研究業績・代表論文
2007-2009年の業績
  1. Tsai, N.-P.; Huq, M.; Gupta, P.; Yamamoto, K.; Kagechika, H.; Wei, L.-N. Activation of Testicular Orphan Receptor 4 by Fatty Acids. Biochim. Biophys. Acta- Gene Regul. Mech. 2009, 1789, 734-740.
  2. Kudo, M.; Hanashima, T.; Muranaka, A.; Sato, H.; Uchiyama, M.; Azumaya, I.; Hirano, T.; Kagechika, H.; Tanatani, A. Identification of Absolute Helical Structures of Aromatic Multi-layered Oligo(m-phenylurea)s in Solution. J. Org. Chem. 2009, 74, 8154-8163.
  3. Hatanaka, M.; Shimba, S.; Sakaue, M.; Kondo, Y.; Kagechika, H.; Kokame, K.; Miyata, T.; Hara, S. Hypoxia-Inducible Factor-3α Functions as an Accelerator of 3T3-L1 Adipose Differentiation. Biol. Pharm. Bull. 2009, 32, 1166-1172.
  4. Suzuki, K.; Takahashi, K.; Nishinaki-Mogami, T.; Kagechika, H.; Yamamoto, M.; Itabe, H. Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells. Biol. Pharm. Bull. 2009, 32, 1177-1182.
  5. Satoh, T.; Higuchi, Y.; Kawakami, S.; Hashida, M.; Kagechika, H.; Shudo, K.; Yokoyama, M. Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' rerease control. J. Controlled Release 2009, 136, 187-195.
  6. Kurosu, T.; Ohki, M.; Wu, N.; Kagechika, H.; Miura, O. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009, 69, 3927-3936.
  7. Ohashi, E.; Kogai, T.; Kagechika, H.; Brent, G. A. Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells. Cancer Res. 2009, 69, 3443-3450.
  8. Bourhis, E.; Maheux, J.; Paquet, B.; Kagechika, H.; Shudo, K.; Rompr?, P.; Rouillard, C.; L?vesque, D. The transcriotion factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities. Psychopharmacol., 2009, 202, 635-648.
  9. Takahashi, Y.; Inoue, J.; Kagechika, H.; Sato, R. ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists. FEBS Lett. 2009, 583, 493-497.
  10. Eshima, K.; Fukaya S.; Sugimoto, A.; Mori, T.; Yokoi, H.; Yamamoto, Y.; Sugiura, S.; Honda, S.; Masuko, N.; Murakami, K.; Yamasaki, Y.; Kagechika, H. Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model. Tumor Biol. 2009, 30, 1-7.
  11. Hirano, T.; Osaki, T.; Fujii, S.; Komatsu, D.; Azumaya, I.; Tanatani, A.; Kagachika, H. Fluorescent visualization of the conformational change of aromatic amide or urea induced by N-methylation. Tetrahedron Lett. 2009, 50, 488-491.
  12. Fujii, S.; Ohta, K.; Goto, T.; Kagechika, H.; Endo, Y. Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure. Bioorg. Med. Chem. 2009, 17, 344-350.
  13. Nishimaki-Mogami, T.; Tamehiro, N.; Sato, Y.; Okuhira, K.; Sai, K.; Kagechika, H.; Shudo, K.; Abe-Dohmae, S.; Yokoyama, S.; Ohno, Y.; Inoue, K.; Sawada, J. The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell line. Biochem. Pharmacol. 2008, 76, 1006-1013.
  14. Kato, T.; Okamoto, I.; Masu, H.; Katagiri, K.; Tominaga, M.; Yamaguchi, K.; Kagechika, H.; Azumaya, I. Polymorphism and Pseudopolymorphism of an Aromatic Amide: Spontaneous Resolution and Crystal-to-Crystal Phase Transition. Cryst. Growth Des. 2008, 8, 3871-3877.
  15. Liu, Y.; Kagechika, H.; Ishikawa, J.; Hirano, H.; Matsukuma, S.; Tanaka, K.; Nakamura, S. Effects of retinoic acids on the dendritic morphology of cultured hippocampal meurons. J. Neurochem. 2008, 106, 1104-1116.
  16. Masu, H.; Katagiri, K.; Kato, T.; Kagechika, H.; Tominaga, M.; Azumaya, I. Chiral Spherical Molecules Constructed from Aromatic Amides: Facile Synthesis and Highly Ordered Network Structure in the Crystal. J Org. Chem. 2008, 73, 5143-5146.
  17. Ishikawa, J.; Sutoh, C.; Ishikawa, A.; Kagechika, H.; Hirano, H.; Nakamura, S. 13-cis-Retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat. Eur. J. Neurosci. 2008, 27, 2363-2372.
  18. Taoda, Y.; Sawabe, T.; Endo, Y. Yamaguchi, K.; Fujii, S.; Kagechika, H. Identification of An Intermediate in the Deboronation of ortho-Carborane: An Adduct of ortho-Carborane with Two Nucleophiles on One Boron Atom. Chem. Commun. 2008, 2049-2051.
  19. Ishida, S.; Tanabe, H.; Shinozaki, Y.; Koyano, S.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.;Ohno, Y.; Inoue, K. How DNA Microarray Technology Contributes to the Retinoid Evaluations. In 'Vitamin A: New Research' Chapter 5, pp71-92, Nova Scinece Publishers, Inc., NY, 2007.
  20. Okamoto, I.; Yamasaki, R.; Sawamura, M.; Kato, T.; Nagayama, N.; Takeya, T.; Tamura, O.; Masu, H.; Azumaya, I.; Yamaguchi, K.; Kagechika, H.; Tanatani, A. Redox-Induced Conformational Alteration of N,N-Diarylamides. Org. Lett. 2007, 9, 5545-5547.
  21. Matsumoto, A.; Mizukami, H.; Mizuno, S.; Umegaki, K.; Nishikawa, J.; Shudo, K.; Kagechika, H.; Inoue, M. -Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem. Pharmacol. 2007, 74, 256-264.
  22. Dai, X.; Sayama, K.; Shirakata, Y.; Hanakawa, Y.; Yamasaki, K.; Tokumaru, S.; Yang, L.; Wang, X.; Hirakawa, S.; Tohyama, M.; Yamauchi, T.; Kadowaki, T.; Kagechika, H.; Hashimoto, K. STAT5 /PPAR Pathway Regulates Involucrin Expression in Keratinocyte Differentiation. J. Invest. Dermatol. 2007, 127, 1728-1735.
  23. Komatsu, T.; Hirano, T.; Songkram, C.; Kawachi, E.; Kagechika, H. Novel Thyroid Hormone Receptor Antagonists With An N-Alkylated Diphenylamine Skeleton. Bioorg. Med. Chem. 2007, 15, 3115-3126.
  24. Hirano, T.; Hiromoto, K.; Kagechika, H. Development of a Library of 6-Arylcoumarins as Candidate Fluorescent Sensors. Organic Lett. 2007, 9, 1315-1318.
  25. Saito, A.; Sugawara, A.; Uruno, A.; Kudo, M.; Kagechika, H.; Sato, Y.; Owada, Y.; Kondo, H.; Sato, M.; Kurabayashi, M.; Imaizumi, M.; Tsuchiya, S.; Ito, S. All-trans Retinoic Acid Induces In Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling. Endocrinol. 2007, 148, 1412-1423.
【総説・著書】
  1. Hirano, T.; Kagechika, H. Thyromimetics: a review of recent reports and patents (2004 - 2009). Expert Opinion 2010, 20, 213-228.
  2. 岡本巌、影近弘之、棚谷綾．環境応答型芳香族アミド化合物の構造変換と動的制御．有機合成化学協会誌 2009, 67, 1240-124.
  3. Hirano, T.; Kagechika, H. Construction of Coumarin Library for Development of Fluorescent Sensors, In 'Combinatorial methodologies for development of chemical and biological sensors' Ed. by Potyrailo, R. A.; Mirsky, V. M. Chapter 18, Springer, pp 441-451, 2009.
  4. 影近弘之、棚谷綾．フォルダマー、In超分子サイエンス＆テクノロジー?基礎からイノベーションまで（国武豊喜監修）第３章、第１節、pp 467-476、NTS、2009.
  5. Kagechika, H.; Tanatani, A. Nuclear Receptor Drug Discovery in Gene Family Based Molecular Design, Edited by Karen Lackey. Chapter 9., Wiley-Interscience, 275-316, 2008.
  6. 影近弘之：核内受容体を標的とするケミカルバイオロジー研究．日薬理誌 2008, 132, 11-17.
  7. 影近弘之：レチノイドによるがんの予防と治療 In アンチエイジング・ヘルスフード?抗加齢・疾病予防・健康長寿延長への応用?（水島裕監修、Science Forum、2008年１月）pp 277-285.
  8. Miwako, I.; Kagechika, H. Tamibarotene. Drugs of Today 2007, 43, 563-568.
  9. 棚谷綾、影近弘之：有機化合物でつくる機能性らせん分子．化学と教育 2007, 55, 406-409.
  10. 影近弘之：核内受容体PPAR-RXRを分子標的とした抗糖尿病薬の創製．糖尿病学の進歩 2007, 41, 112-118.
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