1.Genetic Factors for Cardiac
Diseases
A. Idiopathic Cardiomyopathy
・Investigation
on genes for sarcomere in idiopathic cardiomyopathy (1)
・Identification of mutations in the known genes for hypertrophic
cardiomyopathy (HCM) (2), (3)
・Identification of a novel disease gene for HCM (4)
・Frequency of disease-related mutations in the Japanese patients
with HCM (5)
・Identification of disease-related mutations in dilated cardiomyopathy
(DCM) (6)
・Identification of another novel disease gene for both HCM and
DCM (7), (8), (9)
→Moleular pathogenesis of idiopathic cardiomyopathies (a novel
hypothesis) (10)
・Characterization and functional analyses of novel genes expressed
in the cardiac muscle.
・Making animal model for cardiomyopathy by using a novel heart-specific
gene
B. Idiopahic Arrythmias
・Identification of mutations of channel genes in hereditaty arrythmias
C. Myocardial Infarction
・Investigation on the reported disease-associated
polymorphisms
・Identification of novel genetic factors related with the disease
in Japanese (11)
D. Hypertensive Heart Disease
・Identification of polymorphisms associated with hypertensive
cardiac hypertrophy
・Analysis of genes expressed in cardiac muscles from hypertensive
rat model
→Search for candidates of genes for hypertensive heart disease
(12)
2.Genetic Factors for Autoimmune
Diseases
A. Analysis of HLA region
・Association studies for insulin-dependent diabetes mellitus
(IDDM) (13)
・Association studies for Graves disease (14)
・Association studies for Takayasu arteritis (15)
・Association studies for Buerger disease (16)
・Association studies for ohter autoimmune diseases
→SLE, rheumatoid arthritis, Hahimoto disease, ulcerative colitis,
Crohn disease, etc.
B. Analysis of other genes
・Search for polymorphisms in the immune-related genes
and their use in association studies
3.Genetic Factors for Colon
Cancer
A. Mutations in cancer-related
genes
・Comparative analysis of somatic mutations in cancer-related
genes between ordinary colon cancers
and those associated with mismatch-repair deficieny
(17)
・Search for a novel cancer-related genes for hereditary colon
cancer without mismatch-repair defects
4.Other Researches
A. Analysis of microsatellites
・Investigation on the generation of microsatellite
polymorphisms (18)
・Functional analysis of microsatellites in regulation of gene
expression (19)
B. Analysis of Matrix Proteins
・Structure, distribution and function of matrix preteins
・Immunogenisity of allogeneic collagens
・Anti-cancer function of collagen-related molecules