業績 Achievements

原著論文

• Du X, Yada E, Terai Y, Takahashi T, Nakanishi H, Tanaka H, Akita H, Itaka K. Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery. Pharmaceutics 15(9): 2291, 2023
• Zhang M, Fukushima Y, Nozaki K, Nakanishi H, Deng J, Wakabayashi N, Itaka K. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA. Inflammation and Regeneration 43:32, 2023
• Free K, Nakanishi H, Itaka K. Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection. Pharmaceutics 15(1): 213, 2023
• Cui J, Shibata Y, Itaka K, Zhou J, Zhang J. Unbiased comparison and modularization identify time-related transcriptomic reprogramming in exercised rat cartilage: Integrated data mining and experimental validation. Front Physiol. 13: 974266, 2022
• Deng J, Fukushima Y, Nozaki K, Nakanishi H, Yada E, Terai Y, Fueki K, Itaka K. Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist. Pharmaceutics 14(9): 1785, 2022
• Kida H, Feril LB, Irie Y, Endo H, Itaka K, Tachibana K. Influence of Nanobubble Size Distribution on Ultrasound-Mediated Plasmid DNA and Messenger RNA Gene Delivery. Front Pharmacol. 13: 855495, 2022
• Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X, Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y. Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy. Prog Neurobiol. 216: 102288, 2022
• Pezzotti G, Zhu W, Terai Y, Marin E, Boschetto F, Kawamoto K, Itaka K. Raman spectroscopic insight into osteoarthritic cartilage regeneration by mRNA therapeutics encoding cartilage-anabolic transcription factor Runx1. Mater Today Bio 13: 100210, 2022
• Nakanishi H, Yoshii T, Tsukiji S, Saito H. A protocol to construct RNA-protein devices for photochemical translational regulation of synthetic mRNAs in mammalian cells. STAR Protoc. 3(2): 101451, 2022
• Nakanishi H, Saito H, Itaka K. Versatile Design of Intracellular Protein-Responsive Translational Regulation System for Synthetic mRNA. ACS Synth Biol. 11(3): 1077-1085, 2022
• Oyama N, Kawaguchi M, Itaka K, Kawakami S. Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice. Pharmaceutics 13(11): 1810, 2021
• Nakanishi H, Yoshii T, Kawasaki S, Hayashi K, Tsutsui K, Oki C, Tsukiji S, Saito H. Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells. Cell Chemical Biology 28(5): pp662-674.e5, 2021
• Fukushima Y, Uchida S, Imai H, Nakatomi H, Kataoka K, Saito N, Itaka K. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials 270: 120681, 2021
• Li J, Sasaki N, Itaka K, Terpstra M, Levato R, Matsusaki M. Regulation of Chondrocyte Differentiation by Changing Intercellular Distances Using Type II Collagen Microfibers. ACS Biomaterials Science & Engineering. 6 (10), 5711-5719, 2020
• Uchida S, Yanagihara K, Matsui A, Kataoka K, Itaka K. mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy. Micromachines 11(4): 426, 2020
• Crowley ST, Fukushima Y, Uchida S, Kataoka K, Itaka K. Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA. Mol Ther Nucleic Acids 17: 465-476, 2019
• Omura T, Fukushima Y, Yoshikawa G, Matsuhashi A, Sato D, Endo T, Sato K, Inoue M, Saito A, Tsutsumi K. Cerebral hyperperfusion syndrome after a burr hole drainage surgery for chronic subdural hematoma. World Neurosurg. 124: 5-8, 2019.
• Lin CY, Crowley S, Uchida S, Komaki Y, Kataoka K, Itaka K. Treatment of intervertebral disk disease by administration of messenger RNA encoding a cartilage-anabolic transcription factor. Mol Ther Nucleic Acids 16: 162-171, 2019
• Crowley S, Kataoka K, Itaka K. Combined CatWalk Index: an improved method to measure mouse motor function using the automated gait analysis system. BMC Research Notes11:263, 2018
• Yanagihara K, Uchida S, Ohba S, Kataoka K, Itaka K. Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids. Molecular Therapy - Methods & Clinical Development. 9: 358-366, 2018
• Horiuchi N, Shibata K, Saito H, Iwabuchi Y, Wada N, Nozaki K, Hashimoto K, Tanaka Y, Nagai A, Yamashita K. Size control synthesis of hydroxyapatite plates and their application in the preparation of highly oriented films. Cryst Growth Des 18(9): 5038-5044, 2018
• Matsui A, Uchida S, Hayashi A, Kataoka K, Itaka K. Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection. J Control Release. 285; 1-11, 2018
• Uchida S, Yoshinaga N, Yanagihara K, Yuba E, Kataoka K, Itaka K. Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for e?ective vaccination. Biomaterials. 150:162-170, 2018
• Horiuchi N, Madokoro K, Nozaki K, Nakamura M, Katayama K, Nagai A, Yamashita K. Electrical conductivity of polycrystalline hydroxyapatite and its application to electret formation. Solid State Ionics 315: 19-25, 2018
• Inokoshi M, Shimizu H, Nozaki K, Takagaki T, Yoshihara K, Nagaoka N, Zhang F, Vleugels J, Van Meerbeek B, Minakuchi S. Crystallographic and morphological analysis of sandblasted highly translucent dental zirconia. Dent Mater 34(3): 508-518, 2018
• Fujita K, Nozaki K, Horiuchi N, Yamashita K, Miura H, Nagai A. Regulation of periodontal ligament-derived cells by type III collagen-coated hydroxyapatite. Biomed Mater Eng 29(1): 15-27, 2018
• Uraba A, Nemoto R, Nozaki K, Inagaki T, Omori S, Miura H. Biomechanical behavior of adhesive cement layer and periodontal tissues on the restored teeth with zirconia RBFDPs using three-kinds of framework design: 3D FEA study. J Prosthodont Res 62(2): 227-233, 2018
• Anraku Y, Kuwahara H, Fukusato Y, Mizoguchi A, Ishii T, Nitta K, Matsumoto Y, Toh K, Miyata K, Uchida S, Nishina K, Osada K, Itaka K, Nishiyama N, Mizusawa H, Yamasoba T, Yokota T, Kataoka K. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nature Communications 8: 1001, 2017
• Yamada R, Nozaki K, Horiuchi N, Yamashita K, Nemoto R, Miura H, Nagai A. Ag nanoparticle-coated zirconia for antibacterial prosthesis. Mater Sci Eng C Mater Biol Appl 78: 1054-1060, 2017
• Iwata N, Nozaki K, Horiuchi N, Yamashita K, Tsutsumi Y, Miura H, Nagai A. E?ects of controlled micro-/nanosurfaces on osteoblast proliferation. J Biomed Mater Res A 105(9): 2589-2596, 2017
• Igeta K, Kuwamura Y, Horiuchi N, Nozaki K, Shiraishi D, Aizawa M, Hashimoto K, Yamashita K, Nagai A. Morphological and functional changes in RAW264 macrophage-like cells in response to a hydrated layer of carbonate-substituted hydroxyapatite. J Biomed Mater Res A 105(4): 1063-1070, 2017
• Liza S, Hieda J, Akasaka H, Ohtake N, Tsutsumi Y, Nagai A, Hanawa T. Deposition of boron doped DLC ?lms on TiNb and characterization of their mechanical properties and blood compatibility. Sci Technol Adv Mater. 18(1): 76-87, 2017
• Wada N, Horiuchi N, Nishio M, Nakamura M, Nozaki K, Nagai A, Hashimoto K, Yamashita K. Crystallization of calcium phosphate in agar hydrogels in presence of polyacrylic acid under double di?usion conditions. Crystal Growth & Design. 17(2): 604-611, 2017
• Shen D, Horiuchi N, Nozaki K, Miyashin M, Yamashita K, Nagai A. Synthesis and enhanced bone regeneration of carbonate substituted octacalcium phosphate. Bio-Medical Materials and Engineering 28(1): 9-21, 2017
• Matsukawa K, Nemoto R, Nozaki K, Kubo M, Inagaki T, Yoshida K, Miura H. The in?uence of the framework thickness on surface strain of the 3-unit Zirconia resin- bonded ?xed dental prostheses under the functional loading. Asian Paci?c Journal of Dentistry 17(1): 1-7, 2017
• Horiuchi N, Iwasaki Y, Nozaki K, Nakamura M, Hashimoto K, Nagai A, Yamashita K. A Critical Phenomenon of Phase Transition in Hydroxyapatite Investigated by Thermally Stimulated Depolarization Currents Journal of the American Ceramic Society 100(2): 501-505, 2017
• Minamifuchi M, Nemoto R, Uraba A, Omori S, Nozaki K, Miura H.　Evaluating the optimal design of zirconia based resin-bonded ?xed dental prostheses using ?nite element anaysis. The Journal of the Japan Academy of Digital Dentistry 7(2): 169-174, 2017
• Perche F, Uchida S, Akiba H, Lin CY, Ikegami M, Dirisala A, Nakashima T, Itaka K, Tsumoto K, Kataoka K. Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer. Curr Alzheimer Res. 14(3):295-302. 2017
• Lin CY, Perche F, Ikegami M, Uchida S, Kataoka K, Itaka K. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. J Control Release. 235:268-75, 2016
• Uchida S, Hayakawa K, Ogata T, Tanaka S, Kataoka K, Itaka K. Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids. Biomaterials. 109:1-11, 2016
• Uchida H, Itaka K, Uchida S, Ishii T, Suma T, Miyata K, Oba M, Nishiyama N, Kataoka K. Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure. J Am Chem Soc. 138(5):1478-81, 2016
• Uchida S, Kinoh H, Ishii T, Matsui A, Tockary TA, Takeda KM, Uchida H, Osada K, Itaka K, Kataoka K. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials. 82:221-8, 2016
• Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung U, Ohba S. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 6: 18743, 2016
• Okuda T, Suzuki Y, Kobayashi Y, Ishii T, Uchida S, Itaka K, Kataoka K, Okamoto H. Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying. Pharmaceutics. 7(3): 233-54, 2015
• Matsui A, Uchida S, Ishii T, Itaka K, Kataoka K. Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases. Sci Rep. 5:15810, 2015
• Li Y, Osada K, Chen Q, Tockary TA, Dirisala A, Takeda KM, Uchida S, Nagata K, Itaka K, Kataoka K. Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression. Biomacromolecules. 16(9): 2664-71, 2015
• Itaka K, Uchida S, Matsui A, Yanagihara K, Ikegami M, Endo T, Ishii T, Kataoka K. Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation. J Vis Exp . 101: e52384, 2015
• Uchida S, Kataoka K, Itaka K. Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity. Pharmaceutics. 7(3):137-51, 2015
• Chen Q, Osada K, Pennisi M, Uchida S, Tockary TA, Dirisala A, Li Y, Takeda KM, Oniyanagi S, Itaka K, Kataoka K. A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft Matter. 11(14):2718-22, 2015
• Baba M, Itaka K, Kondo K, Yamasoba T, Kataoka K. Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. J Control Release. 201:41-8，2015
• Hayakawa K, Uchida S, Ogata T, Tanaka S, Kataoka K, Itaka K. Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. J Control Release. 197:1-9，2015
• Uchida H, Itaka K, Nomoto T, Ishii T, Suma T, Ikegami M, Miyata K, Oba M, Nishiyama N, Kataoka K.　Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J Am Chem Soc. 136(35):12396-405, 2014
• Dirisala A, Osada K, Chen Q, Tockary TA, Machitani K, Osawa S, Liu X, Ishii T, Miyata K, Oba M, Uchida S, Itaka K, Kataoka K. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials. 35(20):5359-68, 2014
• Nagata K, Itaka K, Baba M, Uchida S, Ishii T, Kataoka K. Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury. J Control Release. 20;183C:27-34, 2014
• Ge Z, Chen Q, Osada K, Liu X, Tockary TA, Uchida S, Dirisala A, Ishii T, Nomoto T, Toh K, Matsumoto Y, Oba M, Kano MR, Itaka K, Kataoka K. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials. 35(10):3416-26, 2014
• Uchida S, Itaka K, Nomoto T, Endo T, Matsumoto Y, Ishii T, Kataoka K. An injectable spheroid system with genetic modification for cell transplantation therapy. Biomaterials. 35(8):2499-506, 2014
• Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H. Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun. 4:2316, 2013
• Theofilus A. Tockary, Kensuke Osada, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, and Kazunori Kataoka. Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers. Macromolecules 46 (16), 6585?6592, 2013
• Ohgidani M, Furugaki K, Shinkai K, Kunisawa Y, Itaka K, Kataoka K, Nakano K. Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys. J Control Release. 10;167(3):238-47, 2013
• Uchida S, Itaka K, Uchida H, Hayakawa K, Ogata T, Ishii T, Fukushima S, Osada K, Kataoka K. In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle. PLoS One. 8(2):e56220, 2013
• Endo T, Itaka K, Shioyama M, Uchida S, Kataoka K. Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation. Drug Deliv. and Transl. Res. 2:398?405, 2012.
• Kumagai M, Shimoda S, Wakabayashi R, Kunisawa Y, Ishii T, Osada K, Itaka K, Nishiyama N, Kataoka K, Nakano K. Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. JControl Release. 160(3):542-51, 2012
• Uchida S, Itaka K, Chen Q, Osada K, Ishii T, Shibata MA, Harada-Shiba M, Kataoka K. PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Mol Ther 20(6):1196-203, 2012.
• Chen Q, Osada K, Ishii T, Oba M, Uchida S, Tockary TA, Endo T, Ge Z, Kinoh H, Kano MR, Itaka K, Kataoka K. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials. 33:4722-30, 2012
• Suma T, Miyata K, Ishii T, Uchida S, Uchida H, Itaka K, Nishiyama N, Kataoka K. Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 33: 2770-9, 2012
• Osada K, Shiotani T, Tockary TA, Kobayashi D, Oshima H, Ikeda S, Christie RJ, Itaka K, Kataoka K. Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials. 33(1):325-32, 2012
• Uchida H, Miyata K, Oba M, Ishii T, Suma T, Itaka K, Nishiyama N, Kataoka K. Odd-Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles. J Am Chem Soc. 133(39):15524-32, 2011
• Uchida S, Itaka K, Chen Q, Osada K, Miyata K, Ishii T, Harada-Shiba M, Kataoka K. Combination of Chondroitin Sulfate and Polyplex Micelles from Poly(ethylene glycol)- poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} Block Copolymer for Prolonged In Vivo Gene Transfection with Reduced Toxicity. J Control Release. 155(2):296-302, 2011
• Miyata K, Gouda N, Takemoto H, Oba M, Lee Y, Koyama H, Yamasaki Y, Itaka K, Nishiyama N, Kataoka K. Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials. 31(17):4764-70, 2010
• Oba M, Vachutinsky Y, Miyata K, Kano MR, Ikeda S, Nishiyama N, Itaka K, Miyazono K, Koyama H, Kataoka K. Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1. Mol Pharm. 7(2):501-9, 2010
• Lee Y, Ishii T, Kim HJ, Nishiyama N, Hayakawa Y, Itaka K, Kataoka K. Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-Conversional Polyion Complex Micelles. Angew Chem Int Ed Engl. 49(14):2552-2555, 2010
• Itaka K, Osada K, Morii K, Kim P, Yun SH, Kataoka K. Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle. J Control Release. 143(1):112-9, 2010
• Itaka K, Ishii T, Hasegawa Y, Kataoka K. Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials. 31(13):3707-14, 2010
• Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga JI, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H. Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. J Biol Chem. 285(15):11681-91, 2010

総説

• 中西秀之、位髙啓史. RNA修飾による炎症回避が、効果的なmRNAワクチンの開発を可能にした, 科学 93(12): 1065-1069, 2023
• 位髙啓史. mRNA創薬の現状と今後の展望, 医薬品医療機器レギュラトリーサイエンス54(4): 279-285, 2023
• 中西秀之. 細胞・臓器選択的な翻訳を可能にするmRNA医薬の設計, 細胞 55(11): 876-880, 2023
• 位髙啓史. mRNA医薬の再生医療への応用, 細胞 55(11): 891-894, 2023
• 中西秀之、位髙啓史. 細胞死誘導タンパク質をコードした合成mRNAによる選択的細胞除去, バイオマテリアル－生体材料－ 41(4): 332-333, 2023
• 福島雄大、位髙啓史. 神経疾患へのmRNA医薬応用. 脳神経内科98(6): 858-863, 2023
• 位髙啓史. 神経疾患治療へ応用が期待されるmRNA医薬, Clinical Neuroscience 41(5): 621-624, 2023
• 中西秀之、位髙啓史. mRNA医薬とmRNAワクチン, 医学のあゆみ 285(5): 340-347, 2023
• 福島雄大、位髙啓史. mRNA医薬による中枢神経系疾患治療研究. Drug Delivery System 37(3): 247-252, 2022
• 中西秀之、位髙啓史. 指定された期間・細胞種において選択的に薬効を発揮するmRNA医薬のための翻訳制御技術. Drug Delivery System 37(3): 209-220, 2022
• 中西秀之、位髙啓史. mRNAワクチン・mRNA医薬は何を可能にするのか. ファルマシア 58(5): 415-419, 2022
• Nakanishi H, Itaka K. Synthetic mRNA for ex vivo therapeutic applications. Drug Metab Pharmacokinet. 44: 100447, 2022
• Nakanishi H. Protein-Based Systems for Translational Regulation of Synthetic mRNAs in Mammalian Cells. Life 11(1): 1192, 2021
• 位髙啓史．新規創薬・ワクチンモダリティとしてのmRNA．医学のあゆみ「医学のあゆみ」279(10): 988-992, 2021
• 位髙啓史．新しい創薬モダリティとしてのmRNA．BIO Clinica 35(14): 1371-1375, 2021
• 中西秀之、位髙啓史．mRNA医薬・mRNAワクチンの基礎と応用．実験医学増刊号「核酸医薬　本領を発揮する創薬モダリティ」39(17): 2693-2701, 2021
• 位髙啓史．mRNA医薬・mRNAワクチンとは何か．学術の動向 26(10): 38-43, 2021
• 位髙啓史．mRNA医薬の運動器疾患・外傷治療への応用．VIVA! ORTHO, no.20, 8, 2020
• 位髙啓史．mRNA医薬に利用されるキャリア開発：ナノミセル型キャリア．Drug Delivery System 35-1: 27-34, 2020
• 位髙啓史．mRNA医薬の研究開発動向と将来展望．医薬ジャーナル55(2): 627-632, 2019
• 位高啓史, 福島雄大. 【脳神経系へ挑むバイオマテリアル】mRNA 医薬を用いた脳神経疾患の治療戦略. バイオマテリアル-生体材料- 36(3): 220-223, 2018
• 位髙啓史．メッセンジャーRNA医薬を実現するDDS開発と疾患治療への応用．Drug Delivery System（DDS）31(4)：343-351, 2016
• 位髙啓史．メッセンジャーRNA医薬の開発戦略．日薬理誌（Folia Pharmacol.Jpn）148：190-196, 2016．
• Itaka K. Introduction to Special Issue: A New Paradigm of Gene Therapy. Pharmaceutics 8(1), 1; 2016
• 位髙啓史，片岡一則．ナノDDSの再生医療への展開：mRNAデリバリーによる生体内細胞制御．細胞工学 34(10): 946-951，2015
• 位髙啓史．整形外科におけるDDS：再生医療への応用．BIO Clinica 30(7) (特集：DDS技術の医療応用への新展開), 35-40, 2015.
• 位髙啓史，片岡一則．超分子ナノマシンによる薬物・遺伝子のピンポイントデリバリー．泌尿器外科28（臨増），557-558，2015
• 位髙啓史．整形トピックス：脊髄組織で蛋白発現持続を可能とするmRNAデリバリーシステムの開発と脊髄損傷治療への展開．臨床雑誌整形外科65(12): 1248, 20141.11.1（11月号）
• 位髙啓史，片岡一則．ナノ医療．医学のあゆみ249(5): 402, 2014
• 位髙啓史．ナノテクノロジーを応用したドラッグ・核酸デリバリーシステム．東京都病院薬剤師会雑誌．61(3): 187-193, 2012
• 位髙啓史．生体適合性遺伝子ナノキャリアの開発研究と疾患治療への応用．バイオマテリアル30（1） 39-46, 2012
• Itaka K, Kataoka K. Progress and prospects of polyplex nanomicelles for plasmid DNA delivery. Curr Gene Ther 11(6): 457-465, 2011
• 位髙啓史．医療ナノテクノロジーの今は．Astellas Square 5 (5): 16-17, 2009
• Itaka K, Kataoka K. Recent development of nonviral gene delivery systems with virus-like structures and mechanisms. Eur J Pharm Biopharm. 71(3):475-83, 2009

著書

• 中西秀之. 第13節 タンパク質をモジュールとするmRNA翻訳制御システムの構築, mRNAの制御機構の解明と治療薬・ワクチンへの活用 115-136, 2023
• 位髙啓史．口腔科学（戸塚靖則，髙戸毅監修）朝倉書店．6章「口腔領域における治療の展開」6.14「再生医療の応用」3.「遺伝子治療など」．pp.994-996（総ページ数1072）．2013
• 位髙啓史．先端バイオマテリアルハンドブック（エヌ・ティー・エス）第3章「DDS用バイオマテリアル」7節「機能性ポリマーによる遺伝子キャリア」．pp.374-377．秋吉一成，石原一彦，山岡哲二編，2012.
• 位髙　啓史．バイオマテリアルの基礎（監修：日本バイオマテリアル学会）（日本医学館）．第6章　再生医療とバイオマテリアル，第2節　バイオマテリアルとしての細胞　5.骨芽細胞．pp.233-236，2010
• 位髙　啓史，高岡　裕．実践ゲノムの最前線（監修　井村宏夫）（六然社）．第6章　ゲノム科学から次世代ナノ医療へ　①ゲノム情報からナノバイオへ．p.126-127，2009
• 位髙　啓史，片岡　一則．第8章　新興分野人材養成　④医療ナノテクノロジーから医療システムイノベーションへ．p.337-340，2009
• 位髙　啓史．「医療ナノテクノロジー　－最先端医学とナノテクの融合－」（監修：片岡一則）第Ⅱ部第1章「ナノDDS」pp.86-108，2007
• 位髙啓史．口腔科学（戸塚靖則，髙戸毅監修）朝倉書店．6章「口腔領域における治療の展開」6.14「再生医療の応用」3.「遺伝子治療など」．pp.994-996（総ページ数1072）．2013
• 位髙啓史．先端バイオマテリアルハンドブック（エヌ・ティー・エス）第3章「DDS用バイオマテリアル」7節「機能性ポリマーによる遺伝子キャリア」．pp.374-377．秋吉一成，石原一彦，山岡哲二編，2012.
• 位髙　啓史．バイオマテリアルの基礎（監修：日本バイオマテリアル学会）（日本医学館）．第6章　再生医療とバイオマテリアル，第2節　バイオマテリアルとしての細胞　5.骨芽細胞．pp.233-236，2010
• 位髙　啓史，高岡　裕．実践ゲノムの最前線（監修　井村宏夫）（六然社）．第6章　ゲノム科学から次世代ナノ医療へ　①ゲノム情報からナノバイオへ．p.126-127，2009
• 位髙　啓史，片岡　一則．第8章　新興分野人材養成　④医療ナノテクノロジーから医療システムイノベーションへ．p.337-340，2009
• 位髙　啓史．「医療ナノテクノロジー　－最先端医学とナノテクの融合－」（監修：片岡一則）第Ⅱ部第1章「ナノDDS」pp.86-108，2007

報道等

• 2017年10月12日　JIJI.COM「免疫細胞、新技術で活性化＝RNAワクチンで開発－東大など」
• 2017年10月11日　川崎市 KING SKYFRONT web インフォメーション「アジュバント機能を一体化させたmRNAワクチンを開発～mRNAに免疫賦活化作用が強い2本鎖RNA構造を組み込む～」
• 2016年3月23日 日経産業新聞「骨育たぬ病、遺伝子で治療、成長止める受容体妨げ、東大、患者の細胞に導入、マウスで伸び確認」 8ページ 絵写表有
• 2016年1月21日　朝日新聞DIGITAL「ひざ関節症、ｍＲＮＡ注射で治療　東大チーム、マウスで成功」
• 2016年1月21日　朝日新聞DIGITAL apital「ＲＮＡを注射、マウスのひざ関節症を治療／東大チーム」
• 2016年1月21日　朝日新聞「ひざ関節症、mRNA注射で治療」
• 2016年1月15日　科学新聞「転写因子mRNA送達で変形性関節症進行を抑制」
• 2016年1月11日　日本経済新聞「「変形性関節症」進行抑える技術　東大、マウス実験で効果」
• 2016年1月10日　日本経済新聞電子版ニュース「東大、変形性関節症の進行抑制技術を開発」
• 2016年1月7日　東洋経済ONLINE「中高年のひざの痛み､｢治せる時代｣へ一歩前進：変形関節症進行を止める核酸治療」
• 2016年1月6日　マイナビニュース「関節へのmRNA投与で変形性関節症の進行を抑制 - 東大が成功」
• 2016年1月6日　神奈川新聞「遺伝子投与で進行抑制/変形性関節症、マウス実験/東大チーム」
• 2016年1月6日　毎日新聞「変形性関節症：遺伝子で進行抑制 東大がマウス実験、新たな治療方法に道」
• 2016年1月5日　日経電子版「東大、治療用転写因子mRNAの関節内送達により変形性関節症の進行抑制に成功」
• 2016年1月5日　THE WALL STREET JOURNAL「ＲＮＡ入り微粒子を注射＝変形性関節症、マウスで治療－東大」
• 2016年1月5日　時事通信社「ＲＮＡ入り微粒子を注射＝変形性関節症、マウスで治療－東大」
• 2016年1月5日　時事通信社「ＲＮＡ入り微粒子を注射＝変形性関節症、マウスで治療－東大」