Seminar in Seoul, Korea held in June, 2014

NRF A3 Foresight Program 2014 Seminar
-Epigenetic Signatures in Gastric Carcinogenesis-

Date June 20-23, 2014
Venue Seoul National University Cancer Research Institute, Seoul

Summary

NRF A3 Foresight Program 2014 Seminar was held on June 20-23, 2014 at Seoul National University Cancer Research Institute, Seoul, Korea. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analyses. A total of 44 scientists (16 senior and 28 junior) from three nations attended this meeting. One senior speaker made a presentation about his study for 25 minutes. Each of 20 junior speakers was given for 16 minutes in presentation and discussion. After the presentations, we discussed our collaborative researches one by one, and summarized the results of them. We also decided to continuously collaborate with one another after the A3 Foresight program.

Program

June 21 (Sat)

Presentation by junior scientists (I)

Chairpersons:
Zhaojun Liu
Jong-Lyul Park		 Ya-nan Yu (Renji Hospital, School of Medicine, Shanghai Jiaotong University, China): Structural of gut microbiota and dietary fiber intake in human with colorectal adenoma
Naoko Hattori (National Cancer Center Research Institute, Japan): Intestinal Microbes Influence Epigenomic Changes in Colonic Epithelial Cells
Yang Zhang (Peking University Cancer Hospital, China): Screening and preliminary validation of Helicobacter pylori associating aberrant methylated genes in gastric mucosa and blood leukocyte
Younghoon Kim (Seoul National University College of Medicine, Korea): Epigenetic Suppression May Associate with Survival Outcome in Advanced Gastric Carcinoma Patients: A Proposal

Presentation by a senior scientist

Chairperson:
Gyeong Hoon Kang		 Toshikazu Ushijima (National Cancer Center Research Institute, Japan): Epigenetic Risk Diagnosis of Metachronous Gastric Cancer: A Multi-center Prospective Cohort Study

Presentation by junior scientists (II)

Chairpersons:
Shu Shimada
BaoZhen Zhang		 Liang Zong (National Cancer Center Research Institute, Japan): Estimation of the Fraction of Gastric Cancer Cells Using DNA Methylation Markers
Mirang Kim (Korea Research Institute of Bioscience and Biotechnology, Korea): Transcriptome and DNA methylome analyses of gastric cancer stem cells
Xiaopeng Lu (Peking University Health Science Center, China): Identify H4K16 methylation as a new histone modification in human cancer cells
Taketo Nishikawaji (Tokyo Medical and Dental University, Japan): Functional analyses of SETDB2, a histone methyltransferase, in gastric cancers
Sisi Qin (Peking University Cancer Hospital and Institute, China): The phosphorylation states of Kaiso determine its subcellular localization and DNA binding activity

Presentation by junior scientists (III)

Chairpersons:
Masahiro Maeda
Hyang Sook Seol		 Zhaojun Liu (Peking University Cancer Hospital and Institute, China): Prediction of recurrence/metastasis of pN0M0-stage gastric carcinoma using GFRA1, SRF, and ZNF382 methylation as biomarkers: baseline information of a prospective cohort study
Jin-Lin Wang (Shanghai Jiao-Tong University School of Medicine, China): ArhGAP30 promotes p53 acetylation and is an independent prognostic marker for colorectal cancer
Jeong Mo Bae (Seoul National University College of Medicine, Korea): Paradoxically poor clinical outcome of EZH2 overexpression in colorectal cancers
Sanjeev Budhathoki (National Cancer Center, Japan): Dietary heterocyclic amine intake, NAT2 genetic polymorphism and colorectal adenoma risk: The Colorectal Adenoma Study in Tokyo
Jong-Lyul Park (Korea Research Institute of Bioscience and Biotechnology, Korea): Bivalent chromatin marks coupled with methylation on TET1 CGI 3'-shore is associated with its silencing in gastric cancers

Presentation by junior scientists (IV)

Chairpersons:
Isao Oze
Yang Zhang		 Meiting Li (Peking University Health Science Center, China): The sirtuin SIRT6 deacetylates H4 K8Ac in vivo in response to palmitic acid treatment
Keun Hur (Korea Research Institute of Bioscience and Biotechnology, Korea): MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1
Jimin Min (Seoul National University College of Medicine): miR-30a-5p functions as a tumor suppressor gene in gastric cancer
Masahiro Maeda (National Cancer Center Research Institute, Japan): Epigenetic characteristics of Gastric Cancer-Assisted Fibroblasts
Haoyan Chen (Shanghai Jiao Tong University, China): Long Noncoding RNA Profiles Identify Five Distinct Molecular Subtypes of Colorectal Cancer with Clinical Relevance
Fu-bing Tang (Peking University Cancer Hospital & Institute, China): Genetic Polymorphisms of Toll-like Receptor 1 and 10, and H. pylori Susceptibility in a Chinese Population

June 22 (Sun)

Presentation by junior scientists (V)

Chairpersons:
Naoko Hattori
Jin Kim		 Jiwoon Choi (Seoul National University College of Medicine, Korea): Analysis of MET mRNA expression in gastric cancers using RNA in situ hybridization assay
Ayuna Sakamoto (Tokyo Medical and Dental University, Japan): Roles and epigenetic expression changes of Twist1 in diffuse-type gastric cancer cell lines of an E-cadherin/p53-deficient mouse model
Qiaoyan Yang (Peking University Health Science Center, China): Casein Kinase 2, a serine/threonine protein kinase, phosphorylates histone methyltransferase G9a in response to DNA Damage
Wei Tian (Peking University Cancer Hospital and Institute, China): IKBKE enhances cell-size and anti-apoptosis by phosphorylation p70S6K in Ser-427

Presentation by junior scientists (VI)

Chairpersons:
Haoyan Chen
Jong-Lyul Park		 Minkyo Song (Seoul National University College of Medicine, Korea): Obesity at Adolescence and Gastric Cancer Risk
BaoZhen Zhang (Peking University Cancer Hospital & Institute, China): CDH1 -73A>C variation affects survival of patients with sporadic gastric cancers through its promoter hypermethylation
Isao Oze (Aichi Cancer Center Research Institute, Japan): Cumulative risk models of gastric cancer by PSCA polymorphism, Helicobacter Pylori infection and smoking history in Japan
Shu Shimada (Tokyo Medical and Dental University, Japan): Identification of selective inhibitors of mouse E-cadherin/p53-deficient diffuse-type gastric cancer cells by screening a library of known compounds

General discussion

Chairpersons:
Woo Ho Kim		 R1) Yasuhito Yuasa, Taichi Shimazu, Han-Kwang Yang, Kaifeng Pan

R2) Woo Ho Kim, Weiguo Zhu, Yoshimitsu Akiyama, Yong-Sung Kim

R3) Dajun Deng, Toshikazu Ushijima, Gyeong Hoon Kang, Yang Yang

R4) Hiroshi Fukamachi, Sejin Jang, Zheming Lu