【田中教授の研究業績】  原著論文  総説  田中教授の論文引用数

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【平岡助教の研究業績】  原著論文  総説
 

田中教授の原著論文

<2015年以降>
Sugiyama, K., Aida, T., Nomura, M., Takayanagi, R., Zeilhofer, HU., Tanaka, K. Calpain-dependent degradation of nucleoporins contributes to motor neuron death in a mouse model of chronic excitotoxicity. J Neurosci doi: 10.1523/JNEUROSCI.0730-17.2017.

Miyazaki, T., Yamasaki, M., Hashimoto, K., Kohda, K., Yuzaki, M., Shimamoto, K., Tanaka, K., Kano, M., Watanabe, M. Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.1617330114, 2017.


Kubo, K., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, KF., Tanaka, K., Takashima, S., Nakayama, M., Itoh, M., Hirata, Y., Antalffy, B., Armstrong, DD., Yamada, K., Inoue, K., Nakajima, K. Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight 2. e88609, 2017.


Nakamori, T., Kato, T., Sakagami, H., Tanaka, K., Ohki-Hamazaki, H. Regulation of visual wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells. Sci Rep 7. 42927, 2017.

Aida, T., Nakade, S., Sakuma, T., Ishikubo, H., Usami, T., Aizawa, H., Yamamoto, T., Tanaka, K. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ. BMC Genomics 17:979, 2016

Dong, Z., Shinmei, Y., Dong, Y., Inafuku, S., Fukuhara, J., Ando, R., Kitaichi, N., Kanda, A., Tanaka, K., Noda, K., Harada, T., Chin, S., Ishida, S. Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma. Heliyon 2:e00191, 2016.

Perkins, EM., Suminaite, D., Clarkson, YL., Lee, SK., Lydon, AR., Rothstein, JD., Wyllie, DJ.,
Tanaka, K. Jackson, M. Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse models are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST. Hum Mol Genet pii: ddw274,(2016).

Ageta-Ishihara, N., Yamazaki, M., Konno, K., Nakayama, H., Abe, M., Hashimoto, K., Nishioka, T., Kaibuchi, K., Hattori, S., Miyakawa, T., Tanaka, K., Huda, F., Hrai, H., Hashimoto, K., Watanabe, M., Sakimura, K., Kinoshita, M. A CDC42EP4/septin-based perisynaptic glial scaffold that facilitates glutamate clearance. Nature Commun 6:10090, 2015.


Ishii, K., Kubo, K., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K., Takata, N., Tanaka, K., Mimura, M., Tohyama, C., Kakeyama, M., Nakajima, K. Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits. J Neurosci 35. 12432-12445, 2015.

Yanagisawa, M., Aida, T., Takeda, Namekata, K., Harada, T., Shinagawa, R., Tanaka, K.
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter (GLAST) expression neural cell death in a model of normal tension glaucoma. Cell Death Dis 6. e1693, 2015.


Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka KF, Sakuma T, Yamamoto T, Tanaka K. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol. 2015, 16:87

Kimura, A., Guo, X., Noro, T., Harada, C., Tanaka, K., Namekata, K., Harada, T Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma. Neurosci Lett 588. 108-113, 2015.

Nakamori, T., Sato, K., Kinoshita, M., Kanamatsu, T., Sakagami, H., Tanaka, K., Ohki-Hamazaki, H. Positive feedback of NR2B-containing NMDA receptor activity is the initial step toward visual imprinting: a model for juvenile learning. J Neurochem 132. 110-123, 2015.

Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Götz M, Hirase H, Tanaka K. Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice. Neuropsychopharmacology. 2015 Feb 9. doi: 10.1038/npp.2015.26.



<2010年〜2014年>

Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R, Ozawa K, Tanaka K, Aizawa H. Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance. Journal of Neuroscience 34:16273–16285. 2014


Aizawa, H., Cui, W., Tanaka, K., Okamoto, H. Hyperactivation of the habenula as a link between depression and sleep disturbance. Front Hum Neurosci 7:826, (2013)

Aida, T., Imahashi, R., Tanaka, K. Translating human genetics into mouse: The impact of ultra-rapid in vivo genome editing. Develop Growth Differ (in press)

Schreiner, A.E., Durry, S., Aida, T., Stock, M.C., Rüther, U., Tanaka, K., Rose, C.R., Kafitz, K.W. Laminar and subcellular heterogeneity of glast and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus. J Comp Neurol. doi: 10.1002/cne.23450.

Bai, N., Aida, T., Yanagisawa, M., Katou, S., Sakimura, K., Mishina, M., Tanaka K. NMDA receptor subunits have differential roles in NMDA-induced neurotoxicity in the retina. Mol Brain 6. 34, 2013.

Namekata, K., Kimura, A., Kawamura, K., Guo, X., Harada, C., Tanaka, K., Harada, T. Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell Death Differ doi: 10.1038/cdd.2013.91

Hiraoka, Y., Komine, O., Nagaoka, M., Bai, N., Hozumi, K., Tanaka, K. Delta like 1 regulates Bergmann glial differentiation during cerebellar development. Mol Brain 6. 25, 2013.

Bai, N., Hayashi, H., Aida, T., Namekata, K., Harada, T., Mishina, M., Tanaka, K. Dock3 interaction with a glutamate-receptor NR2D subunit preotects neurons from excitotoxicity. Mol Brain 6. 22, 2013.

Maekawa, F., Sakurai, M., Yamashita, Y., Tanaka, K., Haraguchi, S., Yamamoto, K., Tsutsui, K., Yoshioka, H., Mutakami, S., Maeda, T., Tadano, R., Goto, T., Tomonari, K., Oka, T., Ohara, K., Shiraishi, J., Bungo, T., Tsudzuki, M., Ohki-Hamazki, H. A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras. Nature Commun 4. 1372, 2013.

Hayashi, H., Eguchi, Y., Fukuchi-Nakanishi, Y., Takeya, M., Nakagata, N., Tanaka, K., Vance, JE., Tanihara, H. A potential therapeutic function of apolipoprotein E-containing lipoproteins for normal tension glaucoma. J Biol Chem 287. 25395-25406, 2012.

Suzuki, K., Maekawa, F., Suzuki, S., Nakamoi, T., Sugiyama, H., Kanamatsu, T., Tanaka, K., Ohki-Hamazaki, H. Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks. J Neurochem 123. 800-810, 2012.

Aida, T., Ito, Y., Takahashi, Y.K., Tanaka, K. Overstimulation of NMDA Receptors Impairs Early Brain Development in vivo. PLoS One 7. e36853, 2012.

Karlsson, R-M., Adwmark, L., Molander, A., Perreau-Lenz, S., Singley, E., Solomon, M., Holmes, A., Tanaka, K., Lovinger, DM., Spanagel, R., Heiling, M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropsychopharmacology 63. 181-189, 2012.

Tsai, M-C., Tanaka, K., Overstreet-Wadiche, L., Wadiche, JI. Neuronal glutamate transporters regulate glial excitatory transmission. J Neurosci 32. 1528-1535, 2012.

Mookherjee, P., Green, P.S., Watson, G.S., Marques, M.A., Tanaka, K., Meeker, K.D., Meabon, J.S., Li, N., Zhu, P., Olson, V.G., Cook, D.G. GLT-1 loss accelerates cognitive deficits onset in an Alzheimer’s disease animal model. J Alzheimers Dis 26. 447-455, 2011.

Komine, O., Nagaoka, M., Hiraoka, Y., Hoshino, M., Kawaguchi, Y., Pear, E.S., Tanaka, K. RBP-J promotes the maturation of neuronal progenitors. Dev Biol 354. 44-54, 2011.

Harada, C., Guo, X., Namekata, K., Kimura, A., Nakamura, K., Tanaka, K., Parada, L.F., Harada, T. Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration. Nature Communicatons 2. 189, 2011.

Harada, C., Namekata, K., Guo, X., Yoshida, H., Mitamura, Y., Matsumoto, Y., Tanaka, K., Ichijo, H., Harada, T. ASK1 deficiency attenuates neural cell death in a GLAST deficient mice, a model of normal tension glaucoma. Cell Death Diffe 17. 1751-1759, 2010.

Paukert, M., Huang, Y.H., Tanaka, K., Rothstein, J.D., Bergles, D.E. Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. J Neurosci 30. 7290-7299, 2010.

Swartling, F.J., Grimmer, M., Hackett, C.S., Northcott, P.A., Fan, Q-W., Goldenberg, D.D., Lau, J., Masic, S., Nguyen, K., Yakovenko, S., Zhe, X-N., Glimer, H.C.F., Collins, R., Nagaoka, M., Phillips, J.J., Jenkins, R.B., Tihan, T., Vandenberg, S.R., James, C.D., Tanaka, K., Taylor, M.D., Weiss, W.A., Chesler, L. Pleiotropic Role for MYCN in medulloblastoma. Genes Dev 24. 1059-1072, 2010.

Woltjer, RL., Duerson K., Fullmer, JM., Mookherjee, P., Ryan, AM., Montine, TJ., Kaye, JA., Quinn, JF., Silbert, L., Erten-Lyons, D., Leverenz, JB., Bird, TD., Pow, DV., Tanaka, K., Watson, S., Cook, DG. Aberrant detergent-insoluble EAAT2 accumulates in Alzheimer's disease. J Neuropath Exp Neur 69. 667-676, 2010.

Nakamori, T., Sato, K., Atoji, Y., Kanamatsu, T., Tanaka, K., Ohki-Hamazaki, H. Demonstration of a neural circuit critical for the imprinting behavior in chicks. J Neurosci 30. 4467-4480, 2010.


<2005年〜2009年>

Namekata, K., Harada, C., Guo, X., Kikushima, K., Kimura, A., Fuse, N., Mitamura, Y., Kohyama, K., Matsumoto, Y., Tanaka, K., Harada, T. Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1 deficient mice. Neurosci Letters 465. 160-164, 2009.

Omrani, A., Melone, M., Bellesi, M., Safiulina, V., Aida, T., Tanaka, K., Cherubini, E., Conti, F. Up-regulation of GLT-1 severely impairs LTD at mossy fibers-CA3 synapses. J Physiol 587. 4575-4588, 2009.

Soma, M., Aizawa, H., Ito, Y., Maekawa, M., Osumi, N., Nakahira, E., Okamoto, H., Tanaka, K., Yuasa, S. Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation. J Comp Neurol. 513. 113-128, 2009.

Karlsson, RM., Tanaka, K., Saksida, LM., Bussey, TJ., Heilig, M., Holmes, A. Assessment of glutamate transporter GLAST (EAAT1) deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology 34. 1578-1589, 2009.

Karlsson, RM., Tanaka, K., Heilig, M., Holmes, A.Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist.Biol Pschiatry. 64. 810-814, 2008.

Takasaki, C., Okada, R., Mitani, A., Fukaya, M., Yamasaki, M., Fujihara, Y., Shirakawa, T., Tanaka, K., Watanabe, M. Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. J Neurosci. 28. 4995-5006, 2008.

Kiryk, A., Aida, T., Tanaka, K., Banerjee, P., Wilczynski, G.M., Meyza, K., Knapska, E., Filipkowaski, R.K., Kaczmarek, L., Danysz, W. Behavioral characterization og GLT1(+/-) mice as a model of mild glutamatergic hyperfunction. Neurotox Res 13. 19-30, 2008.

Nikkuni, O., Takayasu, Y., Iino, M., Tanaka, K., Ozawa, S. Facilitated activation of metabotropic glutamate receptors in cerebellar Purkinje cells in glutamate transporter EAAT4-deficient mice. Neurosci Res 59. 296-303, 2007.

Komine, O., Nagaoka, M.,Watase, K., Gutmann, D.H., Tanigaki, K., Honjo, T., Radtke, F., Saito, C., Chiba, S., Tanaka, K. The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Dev Biol 311. 238-250, 2007.

Tanimoto, S., Suzuki, M., Ue, T., Okumichi, H., Aoyama, H., Souchelnytskyi, S., Tanaka, K., Agarwal, N., Mishima H.K., Kanamoto, T. Proteomics in retina of Excitory Acid Carrier 1 (EAAC1) knockout mice. Proteomics Science 5. 13, 2007.

Maekawa, F., Nakamori, T., Uchimura, M., Fujiwara, K., Yada, T., Tsukahara, S., Kanamatsu, T., Tanaka, K., Ohki-Hamazaki, H. Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior. J Neurochem 102.1645-1657, 2007.

Harada, T., Harada, C., Nakamura, K., Qua, H-M.A., Okumura, A., Namekata, K., Saeki, T., Aihara, M., Yoshida, H., Mitani, A., Tanaka, K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 117. 1763-1770, 2007.

Takatsuru, Y., Iino, M., Tanaka, K., Ozawa, S. Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses. Neuroscie Lett 420. 85-89, 2007.

Maekawa, F., Komine, O., Sato, K., Kanamatsu, T., Uchimura M., Tanaka, K., Ohki-Hamazaki, H. Imprinting modulates processing of visual information in the visual wulst of chicks. BMC Neuroscience. 7.75, 2006. (http://www.biomedcentral.com/1471-2202/7/75)

Pardo, A., Wong, V., Benson, L., Dykes, M., Tanaka, K., Rothstein, J. D., Maragakis, N. J. Loss of yhe astrocyte glutamate transporter GLT1 modifies in SOD1G39A mice. Exp Neurol 201. 120-130, 2006.

Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., Yanagisawa, M. The dorsomedial hypothalamic nucleus as a food-entrainable cirdadian pacemaker. Proc. Natl. Acad. Sci. USA. 103. 12150-12155, 2006.

Matsugami, RT., Tanemura, K., Mieda, M., Nakamori, R., Yamada, K., Kondo, T., Ogawa, M., Obata, K., Watanabe, M., Hashikawa, T., Tanaka, K. Indispensability of glutamate transporters GLAST and GLT1 to brain developmaent. Proc. Natl. Acad. Sci. USA. 103. 12161-12166. 2006.

Kiryu-Seo, S., Gamo, K., Tachibana, T., Tanaka, K., Kiyama, H. Unique anti-apoptotic activity of EAAC1 in injured motor neurons. EMBO J 25. 3411-3421. 2006.

Glowatzki, E., Cheng, N., Hiel, H., Yi, E., Tanala, K., Ellis-Davies, G. C. R., Rothsetin, J. D., Gergles, D. E. The glutamate-aspartate transporter(GLAST) mediates uptake at inner hair cell afferent synapses in the mammalian cochlea. J Neurosci 26. 7659-7664, 2006.

Takayasu, Y., Iino, M., Shimamoto, K., Tanaka, K., Ozawa, S. Glial glutamate transporters maintain one-to-one synapses by preventing glutamate spillover. J Neurosci 26. 6563-6572, 2006.

Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kuhn, R., Gotz, M. Inducible gene deletion in astroglia and radial glia-avaluable tool for functional and lineage analysis. Glia. 54. 21-34, 2006.

Yamashita, A., Makita, K., Kuroiwa, T., Tanaka, K. Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death : An in vivo study using a cardiac model in mice lacking GLAST or EAAT4. Neurosci Res. 55. 264-270, 2006.

Hasegawa, J., Obara, T., Tanaka, K., Tachibana, M. High-density presynaptic transporters are required for glutamate removal from the first visual synapse. Neuron. 50. 63-74, 2006.

Iwabuchi, M., Tanaka, K., Ohki-Hamazaki, H. Ovwrexpression of gastrin-releasing peptode receptor induced layer disorganization in brain. Neuroscience.138. 109-122, 2006.

Takatsuru, Y., Takayasu, Y., Iino, M., Nikkuni, O., Ueda, Y., Tanaka, K., Ozawa, S. Roles of Glial Glutamate transporters in shaping EPSCs at the climbing fiber Purkinje cell synappses. Neurosci res. 54. 140-148, 2006.

Harada, C., Nakamura, K., Namakata, K., Okumura, A., Tanaka, K., Ichijo, H., Harada, T. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am. J. Pathol. 168. 261-269, 2006.

Harada, C., Harada, T., Nakamura, K., Sasaki, Y., Tanaka, K., parada, L. F. Effects of p75NTR on the regulation of naturally occurring cell death retinal ganglion cell number on the mouse eye. Dev Biol. 290. 57-65, 2006.

Herard, AS., Dubois, A., Escartin C., Tanaka, K., Delzescaux, T., hantraye, P,. Bonvento, G. Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transpoeter GLT-1. Eur. J. Neurosci. 22. 1807-1811, 2005.

Tanaka, K. Antibiotics rescue neurons from glutamate attack. Trends Mol Med. 11. 259-262, 2005.

Harada, C., Harada, T., hun-Meng A. Quah., Namekata, K., Yoshida, K., Ohno, S., Tanaka, K., Luis, F. Role of Neurotrophin-4/5 in Neural Cell Death during Retinal Development and Ischemic Retinal Injury In Vivo. Invest. Opyhalmol. Vis. Sci. 46. 669-673, 2005.

•Sarthy, V. P., Pignataro, L., Pannicke, T., Weick, M., Reichenbach, A., Harada, T., Tanaka, K., Marc, R. Glutamate transpoeter in retinal Muller cells fromglutamate/aspartate transpoeter (GLAST) kockout mice. Glia. 49. 184-196, 2005.


<2000年〜2004年>

•Sarthy, V. P., Dudley, V. J., Tanaka, K. Retinal glucose metabolism in mice lacking the L-glutamate/aspartate transporter. Vis. Neurosci. 21. 367-643, 2004.

•Sarthy, V.P., Pignataro, L., Marc, R., Tanaka, K. The contribution of a glial glutamate transporter to GABA synthesis in the retina. NeuroReport. 15. 1895-1898, 2004.

•Huang, Y.H., Tanaka, K., Rothstein J.D., Bergles D.E. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J. Neurosci. 24. 4498-4509, 2004.

•Chen, W., Mahadomrongkul, V., Berger, U. V., Bassan, M., DeSilva, T., Tanaka, K., Irwin, N., Aoki, C., Rosenberg, P. A. The glutamate transporter GLT1a insexpressed in excitatory axon terminals of mature hippocampal neurons. J. Neurosci. 24. 1136-1148, 2004.

•Maekawa, F., Tsukahara, S., Tanaka, K., Ohki-Hamazaki, H. Distributions of two chiken bonbesin receptor, bombesin receptor subtype-3.5(chBRS-3.5) and gastrin-releasing peptide receptor(chGRP-R) mRNA's in chicken telencephalon. Neuroscience. 125. 569-582, 2004.

•Maekawa, F., Quah, H-M. A., Wada, E., Wada, K., Tanaka, K., Ohki-Hamazaki, H. Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3(BRS-3). Diabetes. 53. 570-576, 2004.

•Harada, C,, Harada, T., Mitamura, Y., Quah, H-M. A., Ohtsuka, K., Kotake, S., Ohno, S., Wada, K., Takeuchi,S.,Tanaka, K. Diverse NF-kB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopaty. Mol. Vision. 10. 31-36, 2004.

•Huang, Y., Dykes Hoberg, M., Tanaka, K., Rothstein J. D., Bergles D. E. Climbing fiber activation of EAAT4 transporters and kainite receptors in cerebellar Purkinje cells. J. Neurosci. 24. 103-111, 2004.

•Harada, T., Harada, C., Wang, Y. L., Osaka, Y. L., Osaka, H., Amanai, K., Tanaka, K., Setsuie, R., Sakurai, M., Sato, Y., Nada, M., and Wada, K. Role of ubiquitin carboxy terminal hydrolase-L1 in neural ceii apoptosis induced by ischemic retinal injury in vivo. American Jounal of Pathology. 164. 59-64, 2004.

•Jin, Z. H., Kikuchi, T., Tanaka, K., Kobayashi, T. Expression of GLAST in the developing mouse cochlea.
Tohoku J. Exp. Med. 200. 137-144, 2003.

•Harada, C., Harada, T., Quah, H.-M.A., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L.F., Tanaka, K.Potential role of glial cell line-derived neurotrophic factor receptor in Muller glial cells during light-induced retinal degeneration. Neuroscience. 122. 229-235, 2003.

•Mitani,A.,Tanaka,K.Functional Changes of Glial Glutamate Transporter GLT-1 during Ischemia:An In vivo Study in the Hippocampal CA1 of Normal Mice and of Mutant Mice Lacking GLT-1.J Neurosci. 23. 7176-7182, 2003.

•Voutsinos-Porche, B., Knott, G., Tanaka ,K., Quairiaux ,c., Welker ,E., Bonvento ,G. Glial glutamate transporters and maturation of the mouse somatosensory cortex. Cereb.Coretx. 13. 1110-1121, 2003.

•Iwabuchi ,M., Ui-Tei ,K., Yamada ,Y., Matsuda ,Y., Sakai ,Y., Tanaka ,K., Ohki-Hamazaki ,H. Molecular cloning and characterzation of avian bombesin-like peptide receptors:New tools for investigating molecular basis for ligand selectivity. Brit J Pharmacol. 139.

•Mitamura, Y., Harada, T., Harada, C., Ohtsuka, K., Kotake, S., Ohno, S., Tanaka, K., Takeuchi, S., Wada K. NF-kB in epiretinal membranes after human diabetic retinopathy. Diabetologia. 46. 699-703, 2003.

•Okada, T., Yamada, N., Tsuzuki, K., Horikawa, HP., Tanaka, K. and Ozawa, S. Long-term potentiation in the hippocampal CA1 area and dentategyrus plays different roles in spatial learning. Eur. J. Neurosci. 17. 341-349, 2003.

•Voutsinos-Porche, B.,Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J-Y., Magistretti, PJ., and Pellerin, L. Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. Neuron. 37. 275-286, 2003.

•Nishizaki, T., Nagai, K., Nomura, T., Tada, H., Kanno, T., Tozaki, T., Li, X., Kondoh, T., Kodama, N., Takahashi, E., Sakai, N., Tanaka, K., and Saito, N. A new neuromodulator pathway with a glial contribution mediated via A2a adrenergic receptors.Glia. 39. 133-147, 2002.

•Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, K., Ohno, S., Mamada, H. Tanaka, K. Parada L.F., and Wada, K. Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.J. Neurosci. 22. 9228-9236, 2002.

•Katagiru, H., Tanaka, K. and Manabe, T. Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction. Eur. J. Neurosci. 14. 547-553, 2001.

•Sugiyama, T., Sadzuka, Y., Tanaka, K. and Sonobe, T. Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicolgy Lett. 121. 89-96, 2001.

•Gray, C., Marie, H., Arora, M., Tanaka, K., Boyde, A., Jones, S. and Attwell, D. Glutamate does not play a major role in controlling bone growth. J. Bone Miner. Res. 16. 742-749, 2001.

•Yamada, K., Fukaya, M., Shibata, T., Kurihara, H., Tanaka, K., Inoue, Y. and Watanabe, M. Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth of cerebellar Purkinje cells. J. Comp. Neurol. 418. 106-120, 2000.

•Hakuba, N., Koga, K., Gyo, K., Usami, S. and Tanaka, K. Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J. Neurosci. 20. 8750-8753, 2000.


<1995年〜1999年>

•Fukaya, M., Yamada, K., Nagashima, M., Tanaka, K. and Watanabe, M. Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella.
Neurosci. Res. 34. 165-175, 1999.

•Mennerick, S., Shen, W., Xu, W., Benz, A., Tanaka, K., Shimamoto, K., Isenberg, K., Krause, J. E. and Zorumski, C. F. Substrate turnover by transporters curtails synaptic glutamate transients. J. Neurosci. 19. 9242-9251, 1999.

•Watanabe, T., Morimoto, K., Hirao, T., Suwaki, H., Watase, K. and Tanaka, K. Amygdala-Kindled and Pentylenetrazole-Induced Seizures in Glutamate Transporter GLAST-deficient Mice.Brain Res. 845. 92-96, 1999.

•Kojima, S., Nakamura, T., Nidaira, T., Nakamura, K., Ooashi, N., Ito, E., Watase, K., Tanaka, K., Wada, K., Kudo, Y. and Miyakawa, H. Optical detection of synaptically induced glutamate transport in hippocampal slices.
J Neurosci. 19. 2580-2588, 1999.

•Harada, T., Harada, C., Watanabe, M., Inoue, Y., Sakagawa, T., Nakayama, N., Sasaki, S., Okuyama, S., Watase, K., Wada, K. and Tanaka, K. Functions of the two glutamate transporters GLAST and GLT-1 in the retina.
Proc. Natl. Acad. Sci. USA. 95. 4663-4666, 1998.

•Hirano, T., Morimoto, K., Yamamoto, Y., Sato, H., Watanabe, T., Sato, K., Sato, S., Yamada, N., Tanaka, K. and Suwaki, H. Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats. Mol. Brain Res. 54. 49-55, 1998.

•Nonaka, M., Kohmura, E., Yamashita, T., Shimada, S., Tanaka, K., Yoshimine, T., Tohyama, M. and Hayakawa, T. Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure. Mol. Brain Res. 55. 54-60, 1998.

•Watase, K., Hashimoto, K., Kano, M., Yamada, K., Watanabe, M., Inoue, Y., Okuyama, S., Kawashima, N., Hori, S., Takimoto, M., Wada, K. and Tanaka, K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur. J. Neurosci. 10. 976-988, 1998.

•Yamada, K., Watanabe, M., Shibata, T., Tanaka, K. and Inoue, Y. Transient axonal localization of glutamate transporter GLT-1 in developing mouse spinal cord. J. Neurosci. 18. 5714-5722, 1998.

•Yamashita, H., Kawakami, H., Zhang, Y.-X., Tanaka, K. and Nakamura, S. Effects of amino acid ergot alkaloids on glutamate transport via human glutamate transporter hGluT-1. J. Neurol. Sci. 155. 31-36, 1998.

•Itoh, M., Watanabe, Y., Watanabe, M., Tanaka, K., Wada, K. and Takashima, S. Expression of a glutamate transporter subtype, EAAT4, in the developing human cerebellum. Brain Res. 767. 265-272, 1997.

•Maeno-Hikichi, Y., Tanaka, K., Shibata, T., Watanabe, M., Inoue, Y., Mukainaka, Y. and Wada, K. Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter.
Mol. Brain Res. 48. 176-180, 1997.

•Shibata, T., Yamada, K., Watanabe, M., Ikenaka, K., Wada, K., Tanaka, K. and Inoue, Y. Glutamate transporter GLAST is expressed in the radial glia-astrocyte of developing mouse spinal cord. J. Neurosci. 17. 9212-9219, 1997.

•Suh, J.-G., Ichihara, N., Saigoh, K., Nakabayashi, O., Yamanishi, T., Tanaka, K., Wada, K. and Kikuchi, T. An in-frame deletion in peripheral myelin protein-22 gene causes hypomyelination and cell death of the schwann cells in the new trembler mutant mice. Neuroscience. 79. 735-744, 1997.

•Tanaka, J., Ichikawa, R., Watanabe, M., Tanaka, K. and Inoue, Y. Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses. NeuroReport. 8. 2461-2464, 1997.

•Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., Okuyama, S., Kawashima, N., Hori, S., Takimoto, M. and Wada, K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 276. 1699-1702, 1997.

•Yamada, K., Wada, S., Watanabe, M., Tanaka, K., Wada, K. and Inoue, Y. Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci. Res. 27. 191-198, 1997.

•Hagiwara, T., Tanaka, K., Takai, S., Maeno-Hikichi, Y., Mukainaka, Y. and Wada, K. Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3. Genomics. 33. 508-515, 1996.

•Maeno, H., Yoshimura, R., Fujita, S., Su, Q., Tanaka, K., Wada, K. and Kiyama, H. Cloning and characterization of the rat neurotensin receptor gene promoter. Mol. Brain Res. 40. 97-104, 1996.

•Nakayama, T., Kawakami, H., Tanaka, K. and Nakamura, S. Expression of three glutamate transporter subtype mRNAs in human brain regions and peripheral tissues. Mol. Brain Res. 36. 189-192, 1996.

•Shibata, T., Watanabe, M., Tanaka, K., Wada, K. and Inoue, Y. Dynamic changes in expression of glutamate transporter mRNAs in developing brain. NeuroReport. 7. 705-709, 1996.

•Yamada, K., Watanabe, M., Shibata, T., Tanaka, K., Wada, K. and Inoue, Y. EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. NeuroReport. 7. 2013-2017, 1996.

•Yamashita, T., Kohmura, E., Yuguchi, T., Shimada, S., Tanaka, K., Hayakawa, T. and Tohyama, M. Changes in glutamate/aspartate transporter (GLAST/GluT-1) mRNA expression following facial nerve transection.
Mol. Brain Res. 38. 294-299, 1996.

•Mukainaka, Y., Tanaka, K., Hagiwara, T. and Wada, K. Molecular cloning of two glutamate transporter subtypes from mouse brain. Biochem. Biophys. Acta. 1244. 233-237, 1995.

•Suh, J. G., Yamanishi, T., Matsui, K., Tanaka, K. and Wada, K. Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5. Genomics. 27. 549-551, 1995.

•Takai, S., Yamada, K., Kawakami, H., Tanaka, K. and Nakamura, S. Localization of the gene (SLC1A3) encoding human glutamate transporter (GluT-1) to 5p13 by fluorescence in situ hybridization.
Cytogenet Cell Genet. 69. 209-210, 1995.

•Yamashita, H., Kawakami, H., Zhang, Y.-X., Hagiwara, T., Tanaka, K. and Nakamura, S. Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1. Eur. J. Pharmacol. 289. 387-390, 1995.

•Yamashita, H., Kawakami, H., Zhang, Y.-X., Tanaka, K. and Nakamura, S. Neuroprotective mechanism of bromocriptine. Lancet. 346. 8985: 1305, 1995.


<1990年〜1994年>

•Kawakami, H., Tanaka, K., Nakayama, T., Inoue, K. and Nakamura, S. Cloning and expression of a human glutamate transporter.Biochem. Biophys. Res. Commun. 199. 171-176, 1994.

•Otori, Y., Shimada, S., Tanaka, K., Ishimoto, I., Tano, Y. and Tohyama, M. Marked increase in glutamate-aspartate transporter (GLAST/GLuT-1) mRNA following transient retinal ischemia. Mol. Brain Res. 27. 310-314, 1994.

•Suh, J. G., Oda, K., Tanaka, K., Yorifuji, H., Tomita, T. and Wada, K. Pathophysiological study of axonal degeneration in the Gracile Axonal Dystrophy (gad) mutant mice. Biomed. Res. 15. 241-246, 1994.

•Tanaka, K. Pharmacological characterization of a cloned rat glutamate transporter (GluT-1). Mol. Brain Res. 21. 1-2: 167-170, 1994.

•Tanaka, K. Expression cloning of a rat glutamate transporter. Neurosci. Res. 16. 149-153, 1993.

•Tanaka, K. Cloning and expression of a glutamate transporter from mouse brain. Neurosci. Lett. 159. 1-2: 183-186, 1993.

•Koyano, K., Tanaka, K. and Kuba, K. A patch-clamp study on the muscarine-sensitive potassium channel in bullfrog sympathetic ganglion. J. Physiol. 454. 231-246, 1992.

•Tanaka, K., Koyano, K. and Kuba, K. A muscarine-activated voltage-independent K+ channel in cultured bullfrog sympathetic neurones. Neurosci. Lett. 121. 191-193, 1991.

•Tanaka, K., Masu, M. and Nakanishi, S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron. 4. 847-854, 1990.


<1986年〜1989年>

•Yokota, Y., Sasai, Y., Tanaka, K., Fujiwara, T., Tsuchida, K., Shigemoto, R., Kakizuka, A., Ohkubo, H. and Nakanishi, S. Molecular characterization of a functional cDNA for rat substance P receptor. J. Biol. Chem. 264. 17649-17652, 1989.

•Tanaka, K. and Kuba, K. The Ca2+-sensitive K+-currents underlying the slow afterhyperpolarization of bullfrog sympathetic neurones. Pfluegers Archiv. 410. 234-242, 1987.

•Tanaka, K., Minota, S., Kuba, K., Koyano, K. and Abe, T. Differential effects of apamin on Ca2+-dependent K+ currents in bullfrog sympathetic ganglion cells. Neurosci. Lett. 69. 233-238, 1986.

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田中教授の総説論文
田中光一:CRISPR/Cas9によるゲノム編集 LiSA 24、649-658 2017

田中光一:グリア型グルタミン酸トランスポーター機能障害と精神疾患 日本生物学的精神医学会誌 28、77-83 2017

田中光一:グルタミン酸 Clinical Neuroscience、35: 1412-1416, 2017

相田知海、田中光一:CRISPR/Casでマウスゲノムを自在に操る. 生化学誌 88(1):119-123 (2016)

田中光一:グルタミン酸輸送体機能障害と精神疾患.日本臨床 74(1):163-173 (2016)

田中光一:グルタミン酸と精神疾患:モノアミンを超えて.日本薬理学雑誌 142:291-296 (2013)
PDF

田中光一:精神疾患におけるグルタミン酸トランスポーターの役割.日本生物学的精神医学会誌 23:157-161 (2013)

田中光一:脳の形成とグルタミン酸.BRAIN AND NERVE 65:1121-1132 (2013)

田中光一:精神神経疾患とグルタミン酸神経伝達:基礎医学的観点から.脳21 16:310-315 (2013)

田中光一:正常眼圧緑内障とグルタミン酸トランスポーター.眼薬理 26:54-57 (2012)

田中光一:精神神経疾患におけるグルタミン酸トランスポーターの役割. 細胞工学 31:580-585 (2012)

田中光一:アストロサイトと精神神経疾患. Clinical Neuroscience 29:1286-1288 (2011)

相田知海、田中光一:グルタミン酸トランスポーター. 生体の科学 61:398-399 (2010)

相田知海、田中光一:自閉症. Clinical Neuroscinece 28:912-915 (2010)

相田知海、武田拓也、田中光一:グルタミン酸代謝異常疾患としての正常眼圧緑内障. 実験医学 27:1291-1295 (2009)

相田知海、田中光一:グルタミン酸トランスポーターと精神神経疾患. 遺伝子医学MOOK 12:212-217 (2008)

相田知海、田中光一:グルタミン酸トランスポーターの中枢神経系における役割. Clinical Neuroscience 26:
  1072-1076 (2008)

田中光一:アストロサイトにおけるグルタミン酸トランスポーターの機能. Brain and Nerve 59:677-688 (2007)

田中光一:グルタミン酸トランスポーターと脳形成. 日薬理誌 130:455-457 (2007)

田中光一:神経障害をきたす中毒物質:グルタミン酸. Clinical Neuroscience 25:902-904 (2007)

田中光一:正常眼圧緑内障発症メカニズムを疾患モデルマウスを用いて解明. メディカルバイオ 4:14-15 (2007)

田中光一:神経幹細胞の分化過程のメカニズム. 分子精神医学 7:86-91 (2007)

田中光一:グルタミン酸トランスポーターと脳の発生. 脳21 8:377-381 (2005)

Tanaka K. Antibiotics rescue neuron from glutamate attack. Trends Mol Med 11:259-262 (2005)

田中光一:シナプス伝達とグルタミン酸トランスポーター. 実験医学 21:2386-2392 (2003)

田中光一:グルタミン酸と神経細胞死. 老年精神医学雑誌 14:1423-1431 (2003)

田中光一:グルタミン酸トランスポーターと神経細胞死. 脳の科学 24:329-336 (2002

田中光一:トランスポーターと精神疾患. 現代医療 33:43-48 (2001)

田中光一:グルタミン酸トランスポーターの機能解析. ブレインサイエンスレビュー医学書院 pp82-96 (2001)

田中光一:グルタミン酸神経毒性. 脳神経科学イラストレイテッド羊土社 pp266-272 (2002)

田中光一:グルタミン酸トランスポーターとてんかん. 神経研究の進歩 44:13-22 (2000)

Tanaka k.:Function of glutamate transporters in the brain. Neurosci.Res. 37:15-19 (2000)

田中光一:イオンポンプおよびトランスポーター. 脳の科学 21 (増刊):53-60 (1999)

[Top]

 

相田准教授の原著論文

<2015年以降>

Aida, T., Nakade, S., Sakuma, T., Ishikubo, H., Usami, T., Aizawa, H., Yamamoto, T., Tanaka, K. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ. BMC Genomics 17:979, 2016

Yanagisawa, M., Aida, T., Takeda, Namekata, K., Harada, T., Shinagawa, R., Tanaka, K.
Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter (GLAST) expression neural cell death in a model of normal tension glaucoma. Cell Death Dis 6. e1693, 2015.


Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka KF, Sakuma T, Yamamoto T, Tanaka K. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol. 2015, 16:87

Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Götz M, Hirase H, Tanaka K. Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice. Neuropsychopharmacology. 2015 Feb 9. doi: 10.1038/npp.2015.26.



<2010年〜2014年>


Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R, Ozawa K, Tanaka K, Aizawa H. Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance. Journal of Neuroscience 34:16273–16285. 2014

Aida, T., Imahashi, R., Tanaka, K. Translating human genetics into mouse: The impact of ultra-rapid in vivo genome editing. Develop Growth Differ 2014 Jan;56(1):34-45. doi: 10.1111/dgd.12101.

Schreiner, A.E., Durry, S., Aida, T., Stock, M.C., Rüther, U., Tanaka, K., Rose, C.R., Kafitz, K.W. Laminar and subcellular heterogeneity of glast and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus. J Comp Neurol. doi: 10.1002/cne.23450.

Bai, N., Aida, T., Yanagisawa, M., Katou, S., Sakimura, K., Mishina, M., Tanaka K. NMDA receptor subunits have differential roles in NMDA-induced neurotoxicity in the retina. Mol Brain 6. 34, 2013.

Bai, N., Hayashi, H., Aida, T., Namekata, K., Harada, T., Mishina, M., Tanaka, K. Dock3 interaction with a glutamate-receptor NR2D subunit preotects neurons from excitotoxicity. Mol Brain 6. 22, 2013.

Aida, T., Ito, Y., Takahashi, Y.K., Tanaka, K. Overstimulation of NMDA Receptors Impairs Early Brain Development in vivo. PLoS One 7. e36853, 2012.


<2005年〜2009年>

Omrani, A., Melone, M., Bellesi, M., Safiulina, V., Aida, T., Tanaka, K., Cherubini, E., Conti, F. Up-regulation of GLT-1 severely impairs LTD at mossy fibers-CA3 synapses. J Physiol 587. 4575-4588, 2009.

Hashimoto, K.,Aida, T. Antibody patenting without antibodies: a global trend. Nat. Biotechnol.26.1341-1343, 2008.

Kiryk, A., Aida, T., Tanaka, K., Banerjee,P., Wilczynski, GM., Meyza, K., Knapska, E., Filipkowski, RK., Kaczmarek,L., Danysz, W. Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction. Neurotox. Res.13,19-30 2008.

Aida, T., Konishi, A., Hagiwara, M., Hashimoto, K. Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip. Nat.Biotechnol. 25. 533-535, 2007.

[Top]

 

相田准教授の総説論文

相田知海、田中光一:CRISPR/Casでマウスゲノムを自在に操る. 生化学誌 88(1):119-123 (2016)

相田知海、田中光一:グルタミン酸トランスポーター. 生体の科学 61:398-399 (2010)

相田知海、田中光一:自閉症. Clinical Neuroscinece 28:912-915 (2010)

相田知海、武田拓也、田中光一:グルタミン酸代謝異常疾患としての正常眼圧緑内障. 実験医学 27:1291-1295 (2009)

相田知海、田中光一:グルタミン酸トランスポーターと精神神経疾患. 遺伝子医学MOOK 12:212-217 (2008)

相田知海、田中光一:グルタミン酸トランスポーターの中枢神経系における役割. Clinical Neuroscience 26:1072-1076 (2008)

[Top]

 

石田助教の原著論文

<2015年以降>

Marsan E*, Ishida S*, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N,Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T,Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. Depdc5 knockout rat:A novel model of mTORopathy. Neurobiol Dis. 2016 May;89:180-9. (*Equally contributed)

Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D,
Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E,
Andermann F, Leguern E, Chassoux F, Picard F. Familial focal epilepsy with focal
cortical dysplasia due to DEPDC5 mutations. Ann Neurol. 2015 Apr;77(4):675-83.


<2010年〜2014年>


Boillot M, Huneau C, Marsan E, Lehongre K, Navarro V, Ishida S, Dufresnois B,
Ozkaynak E, Garrigue J, Miles R, Martin B, Leguern E, Anderson MP, Baulac S.
Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures.
Brain. 2014 Nov;137(Pt 11):2984-96.

Picard F, Makrythanasis P, Navarro V, Ishida S, de Bellescize J, Ville D,
Weckhuysen S, Fosselle E, Suls A, De Jonghe P, Vasselon Raina M, Lesca G,
Depienne C, An-Gourfinkel I, Vlaicu M, Baulac M, Mundwiller E, Couarch P, Combi
R, Ferini-Strambi L, Gambardella A, Antonarakis SE, Leguern E, Steinlein O,
Baulac S. DEPDC5 mutations in families presenting as autosomal dominant nocturnal
frontal lobe epilepsy. Neurology. 2014 Jun 10;82(23):2101-6.

Fumoto N, Mashimo T, Masui A, Ishida S, Mizuguchi Y, Minamimoto S, Ikeda A,
Takahashi R, Serikawa T, Ohno Y. Evaluation of seizure foci and genes in the
Lgi1(L385R/+) mutant rat. Neurosci Res. 2014 Mar;80:69-75.

Ishida S, Picard F, Rudolf G, Noé E, Achaz G, Thomas P, Genton P, Mundwiller
E, Wolff M, Marescaux C, Miles R, Baulac M, Hirsch E, Leguern E, Baulac S.
Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nat Genet. 2013
May;45(5):552-5.

Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S, Tanabe K,
Yanagi A, Tachibana A, Hirose J, Yomoda J, Morimoto S, Kuramoto T, Voigt B,
Watanabe T, Hiai H, Tateno C, Komatsu K, Serikawa T. Generation and
characterization of severe combined immunodeficiency rats. Cell Rep. 2012 Sep
27;2(3):685-94.

Baulac S*, Ishida S*, Mashimo T, Boillot M, Fumoto N, Kuwamura M, Ohno Y,
Takizawa A, Aoto T, Ueda M, Ikeda A, LeGuern E, Takahashi R, Serikawa T. A rat
model for LGI1-related epilepsies. Hum Mol Genet. 2012 Aug 15;21(16):3546-57.
(*Equally contributed)

Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A,
Kaneko S, Serikawa T, Mashimo T. Kcna1-mutant rats dominantly display myokymia,
neuromyotonia and spontaneous epileptic seizures. Brain Res. 2012 Jan
30;1435:154-66.


<2005年〜2009年>


Kodama H, Denso, Okazaki F, Ishida S. Protective effect of humus extract
against Trypanosoma brucei infection in mice. J Vet Med Sci. 2008
Nov;70(11):1185-90.

[Top]

 

石田助教の総説論文

石田紗恵子 「DEPDC5遺伝子の変異が常染色体優性焦点性てんかんをひき起こす」ライフサイエンス 新着論文レビュー 大学共同利用機関法人 情報・システム研究機構 ライフサイエンス統合データベースセンター 2013年 4月 19日公開 http://first.lifesciencedb.jp/archives/6898 


<著書>

石田紗恵子、池田昭夫
「臨床てんかん学」第11章 てんかんおよびてんかん類似症候群(L-13) さまざまな焦点を伴う家族性部分てんかん 医学書院2015年11月1日発刊

石田紗恵子
「神経症候群 第2版 Ⅵ」 8.その他の重要な病態 (21)多様な焦点を示す家族性焦点性てんかん 日本臨牀社2014年12月20日発刊 

石田紗恵子、芹川忠夫
疾患モデルマウス 表現型解析指南 標準解析から専門解析まで」第2章 脳神経系/中枢系/てんかん 中山書店「2011年12月28日発刊


[Top]

 

平岡助教の原著論文

<2015年以降>
Miyazaki S, Hiraoka Y, Hidema S, Nishimori K. Prenatal minocycline treatment alters synaptic protein expression, and rescues reduced mother call rate in oxytocin receptor-knockout mice. Biochem Biophys Res Commun 472:319-23, 2016.

Kasahara Y, Tateishi Y, Hiraoka Y, Otsuka A, Mizukami H, Ozawa K, Sato K, Hidema S, Nishimori K. Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions. Front Endocrinol (Lausanne) 6:180, 2015.

Hidema S, Fukuda T, Hiraoka Y, Mizukami H, Hayashi R, Otsuka A, Suzuki S, Miyazaki S, Nishimori K. Generation of Oxtr cDNA(HA)-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner.
J Cell Biochem 117:1099-111, 2016.

Jurek B, Slattery DA, Hiraoka Y, Liu Y, Nishimori K, Aguilera G, Neumann ID, van den Burg EH Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3. J Neurosci 35:12248-60, 2015.

Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T. Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology 101:35-44, 2015.



<2010年〜2014年>


Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T. Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett 588:4404-12, 2014.

Hiraoka Y, Komine O, Nagaoka M, Bai N, Hozumi K, Tanaka K. Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development. Mol Brain. 6:25, 2013.

Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K. RBP-J promotes the maturation of neuronal progenitors. Dev Biol 354:44-54, 2011.


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平岡助教の総説論文




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