Kohsuke TAKEDA      papers

武田 弘資
略歴
 1983年３月 東京学芸大学附属高等学校　卒業
  1989年３月 東京医科歯科大学歯学部　卒業
  1989年?1991年 東京医科歯科大学歯学部　口腔外科学第一講座（専攻生）
  1991年?1995年 東京医科歯科大学大学院歯学研究科（顎顔面外科学専攻）
  1995年３月 同　修了（歯学博士）
  1995年４月 (財)癌研究会癌研究所嘱託研究員、日本学術振興会特別研究員（がん）
  1998年４月 日本学術振興会研究員（未来開拓学術研究推進事業）
  1999年４月 東京医科歯科大学歯学部 助手
  2003年４月 東京大学 大学院薬学系研究科 講師
  2005年４月 東京大学 大学院薬学系研究科 准教授
  2012年４月 長崎大学 大学院医歯薬学総合研究科 生命薬科学専攻 細胞制御学分野 教授

 

Selected Papers

  1. Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K.
    Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
    PloS ONE, in press.

  2. Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo,H.
    p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
    J. Cell Sci. 124, 3006-3016 (2011).

  3. Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H.
    Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.
    Genetics, 187, 785-792 (2011).

  4. Hayakawa, Y., Hirata, Y., Nakagawa, H., Sakamoto, K., Hikiba, Y., Kinoshita, H., Nakata, W., Takahashi, R., Tateishi, K., Tada, M., Akanuma, M., Yoshida, H., Takeda, K., Ichijo, H., Omata, M., Maeda, S., Koike, K.
    Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
    Proc. Natl. Acad. Sci. USA., 108, 780-785 (2011).

  5. Okamoto, M., Saito, N., Kojima, H., Okabe, T., Takeda, K., Ichijo, H., Furuya, T. and Nagano, T.
    Identification of novel ASK1 inhibitors using virtual screening.
    Bioorg. Med. Chem., 19, 486-489 (2011).

  6. Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B. and Takahashi, R.
    The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila.
    PLoS Genet. 6, e1001229 (2010).

  7. Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H.
    CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
    EMBO J., 29, 2501-2514 (2010).

  8. Kumakura, K., Nomura, H., Toyoda, T., Hashikawa, K., Noguchi, T., Takeda, K., Ichijo, H., Tsunoda, M., Funatsu, T., Ikegami, D., Narita, M., Suzuki, T., Matsuki, N.
    Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.
    Neurosci. Res., 66, 313-320 (2010).

  9. Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A., and Ichijo, H. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.
    Mol. Cell, 36, 805-818 (2009).

  10. Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., and Ichijo, H. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
    Proc. Natl. Acad. Sci. USA., 106, 12301-12305 (2009).

  11. Kundu, M., Pathak, S. K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S., Noguchi, T., Takeda, K., Ichijo, H., Thien, C. B. F., Langdon, W. Y., Basu, J. A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
    Nat. Immunol., 10, 918-926 (2009).

  12. Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A., and Ichijo, H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
    EMBO J., 28, 843-853 (2009).

  13. Nagai, A., Kadowaki, H., Maruyama, T., Takeda, K., Nishitoh, H., and Ichijo, H. USP14 inhibits ER-associated degradation via interaction with IREα.
    Biochem. Biophys. Res. Commun., 379, 995-1000 (2009).

  14. Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., and Ichijo, H. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
    Genes. Dev., 22, 1451-1464 (2008).

  15. Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., and Ichijo, H. Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracellular ATP-induced apoptosis in macrophage.
    J. Biol. Chem., 283, 7657-7665 (2008).

  16. Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K., and Ichijo, H. Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
    Mol. Cell. Biol., 27, 8152-8163 (2007).

  17. Kani, S., Nakayama, E., Yoda, A., Onishi, N., Sougawa, N., Hazaka, Y., Umeda, T., Takeda, K., Ichijo, H., Hamada, Y., and Minami, Y. Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.
    Genes Cells, 12, 919-928 (2007).

  18. Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K., and Ichijo, H. ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
    J. Cell Biol., 176, 903-909 (2007).

  19. Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., and Ichijo, H. Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1.
    J. Biol. Chem., 282, 7522-7531 (2007).

  20. Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T., and Iwatsubo, T. GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease.
    Biochemistry, 46, 1380-1388 (2007).

  21. Mizumura, K., Takeda, K., Hashimoto, S., Horie, T. and Ichijo, H. Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.
    J. Cell. Physiol., 206, 363-370 (2006).

  22. Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J., and Ichijo, H. Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.
    J. Biol. Chem., 280, 37033-37040 (2005).

  23. Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K., and Ichijo, H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
    Nat. Immunol., 6, 587-592 (2005).

  24. Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T., and Ichijo, H. Amyloid ß induces neuronal cell death through ROS-mediated ASK1 activation.
    Cell Death Differ., 12, 19-24 (2005).

  25. Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya-Tsuji, J., Matsumoto, K., and Ichijo, H. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
    EMBO Rep., 5, 161-166 (2004).

  26. Yamagishi, S., Yamada, M., Koshimizu, H., Takai, S., Hatanaka, H., Takeda, K., Ichijo, H., Shimoke, K., and Ikeuchi, T. Apotosis-signal regulating kinase-1 Is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.
    J. Biochem., 133, 719-724 (2003).

  27. Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A. and Ichijo, H.　Phosphorylation and inactivation of Mcl-1 by c-Jun N-terminal kinase (JNK) in response to oxidative stress.
    J. Biol. Chem., 277, 43730-43734 (2002).

  28. Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade.
    J. Biol. Chem., 277, 40703-40709 (2002).

  29. Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
    Genes Dev., 16, 1345-1355 (2002).

  30. Yanagisawa, M., Nakashima, K., Takeda, K., Ochiai, W., Takizawa, T., Ueno, M., Takizawa, M., Shibuya, H. and Taga, T. Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.
    Genes Cells, 6, 1091-1099 (2001).

  31. Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. and Greene W.C. HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell.
    Nature, 410, 834-838 (2001).

  32. Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T. and Ichijo, H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
    EMBO reports, 2, 222-228 (2001).

  33. Sawada, Y., Nakamura, K., Doi, K., Takeda, K., Tobiume, K., Saitoh, M., Morita, K., Komuro, I., Kurt De Vos, Sheetz, M. and Ichijo, H. Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
    J. Cell Sci.114, 1221-1227 (2001).

  34. Mochida, Y., Takeda, K., Saitoh, M., Nishitoh, H., Amagasa, T., Ninomiya-Tsuji, J., Matsumoto, K. and Ichijo, H. ASK1 inhibits Interleukin-1-induced NF-kB activity through disruption of TRAF6-TAK1 interaction.
    J. Biol. Chem., 275, 32747-32752 (2000).

  35. Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., and Takeda, K. Execution of ASK1-induced apoptosis by the mitochondria-dependent caspase activation.
    J. Biol. Chem., 275, 26576-26581 (2000).

  36. Takeda, K., Hatai, T., Hamazaki, T. S., Nishitoh, H., Saitoh, M., and Ichijo, H. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells.
    J. Biol. Chem., 275, 9805-9813 (2000).

  37. Kanamoto, T., Mota, M., Takeda, K., Rubin, L. L., Miyazono, K., Ichijo, H., and Bazenet, C. E.  Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
    Mol. Cell. Biol., 20, 196-204 (2000).

  38. Yasuda, S., Inoue, K., Hirabayashi, M., Higashiyama, H., Yamamoto, Y., Fuyuhiro, H., Komure, O., Tanaka, F., Sobue, G., Tsuchiya, K., Hamada, K., Sasaki, H., Takeda, K., Ichijo, H., and Kakizuka, A.  Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies.
    Genes Cells, 4, 743-756 (1999).

  39. Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T. K., Enomoto, S., Kawabata, M., Kato, M., Ichijo, H., and Miyazono, K.  Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblastic and chondroblastic differentiation.
    Mol. Biol. Cell, 10, 3801-3813 (1999).

  40. Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., and Ichijo, H.  ASK1 is essential for JNK/SAPK activation by TRAF2.
    Mol. Cell, 2, 389-395 (1998).

  41. Takeda, K., Ichijo, H., Fujii, M., Mochida, Y., Saitoh, M., Nishitoh, H., Sampath, T. K., and Miyazono, K.  Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
    J. Biol. Chem., 273, 17079-17085 (1998).

  42. Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., and Ichijo, H.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
    EMBO J., 17, 2596-2606 (1998).

  43. Takase, M., Imamura, T., Sampath, T. K., Takeda, K., Ichijo, H., Miyazono, K., and Kawabata, M.  Induction of Smad6 mRNA by bone morphogenetic proteins.
    Biochem. Biophys. Res. Commun., 244, 26-29 (1998).

  44. Tobiume, K., Inage, T., Takeda, K., Enomoto, S., Miyazono, K., and Ichijo, H.  Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.
    Biochem. Biophys. Res. Commun., 239, 905-910 (1997).

 

Review Articles

  1. Takeda, K. PGAM5: A novel type of protein serine threonine phosphatase that exists in the mitochondria.
    J. Oral Biosci.     (review article), 53, 122-127 (2011).　

  2. Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.
    Apoptosis signaling kinases: from stress response to health outcomes.
    Antioxid. Redox Signal. (review article), 15, 719-761 (2011).

  3. Matsuzawa, A., Takeda, K. and Ichijo, H. ASK1: Molecule Pages,
    UCSD-Nature Signaling Gateway, (review article) (2010) (doi:10.1038/mp.a002816.01).

  4. Maruyama, J., Naguro, I., Takeda, K., and Ichijo, H. Stress-activated MAP kinase cascades in cellular senescence.
    Curr. Med. Chem., (review article), 16, 1229-1235 (2009).

  5. Hatanaka, R., Sekine, Y., Hayakawa, T., Takeda, K., and Ichijo, H. Signaling pathways in invertebrate immune and stress response.
    Invertebrate Survival Journal, (review article), 6, 32-43 (2009).

  6. Takeda, K., Noguchi, T., Naguro, I., and Ichijo, H. Apoptosis signal-regulating kinase 1 in stress and immune response.
    Annu. Rev. Pharmacol. Toxicol., (review article), 48, 199-225 (2008).

  7. Fujisawa, T., Takeda, K., and Ichijo, H. ASK family proteins in stress response and disease.
    Mol. Biotechnol., (review article), 37, 13-18 (2007).

  8. Murakami, S., Noguchi, T., Takeda, K., and Ichijo, H. Stress signaling in cancer.
    Cancer Sci., (review article), 98, 1521-1527 (2007).

  9. Nagai, H., Noguchi, T., Takeda, K., and Ichijo, H. Pathophysiological roles of ASK1-MAP kinase signaling pathways.
    J. Biochem. Mol. Biol., (review article), 40, 1-6 (2007).

  10. Fujino, G., Noguchi, T., Takeda, K., and Ichijo, H. Thioredoxin and protein kinases in redox signaling.
    Semin. Cancer Biol., (review article), 16, 427-735 (2006).

  11. Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K., and Ichijo, H. The ASK1-MAP kinase pathways in the immune and stress responses.
    Microbes Infect., (review article), 8, 1098-1107(2006).

  12. Sekine, Y., Takeda, K., and Ichijo, H. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. ?
    Curr. Mol. Med., (review article), 6, 87-97 (2006).

  13. Takeda, K., Noguchi, T., and Ichijo, H. ASK1 signalosome: a signaling complex essential for stress responses.
    Cell Struct Funct. (review article), 28, 23-29 (2003).

  14. Matsukawa, J., Matsuzawa, A., Takeda, K., and Ichijo, H. The ASK1-MAP kinase cascades in mammalian stress response.
    J. Biochem. (review article), 136, 261-265 (2004).

  15. Takeda, K., Matsuzawa, A., Nishitoh, H., and Ichijo, H. Roles of MAPKKK ASK1 in stress-induced cell death.
    Cell Struct Funct. (review article), 28, 23-29 (2003).

  16. Takeda, K. and Ichijo, H. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
    Genes Cells (review article), 7, 1099-1111 (2002).

  17. Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K., and Ichijo, H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
    Antioxid. Redox Signal(review article), 4, 415-425 (2002).