近年の研究業績

原著論文

    2010年

  1. Ichijima Y, Yoshioka K, Yoshioka Y, Shinohe K, Fujimori H, Unno J, Goto H, Inagaki M, Takagi M, Mizutani S, & Teraoka H: DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS ONE 2010; 5: e8821.

  2. Masaki H, Nishida T, Sakasai R, & Taraoka H: DPPA4 modulates chromatin structure via association with core histone H3 and DNA in mouse embryonic stem cells. Genes to Cells (in press)

  3. Sakasai R, Teraoka H, & Tibbets RS: Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.DNA Repair 2010; 9: 76-82.

    4. 2009年

  4. Shikanai M, Asahina K, Iseki S, Teramoto K, Nishida T, Shimizu-Saito K, Ota M, Eto K, & Taraoka H: A noval method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem. Biophys. Res. Commun. 2009; 381: 276-282.

  5. Shibata A, Ogino H, Maeda D, Tsutsumi M, Nohmi T, Nakagama H, Sugimura T, Teraoka H, & Masutani M.: Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. Mutat. Res.-Fund. Mol. M. 2009; 664: 20-27.

    6. 2008年

  6. Ikeda R, Nishida T, Watanabe F, Shimizu-Saito K, Asahina K, Horikawa S, & Teraoka H: Involvement of CCAAT/enhancer binding protein-β (C/EBPβ) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression. Intern. J. Biochem. Cell Biol.　2008;40:1956-1969.

  7. Fujimori H, Asahina K, Shimizu-Saito K, Ikeda R, Tanaka Y, Teramoto K, Morita I, ＆ Teraoka H: VEGF promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J. Hepatol. 2008; 48: 962-973.

    8. 2007年

  8. Irie T, Asahina K, Shimizu-Saito K, Teramoto K, Arii S & Teraoka H: Hepatic progenitor cells in the mouse extrahepatic bile duct after a bile duct ligation. Stem Cells Develop. 2007; 16 : 979-987

  9. Masaki H, Nishida T, Kitajima S, Asahina K & Teraoka H: Developmental pluripotency-associated 4 (Dppa4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J.Biol.Chem. 2007; 282: 33034-33042

  10. Sakyo T, Naraba H, Teraoka H & Kitagawa T: The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in non-polarized mammalian cells. FEBS J. 2007; 274: 2843-2853.

  11. Kida Y, Asahina K, Teraoka H, Gitelman I & Sato T: Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J. Histochem. Cytochem. 2007; 55: 661-673.

  12. Asahina K, Teramoto K, Arii S & Teraoka H: Transplantation of embryonic sem cell-derived hepatocytes and risk of teratoma formation. Chapter 1 (pp. 1-22) In STEM CELLS AND CANCER (Nova Science Publishers, 2007)

  13. Hirota M, Fujiwara T, Mineshita S, Sugiyama H & Teraoka H: Distamycin A enhances cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Intern. J. Biochem. Cell Biol. 2007; 39: 988-996.

  14. Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Zeng W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde J-M & Takeda S: RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol. Cell. Biol. 2007; 27: 2562-2571.

  15. Kakinuma S, Asahina K, Okamura K, Teramoto K, Tateno C, Yoshizato K, Tanaka Y, Yasumizu T, Sakamoto N, Watanabe M & Teraoka H: Human cord blood cells transplanted into chronic-damaged liver exhibit similar characteristics to functional hepatocytes. Transplant. Proc. 2007; 39: 240-243.

    16. 2006年

  16. Asahina K, Teramoto K & Teraoka H: Embryonic stem cells: Hepatic differentiation and regenerative medicine for the treatment of liver disease. Curr. Stem Cell Res. Ther. 2006; 1: 139-156.

  17. Asahina K, Shiokawa M, Ueki T, Yamasaki C, Aratani A, Tateno C & Yoshizato K: Multiplicative mononuclear small hepatocytes in adult rat liver: their isolation as a homogeneous population and localization to periportal zone. Biochem. Biophys. Res. Commun. 2006; 342: 1160-1167.

  18. Liao H, Aoyama C, Ishidata K & Teraoka H: Deletion and alanine mutation analyses for the formation of active homo- or hetero-dimer complexes of mouse choline kinase-αand -β. BBA-Molecular and Cell Biology of Lipids 2006; 1761: 111-120.

  19. Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K & Teraoka H: Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells 2006; 11: 237-246.

  20. Okamura K, Asahina K, Fujimori H, Ozeki R, Shimizu-Saito K, Tanaka Y, Teramoto K, Arii S, Takase K, Kataoka M, Soeno Y, Tateno C, Yoshizato K & Teraoka H: Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver. Histochem. Cell Biol. 2006; 125: 247-257.

    21. 2005年

  21. Emoto K, Tateno C, Hino H, Amano H, Imaoka Y, Asahina K, Asahara T & Yoshizato K: Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes. Hum. Gene Ther. 2005; 16: 1168-1174.

  22. Ichijima Y, Sakasai R, Okita N, Asahina K, Mizutani S & Teraoka H: Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem. Biophys. Res. Commun. 2005; 336: 807-812.

  23. Kobayashi T, Tanaka H, Kuwana H, Inoshita S, Teraoka H, Sasaki S & Terada Y: Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem. Biophys. Res. Commun. 2005; 336: 585-595.

  24. Teramoto K, Asahina K, Kumashiro Y, Kakinuma S, Chinzei R, Shimizu-Saito K, Tanaka Y, Teraoka H & Arii S: Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells. J. Hepatobiliary Pancreat. Surg. 2005; 12: 196-202. Review.

  25. Kumashiro Y, Teramoto K, Shimizu-Saito K, Asahina K, Teraoka H & Arii S: Isolation of hepatocyte-like cells from mouse embryoid body cells. Transplant. Proc. 2005; 37: 299-300.

  26. Teramoto K, Hara Y, Kumashiro Y, Chinzei R, Tanaka Y, Shimizu-Saito K, Asahina K, Teraoka H & Arii S: Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies. Transplant. Proc. 2005; 37: 285-286.

  27. Kumashiro Y, Asahina K, Ozeki R, Shimizu-Saito K, Tanaka Y, Kida Y, Inoue K, Kaneko M, Sato T, Teramoto K, Arii S & Teraoka H: Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source. Transplantation 2005; 79: 550-557.

  28. Shibata A, Kamada N, Masumura K, Nohmi T, Kobayashi S, Teraoka H, Nakagama H, Sugimura T, Suzuki H & Masutani M: Parp-1 deficiency causes an increase of deletion mutations and insertions /rearrangements in vivo after treatment with an alkylating agent. Oncogene 2005; 24: 1328-1337.

    29. 2004年

  29. Asahina K, Fujimori H, Shimizu-Saito K, Kumashiro Y, Okamura K, Tanaka Y, Teramoto K, Arii S & Teraoka H: Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells 2004; 9: 1297-1308.

  30. Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T & Yoshizato K: Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol. 2004; 165: 901-912.

  31. Watanabe F, Fukazawa H, Masutani M, Suzuki H, Teraoka H, Mizutani S & Uehara Y: Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response. Biochem. Biophys. Res. Commun. 2004; 319: 596-602.

  32. Shinohara K, Narita A, Oyoshi T, Bando T, Teraoka H & Sugiyama H: Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides. J. Am. Chem. Soc. 2004; 126: 5113-5118.

  33. Shibata A, Masutani M, Kamada N, Masumura K, Nakagama H, Kobayashi S, Teraoka H, Suzuki H & Nohmi T: An efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes. Environ. Mol. Mutagen. 2004; 43: 204-207.

    34. 2003年

  34. Watanabe F, Masutani M, Kamada N, Suzuki H, Nakagama H, Sugimura T & Teraoka H: Impairment in S-phase entry of splenocytes of Parp-1 knockout mice. Proc. Jpn. Acad. 2003; 79: 248-251.

  35. Namekawa S, Ichijima Y, Hamada, F, Kasai N, Iwabata K, Nara T, Teraoka H, Sugawara F & Sakaguchi K: DNA ligase IV from a Basidiomycete, Coprinus cinereus, and its expression during meiosis. Microbiology 2003; 149: 2119-2128.

  36. Namekawa S, Hamada F, Ishii S, Ichijima Y, Yamaguchi T, Nara T, Kimura S, Ishizaki T, Iwabata K, Koshiyama A, Teraoka H & Sakaguchi K: Coprinus cinereus DNA ligase I during meiotic development. BBA-Gene Structure and Expression 2003; 1627: 47-55.

  37. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K, Yasumizu T & Teraoka H: Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003; 21: 217-227.

  38. Watanabe F, Shinohara K, Teraoka H, Komatsu K, Tatsumi K, Suzuki F, Sagara M, Tsuji H & Ogiu T: Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression. Int. J. Biochem. Cell Biol. 2003; 35: 432-440.

  39. Kurosawa A, Shinohara K, Watanabe F, Shimizu-Saito K, Koiwai O, Yamamoto K & Teraoka H: Human neutrophils isolated from peripheral blood contain Ku protein but not DNA-dependent protein kinase. Int. J. Biochem. Cell Biol. 2003; 35: 86-94.

    40. 2002年

  40. Tsuchida R, Miyachi J, Shen L, Takagi M, Tsunematsu Y, Saeki M, Honna T, Yamada S, Teraoka H, Kato J & Mizutani S: Expression of cyclin-dependent kinase inhibitor p27/Kip1 and AP-1 coactivator p38/Jab1 correlates with differentiation of embryonal Rhabdomyosarcoma. Jpn. J. Cancer Res. 2002;93:1000-1006.

  41. Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M & Yoshizato K: Characterization of human stellate cell activation-associated protein and its expression in human liver. BBA-Gene Structure and Expression 2002;1577: 471-475.

  42. Chinzei R, Tanaka Y, Shimizu-Saito K, Hara Y, Kakinuma S, Watanabe M, Teramoto K, Arii S, Takase K, Sato C, Terada N & Teraoka H: Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 2002; 36: 22-29.

  43. Asahina K, Sato H, Yamasaki C, Kataoka M, Shiokawa M, Katayama S, Tateno C & Yoshizato K: Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am. J. Pathol. 2002;160:2191-2205.

  44. Yoneya R, Nagashima Y, Sakaki K, Hagiwara K, Teraoka H, Ozasa H & Horikawa S: Hemolysate pretreatment ameliorates the ischemic acute renal injury in rats. Nephron 2002; 92: 407-413.

  45. Tsuchida R, Yamada T, Takagi M, Shimada A, Ishioka C, Igarashi T, Chessa L, Delia D, Teraoka H & Mizutani S: Detection of ATM grene mutation in human glioma cell line M059J by a rapid frame-shift/stop codon assay in yeast. Radiat. Res. 2002; 158: 195-201.

  46. Yamanaka S, Katayama E, Yoshioka K, Nagaki S, Yoshida M & Teraoka H: Nucleosomal linker proteins HMGB1and histone H1 differentially enhance DNA ligation reactions. Biochem. Biophys. Res. Commun. 2002;292:268-273.

    47. 2001年- 1997年

  47. Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S & Yoshizato K: Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J. Biol. Chem. 2001;276:25318-25323.

  48. Ito K, Ikeda S, Kojima N, Miura M, Shimizu-Saito K, Yamaguchi I, Katsuyama I, Sanada K, Iwai T, Senoo H & Horikawa S: Correlation between the expression of methionine adenosyltransferase and the stages of human colorectal carcinoma. Surgery Today 2000;30:706-710.

  49. Yoneya R, Ozasa H, Nagashima Y, Koike Y, Teraoka H, Hagiwara K & Horikawa S: Hemin pretreatment ameliorates aspects of the nephropathy induced by mercuric chloride in the rat. Toxicol. Lett. 2000;116:223-229.

  50. Yanokura M, Takase K, Yamamoto K & Teraoka H: Cell Death and cell-cycle arrest induced by incorporation of [3H]thymidine into human haemopoietic cell lines. Int. J. Rad. Biol. 2000;76:295-303.

  51. Utoh R, Asahina K, Suzuki K, Kotani K, Obara M & Yoshizato K: Developmentally and regionally regulated participation of epidermal cells in the formation of collagen lamella of anuran tadpole skin. Dev. Growth Differ. 2000;42:571-580.

  52. Oomizu S, Sahuc F, Asahina K, Inamatsu M, Matsuzaki T, Sasaki M, Obara M & Yoshizato K: Kdap , a novel gene associated with the stratification of the epithelium. Gene 2000;256:19-27.

  53. Morio T, Hanissian SH, Bacharier LB, Teraoka H, Nonoyama S, Seki M, Kondo J, Nakano H, Lee S-K, Geha PS & Yata J: Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity 1999;11:339-348.

  54. Ito K, Miwa N, Hagiwara K, Yano T, Shimizu-Saito K, Goseki N, Iwai T & Horikawa S: Regulation of methionine adenosyltransferase activity by glutathione level in rat liver during ischemia-reperfusion. Surgery Today 1999;29:1053-1058.

  55. Asahina K, Obara M & Yoshizato K: Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb. Dev. Dyn. 1999;216:59-71.

  56. Asahina K, Utoh R, Obara M & Yoshizato K: Cell-type specific and thyroid hormone-dependent expression of genes of α(I) and α2(I) collagen in intestine during amphibian metamorphosis. Matrix Biol. 1999;18:89-103.

  57. Yumoto Y, Shirakawa H, Yoshida M, Suwa A, Watanabe F & Teraoka H: High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. J. Biochem. 1998;124:519-527.

  58. Nagaki S, Yamamoto M, Yumoto Y, Shirakawa H, Yoshida M & Teraoka H: Non histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Biochem. Biophys. Res. Commun. 1998;246:137-141.

  59. Asahina K, Oofusa K, Obara M & Yoshizato K: Cloning and characterization of the full length cDNA encoding α2 type I collagen of bullfrog Rana catesbeiana. Gene 1997;194:283-289.

  60. Nagasawa M, Watanabe F, Suwa A, Yamamoto K, Tsukada K & Teraoka H: Nuclear translocation of the catalytic component of DNA-dependent protein kinase upon growth stimulation in normal human T lymphocytes. Cell Struct. Funct. 1997;22:585-594.

  61. Chibazakura T, Watanabe F, Kitajima S, Tsukada K, Yasukochi Y & Teraoka H: Phosphorylation of human general transcription factors TATA-binding protein and transcription factor IIB by DNA-dependent protein kinase. Synergistic stimulation of RNA polymerase II basal transcription in vitro. Eur. J. Biochem. 1997;247:1166-1173.

  62. Shimizu-Saito K, Horikawa H, Kojima N, Shiga J, Senoo H & Tsukada K: Differential expression of S-adenosylmethionine synthetase isozymes in different cell types of rat liver. Hepatology 1997;26:424-431.

    63.

著書・総説など

  1. 寺岡弘文、藤森浩彰、鹿内弥磨：胚性幹細胞から肝細胞系譜への分化誘導　特集：肝幹細胞をめぐる最近の知見 肝胆膵 2008;57:383-393

  2. 入江　工、朝比奈欣治、斉藤佳子、寺本研一、有井滋樹、寺岡弘文：肝外胆管に存在する幹細胞、再生医学シリーズ Organ Culture 2008;14:331-335

  3. 寺本研一、神代祐至、入江工、有井滋樹、朝比奈欣治、齊藤佳子、寺岡弘文：ES細胞からの肝細胞分化誘導； サイトプロテクション pp 31-35、癌と化学療法社、2006.

  4. 岡村健太郎、朝比奈欣治、齊藤佳子、高瀬浩造、寺岡弘文：カニクイザルES細胞からの肝細胞分化誘導、 再生医療 2006; 5: 52-58.

  5. 朝比奈欣治、立野知世、吉里勝利：成体肝前駆細胞分離法、 細胞 2005; 37: 34-37.

  6. 寺岡弘文：ES細胞、臍帯血を用いた肝臓の再生医療 、鶴見医学 2005; 31: 213-219.

  7. 朝比奈欣治：私の学会聞き歩き、第58回日本細胞生物学会大会、 細胞工学 2005; 24: 984-986.

  8. 朝比奈欣治、立野知世、吉里勝利：組織幹細胞；田畑泰彦、岡野光夫（編）： ティッシュエンジニアリング2005 pp 3-10, 日本医学館、 2005.

  9. 寺岡弘文、朝比奈欣治、齊藤佳子: ES細胞･臍帯血細胞と肝細胞移植（特集：肝臓、小腸移植の最前線　テーマ５：臨床応用への挑戦）小児外科 2004; 36: 779-784.

  10. 朝比奈欣治、立野知世、吉里勝利 : 絵とき再生医学入門　幹細胞の基礎知識から再生医療の実際までイッキにわかる！ 2004; 羊土社.

  11. 朝比奈欣治、齊藤佳子、寺岡弘文、柿沼 晴、寺本研一: 臍帯血有核細胞からの肝臓再生医療の可能性、（特集：臍帯血由来細胞と再生医療・細胞治療の展望、寺岡弘文編）細胞 2004; 36: 56-59.

  12. 寺岡弘文: 臍帯血由来細胞と再生医療の近未来 （特集：臍帯血由来細胞と再生医療・細胞治療の展望、寺岡弘文編）細胞 2004; 36: 42-43.

  13. 寺岡弘文：DNAリガーゼ (ATP). 廣川タンパク質化学　第４巻　4.5イソメラーゼ・リガーゼ（福井哲也・伊藤正樹編集）廣川書店、pp. 341-346 (2003).

  14. 寺岡弘文：DNA複製に関与する酵素 (4) DNAリガーゼ.　生物薬科学実験講座　第８巻　遺伝子 [II]（名取俊二・中西義信編集）廣川書店、pp. 227-236 (2003).

  15. 寺岡弘文：胚性幹細胞（ES細胞）・組織幹細胞と再生医療（特集：明日の新技術）. 医療とコンピュータ　2002;45(1): 7-12.

  16. 朝比奈欣治、立野知世：組織幹細胞と間葉系幹細胞.　medicina　2002;39(3): 453-455.

  17. 山縣彰、朝比奈欣治、吉里勝利：幹細胞・再生研究；辻本豪三, 田中利男（編）： フローチャートでみる先端バイオ研究の進め方 pp 34-40, 羊土社, 2001.

  18. 朝比奈欣治、立野知世、吉里勝利：再生医学-ES細胞と組織幹細胞. 　Journal of Gastrointestinal Research 2001;9: 205-211.

  19. 鈴木賢一、朝比奈欣治、吉里勝利：変態, 浅島誠（編）：現代化学増刊39 　ボディープランと器官形成 pp 64-72、東京化学同人、2001.

  20. 寺岡弘文、渡邊文晶: DNA依存性プロテインキナーゼ「総説」. 　生化学 2000;72: 26-37.

  21. 小原政信、朝比奈欣治、吉里勝利: コラーゲンと組織・器官形成「総説」. 生化学　1998;70: 265-279.

  22. 寺岡弘文: DNA依存性プロテインキナーゼとSCID.　遺伝子医学 1997;1: 232-237.


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