東京医科歯科大学 グローバルCOEプログラム 歯と骨の分子疾患科学 国際教育研究拠点〜デント・メドミクスのインテリジェンスパブ

Publication

Johji Inazawa, M.D., Ph.D. 稲澤譲治

1.

Iriyama T, Takeda K, Nakamura H, Motimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chiba K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H: ASK1 amd ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis .EMBO J. 2009 [Epub ahead of print]

2.

Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O. Actinin-4 gene amplification in ovarian cancer. a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol. 2009 [Epub ahead of print]

3.

Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y . PH domain-only protein PHLDA3 is a p53- regulated repressor of akt. Cell 136:535-50,2009

4.

Arai E, Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. Carcinoqenesis 99:1940-9, 2009.

5.

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T. SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. J Biol Chem. 284:3334-44,2008.

6.

Ishihara T, Tsuda H, Hotta A, Kozaki K, Yoshida A, Jaeduk Yoshimura Noh, Ito K, Imoto I, Inazawa J. ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization. Cancer Sci.99:1940-49, 2008

7.

Hayashi S, Okamoto N, Makita Y, Hata A, Imoto I, Inazawa J. Heterozygous Deletion at 14q22.1-q22.3 including the BMP4 gene in a patient with psychomotor retardation, congenital corneal opacity and feet polysyndactyly. Am J Med Genet A.146A:2905-10, 2008

8.

Arai E, Ushijima S, Tsuda H, Fujimoto H, Hosoda F, Shibata T, Kondo T, Imoto I, Inazawa J, Hirohashi S, Kanai Y. Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization. its association with DNA methylation alteration and patient outcome. Clin Cancer Res. 14:5531- 9, 2008

9.

Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J,Hirohashi S, Yamada T. Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res.14:5348-56, 2008

10.

Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, Mizutani S. Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Cancer Sci.99:1539-45, 2008

11.

Hayashi S, Mizuno S, Migita O, Okuyama T, Makita Y, Hata A, Imoto I, Inazawa J. The CASK gene harbored in a deletion detected by Array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation. Am J Med Genet A.146A:2145-51, 2008

12.

Nakajima T, Yasui K, Zen K, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Inazawa J, Okanoue T. Activation of B-Myb by E2F1 in hepatocellular carcinoma. Hepatol Res.38:886-95, 2008

13.

Qi S, Mogi S, Tsuda H, Tanaka Y, Kozaki K, Imoto I, Inazawa J, Hasegawa S, Omura K. Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. Int J Oral Maxillofac Surg.37:1047-53, 2008

14.

Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I. Frequent inactivation of a putative conditional tumor-suppressor gene, angiopoietin-like protein 2, in ovarian cancer. Cancer Res.68:5067-75, 2008

15.

Nakamura E, Kozaki K, Tsuda H, Suzuki, E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I. Frequent silencing of a 284 Annual Report 2008 putative tumor suppressor gene melatonin receptor 1A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci.99:1390-400, 2008

16.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res. 68:2094-2105, 2008

17.

Suzuki A, Shibata T, Murakami Y, Horii A, Shiratori K, Hirohashi S, Inazawa J, Imoto I. Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization. Cancer Sci.99:986-94, 2008

18.

Tanaka S, Arii S, Yasen M, Moqushi K, Su NT, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H. Aurora kinase B is a predictive factor for the aggressive recurrence of hepatocellular carcinoma after curative hepatectomy. Br J Surg.95:611-619, 2008

19.

Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez BVJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S. Overexpressed NF-{kappa} B inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood.111:5118-29, 2008

20.

Zhao C, Inoue J, Imoto I, Otsuki T, Iidab S, Ueda R, Inazawa J. POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17. Oncogene.27:63-75, 2008

21.

Takano K, Nakagawa E, Inoue K, Kamada F, Kure S, Goto Y; Japanese Mental Retardation Consortium. Am J Med Genet B Neuropsychiatr Genet. 147B:479-84, 2008.