Member

Research Theme

1. Design of Dynamic Biomaterials Surfaces
   Biomaterials surfaces with dynamic properties are designed by utilizing a molecularly movable architecture of polyrotaxanes, and examined their effects on a variety of interactions with living body.
2. Medicinal Chemistry of Nuclear Receptors
   Biologically active ligands are introduced into cyclic molecules in polyrotaxanes, and examined the effects of their movability on multivalent interactions with receptor proteins and the subsequent events including intracellular metabolisms.
3. Design of Intracellularly Functionalizing Biomaterials
   Cytocleavable polyrotaxanes are designed by introducing intracellularly cleavable linkages into the polyrotaxanes, and their practical applications such as a gene delivery are examined.
4. Design of Liposomal Device and Hybrid Nanomaterials
   Functional supramolecular assembly systems such as liposomes, lipid nanotube network, and organic-inorganic hybrid nanomaterials are investigated for potential biomedical applications.

Publications

1. Yui N. Supramolecular Surfaces Modulating Cellular Response. Adv. Sci. Tech., 76:10-15, 2010.
2. Nagahama K, Ohmura J, Sakaue H, Ouchi T, Ohya Y, Yui N. Preparation of nano-aggregates through self-assembly of amphiphilic polyrotaxane composed of PLLA-PEG-PLLA triblock copolymer and α-cyclodextrin. Chem. Lett, 39:250-251, 2010.
3. Yamada Y, Nomura T, Harashima H, Yamashita A, Katoono R, Yui N. Intranuclear DNA release is a determinant of transfection activity for a non-viral vector: biocleavable polyrotaxane as a supramolecularly dissociative condenser for efficient intracellular DNA release. Bio. Pharm. Bull., 33:1218-1222, 2010.
4. Shaheen S. M., Akita H, Yamashita A, Katoono R, Yui N, Biju V, Ishikawa M, Harashima H. Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET. Nucleic Acid Res. in press, 2010.
5. Katoono R, Kobayashi Y, Yui N. Preparation of loose-fit polyrotaxane composed of α-cyclodextrin and poly(ethylene glycol) derivatives through the slipping-expanding protocol. Chem. Lett., 39:892-893, 2010.
6. Fukuda T, Matsumoto E, Yui N, Miura Y. Peculiar wettability based on orientational change of self-assemblied hemispherical PAMAM dendrimer layer. Chem. Lett., 39:923-925, 2010.
7. Sasaki Y, Akiyoshi K. Development of an Artificial Chaperone System Based on Cyclodextrin. Curr. Pharm. Biotechnol., 11:300-305, 2010.
8. Sasaki Y, Shioyama Y, Tian WJ, Kikuchi JI, Hiyama S, Moritani Y, Suda T. A nanosensory device fabricated on a liposome for detection of chemical signals. Biotechnol. Bioeng., 105:37-43, 2010.
9. Sasaki Y, Nomura Y, Sawada S, Akiyoshi K. Polysaccharide Nanogel-Cyclodextrin System as An Artificial Chaperone for In Vitro Protein Synthesis of Green Fluorescent Protein. Polymer J., 42:823, 2010.
10. Yasuhara K, Wang Z, Ishikawa T, Kikuchi J, Sasaki Y, Hiyama S, Moritani Y, Suda T. Specific delivery of transport vesicles mediated by complementary recognition of DNA signals with membrane-bound oligonucleotide lipids. Supramol. Chem., 2010. in press
11. Sasaki Y, Akiyoshi K. Nanogel Engineering for New NanoBiomaterials: From Chaperoning Engineering to Biomedical Applications. Chem. Rec., 10:366-376, 2010.
12. 佐々木善浩，秋吉一成．ナノゲルを基盤とするナノバイオエンジニアリング．人工臓器，39(3), 197-201, 2010.
13. Yui N. Controlling molecular mobility as nanobio-interfaces. Nanobio-Interfaces in Relation to Molecular Mobility, 1-6, 2010.
14. Sasaki Y, Abe K, Akiyoshi K. Construction of a 3D-liposomal array for Biochip Applications. Nanobio-Interfaces in Relation to Molecular Mobility, 97-102, 2010.