Name Takeshi Matsui, PhDAffiliation Medical Top Track (MTT) Program
Title Junior MTT Fellow
Subjects of Research
Stratified Epithelial Development and Cancer Progression
Research Summary
An individual is composed of various kinds of tissue, and the cells that compose each of those tissues have a multitude of specializations to meet the needs of those tissues. In particular, the epithelial cell layer, which covers the body and lumen surfaces, accomplishes a unique physiological function by acting as a cell sheet covering each individual tissue, establishing a separate space for the environment of each tissue and organ. It is well known that 90% of malignant tumors originate from epithelial tissue, so it is expected that gaining an understanding of that formation mechanism may lead to an understanding of the formation mechanism of malignant tumors. Placing particular emphasis on stratified epithelium, intends to uncover the mystery surrounding epithelial tissue through detailed analyses of those formation mechanisms and cancer progression.
Publications
1. Matsui T, Kinoshita-Ida Y, Hayashi-Kisumi F, Hata M, Matsubara K, Chiba M, Katahira-Tayama S, Morita K, Miyachi Y, Tsukita Sh: Mouse homologue of skin-specific retroviral-like aspartic protease (SASPase) involved in wrinkle formation. J. Biol. Chem. 281:27512-25 (2006)
2. Matsui T, Hayashi-Kisumi F, Kinoshita Y, Katahira S, Morita K, Miyachi Y, Ono Y, Imai T, Tanigawa Y, Komiya T, Tsukita Sh: Identification of novel keratinocyte-secreted peptides dermokine-α/-β and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. Genomics 84:384-97 (2004)
Experimental techniques
1. Biochemical analysis
2. Cell biological analysis
3. Molecular biological analysis