Seminar in Guilin, China held in October, 2013

NSFC A3 Foresight Program 2013 Seminar
-Epigenetic Signatures in Gastric Carcinogenesis-

Date October 26-29, 2013
Venue Guilin Ronghu Lake Hotel

Summary

NSFC A3 Foresight Program 2013 Seminar was held on October 26-29, 2013 at Guilin Ronghu Lake Hotel, Guilin, China. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analyses. A total of 34 scientists (16 senior and 18 junior) from three nations attended this meeting. On the first day, recent findings in three countries were presented by 9 senior and 9 junior scientists. On the second day, A3 research summary was presented by 4 senior members, and further cooperation network was discussed. During this meeting, several new collaborative research plans were proposed, and all of them were strongly supported by participants. Thus we hope that new cooperation network will be built soon by collaboration of researchers in three nations.

Program

Oct. 27 (Sun)

Opening remarks Yinglan Zhang (Official of NSFC)
Hujun Jiang (Official of NSFC)

Presentation by senior scientists (I)

Chairperson:
Wei-cheng You
Toshikazu Ushijima		 Keitaro Matsuo (Kyushu University, Japan): One carbon metabolism and risk of cancer
Yong Sung Kim (Korea Research Institute of Bioscience and Biotechnology, Korea): Methylation signatures during intestinal-type gastric carcinogenesis
Haiying Wang (Peking University Health Science Center, China): REG-γ interacts with Sirt7 and induces its ubiquitin-independent protein degradation in response to DNA damage
Gyeong Hoon Kang (Seoul National University College of Medicine, Korea): Hypomethylations of LINE-1 and Alu during multistep carcinogenesis of several tissue types and their potential prognostic values in human epithelial malignancies

Presentation by junior scientists

Chairperson:
Jeong Mo Bae
Isao Oze		 Isao Oze (Aichi Cancer Center Research Institute, Japan): Comparison of circulating miRNA levels between gastric cancer patients and non-cancer controls
Wei Tian (Peking University Cancer Hospital and Institute, China): PRL-3 increases the expression of miR-210 in a HIF1a dependent manner in gastrointestinal cancer cells
Bo Gun Jang (Seoul National University College of Medicine, Korea): Distribution of Lgr5+ cells in human gastric carcinogenesis
Lin-Lin Ren (Shanghai Jiao-Tong University School of Medicine, China): The enhancer of zeste homolog 2 (EZH2) promotes human colorectal cancer invasion via epigenetically suppressing Vitamin D Receptor
Jeong Mo Bae (Seoul National University College of Medicine, Korea): Colorectal cancer classification according to cellular phenotype, and its epigenetic characteristics
Yukie Yoda (National Cancer Center Research Institute, Japan): Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancers
Boyan Song (Peking University Health Science Center, China): Class I HDAC inhibitors suppress 5-aza-2’-deoxycytidine excision by promoting glycosylase MBD4 and UNG degradation
Oh-Hyung Kwon (Korea Research Institute of Bioscience and Biotechnology, Korea): Effects of bile acid on epigenetic alteration associated with CDX2 expression in gastric cancer and normal cells
Liang Zong (National Cancer Center Research Institute, Japan): Isolation of DNA methylation markers to estimate cancer cell contents in gastric cancers.

Seniors’ A3 Research Summary

Chairperson:
Yong Sung Kim
Mingzhou Guo		 Woo Ho Kim (Seoul National University College of Medicine, Korea): Identification of epigenetically silenced genes in human gastric carcinoma
Yang Yang (Peking University Health Science Center, China): The effect of histone methyltransferase SET7/9 on tumors
Yoshimitsu Akiyama (Tokyo Medical and Dental University, Japan): Summary of DNA methylation-related studies of gastric cancer
Yinxuan Chen (Shanghai Jiao-Tong University School of Medicine, China): Jumonji domain–containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
Se Jin Jang (Asan Medical Center, Korea): Development and characterization of a PDX model that reproduces drug responsiveness and the mutation profiles of its original tumor

Oct. 28 (Mon)

Seniors’ A3 Research Summary

Chairperson:
Woo Ho Kim
Yasuhito Yuasa		 Kai-feng Pan (Peking University Cancer Hospital and institute, China): Epigenetic studies in a high risk Chinese population for stomach cancer
Toshikazu Ushijima (National Cancer Center Research Institute, Japan): Summary of A3 activities at Div. of Epigenomics, NCC
Zheming Lu (Peking University Cancer Hospital and Institute, China) : Summary of A3 activities on metastasis-related methylation signature in gastric carcinomas
Hiroshi Fukamachi (Tokyo Medical and Dental University, Japan): Summary of GC stem cell researches in the A3 project

Summary of A3-Related Publications, and Discussion on Further Cooperation Network

Chairperson:
Dajun Deng		 Participants: All attendants