業績

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最近の主な論文

• Yamazoe M, Sasano T, Ihara K, Takahashi K, Nakamura W, Takahashi N, Komuro H, Hamada S, Furukawa T. Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation. Sci Rep 2021; 11: 5837.
• Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogata H, Furuakwa T, Kuroyanagi H: A missense mutation in the ESESP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Sci Rep 2020; 10: 17894.
• Lee J, Sutani A, Kaneko R, Takeuchi J, Sasano T, Kohda T, Ihara K, Takahashi K, Yamazoe M, Morio T, Furukawa T, Ishino F. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Nat Commun 2020; 11: 4283.
• Hamada S, Hasegawa Y, Oono A, Suzuki A, Takahashi N, Nishimura T, Koyama T, Hagihara M, Tohda S, Furukawa T, Hirao K, Sasano T. Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry. Sci Rep 2018; 8: 16129.
• Natsume Y, Oaku K, Takahashi K, Nakamura W, Oono A, Hamada S, Yamazoe M, Ihara K, Sasaki T, Goya M, Hirao K, Furukawa T, Sasano T. Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation. Circ J 2018; 82: 965-973.
• Ihara K, Sugiyama K, Takahashi K, Yamazoe M, Sasano T, Furukawa T. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping. J Vis Exp 2018; 22: doi: 10.3791/56478.
• Komuro H, Sasano T, Horiuchi N, Yamashita K, Nagai A. The effect of glucose modification for hydroxyapatite nanoparticles on gene delivery. J Biomed Mater Res Part A 2019; 107: 61-66.
• Hamada S, Oono A, Ishihara Y, Hasegawa Y, Akaza M, Sumi Y, Inoue Y, Izumiyama H, Hirao K, Isobe M and Sasano T. Assessment of vascular autonomic function using peripheral arterial tonometry. Heart Vessels. 2017; 32: 260-268.
• Hasegawa Y, Hamada S, Nishimura T, Sasaki T, Ebana Y, Kawabata M, Goya M, Isobe M, Koyama T, Furukawa T, Hirao K and Sasano T. Novel Dielectric Coagulometer Identifies Hypercoagulability in Patients with a High CHADS2 Score without Atrial Fibrillation. PLoS One. 2016; 11: e0156557.
• Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M and Furukawa T. High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b. J Mol Cell Cardiol. 2016; 90: 38-46.
• Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M and Furukawa T. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice. Int Heart J. 2016; 57: 341-349.
• Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N and Furukawa T. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur Heart J. 2016; 37: 1469-1475.

プレスリリース等

2021年4月

科学新聞記事・日経メディカル記事「心房細動で放出される“裸”のミトコンドリアDNAが炎症を引き起こす」

2021年 3月

日本経済新聞記事「脳梗塞　AIが予防」

2021年 3月

「不整脈が全身の炎症を起こすメカニズムを解明」

2020年10月

「変異型タンパク質の細胞質への蓄積が拡張型心筋症を重症化する」

2018年11月

「血液の誘電率変化から凝固因子Xa活性を選択的に評価出来る方法を開発」

2018年 2月

「血中マイクロRNA診断パネルによる心房細動発症予測」
"Potential RNA Markers of Abnormal Heart Rhythms Identified in Circulating Blood"

2017年 3月

"Easy assessment of the vascular autonomic function."

2016年 6月

「血液の固まりやすさを電気で計測」
“Blood Coagulation Detector May Help in Monitoring Stroke Risk”
"Novel coagulation test detects embolic stroke risk"

2016年 3月

"Obesity enhances the risk of arrhythmia."

2015年10月

「運動中の突然死に関連する新たな遺伝子の同定」
"Discovery of novel gene mutations associated with lethal arrhythmias that occur during exercise"

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