研究業績

  • Wen XZ, Akiyama Y, Pan KF, Liu ZJ, Lu ZM, Zhou J, Gu LK, Dong CX, Zhu BD, Ji JF, You WC, Deng DJ: Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J. Gastroenterol. 2010:16:1201–1208.
  • Yuasa Y: Epigenetics in molecular epidemiology of cancer: a new scope. Adv Genet. 2010:71:211-235.
  • Oze I, Matsuo K, Hosono S, Ito H, Kawase T, Watanabe M, Suzuki T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Tajima K, Tanaka H: Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for the risk of upper aerodigestive tract cancer in a Japanese population. Cancer Sci. 2010:101:1875-1880.
  • Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K, Yuasa Y: MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One 2011: 6: e16617.
  • Mimata A, Fukamachi H, Eishi Y, Yuasa Y: Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. Cancer Sci. 2011:102:942-950.
  • Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011:102:1313-1321.
  • Nakao M, Matsuo K, Hosono S, Ogata S, Ito H, Watanabe M, Mizuno N, Iida S, Satoh S, Yatabe Y, Yamao K, Ueda R, Tajima K, Tanaka H: ABO blood group alleles and the risk of pancreatic cancer in Japanese population. Cancer Sci. 2011:102:1076-1080.
  • Rotkrua P, Akiyama Y, Hashimoto Y, Otsubo T, Yuasa Y: MiR-9 down-regulates CDX2 expression in gastric cancer cells. Int. J. Cancer 2011:129: 2611-2620.
  • Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, Jonkers J, Tanaka H, Eishi Y, Yuasa Y. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut 2012:61:344-353.
  • Kawakita D, Matsuo K, Sato F, Oze I, Hosono S, Ito H, Watanabe M, Yatabe Y, Hanai N, Hasegawa Y, Tajima K, Murakami S, Tanaka H: Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma. Ann. Oncol. 2012:23:186-192.
  • Yuasa Y, Nagasaki H, Oze I, Akiyama Y, Yoshida S, Shitara K, Ito S, Hosono S, Watanabe M, Ito H, Tanaka H, Kang DH, Pan K-F, You W-C, Matsuo K. IGF2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer 2012:131:2596-2603.
  • Song M-Y, Pan K-F, Su H-J, Zhang L, Ma J-L, Li J-Y, Yuasa Y, KangDH, Kim YS, You W-C. Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLoS One 2012:7:e33608.
  • Li L, Choi JY, Lee KM, Sung H, Park SK, Oze I, Pan KF, You WC, Chen YX, Fang JY, Matsuo K, Kim WH, Yuasa Y, Kang D. DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology. J. Epidemiol. 2012:22:384-394.
  • Shigematsu Y, Niwa T, Yamashita S, Taniguchi H, Kushima R, Katai H, Ito S, Tsukamoto T, Ichinose M, Ushijima T. Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers. Oncology Letters 2012:4:268-274.
  • Rotkrua P, Shimada S, Mogushi, K, Akiyama Y, Tanaka H, Yuasa Y. Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. Brit. J. Cancer 2013:108:932-940.
  • Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH, Ushijima T. Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Letters 2013:330:33-40.
  • Wang D, Zhou J, Liu X, Lu D, Shen C, Du Y, Wei FZ, Song B, Lu X, Yu Y, Wang L, Zhao Y, Wang H, Yang Y, Akiyama Y, Zhang H, Zhu WG. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc. Natl. Acad. Sci. USA. 2013:110:5516-5521.
  • Matsuo K, Oze I, Hosono S, Ito H, Watanabe M, Ishioka K, Ito S, Tajika M, Yatabe Y, Niwa Y, Yamao K, Nakamura S, Tajima K, Tanaka H. The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. Carcinogenesis 2014:34:1510-1514.
  • Fukamachi H, Seol HS, Shimada S, Funasaka C, Baba K, Kim JH, Park YS, Kim MJ, Kato K, Inokuchi M, Kawachi H, Yook JH, Eishi Y, Kojima K, Kim WH, Jang SJ, Yuasa Y. CD49fhigh cells retain sphere-forming and tumor-initiating activities in human gastric tumors. PLoS ONE 2013:8:e72438.
  • Hashimoto Y, Akiyama Y, Yuasa Y. Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS One 2013:8:e62589.
  • Hattori N, Niwa T, Kimura K, Helin K and Ushijima T. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res. 2013:41:7231-7239.
  • Nakao M, Hosono S, Ito H, Oze I, Watanabe M, Mizuno N, Yatabe Y, Yamao K, Niimi A, Tajima K, Tanaka H, Matsuo K. Cigarette smoking and pancreatic cancer risk: a revisit with an assessment of the nicotine dependence phenotype. Asian Pac. J. Cancer Prev. 2013:14:4409-4413.
  • Chen L, Fu L, Kong X, Xu J, Wang Z, Ma X, Akiyama Y, Chen Y, Fang J. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer. Br. J. Cancer 2014:110:1014-1026.
  • Oze I, Matsuo K, Kawakita D, Hosono S, Ito H, Watanabe M, Hatoooka S, Hasegawa Y, Shinoda M, Tajima K, Tanaka H. Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan. Int. J. Cancer 2014:135:391-400.
  • Yoda Y, Takeshima H, Niwa T, Kim JG, Ando T, Kushima R, Sugiyama T, Katai H, Noshiro H, Ushijima T. Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer 2014:on line