|Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University Japan|
|Division of Aging and Regeneration, The Institute of Medical Science, The University of Tokyo|
|Emi K. Nishimura, M.D., Ph.D|
|1996-2000 :@@Ph.D. Kyoto University Graduate School of Medicine|
|1988-1994 :@@M. D. Shiga University of Medical Science|
|Professional Training and Experience|
|2021- :||Professor, Division of Aging and Regeneration, The Institute of Medical
Science, The University of Tokyo
|2009-present :||Professor, Department of Stem Cell Biology, Medical Research Institute,
Tokyo Medical and Dental University
|2006 :||Professor, Cancer Research Institute, KanazawaUniversity|
|2004 :||Associate Professor, Creative Research Institute gSouseih (CRIS),
|2001:||SPS Postdoctoral Fellow for Research Abroad, Harvard medical School|
|2000 :||Research Fellow, Dana-Farber Cancer Institute, Harvard Medical School|
|2000 :||Received Ph.D. from Kyoto University|
|1994 :||Resident, Department of Dermatology, Kurashiki Hospital|
|1994 :||Graduated from Shiga University of Medical Science|
|2017:||Myron Gordon Award||International Federation of Pigment Cell Societies(IFPCS)|
|2013:||The 2013Rsearch Achievement Award@||American Skin Associations|
|2012:||The 8th Japan Academy Medal Prize||The Japan Academy|
|2012:||Ogawa-Seiji Award||Lydia O'Leary Memorial Foundation|
|2012:||Eighth JSPS PRIZE Award||Japan Society for the Promotion of Science|
|2007:||The Young Scientists' Prize||Ministry of Education, Culture, Sports,ScienceandTechnology-Japan|
|2003:||Minami Memorial Award
(52nd Japanese Dermatological Association Award)
Charles A. King Trust Postdoctoral Research Fellowship
|Japanese Dermatological Association|
|2002:||Shiseido Award||Shiseido Company, Limited|
Japanese Society for Investigative Dermatology
International Society for Stem Cell Research
Japanese Society for Pigment Cell Research
Japanese Association for Cancer Research
Japanese Dermatological Association
Molecular Biology Society of Japan
|`Biodata (Biographic Profile)`|
|Emi K. Nishimura, M.D., Ph.D|
|Dr. Emi Nishimura obtained her MD in 1994 and did her dermatology residency
in Kyoto University Hospital.
She then obtained her PhD in Shin-Ichi Nishikawa's lab at Kyoto University, studying melanocyte development, where she subsequently identified melanocyte stem cells.Dr. Nishimura did her post-doc training in David Fisher's lab in the Dana Farber Cancer Institute, Harvard Medical School, and extended her melanocyte stem cell research there. She then started her own group as an Associate Professor at Hokkaido University, subsequently becoming Professor at Kanazawa University the following year.Her lab then moved to Tokyo Medical and Dental University in 2009. She is currently a Professor in the Department of Stem Cell Biology within the Medical Research Institute of Tokyo Medical and Dental University.
|1.||Morinaga H, Mohri Y, Grachtchouk M, Asakawa K, Matsumura H, Oshima M, Takayama
N, Kato T, Nishimori Y, Sorimachi Y, Takubo K, Suganami T, Iwama A, Iwakura
Y, Dlugosz AA, Nishimura EK.
Obesity accelerates hair thinning by stem cell-centric converging mechanisms.
Nature, 595:266-271, 2021
|2.||Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa
M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura
Dynamic stem cell selection safeguards the genomic integrity of the epidermis.
Developmental Cell, 56,3309-3320, 2021
|3.||Matsumura H, Liu N, Nanba D, Ichinose S, Takada A, Kurata S, Morinaga H,
Mohri Y, De Arcangelis A, Ohno S, Nishimura EK
Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles.
Nature Aging, 1:190-204, 2021
|4.||Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K,
Morinaga H, Mohri Y, De Arcangelis, Geroges-Labousse E, Nanba D, Nishimura EK. :Stem cell competition orchestrates skin homeostasis and ageing.
Nature, 568(7752):344-350, 2019
|5.||Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers
J, Nishimura EK.: Hair follicle aging is driven by transepidermal elimination of stem cells
via COL17A1 proteolysis.
Science, 351(6273):535, 2016
|6.||Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H,
Miyachi Y, Saida T, Nishimura EK.
A melanocyte-melanoma precursor niche in sweat glands of volar skin.
Pigment Cell & Melanoma Research, 27(6):1039-1050, 2014
|7.||Ueno M, Aoto T, Mohri Y, Yokozeki H, Nishimura EK.
Coupling of the radiosensitivity of melanocyte stem cells to their dormancy a hair cycle.
Pigment Cell & Melanoma Research, 27(4):540-551, 2014
|8.||Nishimura EK. Melanocyte stem cells: A melanocyte reservoir in hair follicles for hair and skin pigmentation.
Pigment Cell Melanoma Res., 24(3): 401-410, 2011
S, Tadokoro Y, Inomata K, Binh NT, Nishie W,
Yamazaki S, Nakauchi H, Tanaka Y,
McMillan JR, Sawamura D, Yancey K, Shimizu H,
Hair follicle stem cells provide a functional niche for melanocyte stem cells. Cell Stem Cell, 8, 177-187, 2011
Suzuki M, Igras V, Du J, Lonning S, Miyachi Y, Roes J, Beerman F, Fisher DE.
Key Roles for Transforming Growth Factor ΐ in Melanocyte Stem Cell Maintenance Cell Stem Cell, 6(2):130-140, 2010
K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E,
Masunaga T, Shimizu H, Nishimura EK.
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell, 137(6):1088-99, 2009
|12.||Nishimura, E.K, Granter, S.R., Fisher, D.E. Mechanisms
of hair graying: incomplete melanocyte stem cell maintenance in the niche Science, 307(5710):720-724. 2005
|13.||Nishimura, E.K., Jordan, S.A, Oshima, H., Yoshida, H., Osawa, M., Jackson, I.J.,
Barrandon, Y., Yoshiki, M. Nishikawa, SI.
Dominant Role of the Niche in Melanocyte Stem Cell Fate Determination. Nature, 416(6883):854-60, 2002.