主な業績

【原著論文】

英文

1.    Shimogaki S, Ito S, Komatsu S, Koike R, Miyasaka N, Umezawa K, Kubota T. Inhibition of the NF-kB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome. Mod Rheumatol (in press).

2.    Takayasu A, Miyabe Y, Yokoyama W, Kaneko K, Miyabe C, Fukuda S, Kubota T, Miyasaka N, Nanki T. CCL18 activates fibriblast-like synoviocytes in patients with rheumatoid arthritis. J Rheumatol 40;1026-1028, 2013.

3.    Nanki T, Onoue I, Nagasaka K, Takayasu A, Ebisawa M, Hosoya T, Shirai T, Sugihara T, Hirata S, Kubota T, Harigai M, Miyasaka N. Suppression of elevations in serum C-reactive protein levels by anti-IL-6 autoantibodies in two　patients with severe bacterial infections. Ann Rheum Dis 72;1100-1102, 2013.

4.    Saito R, Matsuoka S, Fujinami Y, Nonaka S, Ichinose S, Kubota T, Okamura N. Role of Moraxella catarrhalis outer membrane protein CD in bacterial cell morphology and autoaggregation. Res Microbiol 164:236-243, 2013.

5.    Nishimura M, Nii T, Trimova G, Miura S, Umezawa K, Ushiyama A, Kubota T. The NF-kB specific inhibitor DHMEQ prevents thrombus formation in a mouse model of antiphospholipid syndrome. J Nephropathol 2:114-121, 2013.

6.    Watanabe K, Sakai R, Koike R, Sakai F, Sugiyama H, Tanaka M, Komano Y, Akiyama Y, Mimura T, Kaneko M, Tokuda H, Iso T, Motegi M, Ikeda K, Nakajima Y, Taki H, Kubota T, Kodama H, Sugii S, Kuroiwa T, Nawata Y, Shiozawa K, Ogata A, Sawada S, Matsukawa Y, Okazaki T, Mukai M, Iwahashi M, Saito K, Tanaka Y, Nanki T, Miyasaka N, Harigai M. Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients. Mod Rheumatol (DOI 10.1007/s 10165-012-0796-5)

7.    Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, Ogura T, Mizusawa H, Imai T, Miyasaka N, Nanki T. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. Arthritis Res Ther 14:R48, 2012.

8.       Kaneko K, Nonomura Y, Watanabe K, Koike R, Kubota T, Harigai M, Inoue Y, Iwai T, Miyasaka N. Nontyphoidal Salmonella abdominal aortic aneurysm in an immunocompromised rheumatoid arthritis patient. J Infect Chemother 15:312-315, 2009.

9.       Ohyanagi N, Ishido M, Suzuki F, Kaneko K, Kubota T, Miyasaka N, Nanki T. Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo. Arthritis Rheum 60:3118-3127, 2009.

10.    Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K. Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome: an attractive target for the NF-kB-specific inhibitor DHMEQ. Ann NY Acad Sci, 1173:137-145, 2009.

11.    Nii T, Kubota T, Nanki T, Komano Y, Harigai M, Kohsaka H, Hirose W, Nagasaka K, Sakurai T, Miyasaka N. Reevaluation of antibody titers one year after influenza vaccination in patients with rheumatoid arthritis receiving TNF blockers. Mod Rheumatol, 19:216-218, 2009.

12.     Harigai M, Kawamoto M, Hara M, Kubota T, Kamatani N, Miyasaka N. Excessive production of interferon- gamma in patients with systemic lupus erythematosus and its contribution to induction of BLyS/ BAFF/TNFSF-13B. J Immunol 181:2211-2219, 2008.

13.    Mizoguchi F, Nakamura S, Iwai H, Kubota T, Miyasaka N. Varicella-zoster virus hepatitis in polymyositis. Mod Rheumatol 18:301-305, 2008.

14.    Kubota T, Nii T, Nanki T, Kohsaka H, Harigai M, Komano Y, Sugihara T, Nonomura Y, Hirose W, Nagasaka K, Sakurai T, Miyasaka N. Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis. Mod Rheumatol 17:531-533, 2007.

15.    Koike R, Kubota T, Hara Y, Ito S, Suzuki K, Yanagisawa K, Uchibori K, Miyasaka N. A case of Muckle-Wells syndrome caused by a novel H312P mutation in NALP3 (cryopyrin). Mod Rheumatol 17:496-499, 2007.

16.    Kubota T, Hoshino M, Aoki K, Ohya K, Komano Y, Nanki T, Miyasaka N, Umezawa K. NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor. Arthritis Res & Ther 9:R97, 2007.

17.    Wakamatsu K, Nanki T, Miyasaka N, Umezawa K, Kubota T. Effect of a small molecule inhibitor of NF-kB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res & Ther 7:R1348-R1359, 2005.

18.    Ochi S, Nanki T, Takada K, Suzuki F, Komano Y, Kubota T, Miyasaka N. Favorable outcomes with tacrolimus in two patients with refractory interstitial lung disease associated with polymyositis/dermatomyositis. Clin Exp Rheumatol 23:707-710, 2005.

19.    Kanai Y, Watanabe M, Kubota T. Interspecific structural differences in nucleosome as revealed by heteroimmunization in mice with human nucleosome. Ann NY Acad Sci 1050:89-96, 2005.

20.    Komano Y, Kubota T, Wakabayashi S, Ochi S, Nonomura Y, Hagiyama H, Nanki T, Kohsaka H, Miyasaka N. A case of paraneoplastic syndrome mimicking adult-onset Still’s disease. Mod Rheumatol 14:410-413, 2004.

21.  Hagiyama H, Kubota T, Komano Y, Kurosaki M, Watanabe M, Miyasaka N. Fulminant hepatitis in an asymptomatic chronic carrier of hepatitis B virus mutant after withdrawal of low-dose methotrexate therapy for rheumatoid arthritis. Clin Exp Rheumatol 22:375-376, 2004.

22.  Nanki T, Urasaki Y, Imai T, Nishimura M, Muramoto K, Kubota T, Miyasaka N. Inhibition of fractalkine ameliorates murine collagen-induced arthritis. J Immunol 173:7010-7016, 2004.

23.  Hagiyama H, Koike R, Nagasaka K, Nonomura Y, Nishio J, Nanki T, Kohsaka H, Kubota T, Miyasaka N. Two cases of acute respiratory distress syndrome resulting from adult-onset Still’s disease. Mod Rheumatol 13:76-80, 2003.

24.  Williams YN, Nosaka Y, Sugita T, Kubota T, Suppression of fibroblast activity by an inhibitor of dipeptidyl peptidase IV: a possible therapeutic strategy for rheumatoid arthritis. Clin Exp Rheumatol 21:685, 2003.

25.  Lu Q, Kanai Y, Kubota T. The emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice. J Med Dent Sci 50:9-15, 2003.

26.  Williams YN, Baba H, Hayashi S, Ikai H, Sugita T, Tanaka S, Miyasaka N, Kubota T. Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis. Clin Exp Immunol 131:68-74, 2003.

27.  Nonomura Y, Koike R, Nishio J, Tsubata R, Kohsaka H, Kubota T, Miyasaka N. Overlap syndrome with cerebral hemorrhage caused by prostaglandin E1 infusion. Int Med 40:265-266, 2001.

28.  Kubota T, Watanabe N, Kaneko T, Satake F, Miura K, Kurosawa Y, Miyasaka N, Kanai Y. Activation of autoreactive T cells that help nucleobindin-injected mice produce anti-DNA antibodies. Immunol Lett 75:111-115, 2001.

29.  Sahara Y, Kubota T, Ichikawa M. Cellular localization of metabotropic glutamate receptors mGluR1, 2/3, 5 and 7 in the main and accessory olfactory bulb of the rat. Neurosci Lett 312:59-62, 2001.

30.  Satake F, Watanabe N, Miyasaka N, Kanai Y, Kubota T. Induction of anti-DNA antibodies by immunization with anti-DNA antibodies: mechanism and characterization. Lupus 9:489-497, 2000.

31.  Sawada M, Isogai S, Miyake S, Kubota T, Yoshizawa Y. Pulmonary pseudallescherioma associated with systemic lupus erythematosus. Int Med 37:1046-1049, 1998.

32.  Nanki T, Koike R, Mizushima N, Kohsaka H, Kubota T, Miyasaka N. Severe anemia due to hemorrhagic gastritis associated with Sjogren's syndrome. Clin Exp Rheumatol 16:105, 1998.

33.  Watanabe N, Kubota T, Miyasaka N, Kanai Y. Enhancement of hydroxyl radical DNA cleavage by serum anti-dsDNA antibodies in SLE. Lupus 7:108-112, 1998.

34.  Kawai M, Hara Y, Kubota T, Shiba K, Hosaki S. A family with high serum leucine aminopeptidase activity derived from a novel variant CD13. Clin Chem 44:215-220, 1998.

35.  Kubota T, Miyauchi M, Miura K, Hirokawa G, Awaya A, Miyasaka N, Kurosawa Y, Kanai Y, Maruyama K. Upregulation of nucleobindin expression in human-activated lymphocytes and non-Hodgkin's lymphoma. Pathol Int 48:22-28, 1998.

36.  Nanki T, Koike R, Mizushima N, Kohsaka H, Kubota T, Miyasaka N. A case of nasal T cell lymphoma with lethal midline granuloma which is clinically indistinguishable from Wegener's granulomatosis. J J Rheumatol 7:183-188, 1997.

37.  Ishida K, Kaneko K, Kubota T, Itoh Y, Miyatake T, Matsushita M, Yamada M. Identification and characterization of an anti-glial fibrillary acidic protein antibody with a unique specificity in a demented patient with an autoimmune disorder. J Nurol Sci 151:41-48, 1997.

38.  Iizuka H, Kubota T, Satake F, Hirokawa G, Miura K, Kurosawa Y, Miyasaka N, Kanai Y. Enhanced expression of nucleobindin in lymphatic organs of lupus-prone mice. Lupus 6:365-370, 1997.

39.  Kubota T, Watanabe N, Kanai Y, Stollar BD. Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies. J Biol Chem 271:6555-6561, 1996.

40.  Kanai Y, Takeda O, Miura K, Amagai M, Kaneko T, Kubota T, Kanai Y, Tanuma S, Kurosawa Y. Induction of autoantibodies in normal mice by injection of nucleobindin and natural occurrence of antibodies against nucleobindin in autoimmune MRL/lpr/lpr mice. Immunol Lett 45:35-42, 1995.

41.  Ohdama S, Yoshizawa Y, Kubota T, Aoki N. Plasma thrombomodulin as an indicator of thromboembolic disease in systemic lupus erythematosus. Int J Cardiol 47:S1-S6, 1994.

42.  Wang S, Miyauchi M, Koshikawa N, Maruyama K, Kubota T, Miura K, Kurosawa Y, Awaya A, Kanai Y. Antigen expression associated with lymph node metastasis in gastric adenocarcinomas. Pathol Int 44:844-849, 1994.

43.  Kubota T, Iizuka H, Bachovchin WW, Stollar BD. Dipeptidyl peptidase IV activity in serum and on lymphocytes of MRL/Mp-lpr/lpr mice correlates with disease onset. Clin Exp Immunol 96: 292-296, 1994.

44.  Ohdama S, Takano S, Miyake S, Kubota T, Sato K, Aoki N. Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am J Clin Pathol 101:109-113, 1994.

45.  Yoshinaga H, Koike R, Maruyama T, Iizuka H, Matsuoka H, Kubota T, Miyasaka N. Still's disease relapse with severe pneumonitis after prolonged remission. Int Med 32:902-905, 1993.

46.  Kubota T, Flentke GR, Bachovchin WW, Stollar BD. Involvement of dipeptidyl peptidase IV in an in vivo immune response. Clin exp Immunol 89:192-197, 1992.

47.  Kubota T, Kanai Y, Miyasaka N. Interpretation of the cross-reactivity of anti-DNA antibodies with cell surface proteins: the role of cell surface histones. Immunol Lett 23:187-194, 1990.

48.  Kanai Y, Kubota T. A novel trait of naturally occurring anti-DNA antibodies: dissociation from immune complexes in neutral 0.3-0.5 M NaCl. Immunol Lett 22:293-300, 1989.

49.  Kubota T, Dang H, Takei M, Miyasaka N, Kanai Y, Talal N. Idiotypic independency of anti-dsDNA and anti-Sm antibodies in SLE sera. Clin.Exp.Rheumatol 7:567-568, 1989.

50.  Kubota T, Kanai Y. Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis. Bull Tokyo Med Dent Univ 36:13-18, 1989.

51.  Kubota T, Tanoue K, Murohashi I, Nara N, Yamamoto N, Yamazaki H, Aoki N. Autoantibody against platelet glycoprotein IIb/IIIa in a patient with non-Hodgkin's lymphoma. Thromb Res 53:379-386, 1989.

52.  Kubota T, Akatsuka T, Kanai Y. A monoclonal anti-double stranded DNA antibody from an autoimmune MRL/Mp-lpr/lpr mouse: specificity and idiotype in serum immunoglobulins. Immunol Lett 14:53-58, 1986.

53.  Kanai Y, Katagiri T, Mori S, Kubota T. An established MRL/Mp-lpr/lpr cell line with null cell properties produces a B cell differentiation factor(s) that promotes anti-single-stranded DNA antibody production in MRL spleen cell culture. Int Archs Allergy appl Immun 81:92-94, 1986.

54.  Miyasaka N, Yamaoka K, Sato K, Kubota T, Okuda M, Nishioka K, Ohya Y, Yamamoto K. An analysis of polyclonal B cell activation in Sjogren's syndrome. Scand J Rheumatol 61(suppl):123-126, 1986.

55.  Kubota T, Akatsuka T, Kanai Y. DNA affinity column chromatography: application in the isolation of distinct antibody populations from SLE sera. Clin exp Immunol 62:321-328, 1985.

56.  Kanai Y, Akatsuka T, Kubota T, Goto S, Stollar BD. MRL/Mp-lpr/lpr mouse derived monoclonal antibodies that recognise determinants shared by poly(ADP-ribose), single stranded DNA and left handed Z-DNA. Clin exp Immunol 59:139-145, 1985.