Pubication 2002-

1.Original Articles 

Ono N., Nakashima N., Rittling S.R., Schipani E., Hayata T., Ezura Y., Soma K., Denhardt D.T., Kronenberg H.M., Noda M. OSTEOPONTIN Negatively Regulates parathyroid hormone receptor signaling in osteoblasts Journal of Biological Chemistry, 2008 (in press) E-Pub

Kawamata A., Izu Y., Yokoyama H., Hayata T., Amagasa T., Wagner E.F., Nakashima K., Ezura Y., Noda M. JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion. Journal of Cellular Biochemistry. 103(4):1037-45, 2008

Mizoguchi F., Mizuno A., Hayata T., Nakashima K., Heller S., Ushida T., Sokabe M., Miyasaka N., Suzuki M., Ezura Y., Noda M. Transient Receptor Potential Vanilloid 4 Deficiency Suppresses Unloading-Induced Bone Loss. Journal of Cellular Physiology. 2008(in press).

Hayata T., Nakamoto T., Ezura Y., Noda M. Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen Biochemical and Biophysical Research Communications. 368(2):205-10, 2008

Chung C.J., Soma K., Rittling S.R., Denhardt D.T., Hayata T., Nakashima K., Ezura Y., Noda M. OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application. Journal of Cellular Physiology 214:614-20, 2008

Suzuki H., Amizuka N., Oda K., Noda M., Ohshima H., Maeda T., Involvement of the klotho protein in dentin formation and mineralization. Anatomical Record 291:183-190, 2008

Suzuki H., Amizuka N., Oda K., Noda M., Ohshima H., Maeda T. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. J Anat. 212(3):275-85, 2008

Nakamoto T, Seo S., Sakai R., Kato T., Kutsuna H., Noda M., Miyasaka N., Kitagawa S. Expression and tyrosine phosphorylation of Crk associated substrate lymphocyte type (Cas-L) protein in human neutrophils. Journal of Cellular Biochemistry, 2008 (in press)

Lejard V., Brideau G., Blais F., Salingcarnboriboon R., Wagner G., Roehrl M.H., Noda M., Duprez D., Houillier P., Rossert J. Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. Journal of Biological Chemistry 15;282:17665-75, 2007

Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., Denhardt D.T., Nifuji A., Noda M. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells Journal of Endocrinology 193:235-43, 2007

Hino K, Nakamoto T, Nifuji A, Morinobu M, Ezura Y, Yamamoto H, Noda M. Deficiency of CIZ, a nucleocytoplasmic shuttling protein, prevents unloading-induced bone loss through the enhancement of osteoblastic bone formation in vivo. Bone 40:852-860 2007.

Okuda N., Takeda S., Shinomiya K., Muneta T., Itoh S., Noda M., Asou Y. ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation Bone. 40:281-92. 2007

Nguyen S.T., Hasegawa S., Tsuda H., Tomioka H., Ushijima M., Noda M., Omura K and Miki Y Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. Cancer Science 98:740-6, 2007

Saita Y., Takagi T., Kitahara K., Usui M., Ezura Y., Nakashime K., Kurosawa H., Ishii S., Noda M. Lack of schnurri-2 expression associates with reduced bone remodeling and osteopenia. Journal of Biological Chemistry 282:12907-15, 2007

Kato N., Kitahara K., Rittling S.R., Nakashima K., Denhardt D.T., Kurosawa H., Ezura Y., Noda M. Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone. Journal of Endocrinology. 2007;193:171-82

Hayashi C., Rittling S., Hayata T., Amagasa T., Denhardt D. T., Ezura Y., Nakashima K., Noda M. Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration. Journal of Cellular Biochemistry. 101:979-86, 2007

Washio-Oikawa K., Nakamura T., Usui M., Yoneda M., Ezura Y., Ishikawa I., Kazuhisa N., Noda T., Yamamoto T., Noda M. Cnot7 Null Mice Exhibit High Bone Mass Phenotype and Modulation of BMP Actions. Journal of Bone Mineral Research 22:1217-23, 2007

Shimoyama A., Wada M., Ikeda F., Hata K., Matsubara T., Nifuji A., Noda M, Amano K., Yamaguchi A., Nishimura R., Yoneda T. Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function. Molecular Biology of the Cell 18:2411-8, 2007

Kato N., Hasegawa U., Morimoto N., Saita Y., Nakashima K., Ezura Y., Kurosawa H., Akiyoshi K., Noda M. Nanogel-based delivery system enhances PGE(2) effects on bone formation. Journal of Cellular Biochemistry 101:1063-70, 2007

Ono N., Nakashima K., Schipani E., Hayata T., Ezura Y., Soma K., Kronenberg H.M., Noda M. Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption. Journal of Biological Chemistry 282:25509-16, 2007

Yamashita T., Yao Z., Li F., Zhang Q., Badell I.R., Schwarz E.M., Takeshita S., Wagner E.F., Noda M., Matsuo K., Xing L., Boyce B.F. NF-kB p50 and p52 regulate RANKL and TNF-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. Journal of Biological Chemistry 282:18245-53, 2007

Kanda T., Yoshida Y., Izu Y., Nifuji A., Ezura Y., Nakashima K., Noda M. PlexinD1 deficiency induces defects in axial skeletal morphogenesis. Journal of Cellular Biochemistry 101:1329-37,2007

Inoue K, Mikuni-Takagaki Y, Oikawa K, Itoh T, Inada M, Noguchi T, Park JS, Onodera T, Krane SM, Noda M, Itohara S. A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem. 281:33814-33824, 2006.

Washio-Oikawa K, Nakamura T, Usui M, Yoneda M, Ezura Y, Ishikawa I, Nakashima K, Yamamoto T, Noda M. Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro. J Cell Biochem. 99:538-544, 2006.

Hino K, Nifuji A, Morinobu M, Tsuji K, Ezura Y, Nakashima K, Yamamoto H, Noda M. Unloading-induced bone loss was suppressed in gold-thioglucose treated mice. J Cell Biochem. 99:845-852, 2006.

Ishijima M, Ezura Y, Tsuji K, Rittling SR, Kurosawa H, Denhardt DT, Emi M, Nifuji A, Noda M. Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res. 312:3075-3083, 2006.

Suzuki H, Amizuka N, Noda M, Amano O, Maeda T. Histological and immunohistochemical changes in the submandibular gland in klotho-deficient mice. Arch Histol Cytol. 69:119-128, 2006.

Harmey D, Johnson KA, Zelken J, Camacho NP, Hoylaerts MF, Noda M, Terkeltaub R, Millan JL. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res. 21:1377-1386, 2006.

Ruchanee Salingcarnboriboon, Kunikazu Tsuji, Toshihisa. Komori, Kazuhisa Nakashima, Yoichi Ezura, Masaki. Noda. Runx2 is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in Vivo. Endocrinology 147:2296-2305, 2006

Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano T, Taketani Y, Nifuji A, Denhardt DT, Noda M. Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts. Endocrinology. 147:3040-3049, 2006

Morinobu M, Nakamoto T, Hino K, Tsuji K, Shen ZJ, Nakashima K, Nifuji A, Yamamoto H, Hirai H, Noda M. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation.  Journal of Experimental Medicine. 201(6):961-70, 2005

"JEM commentary to CIZ paper "

H.Kondo, A. Nifuji, S. Takeda、Y.Ezura, S.Rittling, D.Denhardt, K. Nakashima, G.Karsenty, M.Noda Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system Journal of Biological Chemistry (in press) 2005

Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G.Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 434(7032):514-20 2005

Usui M, Yoshida Y, Tsuji K, Oikawa K, Miyazono K, Ishikawa I, Yamamoto T, Nifuji A, Noda M. Tob-deficiency super-enhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proceedings of the National Academy of Science U.S.A. 101(17): 6653-6658, 2004

Nifuji A, Kellermann O, Noda M. Noggin inhibits chondrogenic but not osteogenic differentiation in a mesodermal stem cell line C1 and skeletal cells. Endocrinology 145:3434-3442, 2004

Maeda Y., Tsuji K., Nifuji A., Noda M. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. Journal of Cellular Biochemistry 93:337-334, 2004

Chung J. C, Tsuji K, Nifuji A, Komori T, Soma K, Noda M. Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice. Journal of Medical and Dental Sciences 51:105-113, 2004

Tsuji K, Komori T, Noda M. Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablation. Journal of Bone and Mineral Research 19:1481-1489, 2004

Ohyama Y, Nemoto Y, Rittling SR, Tsuji K, Amagasa T, David D. T, Nifuji A, Noda M. Osteopontin_deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastgenesis in cocultures. Journal of Bone and Mineral Research 19:1706-1711, 2004

Morinobu M., Ishijima M., Rittling SR., Tsuji K., Yamamoto H., Nifuji A., David D. T., Noda M. Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. Journal of Bone and Mineral Research 18(9):1706-15, 2003

Takamoto M., Tsuji K., Yamashita T., Sasaki H., Yano T., Taketani Y., Komori T., Nifuji A., Noda M. Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-_B ligand gene expression in chondrocytes. Journal of Endocrinology 177(3):413-21, 2003

Salingcarnboriboon R., Yoshitake H., Tsuji K., Obinata M., Amagasa T., Nifuji A., Noda M. Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Experimental Cell Research 287(2):289-300, 2003

Maeda Y., Noda M., Coordinated development of embryonic long bone on chorio-allantoic membrane in ovo prevents perichondrium-derived suppressive signals against cartilage growth. Bone 32(1):27-34, 2003

Yagi K., Tsuji K., Nifuji A., Shinomiya K., Noda M. Bone morphogenetic protein-2 enhances Osterix gene expression in chondrocytes. Journal of Cellular Biochemistry 88: 1077-1083, 2003

Kitahara K., Ishijima M., Rittling SR., Tsuji K., Kurosawa H., Nifuji A., Denhardt DT., Noda M. Osteopontin-deficiency induces parathyroid hormone enhancement of cortical bone formation. Endocrinology 144(5):2132-40, 2003

YumotoK., Ishijima,M., Rittling,S.R., Tsuji,K., Tsuchiya, Y., Kon,S., Nifuji,A., Uede, T., Denhardt, D.T., and Noda,M., Osteopontin-Deficiency Protects Joints Against Destruction in Anti-Type II Collagen Antibody-Induced Arthritis in Mice. Proceedings of the National Academy of Sciences USA 99: 4556-4561, 2002.

Kashimada K., Yamashita T., Tsuji K., Nifuji A., Mizutani S., Nabeshima Y., Noda M. Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment. Journal of Endocrinology 174:403-410, 2002

Yamashita T., Okada S., Higashino K., Nabeshima Y., Noda M. Double mutations in Klotho and osteoprotegerin gene loci rescued osteopetrotic phenotype. Endocrinology 143(12):4711-7,2002

Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., David T. D., Nifuji A., and Noda M. Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. Journal of Bone and Mineral Research 17: 661-7, 2002

Usui M, Yoshida Y, Yamashita T, Tsuji K, Ishikawa I, Yamamoto T, NifujiA and Noda M Enhancing effect of Tob deficiency on bone formation is specific to BMP-induced osteogenesis. Journal of Bone and Mineral Research17 : 1026-1033, 2002.

Yoshikawa M, Uchida S, Ezaki J, Rai T, Hayama A, KobayashK, Kida Y, Noda M, Koike M, Uchiyama Y, Marumo F, Kominami E and Sasaki S. CLC-3 deficiency leads to phoenotypes similar to human neuronal ceroid lipofuscinosis. Genes to Cell 7: 597-605 , 2002

Asou Y., Nifuji A., Tsuji K., Shinomiya K., Olson EN., Koopman P., Noda M. Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage. Journal of Orthopedic Research. 20(4):827-833, 2002.

Shen ZJ., Nakamoto T., Tsuji K., Nifuji A., Miyazono K., Komori T., Hirai H., Noda M. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. Journal of Biological Chemistry 277:29840-29846, 2002