Meeting in Okinawa held in February, 2011

JSPS A3 Foresight Program 2011 Meeting
-Epigenetic Signatures in Gastric Carcinogenesis-

Date February 20-23, 2011
Venue ANA Intercontinental Hotel Manza Beach Resort

Summary

JSPS A3 Foresight Program 2011 Seminar was held on February 20-23, 2011 at ANA Intercontinental Hotel Manza Beach Resort, Okinawa, Japan. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analysis. A total of 18 scientists (13 senior and 5 junior) from three nations attended this seminar. On the first day, there were presentations on how the research on human materials was regulated by the Institutional Review Board in each country, and an enthusiastic discussion was made on how to propel collaborative work in each research group. On the next day, some recent findings in three countries were presented and discussed. During this seminar, several new collaborative research plans were proposed, and most were strongly supported by participants. Thus we hope that new results will be obtained soon by collaboration of researchers in three nations.

Program

Feb. 21 (Mon)

Chairperson:
Yasuhito Yuasa		 Keitaro Matsuo (Aichi Cancer Center Research Institute, Japan): Current research guidelines about use of human genetic resources in Japan
Huanping Zhang (Peking University Cancer Hospital, China): Current status of informed consents at Peking University Cancer Hospital and administration of human genetic resources in China
Woo Ho Kim (Seoul National University College of Medicine, Korea): IRB policy for clinical research with human biological specimens

Group Discussion on Collaborative Research Themes

R-1 Risk factors of GC accounting for host epigenetic alterations among three nations
R-2 Investigation of mechanisms of gene-specific silencing of tumor-suppressor genes during gastric carcinogenesis
R-3 DNA methylome and its applications on subtyping of gastric carcinomas
R-4 Epigenetic changes in GC stem cells

Feb. 22 (Tue)

Chairperson:
Woo Ho Kim		 Yasuhito Yuasa (Tokyo Medical and Dental University, Japan): Mouse models of diffuse-type gastric cancer by inactivating E-cadherin and p53
Dajun Deng (Peking University Cancer Hospital & Institute, China): Introduction of DHPLC as a fast quantitative assay for detection of methylation of CpG islands
Yong Sung Kim (Korea Research Institute of Bioscience and Biotechnology): Epigenome signature during gastric carcinogenesis detected by MBD-seq and RRBS technologies

Discussions by All the Participants