遺伝生化 業績

遺伝生化


Department of Biochemical Genetics,Medical Research Institute,Tokyo Medical and Dental Univ.

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研究業績(2000年以降)
1999年以前の業績及びその他の業績は各スタッフの研究者総覧へ。


●発表論文

2009
Rondon, GA, H. Mischo, J. Kawauchi and N.J.Proudfoot. Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae. Mol Cell 36, 88-98, 2009

Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa N, Shirakawa I, Usami T, Tsukahara T, Nakayama K, Miyamoto Y, Yasuda K, Matsuda J, Kamei Y, Kitajima S, Ogawa Y. ATF3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res.105, 25-32, 2009

Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, Adachi-T M, Tanaka Y, and Kitajima S. Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells. Nucleic Acids Res 37, 1438-1451, 2009

Turchi L, Fareh M, Aberdam E, Kitajima S, Simpson F, Wicking C, Aberdam D, and Virrole T. ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV. Cell Death and Differentiation 16, 728-737, 2009

Okada M, Sakai T, Nakamura T, Adachi TM, Kitajima S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Kasuga M. Skp2 promotes adipocyte differentiation via a p27kip1-independent mechanism in primary mouse embryonic fibroblasts. Biochem Biophys Res Commun 379, 249-254, 2009

2008
Kawauchi, J., H. Mischo, P. Braglia, A. Rondon and N. J. Proudfoot. Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes Dev 22, 1082-1092, 2008 (Faculty of 1000 Biology)

Yasukawa T, Kamura T, Kitajima S, Conaway RC, Conaway JW, Aso T. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. EMBO J. 27: 3256-3266, 2008 (
Faculty of 1000 Biology)

Turchi L, Aberdam E, Mazure N, Pouyssegur J, Deckert M, Kitajima S, Aberdam D, Virrole T. Hif-2alpha mediates UV-induced apoptosis through a novel ATF3 dependent death pathway. Cell Death and Differentiation 15:1472-1480, 2008

Mayer SI, Dexheimer V, Nishida E, Kitajima S, Thiel G. Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr1, CREB and ATF2 following GnRH receptor stimulation. Endocrinology 149: 6311-6325, 2008

Nakamura K, Sakaue H, Nishizsawa A, Matsuki Y, Gomi H, Watanabe E, Hiramatsu R, Adachi T.M, Kitajima S, Noda T, Ogawa W, Kasuga M. PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression. J Biol Chem 283:17702-17711, 2008

Lee S-A, Lee S-Y, Cho I-H, Oh M-A, Kang E-S, Kim Y-B, Seo WD, Choi S, Nam JO, Adachi TM, Kitajima S, Ye S-K, Kim S, Hwang Y-J, Kim I-S, Park KH, Lee JW. Tetraspanin TM4SF5 mediates epithelial-mesenchymal transition leading to loss of contact inhibition. J. Clin Invest 118:1354-1366, 2008

Adachi TM, Takagi H, Hashimoto K, Goto K, Hidaka T, Koshimizu U, Yamada K, Goto I, Maejima Y, Isobe M, Nakayama KI, Inomata N, Kitajima S. Cardiomyocyte proliferation and protection against post-myocardail infarctiosn heart failure by cyclin D1 and SCFSkp2 ubiquitin ligase. Cardiovascular Res. 80:181-190, 2008 (Editorial comment)

Adachi-T M, Goto I, Yamada K, Kitajima S. Differential regulation of cyclin D1 and D2 in protecting against cardiomyocyte proliferation. Cell Cycle 7: 3768-3774, 2008

Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Adachi-Tamamori M, Kitajima S, and Sadoshima J. Distinct roles of GSK-3a and GSK-3b phosphorylation in the heart under pressure overload. Proc Natl Acad Sci USA 105: 20900-20905, 2008

Nakamura N, Yoshida M, Umeda M, Huang Y, Kitajima S, Inoue Y, Ishikawa I, Iwai T. Extended exposure of lipopolysaccharide fraction from Porphyromonas gingivalis facilitates mononuclear cell adhesion to vascular endothelium via Toll-like receptor-2 dependent mechanism. Atherosclerosis 196:59-67, 2008

2007
Jones, H. S., J. Kawauchi*, P. Braglia, C. M. Alen, N. A. Kent, and N. J. Proudfoot. RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA. Nat Struct Mol Biol 14, 123-130, 2007 (* first author equivalent) (Faculty of 1000 Biology)

Miyata K, Yasukawa T, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, Tamamori-Adachi M, Ohnishi Y, Ohtsuki Y, Nakabeppu Y, Kitajima S, Onishi S, Aso T. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. Cell Death and Differentiation 14:716-726, 2007

Yasukawa T, Sugimura K, Fukuda M, Yamazaki K, Kitajima S, Okumura K, Aso T. Functional characterization of a mammalian transcription factor, Elongin A. Biochem Biophys Res Commun 352:237-243, 2007

Tanaka Y, Katagiri Z, Kawahashi K, Kioussis D, Kitajima S. Mammalian trithorax group protein ASH1 methylates histone H3 lysine 36 GENE 397:161-168, 2007 (Faculty of 1000 Biology)

Masaki H, Nishida T, Kitajima S, Asahina K, Teraoka K. Dppa4 associated with active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J Biol Chem 282:33034-33042, 2007

2006
Hua B, Adachi TM, Yang L, Tamura K, Morioka M, Tanaka Y, Kitajima S. A splice variant of stress response gene ATF3 counteracts NF-kB-dependent anti-apoptosis through inhibiting recruitment of CBP/p300 co-activator. J Biol Chem, 281:1620-1629, 2006

Yamaguchi K, Lee S-H, Kin J-S, Wimalasena Y, Kitajima S, Baek SJ. Activating transcription factor 3 and early growth response-1 are the novel targets of LY294002 in a PI3K independent pathway. Cancer Res. 66:2376-2384, 2006

2005
Tamura K, Hua B, Adachi S, Guney I, Kawauchi J, Morioka M, Tamamori-Adachi M, Tanaka Y, Nakabeppu Y, Sunamori M, Sedivy JM, Kitajima S. Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J. 24: 2590-2601, 2005

Takahashi T, Yamasaki F, Sudo T, Itamori H, Adachi S, Tamamori-Adachi M, Ueno NT. Cyclin A-associated kinase activity is needed for palitaxel sensitivity. Mol Cancer Ther. 4: 1039-1046, 2005

2004
Adachi-T M, Hayashida K, Nobori K, Omizu C, Yamada K, Sakamoto N, Kamura T, Fukuda K, Ogawa S, Nakayama I. K, and Kitajima S. Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation. J Biol Chem. 279: 50429-50436, 2004

Kinjo K, Miyakawa Y, Uchida H, Kitajima S, Ikeda Y, Kizaki M. All-transretinoic acid directly up-regulates thrombopoietin transcription in human bone marrow stromal cells. Exp Hematol 32:45-51, 2004

2003
Yamazaki K, Aso T, Ohnichi Y, Ohno M, Tamura K, Shuin T, Kitajima S, Nakabeppu Y.  Mammalian Elongin A Is not essentual for cell viability but required for proper cell-cycle progression with limited alteration of gene expression. J Biol Chem 278: 13585-13589, 2003

Adachi-Tamamori M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, Kawauchi J, Sunamori M, Kitajima S, Ikeda M-A. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res 92: e12-e19, 2003

Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda M. Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene 22: 8723-8730, 2003

Ma K, Araki K, Ichwan SJA, Suganuma T, Tamamori-Adachi M, Ikeda M. E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. Mol Cancer Res. 1: 438-444, 2003

2002
Kawauchi J, Zhang C, Nobori K, Hashimoto Y, Adachi T M, Noda A, Sunamori M, Kitajima S.  Transcriptional repressor ATF3 protects human umbilical vein endothelial cells from TNF--induced apoptosis through down-regulation of p53 transcription. J Biol Chem 277: 39025-39034, 2002

Zhang C, Gao C, Hashimoto Y, Kawauchi J, Tsuchida N, Kitajima S. Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun 297: 1302-1310, 2002

Nobori K, Ito H, Adachi T M, Adachi S, Ono Y, Kawauchi J, Kitajima S, Marumo F, Issobe M.  ATF3 Inhibits Doxorubicin-induced Apoptosis in Cardiac Myocytes: A Novel Cardioprotective Role of ATF3. J Mol Cell Cardiol 34:1387-1397, 2002

Adachi T M, Ito H, Nobori K, Hayashida K, Kawauchi J, Adachi S, Ikeda M, Kitajima S.  Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in cuture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun 296:274-280, 2002

Yamazaki Y, Guo L, Sugahara K, Zhang C, Enzan H, Nakabeppu Y, Kitajima S, Aso T.  Identification and characterization of a novel transcription elongation factor elongin A3. J Biol Chem 277:26444-26451, 2002

Hashimoto Y, Zhang C, Kawauchi J, Imoto J, Adachi TM, Inazawa J, Amagasa T, Hai T, Kitajima S. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res 30:2398-2406, 2002

Tanaka M, Ueda A, Kanamori, H, Ideguchi H, Yang J, Kitajima S, Ishigatusubo Y. Cell cycle dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1. J Biol Chem 277:10719-10726, 2002

Nawa T, Nawa T. M, Adachi M, Uchimura I, Shimokawa R, Fujiwara K, Tanaka A, Numano F, Kitajima S. Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and functional involvement in cell death of vascular endothelial cells. Atherosclerosis 161:281-291, 2002

2001
Zhang C, Cai Y, Adachi M, Oshiro S, Aso T, Kaufman R. J, Kitajima S. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276:35867-35874, 2001

Zhang C, Kawauchi J, Adachi T.M, Hashimoto Y, Oshiro S, Aso T, Kitajima S. Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun 289:718-724, 2001

Adachi S, Ito H, Tamamori-Adachi M, Ono Y, Nozato T, Abe S, Ikeda M, Narumo F, Hiroe M. Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes. Circ Res. 88: 408-414, 2001

2000
Aso T, Yamazaki K, Aigaki T, Kitajima S. Drosophila von Hippel-Lindau tumor suppressor complex posseses E3 ubiquitin ligase activity. Biochem Biophys Res Commun 276:355-361, 2000

Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M. Identification and characterization of elongin A2, a new member of the elongin family of transcription elongation factors, specfically expressed in the testis. J Biol Chem 275:6546-6552, 2000

Cai Y, Zhang C, Nawa T, Aso T, Tanaka M, Oshiro S, Ichijo H, Kitajima S. Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood 96:2140-2148, 2000

Nawa T, Nawa, T. M, Cai Y, Zhang C, Uchimura I, Narumi S, Numano F, Kitajima S. Repression of TNF-a-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochem Biophys Res Commun 275:406-411, 2000


●著書・総説など

北嶋繁孝:ATF3の細胞運命制御と疾患との関わり 実験医学特集:転写因子による生命現象の統合制御 25(10):212-217、2007

安達三美、北嶋繁孝:再生と細胞周期 キーワードで理解する細胞周期イラストマップ 羊土社 154-161、2005

安達(玉盛)三美、北嶋繁孝:心筋細胞の再生をめざした細胞周期機構の解明 分子細胞治療 3:47-53,2004

川内潤也、北嶋繁孝:転写制御機構 臨床検査 48:75-85、2004

北嶋繁孝、川内潤也、巴銀花:異常蛋白質ストレス(特に小胞体ストレス)シグナル伝達 臨床検査 47:535-544、2003

北嶋繁孝、麻生悌二郎、山崎勝久:転写伸長因子の機能:転写制御複合体形成のダイナミクス 蛋白質核酸酵素増刊号 転写伸長因子の機能:TFIIFとエロンガン 45:1513-1522, 2000

北嶋繁孝:TFIIFの構造と転写における役割  医学のあゆみ(転写因子と疾患)190(6):622-627、1999

Kitajima S, Cai Y, Tanaka M, Nawa T, Oshiro S: Mechanism of transcription by RNA polymerase II - a molecular basis of regulated   gene expression -. J Med Dent Sci 45(2): 59-67, 1998

北嶋繁孝,祭勇,田中真希子,名和知久礼,大城聡:転写因子と疾患 臨床化学(転写制御と臨床化学)27(2):52-58、199
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