PUBLICATIONS

ARTICLES

 

Tanaka, D.H., Li, S., Mukae, S. and Tanabe, T. (2021) Genetic recombination in disgust-associated bitter taste-responsive neurons of the central nucleus of amygdala in male mice Neuroscience Letters 742: 135456.


Saegusa, H., Li, X., Wang,X., Kayakiri, M. and Tanabe, T. (2020) Knockdown of microglial Cav2.2 N-type voltage-dependent Ca2+ channel ameliorates behavioral deficits in a mouse model of Parkinsonfs disease, FEBS Letters 594: 2914-2922. doi: 10.1002/1873-3468.13853.


Mikeli, M., Fujikawa, M., Nagahisa, K., Yasuda, S., Yamada, N. and Tanabe, T. (2020) Contribution of GPD2/mGPDH to an alternative respiratory chain of the mitochondrial energy metabolism and the stemness in CD133-positive HuH-7 cells Genes to Cells 2020;25:139-148. https ://doi.org/10.1111/gtc.12744


Tanaka, D.H. and Tanabe, T. (2019) Changing consciousness epistemically (CHANCE): An empirical method to convert the subjective content of consciousness into scientific data. J. Mind Behav. 40: 177-190


Huntula, S., Saegusa, H., Wang, X., Zong, S. and Tanabe, T. (2019) Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response. Cell calcium 82: 102059. https://doi.org/10.1016/j.ceca.2019.102059

Tanaka, D.H., Li, S., Mukae, S. and Tanabe, T. (2019) Genetic access to gustatory disgust-associated neurons in the interstitial nucleus of the posterior limb of the anterior commissure in male mice Neuroscience 413:45-63.

Wang, X., Saegusa, H., Huntula, S. and Tanabe, T. (2019) Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinsonfs disease model. Scientific Reports 9:9138.


Tanaka, D.H. and Tanabe, T. (2018) CHANCE: a method that enables a researcher to fully know the content of consciousness of a subject in scientific experiments. bioRxiv doi:


Tanaka, D.H. and Tanabe, T. (2018) A Conjecture for Objectification of the Content of Consciousness. viXra:1804.0169.


Kondo, D., Saegusa, H. and Tanabe, T. (2018) Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor
pathway for induction and maintenance of neuropathic pain. Biochem. Biophys. Res. Commun. 499: 253-259.


Kishikawa, J.I., Inoue, Y., Fujikawa, M., Nishimura, K., Nakanishi, A., Tanabe, T., Imamura, H. and Yokoyama, K. (2018) General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. PLoS ONE 13(1):e0190213. doi: 10.1371.


Fujikawa, M., Sugawara, K., Tanabe, T. and Yoshida, M. (2015) Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex. FEBS Letters 589: 2707-2712.


Saegusa, H. and Tanabe, T. (2014) N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem. Biophys. Res. Commun.  450:142-147.


Kurihara, T., Sakura,i E., Toyomoto, M., Kii, I., Kawamoto, D., Asada, T., Tanabe, T., Yoshimura, M., Hagiwara, M. and Miyata, A. (2014) Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Molecular Pain 10: 17.


Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S. and Tanabe, T. (2009) Upregulation of casein kinase 1 epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain. Molecular Pain 5: 74.


Li, L., Saegusa, H. and Tanabe, T. (2009) Deficit of heat shock transcription factor 1- heat shock 70kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6. Genes to Cells 14: 1253-1269.


Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S. and Tanabe, T. (2009) Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice. J. Pharmacol. Sci. 110: 55-63.


Saegusa, H., Wakamori, M., Matsuda, Y., Wang, J., Mori, Y., Zong, S. and Tanabe, T. (2007) Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Molec. Cell. Neurosci. 34: 261-270.


Kondo, D., Yabe, R., Kurihara, T., Saegusa, H., Zong, S. and Tanabe, T. (2006) Progesterone receptor antagonist is effective for relieving neuropathic pain. Eur. J. Pharm. 54: 44-48.


Osanai, M., Saegusa, H., Kazuno, A., Nagayama, S., Hu, Q., Zong, S., Murakoshi, T. and Tanabe, T. (2006) Altered cerebellar function in mice lacking Cav2.3 Ca2+ channel. Biochem. Biophys. Res. Commun. 344: 920-925.


Takasaki, I., Kurihara, T., Saegusa, H., Zong, S. and Tanabe, T. (2005) Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur. J. Pharm.  524: 80-83.

 

Hu, Q., Saegusa, H., Hayashi, Y. and Tanabe, T. (2005) The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurons. Genes to Cells 10: 87-96.

Yokoyama, K., Kurihara, T., Saegusa, H., Zong, S., Makita, K. and Tanabe, T. (2004). Blocking the R-type (CaV2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance Eur. J. Neurosci. 20: 3516-3519.

Takahashi, E.,
Fukuda, K., Miyoshi, S., Murta, M., Kato, T., Ita, M., Tanabe, T., Ogawa, S. (2004) Leukemia inhibitory factor activates cardiac L-type Ca2+ channels via phosphorylation of serine 1829 in the rabbit CaV1.2 subunit.  Circulation Research  94:1242-1248.

Yokoyama, K., Kurihara, T., Makita, K. and Tanabe, T. (2003) Plastic Change of N-type Ca Channel Expression after Preconditioning is Responsible for Prostaglandin E2-induced Long-lasting Allodynia  Anesthesiology  99: 1364-1370
.

Takei, T., Saegusa, H., Zong, S., Murakoshi, T., Makita, K., and Tanabe, T. (2003). Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel  Neuroscience Letters  350:41-45.

Takei, T., Saegusa, H., Zong, S., Murakoshi, T., Makita, K., and Tanabe, T. (2003) Anesthetic Sensitivities to Propofol and Halothane in Mice Lacking the R-type (Cav2.3) Ca2+ Channel.  Anesthesia and Analgesia 97: 96-103.

Kurihara, T., Nonaka, T. & Tanabe, T. (2003). Acetic acid-conditioning stimulus induces long-lasting antinociception of somatic inflammatory pain. Pharmacol. Biochem. Behavior 74: 841-849.

Han, W., Saegusa, H., Zong, S. and Tanabe, T. (2002) Altered Cocaine Effects in Mice Lacking Cav2.3 (1E) Calcium Channel. Biochem. Biophys. Res. Commun. 299: 299-304.

Abe, M., Kurihara, T., Han, W., Shinomiya, K. & Tanabe, T. (2002). Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain. Spine  27:1517-1525.

Tsunemi, T., Saegusa, H., Ishikawa, K., Nagayama, S., Murakoshi, T., Mizusawa, H. & Tanabe, T. (2002). Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. Journal of Biological Chemistry 277: 7214-7221.

Sakata, Y., Saegusa, H., Zong, S., Osanai, M., Murakoshi, T., Shimizu, Y., Noda, T., Aso, T. & Tanabe, T. (2002) Cav2.3 (
1E) Ca2+ channel participates in the control of sperm function. FEBS Letters  516: 229-233.

Toriyama, H., Wang, L., Saegusa, H., Zong, S., Osanai, M., Murakoshi, T., Noda, T., Ohno, K. & Tanabe, T. (2002) Protective function of Cav2.3 (
1E) Ca2+ channel in ischemic neuronal injury. NeuroReport  13: 261-265.

Matsuda, Y., Saegusa, H., Zong, S., Noda, T. and Tanabe,T. (2001) Mice lacking Cav2.3 (
1E) calcium channel exhibit hyperglycemia. Biochem. Biophys. Res. Commun. 289:791-795.

Ogasawara, M., Kurihara, T., Hu, Q. & Tanabe, T. (2001). Characterization of acute somatosensory pain transmission in P/Q-type Ca2+ channel mutant mice, leaner. FEBS Letters 508: 181-186.

Sakata, Y., Saegusa, H., Zong, S., Osanai, M., Murakoshi, T., Shimizu, Y., Noda, T., Aso, T. & Tanabe, T. (2001) Analysis of Ca2+ currents in spermatocytes from mice lacking Cav2.3 (
1E) Ca2+ channel. Biochem. Biophys. Res. Commun. 288: 1032-1036.


Murakoshi, T., Song, S., Konishi, S. & Tanabe, T. (2001) Multiple G-protein-coupled receptors mediate presynaptic inhibition at single excitatory synapses in the rat visual cortex. Neuroscience Letters 309: 117-120.

Ishikawa, K., Owada, K., Ishida, K., Fujigasaki, H., Li, M., Tsunemi, T., Ohkoshi, N., Toru, S., Mizutani, T., Hayashi, M., Arai, N., Hasegawa, K., Kawanami, T., Kato, T., Makifuchi, T., Shoji, S., Tanabe, T. & Mizusawa, H. (2001). Cytoplasmic and nuclear polyglutamine-aggregates in SCA6 Purkinje cells. Neurology  56: 1753-1756.

Saegusa, H., Kurihara, T., Zong, S., Kazuno, A., Matsuda, Y., Nonaka, T., Han, W., Toriyama, H. & Tanabe, T. (2001). Suppression of inflammatory and neuropathic pain symptoms in mice lacking N-type Ca2+ channel. The EMBO J. 20: 2349-2356.

Kubota, M., Murakoshi, T., Saegusa, H., Kazuno, A., Zong, S., Hu, Q., Noda, T. & Tanabe, T. (2001) Intact LTP and fear memory but impaired spatial memory in mice lacking Cav2.3 (
1E) channel. Biochem. Biophys. Res. Commun. 282: 242-248.

Tateyama, M., Zong, S. Tanabe, T. & Ochi, R. (2001). Properties of
1E Ca2+ channel currents expressed in cultured adult rabbit ventricular myocytes. American J. Physiol., Cell Physiol. 280: C175-C182.

Fujigasaki, H., Uchihara, T., Koyano, S., Iwabuchi, K., Yagishita, S., Makifuchi, T., Nakamura, A., Ishida, K., Toru, S., Hirai, S., Ishikawa, K., Tanabe, T. & Mizusawa, H. (2000) Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains. Experimental Neurology 165: 248-256.

Saegusa, H., Kurihara, T., Zong, S., Minowa, O., Kazuno, A., Han, W., Matsuda, Y., Yamanaka, H., Osanai, M., Noda, T. & Tanabe, T. (2000). Altered pain responses in mice lacking
1E subunit of the voltage-dependent Ca2+ channel. Proc. Natl. Acad. Sci. USA 97: 6132-6137.

Toru, S., Murakoshi, T., Ishikawa, K., Saegusa, H., Fujigasaki, H., Uchida, T., Nagayama, S., Osanai, M., Mizusawa H. and Tanabe, T. (2000). Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function. Journal of Biological Chemistry 275: 10893-10898.

Ishikawa, K., Fujigasaki, H., Saegusa, H., Ohwada, K., Fujita, T., Iwamoto, H., Komatsuzaki, Y., Toru, S., Toriyama, H., Watanabe, M., Ohkoshi, N., Shoji, S., Kanazawa, I., Tanabe, T. & Mizusawa, H. (1999). Abundant expression and cytoplasmic aggregations of alpha1A-voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6. Hum. Molec. Genet. , 8: 1185-1193.

Nakai, J., Tanabe, T., Konno, T., Adams, B.A. & Beam, K.G. (1998). Localization in the II-III loop of the dihydropyridine receptor of a sequence critical for excitation-contraction coupling. Journal of Biological Chemistry, 273: 24983-24986.

Neuhuber, B., Gerster, U., Doering, F., Glossmann, H., Tanabe, T. & Flucher, B. E. (1998). Association of calcium channel
1S and 1a subunits is required for the targeting of 1a but not of 1S into skeletal muscle triads. Proc. Natl. Acad. Sci. USA 95: 5015-5020.

Minabe-Saegusa, C., Saegusa, H., Tsukahara, M., and Noguchi, S. (1998). Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev. Growth & Differ. 40: 343-353.

Urayama, O., Murakoshi, T., Kubota, M., Hara, Y., Chihara, J. and Ikawa, Y. (1997) Coincident induction of Krev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Molecular Brain Research, 45: 331-334.

Adams, B.A. & Tanabe, T. (1997). Structural regions of the cardiac Ca channel
1C subunit involved in Ca-dependent inactivation. J. Gen. Physiol. 110: 379-389.

Adams, B. A., Tanabe, T. & Beam, K. G. (1996). Ca2+ current activation rate correlates with
1 subunit density. Biophys. J. 71: 156-162.

Yassin, M., Zong, S. & Tanabe, T. (1996). G-protein modulation of neuronal class E (
1E) calcium channel expressed in GH3 cells. Biochem. Biophys. Res. Commun. 220: 453-458.

Zong, S., Yassin, M. & Tanabe, T. (1995). G-protein modulation of
1A (P/Q) type calcium channel expressed in GH3 cells. Biochem. Biophys. Res. Commun. 215: 302-308.

Zhou, J., Zong, S. & Tanabe, T. (1995). Modulation of cloned neuronal calcium channels through membrane delimited pathway. Biochem. Biophys. Res. Commun. 208: 485-491.

Takekura, H, Takeshima, H, Nishimura, S, Takahashi, M, Tanabe, T, Flockerzi, V, Hofmann, F, Franzini-Armstrong C (1995). Co-expression in CHO cells of two muscle proteins involved in excitation-contraction coupling. Muscle Res Cell Motil. 16 (5): 465-480.

Adams, B. A., Mori, Y., Kim, M., Tanabe, T. & Beam, K. G. (1994). Heterologous expression of BI Ca2+ channels in dysgenic muscle. J. Gen. Physiol. 104: 985-996.

Takekura, H., Bennett, L., Tanabe, T., Beam, K. G. & Franzini-Armstrong, C. (1994). Restoration of junctional tetrads in dysgenic myotubes by dihydropyridine receptor cDNA. Biophys. J. 67: 793-803.

Zong, S., Zhou, J. & Tanabe, T. (1994). Molecular determinants of calcium-dependent inactivation in cardiac L-type calcium channels. Biochem. Biophys. Res. Commun. 201: 1117-1123.

Pragnell, M., De Waard, M., Mori, Y., Tanabe, T., Snutch, T. P. & Campbell, K. P. (1994). Calcium channel
subunit binds to a conserved motif in the I-II cytoplasmic linker of the 1 subunit. Nature 368: 67-70.

Garcia, J., Tanabe, T. & Beam, K. G. (1994). Relationship of calcium transients to calcium currents and charge movements in myotubes expressing skeletal muscle and cardiac DHP receptors. J. Gen. Physiol. 103: 125-147.

Zhang, J.-F., Randall, A. D., Ellinor, P. T., Horne, W. A., Sather, W. A., Tanabe, T., Schwarz, T. L. & Tsien, R. W. (1993). Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology 32: 1075-1088.

Sather, W. A., Tanabe, T., J.-F. Zhang, Mori, Y., Adams, M. E. & Tsien, R. W. (1993). Distinctive biophysical and pharmacological properties of class A (BI) calcium channel
1 subunits. Neuron 11: 291-303.

Beam, K. G., Adams, B. A., Niidome, T., Numa, S. & Tanabe, T. (1992). Function of a truncated dihydropyridine receptor as both voltage sensor and calcium channel. Nature 360: 169-171.

Tanabe, T., Adams, B. A., Numa, S. & Beam, K. G. (1991). Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics. Nature 352: 800-803.

Mori, Y., Friedrich, T., Kim, M., Mikami, A., Nakai, J., Ruth, P., Bosse, E., Hofmann, F., Flockerzi, V., Furuichi, T., Mikoshiba, K., Imoto, K., Tanabe, T. & Numa, S. (1991). Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350: 398-402.

Adams, B. A., Tanabe, T., Mikami, A., Numa, S. & Beam, K. G. (1990). Intramembrane charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor cDNAs. Nature 346: 569-572.

Tanabe, T., Beam, K. G., Adams, B. A., Niidome, T. & Numa, S. (1990). Regions of the skeletal muscle dihydropyridine receptor critical for excitation-contraction coupling. Nature 346: 567-569.

Tanabe, T., Mikami, A., Numa, S. & Beam, K. G. (1990). Cardiac-type excitation-contraction coupling in dysgenic skeletal muscle injected with cardiac dihydropyridine receptor cDNA. Nature 344: 451-453.

Kaupp, U. B., Niidome, T., Tanabe, T., Terada, S., Boenigk, W., Stuehmer, W., Cook, N. J., Kangawa, K., Matsuo, H., Hirose, T., Miyata, T. & Numa, S. (1989). Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 342: 762-766.

Mikami, A., Imoto, K., Tanabe, T., Niidome, T., Mori, Y., Takeshima, H., Narumiya, S. & Numa, S. (1989). Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340: 230-233.

Tanabe, T., Beam, K. G., Powell, J. A. & Numa, S. (1988). Restoration of excitation-contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA. Nature 336: 134-139.

Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T. & Numa, S. (1987). Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328: 313-318.

Nukada, T., Tanabe, T., Takahashi, H., Noda, M., Haga, K., Haga, T., Ichiyama, A., Kangawa, K., Hiranaga, M., Matsuo, H. & Numa, S. (1986). Primary structure of the
-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett. 197: 305-310.

Nukada, T., Tanabe, T., Takahashi, H., Noda, M., Hirose, T., Inayama, S. & Numa, S. (1986). Primary structure of the
-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 195: 220-224.

Sugimoto, K., Nukada, T., Tanabe, T., Takahashi, H., Noda, M., Minamino, N., Kangawa, K., Matsuo, H., Hirose, T., Inayama, S. & Numa, S. (1985). Primary structure of the
-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 191: 235-240.

Tanabe, T., Nukada, T., Nishikawa, Y., Sugimoto, K., Suzuki, H., Takahashi, H., Noda, M., Haga, T., Ichiyama, A., Kangawa, K., Minamino, N., Matsuo, H. & Numa, S. (1985). Primary structure of the
-subunit of transducin and its relationship to ras proteins. Nature 315: 242-245.

Kubo, T., Noda, M., Takai, T., Tanabe, T., Kayano, T., Shimizu, S., Tanaka, K., Takahashi, H., Hirose, T., Inayama, S., Kikuno, R., Miyata, T. & Numa, S. (1985). Primary structure of
-subunit precursor of calf muscle acetylcholine receptor deducted from cDNA sequence. Eur. J. Biochem. 149: 5-13.

Noda, M., Shimizu, S., Tanabe, T., Takai, T., Kayano, T., Ikeda, T., Takahashi, H., Nakayama, H., Kanaoka, Y., Minamino, N., Kangawa, K., Matsuo, H., Raftery, M. A., Hirose, T., Inayama, S., Hayashida, H., Miyata, T. & Numa, S. (1984). Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature 312: 121-127.

Tanabe, T., Noda, M., Frutani, Y., Takai, T., Takahashi, H., Tanaka, K., Hirose, T., Inayama, S. & Numa, S. (1984). Primary structure of
-subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence. Eur. J. Biochem. 144: 11-17.

Takai, T., Noda, M., Furutani, Y., Takahashi, H., Notake, M., Shimizu, S., Kayano, T., Tanabe, T., Tanaka, K., Hirose, T., Inayama, S. & Numa, S. (1984). Primary structure of
-subunit precursor of calf muscle acetylcholine receptor deduced from the cDNA sequence. Eur. J. Biochem. 143: 109-115.

Noda, M., Furutani, Y., Takahashi, H., Toyosato, M., Tanabe, T., Shimizu, S., Kikyotani, S., Kayano, T., Hirose, T., Inayama, S. & Numa, S. (1983). Cloning and sequence analysis of calf cDNA and human genomic DNA encoding
-subunit precursor of muscle acetylcholine receptor. Nature 305: 818-823.

Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Furutani, Y., Hirose, T., Takashima, H., Inayama, S., Miyata, T. & Numa, S. (1983). Structural homology of Torpedo californica acetylcholine receptor subunits. Nature 302: 528-532.

Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Kikyotani, S., Hirose, T., Asai, M., Takashima, H., Inayama, S., Miyata, T. & Numa, S. (1983). Primary structure of
- and -subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature 301: 251-255.

Noda, M., Takahashi, H., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T. & Numa, S. (1982). Primary structure of
-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299: 793-797.

 


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