Member

Research Theme

1. Studies on Epigenetic Information Stored in Living System
   We are measuring Epigenetic information and memorization stored in living system such as brain (neural network system), Immune system, and cardio systems caused by environmental hysteresis
2. Constructing "On-chip Organ Model" using Nano-Bio Technology
   Fusion of latest technologies of nano- and bio-tech, we aer developing artificial organ model on chip for drug discovery and toxicology use.
3. Bio-computing using "Real Neural Network On Chip"
   We construct fully controlled neural network pattern on chip and are going to be used for calculation.
4. New Drug Discovery Technology applying Single Molecule Measurement.
   We are developing the methods to be able to measure the single molecule level maps in each cells. Using this method, we are designing new approach for Drug Discovery Technology.

Publications

1. Inaoka H, Fukuoka Y, Kohane IS. Lower expression of genes near microRNA in C. elegans germline. BMC Bioinformatics 7:112, 2006.
2. Moriguchi H, Yasuda K. Photothermal microneedle etching: Improved three-dimensional microfabrication method for agarose gel for topographical control of cultured cell communities. Jpn J Appl Phys 45(30):L796-L799, 2006.
3. Matsumura K, Orita K, Wakamoto Y, Yasuda K. Phagocytic response to fully controlled plural stimulation of antigens on macrophage using on-chip microcultivation system. J Nanobiotechnology 4:7, 2006.
4. Kawai-Noma S, Ayano S, Pack CG, Kinjo M, Yoshida M, Yasuda K, Taguchi H. Dynamics of yeast prion aggregates in single living cells. Genes Cells 11(9):1085-1096, 2006.
5. Wakamoto Y, Yasuda K. Quantitative evaluation of cell-to-cell communication effects in cell group class using on-chip individual-cell-based cultivation system. Biochem Biophys Res Commun 349(3):1130-1138, 2006.
6. Ayano S, Wakamoto Y, Yamashita S, Yasuda K. Quantitative measurement of damage caused by 1064-nm wavelength optical trapping of Escherichia coli cells using on-chip single cell cultivation system. Biochem Biophys Res Commun 350(3):678-684, 2006.
7. Kojima K, Kaneko T, Yasuda K. Role of the community effect of cardiomyocyte in the entrainment and reestablishment of stable beating rhythms. Biochem Biophys Res Commun 351(1):209-215, 2006.
8. Umehara S, Pourmand N, Webb CD, Davis RW, Yasuda K, Karhanek M. Current rectification with poly-L-lysine-coated quartz nanopipettes, Nano Letters 6(11):2486-2492, 2006.
9. Gharizadeh B, Akhras M, Nourizad N, Ghaderi M, Yasuda K, Nyr´en P, Pourmand N. Methodological improvements of pyrosequencing technology. J. Biotech. 124(3):504-11, 2006.
10. Wakamoto Y, Yasuda K. Epigenetic inheritance of elongated phenotypes between generations revealed by individual-cell-based direct observation. Meas. Sci. Technol. 17:3171-3177, 2006.