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| Name: |
Masatoshi Hagiwara, M.D., Ph.D. |
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| Current Appointments: |
Professor,
Laboratory of Gene Expression, School of Bioscience
Department of Funcional Genomics, Medical Research Institute
Tokyo Medical and Dental University |
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| Education: |
| 1988 |
Mie University Graduate School of Medicine |
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Ph.D., |
| 1984 |
Mie University School of Medicine |
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M.D. |
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| Academic
Appointments: |
| 1988-1991 |
Assistant Professor, Nagoya University School
of Medicine |
| 1991-1993 |
Fellow, Salk Institute (San Diego, USA) |
| 1993-1995 |
Instructor, Nagoya University School of Medicine |
| 1995-1997 |
Associate Professor, Nagoya University School of Medicine |
| 1997- present |
Professor, Department of Funcional Genomics, Medical
Research Institute |
| 2003- present |
Professor, Laboratory of Gene Expression, School of
Bioscience |
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| Professional
Associations/Affiliations: |
Japanese Society for Chemical Biology
The Japanese Pharmacological Society
The Japanese Association of Anatomists
Molecular Biology Society of Japan
The Japan Endocrine Society
Japanese Cancer Association
The Japanese Biochemical Society
Japanese Society for Circulation Research
The Japanese Society for Neurochemistry
Society for Neuroscience (USA) |
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| Area of Expertise: |
Molecular Biology, Chemical Biology |
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| Research Interests: |
(1) The regulatory mechanism of alternative
splicing of
pre-mRNAs
(2) Development of viral RNA processing inhibitors as
novel
pharmaceutical agents |
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Ohno, G., Hagiwara, M., & Kuroyanagi, H. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes and Dev.,22, 360-374
Kuroyanagi, H., Ohno, G., Mitani, S., & Hagiwara, M. (2007) Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol. Cell. Biol., 27,8612-8621
Nojima,T., Hirose,T.,Kimura,H.,& Hagiwara,M. (2007) The interaction between cap-binding complex and REF is required for intronless mRNA export. J. Biol. Chem. 282,15645-15651.
Kuroyanagi, H., Kobayashi, T., Mitani, S., and Hagiwara, M. (2006) A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo. Nature Methods 3, 909-915.
Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA and Hagiwara M (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 103(30):11329-11333.
Muraki, M., Ohkawara, B.,Hosoya, T., Onogi, H.,Koizumi, J.,Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M. and Hagiwara, M. (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J. Biol. Chem. 279, 24246-24254.
Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inoue, S., Hirose, K., Iino, M. & Hagiwara, M, (2000) A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol. 18, 313-316.
Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, R.M., & Goodman, R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature, 365, 855-859.
Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., & Montminy, R.M. (1993). Stimulus-transcription coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Mol. Cell. Biol., 13, 4852-4859.
Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S. & Montminy, M. (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70, 105-13.
Hagiwara, M., Inagaki, M. & Hidaka, H. (1987) Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide to the active site of cAMP-dependent protein kinase. Mol. Pharmacol. 31, 523-528.
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| San-ikai Award (1988) |
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