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2005年以前のPublication　List

Publication List(仁科博史)
Publication List(和田悌司)

Publication List(仁科博史)


原著論文(1987-2004)


2004

  1. Gen Nishitai, Nao Shimizu, Takahiro Negishi, Hiroyuki Kishimoto, Kentaro Nakagawa, Daiju Kitagawa, Tomomi Watanabe, Haruka Momose, Shinya Ohata, Shuhei Tanemura, Satoshi Asaka, Junko Kubota, Ryota Saito, Hiroki Yoshida, Tak W. Mak, Teiji Wada, Josef M. Penninger, Noriyuki Azuma, Hiroshi Nishina*, and Toshiaki Katada. (2004) Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in ES cells. J. Biol. Chem. 279, 1621-1626. *Corresponding author

  2. Teiji Wada, Nicholas Joza, Hai-ying M. Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin, Schreiber, Erwin F.Wagner, Hiroshi Nishina, and Josef M. Penninger (2004) MKK7 couples stress signaling to G2/M cell cycle progression and cellular senescence. Nat. Cell Biol. 6, 215-226.

  3. Naoki Yamamoto, Shuji Terai, Shinya Ohata, Tomomi Watanabe, Kaoru Omori, Koh Shinoda, Koji Miyamoto, Toshiaki Katada, Isao Sakaida, Hiroshi Nishina, and Kiwamu Okita (2004) A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochem. Biophys. Res. Commun. 313, 1110-1118.

  4. Furutani-Seiki, M., Sasado, T., Morinaga, C., Suwa, H., Niwa, K., Yoda, H., Deguchi, T., Hirose, Y., Yasuoka, A., Henrich, T., Watanabe, T., Iwanami, N., Kitagawa, D., Saito, K., Asaka, S., Osakada, M., Kunimatsu, S., Elmasri, H., Winkler, C., Ramialison, M., Loosli, F., Quiring, R., Carl, M., Grabher, C., Winkler, S., Del Bene, F., Shinomiya, A., Kota, Y., Yamanaka, T., Okamoto, Y., Takahashi, K., Todo, T., Abe, K., Takahama, Y., Tanaka, M., Mitani, H., Katada, T., Nishina, H., Nakajima, N., Wittbrodt, J. and Kondoh, H. (2004) Asystematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech. Dev. 121, 647-658.

  5. Harun Elmasria, Christoph Winkler, Danie Liedtke, Takao Sasado, Chikako Morinaga, Hiroshi Suw, Katsutoshi Niwa, Thorsten Henrich, Yukihiro Hirose, Akihito Yasuoka, Hiroki Yoda, Tomomi Watanabe, Tomonori Deguchi, Norihisa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Felix Loosli, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Joachim Wittbrodt, Keiko Abe, Yousuke Takahama, Katsuhito Takahashi, Toshiaki Katada, Hiroshi Nishina, Hisato Kondoh, and Makoto Furutani-Seiki (2004) Mutations affecting somite formation in the Medaka (Oryzias latipes) . Mech. Dev. 121, 659-671.

  6. Daiju Kitagawa, Tomomi Watanabe, Kota Saito, Satoshi Asaka, Takao Sasado, Chikako Morinaga, Hiroshi Suwa, Katsutoshi Niwa, Akihito Yasuoka, Tomonori Deguch, Hiroki Yoda, Yukihiro Hirose, Thorsten Henrich, Norimasa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Chritoph Winkler, Harun Elmasri, Jochen Wittbrodt, Felix, Loosli, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Toshiaki, Katada, Hiroshi Nishina, Hisato Kondoh, and Makoto Furutani-Seiki (2004) Genetic dissection of the formation of the forebrain in Medaka, Oryzias latipes. Mech. Dev. 121, 673-685.

  7. Tomomi Watanabe, Satoshi Asaka, Daiju Kitagawa, Kota Saito, Ryumei Kurashige, Takao Sasado, Chikako Morinaga, Hiroshi Suwa, Katsutoshi Niwa, Thorsten Henrrich, Yukihiro Hirose, Akihito Yasuoka, Hiroki Yoda, Tomonori Deguchi, Norihisa Iwanami, Sanae Kunimatsu, Masakazu Osakada, Felix Loosl, Rebecca Quiring, Matthias Carl, Clemens Grabher, Sylke Winkler, Filippo Del Bene, Jochen Wittbrodt, Keiko Abe, Yosuke Takahama, Katsuhito Takahashi, Toshiaki Katada, Hiroshi Nishina*, Hisato Kondoh, and Makoto Furutani-Seiki* (2004) Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. Mech. Dev. 121, 791-802.

  8. Masato Matsuoka, Hideki Igisu, Kentaro Nakagawa, Toshiaki Katada, and Hiroshi Nishina (2004) Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced Activation of c-Jun NH2-terminal Kinase in Mouse Embryonic Stem Cells. Toxicol. Lett. 152, 175-181.

  9. Isao Sakaida, Sｈuji Terai, Naoki Yamamoto, Koji Aoyama, Tsuyoshi Ishikawa, Hiroshi Nishina, and Kiwamu Okita (2004) Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40, 1304-1311.

  10. Kaoru Omori, Shuji Terai, Tsuyoshi Ishikawa, Kouji Aoyama, Isao Sakaida, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, and Kiwamu Okita (2004) Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression. FEBS Lett. 578, 10-20.


2003

  1. Hiroyuki Kishimoto, Kentaro Nakagawa, Tomomi Watanabe, Daiju Kitagawa, Haruka Momose, Jungwon Seo, Gen Nishitai, Nao Shimizu, Shinya Ohata, Shuhei Tanemura, Satoshi Asaka, Takayuki Goto, Hiromichi Fukushi, Hiroki Yoshida, Akira Suzuki, Takehiko Sasaki, Teiji Wada, Josef M. Penninger, Hiroshi Nishina*, and Toshiaki Katada (2003) Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells. J. Biol. Chem. 278, 16595-16601.

  2. Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, Ohashi PS (2003) Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur. J. Immunol. 33, 685-696.

  3. Okamura-Oho, Y., Miyashita, T., Nagao, K., Shima, S., Ogata, Y., Katada, T., Nishina, H., and Yamada, M. (2003) Dentatorubral-pallidoluysian atrophy (DRPLA) protein is phosphorylated by c-Jun NH2-Terminal Kinase. Hum. Mol. Genet. 12, 1535-1542.

  4. Haruka Momose, Hiroshi Kurosu, Kenji Kontani, Kyoko Tsujita, Noriko Tsujimoto, Hiroshi Nishina, and Toshiaki Katada. (2003) Dual Phosphorylation of Phosphoinositide 3-Kinase Adaptor Grb2-Associated Binder 2 Is Responsible for Superoxide Formation Synergistically Stimulated by Fc and Formyl-Methionyl-Leucyl-Phenylalanine Receptors in Differentiated THP-1 Cells. J. Immunol. 171, 4227-4234.

  5. Shuji Terai, Isao Sakaida, Naoki Yamamoto, Kaoru Omori, Tomomi Watanabe, Shinya Ohata, Toshiaki Katada, Koji Miyamoto, Koh Shinoda, Hiroshi Nishina, and Kiwamu Okita (2003) An invivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J. Biochem. 134, 551-558.


2002

  1. Kitagawa, D., Tanemura, S., Ohata, S., Shimizu, N., Seo, J., Nishitai, G., Watanabe, T., Nakagawa, K., Kishimoto, H., Wada, T., Tezuka, T., Yamamoto, T., Nishina, H.*, and Katada, T. (2002) Activation of Extracellular Signal-regulated Kinase by Ultraviolet Is Mediated Through Src-dependent Epidermal Growth Factor Receptor Phosphorylation. J. Biol. Chem. 277, 366-371.

  2. Yamamoto, A., Miyazaki, T., Kadono, Y., Takayanagi, H., Miura, T., Nishina, H., Katada, T., Wakabayashi, K., Oda, H., Nakamura, K., and Tanaka, S. (2002) Possible Involvement of I B Kinase 2 and MKK7 in Osteoclastogenesis Induced by Receptor Activator of Nuclear factor B Ligand. J. Bone Miner. Res. 17, 612-621.

  3. Watanabe, T. Nakagawa, K, Ohata, S, Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., Aoki, J., Arai, H., Iwatsubo, T., Mochita, M., Watanabe, T., Satake, M., Ito, Y., Matsuyama, T., Mak, T. W., Penninger, J. M., Nishina, H.*, and Katada, T. (2002) SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF- B-induced anti-apoptosis. Dev. Biol. 250, 332-347.

  4. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T., and Taniguchi, T. (2002) Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling. Dev. Cell 3, 889-901.


2001

  1. Wada, T., Nakagawa, K., Watanabe, T., Nishitai, G., Seo, J., Kishimoto, H., Kitagawa, D., Sasaki, T, Penninger, J. M., Nishina, H.*, and Katada, T. (2001) Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4. J. Biol. Chem. 276, 30892-30897.

  2. Sasaki, T., Wada, T., Kishimoto,, H., Irie-Sasaki, J., Matsumoto, G., Goto, T., Yao, Z., Wakeham, A., Mak, T. W., Suzuki, A., Katada, T., Nishina, H., and Penninger, J. M. (2001) The stress kinase MKK7 is a negative regulator of antigen receptor and growth factor receptor induced proliferation in hematopoietic cells. J. Exp. Med. 194, 757-768.

  3. Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A., Nishina, H., Potter, J., Saris, C. J. M., and Mak, T. W. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15, 569-578.


2000

  1. Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y-Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P., Sarosi, I., Nishina, H., Lipkowitz, S., and Penninger, J. M. (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211-216


1999

  1. Nishina, H., Vaz, C., Billia, P., Nghiem, M., Sasaki, T., Pompa, J. L., Furlonger, K., Paige, C., Hui, C-C., Fischer, K. D., Kishimoto, H., Iwatsubo, T., Katada, T., Woodgett, J. R., and Penninger, J. M. (1999) Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126, 505-516.


1998

  1. Nishina, H., Radvanyl, L., Raju, K., Sasaki, T., Kozieradzki, I., and Penninger, J. M. (1998) Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J. Immunol. 161, 3416-3420.

  2. Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E. M., Wakeham, A. C., Bouchard, D., Kong, Y-Y., Ohteki, T., Shahinian, A., Bachmann, M., Ohashi, P. S., Penninger, J. M., Crabtree, G. R, and Mak, T. W. (1998) The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production. Immunity 8, 115-124.

  3. Fischer, K. D., Kong, Y-Y, Nishina, H., Tedford, K., Marengere, L., Kozieradzki, I., Sasaki, T., Starr, M., Chan, G., Gardener, S., Nghiem, M. P., Bouchard, D., Barbacid, M., Bernstein, A., and Penninger, J. M. (1998) Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology 8, 554-562.

  4. Sasaki, T, Maehama, T, Yamamoto, T., Takasuga, S., Hoshino, S., Nishina, H., Hazeki, O., and Katada, T. (1998) Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 ibroblasts. J. Biochem. 124, 934-939.

  5. H. Kishimoto, H., Hoshino, Ohori, M., Kontani, K., Nishina, H., Suzawa, M., Kato, S., and T. Katada (1998) Molecular mechanism of human CD38 gene expression by retinoic acid: Identification of retinoic acid response element in the first intron. J. Biol. Chem. 273, 15429-15434.


1997

  1. Masuda, W., Takenaka, S., Inageda, K., Nishina, H., Takahashi, K., Katada, T., Tsuyama, S., Inui, H., Miyatake, K., and Nakano, Y. (1997) Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, Euglena gracilis. FEBS. Lett. 405, 104-106.

  2. Nishina, H., Fischer, K. D., Radvanyi, L., Shahinian, A., Hakem, R., Rubie, E. A. , Bernstein, A., Mak, T. W., Woodgett, J. R., and Penninger, J. M. (1997) Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385, 350-353.

  3. Nishina, H., Bachmann, M., Oliveira-dos-Santos, A. J., Kozieradzki, I., Fischer, K. D., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, T. W., Woodgett, J. R., Ohashi, P. S., and Penninger, J. M. (1997) Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase4 (MKK4)-deficient T Lymphocytes. J. Exp. Med. 186, 941-953.

  4. Yao, Z., Diener, K., Wang, X. S., Zukowski, M., Matsumoto, G., Zhou, G., Mo, R., Sasaki, T., Nishina, H., Hui, C. C., Tan, T-H., Woodgett, J. R., and Penninger, J. M. (1997) Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7). J. Biol. Chem. 272, 32378-32383.

  5. Suzuki, A., Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A., Itie, A., Koo, W., Fukumoto, M., Hui, C. C., and Mak, T. W. (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 10, 1242-1252.


1996

  1. Kontani, K., Kukimoto, I., Nishina, H., Hoshino, S., Hazeki, O., Kanaho, Y., and Katada, T. (1996) Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells. J. Biol. Chem. 271, 1534-1537.

  2. Kukimoto, I., Hoshino, S., Kontani, K., Inageda, K., Nishina, H., Takahashi, K., and Katada, T. (1996) Stimulation of ADP-ribosyl cyclase activity of the cell surface antigen CD38 by zinc ions resulting from inhibition of its NAD+ glycohydrolase activity. Eur. J. Biochem. 239, 177-182.

  3. Hara-Yokoyama, M., Kukimoto, I., Nishina, H., Kontani, K., Hirabayashi, Y., Irie, F., Sugiya, H., Furuyama, S., and Katada, T. (1996) Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides. J. Biol. Chem. 271, 12951-12955.


1995

  1. Penninger, J. M., Timms, E., Shahinian, A., Jero-Bremond, A., Nishina, H., Ionescu, J., Hedrick, S. M., and Mak, T. W. (1995) Alloreactive gd Thymocytes Utilize Distinct Costimulatory Signals from Peripheral T Cells. J. Immunol 155, 3847-3855.

  2. Nishina, H., Nimota, K., Kukimoto, I., Maehama, T., Takahashi, K., Hoshino, S., Kanaho, Y., and Katada, T. (1995) Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2. J. Biochem. 118, 1083-1089.

  3. Maehama, T., Nishina, H., Hoshino, S., Kanaho, Y., and Katada, T. (1995) NAD+-dependent ADP-ribosylation of T lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes. J. Biol. Chem. 270, 22747-22751.

  4. Wada, T., Inageda, K., Aritomo, K., Tokita, K., Nishina, H., Takahashi, K., Katada, T., and Sekine, M. (1995) Structural characterization of cyclic ADP-ribose by NMR spectroscopy. Nucleos Nucleot 14, 1301-1314.

  5. Inageda, K., Takahashi, K., Tokita, K., Nishina, H., Kanaho, Y., Kukimoto, I., Kontani, K., Hoshino, S., and Katada, T. (1995) Enzyme properties of Aplysia ADP-ribosyl cyclase: Comparison with NAD glycohydrolase of CD38 antigen. J. Biochem. 117, 125-131.

  6. Ohoka, Y., Kontani, K., Iiri, T., Nishina, H., and Katada, T. (1995) Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. J. Biochem. 117, 190-196.

  7. Inanobe, A., Morishige, K.I., Takahashi, N., Ito, H., Yamada, M., Takumi, T., Nishina, H., Takahashi, K., Kanaho, Y., Katada, T., and Kurachi, Y. (1995) G directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1. Biochem. Biophys. Res. Commun. 212, 1022-1028.

  8. Mizuguchi, M., Otsuka, N., Sato, M., Ishii, Y., Kon, S., Yamada, M., Nishina, H., Katada, T., and Ikeda, K. (1995) Neuronal localization of CD38 antigen in the human brain. Brain Res. 697, 235-240.

  9. Takahashi, K., Kukimoto, I., Tokita, K.I., Inageda, K., Inoue, S.I., Kontani, K., Hoshino, S, Nishina, H., Kanaho, Y., and Katada, T. (1995) Accumulation of cyclic ADP-ribose measured by a specific radioimmunoassay in differentiated human leukemic HL-60 cells with all-trans-retinoic acid. FEBS Lett. 371, 204-208.


1994

  1. Nishina, H., Inageda, K., Takahashi, K., Hoshino, S., Ikeda, K., and Katada, T. (1994) Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity. Biochem. Biophys. Res. Commun. 203, 1318-1323.

  2. Maehama, T., Nishina, H., and Katada, T. (1994) ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified -subunits of GTP-binding proteins. J. Biochem. 116, 1134-1138.

  3. Maehama, T., Sekine, N., Nishina, H., Takahashi, K., and Katada, T. (1994) Characterization of botulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase. Mol. Cell. Biochem. 138, 135-140.


1993

  1. Kontani, K., Nishina, H., Ohoka, Y., Takahashi, K., and Katada, T. (1993) NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface antigen CD38. J. Biol. Chem. 268, 16895-16898.

  2. Yoshida, T., Suzuki, T., Sato, H., Nishina, H., and Iba, H. (1993) Analysis of fra-2 gene expression. Nucleic Acids Res., 21, 2715-2721.


1991

  1. Suzuki, T., Okuno, H., Yoshida, T., Endo, T., Nishina, H., and Iba, H. (1991) Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res. 19, 5537-5542.

  2. Suzuki, T., Hashimoto, Y., Okuno, H., Sato, H., Nishina, H., and Iba, H. (1991) High- level Expression of Human c-jun Gene Causes Cellular Transformation of Chicken Embryo Fibroblasts. Jpn. J. Cancer Res. 82, 58-64.

  3. Inageda, K., Nishina, H., and Tanuma, S. (1991) Mono-ADP-ribosylation of Gs by an Eukaryotic Arginine-specific ADP-ribosyltransferase Stimulates the Adenylate Cyclase System. Biochem. Biophys. Res. Commun. 176, 1014-1019.

  4. Maruta, H., Inageda, K., Aoki, T., Nishina, H., and Tanuma, S. (1991) Characterization of Two Forms of Poly(ADP-ribose)Glycohydrolase in Guinea Pig Liver. Biochemistry. 30, 5907-5912.

  5. Tsai, Y., Abe, H., Maruta, H., Hatano, T., Nishina, H., Sakagami, H., Okuda, T., and Tanuma, S. (1991) Effect of Chemically Defined Tannins on Poly (ADP-ribose) Glycohydrolase Activity. Biochem. Int. 14, 889-897.


1987〜1990

  1. Nishina, H., Sato, H., Suzuki, T., Sato, M.,and Iba, H. (1990) Isolation and characterization of fra-2, an additional member of the fos gene family. Proc. Natl. Acad. Sci. USA 87, 3619-3623.

  2. Iba, H., Shindo, Y., Nishina, H., and Yoshida, T. (1988) Transforming Potential and Growth Stimulating Activity of the v-fos and c-fos Genes Carried by Avian Retrovirus Vectors. Oncogene Res. 2, 121-133.

  3. Fujiwara, K. T., Ashida, K., Nishina, H., Iba, H., Miyajima, N., Nishizawa, M., and Kawai, S. (1987) The Chicken c-fos Gene : Cloning and Nucleotide Sequence Analysis. J. Virol. 61, 4012-4018.



著書・総説（英文）

  1. Hiroshi Nishina*, Teiji Wada, and Toshiaki Katada (2004) [review] Physiological roles of SAPK/JNK signaling pathway. J. Biochem. 136: 123-126. *Corresponding author

  2. Nishina, H.*, Watanabe, T. Nakagawa, K, Ohata, S, Asaka, S., and Katada, T. (2004) [book] SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF- B-induced anti-apoptosis. in Stem Cell and Liver Regeneration (Okita, K., eds) pp. 1-14, Springer-Verlag Tokyo, Inc., Tokyo.

  3. Hiroshi Nishina*, Kentaro Nakagawa, Noriyuki Azuma, and Toshiaki Katada. (2003) [review] Activation Mechanism and Physiological Roles of Stress-Activated Protein Kinase/c-Jun NH2-Terminal Kinase in Mammalian Cells. J. Biol. Regul. Homeost. Agents. 17, 295-302.

  4. Katada, T. , Kontani, K., Wada, T., Hosoda, N., Hoshino, S., and Nishina, H. (2000) [review] Enzymatic and Signal Transduction Properties of CD38/NADase and PC-1/Phosphodiesterase. Chem. Immunol. 75: 60-78.

  5. Nishina, H. and Penninger, J. M. (1998) [book] SEK1. in The gene knockout facts book (Mak, T. W., eds) pp. 933-934, Academic Press, San Diego

  6. Kontani, K., Kukimoto, I., Kanda, Y., Inoue, S., Kishimoto, H., Hoshino, S., Nishina, H., Takahashi, K., Hazeki, O., and Katada, T. (1997) [review] Signal transduction via the CD38/NAD+ glycohydrolase. Adv. Exp. Med. Biol. 419: 421-430.

  7. Katada, T., Iiri, T., Takahashi, K., Nishina, H., and Kanaho, Y. (1995) [book] in Bacterial Toxins and Virulence Factors in Disease (Moss, J., Iglewski, B., Vaughan, M., and Tu, T.A., eds) pp. 459-489, Marcel Dekker, Inc., New York.

  8. Katada, T., Kontani, K., Inanobe, A., Kobayashi, I., Ohoka, Y., Nishina, H., and Takahashi, K. (1994) [book] in Methods in Enzymology (Vol. 237; Heterotrimeric G Proteins) (Iyengar, R., eds) pp. 131-139, Academic Press, San Diego.

  9. Katada, T., Ohoka, Y., Tomita, U., Iiri, T., Nishina, H., and Takahashi, K. (1992) [book] in Neurotransmitter Receptors and Intracellular Signaling (Yoshida, H., and Ui, M., eds) pp. 30-43, Excerpta Medica, Amsterdam.

  10. Tanuma, S., Uchida, K., Suzuki, H., Nishina, H., Maruta, H., Sugimura, T., and Miwa, M. (1992) [book] in ADP-Ribosylation Reaction (Poirier, G., and Moreau, P., eds) pp. 282-285, Springer-Verlag, New York.



著書・総説（和文）

  1. 渡辺智美、仁科博史：メダカを用いた肝形成および肝機能の解明；生化学 76：1454-1458 (2004)

  2. 仁科博史、中川健太郎、堅田利明：SAPK/JNK系の活性化機構と生理的役割；実験医学 22：1551-1556 (2004)

  3. 和田悌司、仁科博史、堅田利明、Josef M Penninger：MKK7のストレス応答によるG2/M期進行、細胞老化抑止の制御；実験医学 22：1398-1400 (2004)

  4. 仁科博史、渡辺智美、大畑慎也、浅香聡、堅田利明：初期肝形成時のシグナル伝達機構；胆肝膵 46巻３号: 295-302 (2003)

  5. 仁科博史、堅田利明：SAPK/JNK系の生理的役割；実験医学 17：113-118 (1999)

  6. 仁科博史、堅田利明：Ｔ細胞機能とSEK1, SEK2；臨床免疫 32：518-524 (1999)

  7. 仁科博史、堅田利明：sek1(SAPK/ERK kinase-1)；Molecular Medicine 34：ノックアウトマウス・データブック：452-453 (1997)

  8. 仁科博史、堅田利明：シグナル伝達分子三量体GTP結合蛋白質の構造と機能；生体の科学 48： 229-235 (1997)

  9. 仁科博史、堅田利明：百日咳毒素；治療学 31：1475-1478 (1997)

  10. 堅田利明、紺谷圏二、柊元 巌、井上晋一、星野真一、櫨木 修、高橋勝宣、仁科博史：シグナル伝達系におけるNAD+代謝酵素とサイクリックADPリボース；日薬理誌 106 (suppl. 1)： 45P-49P (1995)

  11. 堅田利明、仁科博史、高橋勝宣、星野真一、紺谷圏二、前濱朝彦、柊元 巌：シグナル伝達系に登場した新しいNAD+代謝酵素；蛋白質 核酸 酵素 40： 1900-1911 (1995)

  12. 仁科博史、堅田利明：Ｇタンパク質；Annual Review 細胞生物学1993（矢原一郎、御子柴克彦、月田承一郎 編） pp. 271-280　中外医学社 (1993)

  13. 伊庭英夫、仁科博史、佐藤宏宣：fos遺伝子ファミリー；実験医学 8：796-801 (1990)

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Publication List(和田悌司)


原著論文(1996-2004)


2004

  1. Nishitai G, Shimizu N, Negishi T, Kishimoto H, Nakagawa K, Kitagawa D, Watanabe T, Momose H, Ohata S, Tanemura S, Asaka S, Kubota J, Saito R, Yoshida H, Mak TW, Wada T, Penninger JM, Azuma N, Nishina H, Katada T. Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J Biol Chem. 2004 Jan 16; 279(3): 1621-6

  2. Wada T, Joza N, Cheng H-YM., Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. MKK7 couples stress signaling to G2/M cell cycle progression and cellular senescence. Nat Cell Biol. 2004 Mar; 6(3); 215-26

  3. Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, Bloom D, Fathman CG, Liu YC, Penninger JM. Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction. Immunity. 2004 Aug;21(2):167-77

  4. Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 2004 Nov 1;200(9):1167-77.


2003

  1. Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM. Nishina H, Katada T. Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 2003 May 9;278(19): 16595-601. Epub 2003 Mar 06

  2. Crackower MA, Kolas NK, Noguchi J, Sarao R, Kikuchi K, Kaneko H, Kobayashi E, Kawai Y, Kozieradzki I, Landers R, Mo R, Hui CC, Nieves E, Cohen PE, Osborne LR, Wada T, Kunieda T, Moens PB, Penninger JM. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 2003 May 23;300(5623):1291-5.

  3. Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 2003 Jun;18(6):763-75.

  4. Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003 Oct 28;108(17):2147-52

  5. Suzuki N, Suzuki S, Eriksson U, Hara H, Mirtosis C, Chen NJ, Wada T, Bouchard D, Hwang I, Takeda K, Fujita T, Der S, Penninger JM, Akira S, Saito T, Yeh WC. IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol. 2003 Dec 1;171(11):6065-71.


2002

  1. Kitagawa D, Tanemura S, Ohata S, Shimizu N, Seo J, Nishitai G, Watanabe T, Nakagawa K, Kishimoto H, Wada T, Tezuka T, Yamamoto T, Nishina H, Katada T Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation: Its implication in an anti-apoptotic function. J Biol Chem. 2002 Jan 4;277(1): 366-71

  2. Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM. DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002 Jan 11;108(1):31-43.

  3. Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 2002 Apr 18;416(6882):750-6.

  4. Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak T, Penninger J, Nishina H, Katada T. SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-kappaB-Induced Anti-Apoptosis. Dev Biol. 2002 Oct 15;250(2):332.

  5. Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T, Wada T, Nagao T, and Kurose H. G12/13 Mediates 1-Adrenergic Receptor-Induced Cardiac Hypertrophy.Circulation Res. 2002 Nov 15;91(10):961-9.


1996〜2001

  1. Sasaki T*, Wada T*, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC, Oliveira-dos-Santos AJ, Katada T, Nishina H, Penninger JM. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J Exp Med. 2001 Sep 17;194(6):757-68. *Equal contribution

  2. Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, Kitagawa D, Sasaki T, Penninger JM, Nishina H, Katada T. Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4. J Biol Chem. 2001 Aug 17;276(33):30892-7.

  3. Scruel O, Wada T, Kontani K, Sener A, Katada T and Malaisse WJ. Effects of D-glucose and starvation upon the cyclic ADP-ribose content of rat pancreatic islets. Biochem Mol Biol Int. 1998;45(4):783-90

  4. Wada T, Hasegawa Y and Ono H. Characterization of alpha 1-adrenoceptor subtypes in facilitation of rat spinal motoneuron activity. Eur J Pharmacol. 1997;340(1):45-52

  5. Wada T, Otsu T, Hasegawa Y, Mizuchi A and Ono H. Characterization of alpha 1-adrenoceptor subtypes in rat spinal cord. Eur J Pharmacol. 1996;312(2):263-6


著書・総説（英文）

  1. Nishina H, Wada T, Katada T Physiological Roles of SAPK/JNK Signaling Pathway J Biochem. 2004 Sep;136:123-6

  2. Wada T, Penninger JM Stress kinase MKK7, Saviour of Cell Cycle Arrest and Cellular Senescence (review) Cell Cycle. 2004 May;3(5):577-9

  3. Wada T, Penninger JM Mitogen-activated protein kinases in apoptosis regulation (review) Oncogene. 2004 Apr 12;23(16):2838-49

  4. Nakashima T, Wada T, Penninger JM. RANKL and RANK as novel therapeutic targets for arthritis (review). Curr Opin Rheumatol. 2003 May;15(3):280-7.

  5. Katada T, Kontani K, Wada T, Hosoda N, Hoshino S and Nishina H (review). Enzymatic and signal transduction propaties of CD38/NADase and PC-1/phosphodiesterase. Chem Immunol. 2000;75:60-78


著書・総説（和文）

  1. 和田悌司、仁科博史、堅田利明、Josef M Penninger： MKK7のストレス応答によるG2/M期進行、細胞老化抑止の制御；実験医学 22：1398-1400 (2004)

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