1.Genetic Factors for Cardiac Diseases
 A. Idiopathic Cardiomyopathy
 ・Investigation on genes for sarcomere in idiopathic cardiomyopathy  (1)
 ・Identification of mutations in the known genes for hypertrophic cardiomyopathy (HCM) (2), (3)
 ・Identification of a novel disease gene for HCM (4)
 ・Frequency of disease-related mutations in the Japanese patients with HCM (5)
 ・Identification of disease-related mutations in dilated cardiomyopathy (DCM) (6)
 ・Identification of another novel disease gene for both HCM and DCM (7), (8), (9)
   →Moleular pathogenesis of idiopathic cardiomyopathies (a novel hypothesis) (10)
 ・Characterization and functional analyses of novel genes expressed in the cardiac muscle.
 ・Making animal model for cardiomyopathy by using a novel heart-specific gene

 B. Idiopahic Arrythmias
 ・Identification of mutations of channel genes in hereditaty arrythmias

 C. Myocardial Infarction
 ・Investigation on the reported disease-associated polymorphisms
 ・Identification of novel genetic factors related with the disease in Japanese (11)

 D. Hypertensive Heart Disease
 ・Identification of polymorphisms associated with hypertensive cardiac hypertrophy
 ・Analysis of genes expressed in cardiac muscles from hypertensive rat model
  →Search for candidates of genes for hypertensive heart disease (12)

2.Genetic Factors for Autoimmune Diseases
 A. Analysis of HLA region

 ・Association studies for insulin-dependent diabetes mellitus (IDDM) (13)
 ・Association studies for Graves disease (14)
 ・Association studies for Takayasu arteritis (15)
 ・Association studies for Buerger disease (16)
 ・Association studies for ohter autoimmune diseases
   →SLE, rheumatoid arthritis, Hahimoto disease, ulcerative colitis, Crohn disease, etc.

 B. Analysis of other genes
 ・Search for polymorphisms in the immune-related genes and their use in association studies

3.Genetic Factors for Colon Cancer
 A. Mutations in cancer-related genes
 ・Comparative analysis of somatic mutations in cancer-related genes between ordinary colon cancers
  and those associated with mismatch-repair deficieny (17)
 ・Search for a novel cancer-related genes for hereditary colon cancer without mismatch-repair defects

4.Other Researches 
 A. Analysis of microsatellites
 ・Investigation on the generation of microsatellite polymorphisms (18)
 ・Functional analysis of microsatellites in regulation of gene expression (19)

 B. Analysis of Matrix Proteins
 ・Structure, distribution and function of matrix preteins
 ・Immunogenisity of allogeneic collagens
 ・Anti-cancer function of collagen-related molecules

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