essential for the developmental progression to the the late pre-B cell
stage.
J. Exp. Med. 192:
171-181(2000)
●Yoshida, T., Higuchi,
T., Hagiyama, H., Strasser, A., Nishioka, K., and Tsubata, T.
Rapid B cell apoptosis induced
by antigen receptor ligation does not require Fas (CD95/APO-1), the adapter
protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+
and MRL-lpr/lpr mice.
Int. Immunol. 12: 517-526 (2000)
●Tsubata, T., and Honjo,
T.
B cell tolerance and autoimmunity.
Rev. Immunogenet. 2: 18-25 (2000)
●Adachi, T., Wakabayashi,
C., Nakayama, T., Yakura, H., and Tsubata T.
CD72 negatively regulates signaling through the antigen receptor of B cells.
J. Immunol. 164: 1223-1229 (2000)
●Tsubata, T.
Co-receptors on B lymphocytes.
Curr. Opin. Immunol. 11: 249-255 (1999)
●Hagiyama, H., Adachi,
T., Yoshida, T., Nomura, T, Miyasaka, N., Honjo, T., and Tsubata, T.
Signaling through the antigen receptor of B lymphocytes
activates a p53-independent pathway of c-Myc-induced apoptosis.
Oncogene 18: 4091-4098 (1999)
●Tsubata, T.
Apoptosis of mature B cells.
Int. Rev. Immunol. 18: 347-365 (1999)
●Takeuchi, Y., Nishimura, K., Aoki, N., Adachi,
T.,Sato, C., Kitajima, K., and Matsuda, T.
A 42-kDa glycoprotein from chicken egg-envelope, an
avian homolog of the ZPC family glycoproteins in mammalian Zona pellucida. Its
first identification, cDNA cloning and granulosa cell-specific expression.
Eur. J. Biochm. 260: 736-742 (1999)
●Hirayama, F., Aiba, Y., Ikebuchi, K., Sekiguchi,
S., and Ogawa, M.
Differentiation in culture of murine primitive lymphohematopoietic
progenitors toward T-cell lineage.
Blood. 93: 4187-4195 (1999)
●Sato, T., Laver, J.H., Aiba, Y., and Ogawa,
M.
NK cell colony formation from human fetal thymus.
Exp. Hematol. 27: 726-733 (1999)
● Adachi, T., Flaswinkel, H., Yakura, H., Reth,
M., and Tsubata, T.
The B cell surface protein CD72
recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.
In "Proceedings of 10th International Congress of Immunology"
(ed. by G.P.Talwar, I, Nath, N.K.Ganguly, K.V.S.Rao) p.341-344. Monduzzi Editore
S.p.A., Bologna. (1998)
●Adachi, T., Flaswinkel, H., Yakura, H., Reth,
M., and Tsubata, T.
The B cell surface protein CD72 recruits the tyrosine
phosphatase SHP-1 upon tyrosine phosphorylation.
J. Immunol. 160: 4662-4665 (1998)
●Watanabe N., Nomura, T., Takai, T., Chiba, T.,
Honjo, T. and Tsubata, T.
Antigen receptor cross-linking by anti-immunoglobulin
antibodies coupled to cell surface membrane induces rapid apoptosis of normal
spleen B cells.
Scand. J. Immunol. 47: 541-547 (1998)
●Oubihi, M., Kitajima, K., Kobayashi, K., Adachi,
T., Aoki, N., and Matsuda, T.
Development of an enzyme-linked immunosorbent assay-based
method for measuring galactosyltransferase activity using a synthetic glycopolymer
acceptor substrate.
Anal. Biochem. 257: 169-175 (1998)
●Hotta, H., Aoki, N., Nakamura, R., Matsuda,
T. and Adachi, T.
Molecular analysis of a novel protein kinase in maturing
rice seed.
Gene 212: 47-54 (1998)
●Han, H., Nomura, T., Honjo, T., and Tsubata,
T.
Differential modulation of cyclin-dependent kinase
inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells
and positive signaling via CD40.
Eur. J. Immunol. 26: 2425-2432 (1996)
●Nomura, T., Han, H., Howard, M. C., Yagita,
H., Yakura, H., Honjo, T., and Tsubata, T.
Antigen receptor-mediated B cell death is blocked by
signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone
mice.
Int. Immunol. 8: 867-875 (1996)
●Nisitani, S., Tsubata, T., Murakami, M., and
Honjo, T.
Administration of interleukins 5 or 10 activates peritoneal
B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody
transgenic mice.
Eur. J. Immunol. 25: 3047-3052 (1995)
●Murakami, M., Tsubata, T., Shinkura, R., Nisitani,
S., Okamoto, M., Yoshioka, H., Usui, T., Miyawaki, S. and Honjo, T.
Oral administration of lipopolysaccharides activates
B-1 cells in the peritoneal cavity and lamina propria of the gut and induces
autoimmune symptoms in an autoantibody transgenic mouse.
J. Exp. Med. 180: 111-121 (1994)
●Tsubata, T., Murakami, M. and Honjo, T.
Antigen-receptor cross-linking induces peritoneal B-cell
apoptosis in normal but not autoimmunity-prone mice.
Curr. Biol. 4: 8-17 (1994)
●Nisitani, S., Tsubata, T., Murakami, M., Okamoto,
M. and Honjo, T.
The bcl-2 gene product inhibits clonal deletion of
self-reactive B lymphocytes in the periphery but not in the bone marrow.
J. Exp. Med. 178: 1247-1254 (1993)
●Tsubata, T., Wu, J. and Honjo, T.
B-cell apoptosis induced by antigen receptor crosslinking
is blocked by T-cell signal through CD40.
Nature 364: 645-648 (1993)
●Murakami, M., Tsubata, T., Okamoto, M., Shimizu,
A., Kumagai, S., Imura, H. and Honjo, T.
Antigen-induced apoptotic death of Ly-1 B cells responsible
for autoimmune disease in transgenic mice.
Nature 357: 77-80 (1992)
●Tsubata, T. and Nishikawa, S.-I.
Molecular and cellular aspects of early B-cell development.
Curr. Opin. Immunol. 3: 186-192 (1991)
●Tsubata, T. and Reth, M.
The products of pre-B specific genes (l5 and VpreB)
and the immunoglobulin m chain form a complex that is transported onto the cell
surface.
J. Exp. Med. 172: 973-976 (1990)
●Hombach, J., Tsubata, T., Leclercq, L., Stappert,
H. and Reth, M.
Molecular components of the B-cell antigen receptor
complex of the IgM class.
Nature 343: 760-762 (1990)
●Adachi, T., Schamel, W. W. A., Kim, K. -M.,
Watanabe, T., Becker, B., Nielsen, P. J., and Reth, M.
The specificity of association of the IgD molecule
with the accessory proteins BAP/31/BAP29 lies in the IgD transmembrane sequence.
EMBO J. 15:1534-1541 (1996)
●Tada, Y., Nakase, M., Adachi, T., Nakamura,
R., Shimada, H., Takahashi, M., Fujimura, T. and Matsuda, M.
Reduction of 14-16 kDa allergenic proteins in transgenic
rice plants by antisense gene.
FEBS Lett. 391: 341-345 (1996)
●Apel, W. T., Scherer, A., Adachi, T., Auch,
D., Ayane, M., and Reth, M.
The ribose 5-phosphate isomerase-encoding gene is located
immediately downstream from that encoding murine immunoglobulin k.
Gene 156: 191-197 (1995)
●Terashima, M., Kim, K. -M., Adachi, T., Nielsen,
P. J., Reth, M., Kohler, G. and Lamers, M. C.
The IgM antigen receptor of B lymphocytes is associated
with prohibitin and a prohibitin-related protein.
EMBO J. 13: 3782-3792 (1994)
●Kim, K. -M., Adachi, T., Nielsen, P. J., Terashima,
Lamers, M. C., M., Kohler, G. and Reth, M.
Two new proteins preferntially associated with membrane
immunoglobulin D.
EMBO J. 13: 3793-3800 (1994)
