2007年

1. Nakanishi J, Wada Y, Matsumoto K, Azuma M, Kikuchi K, Ueda S. Over expression of B7-H1 (PD-L1) significantly associated with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother 56: 1173-1182, 2007.
2. Tanaka K, Piao J, Omura K, Azuma M. Multipotency of CD11bhigh Gr-1+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice. Oral Oncology. 43:586-592, 2007.
3. Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, Nakamura S, Enomoto K, Yagita H, Azuma M, Nakajima Y. Clinical significance and therapeutic potential of the Programmed Death-1 ligand /Programmed Death-1 pathway in human pancreatic cancer. Clin Cancer Res 13 (7): 2151-2157, 2007.
4. Yadav D, Fine C, Azuma M, Sarvetmick N. B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol. Immunol. 44:2616-2624, 2007.
5. Kitazawa Y, Fujino M, Wang Q, Kimura H, Azuma M, Kubo M, Abe R, Li X. Involvement of the PD-1/PD-L1 pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses. Transplantation. 83: 774-782, 2007.
6. Oikawa T, Takahashi H, Ishikawa T, Hokari A, Otuski N, Azuma M, Zeniya M, Tajiri H. Intrahepatic expression of the costimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol Int 57: 485-492, 2007.
7. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Nguyen L, Vadivel N, Trikudanathan S, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Mechanisms of PD-L1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007.
8. Seko Y, Yagit H, Okumura K, Azuma M, Nagai R. Roles of programmed death-1 (PD-1) / PD-1 ligands pathway in the development of murine cute myocarditis caused by coxsackievirus B3. Cradiovasc Res 75: 158-167, 2007.
9. Kawano A, Shimoda S, Kamihira T, Ishikawa F, Niiro H, Soejima Y, Takemori A, Maehara Y, Nakamura M, Komori A. Migita K, Ishibashi H, Azuma M, Gershwin ME, Harada M. Perioheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis. J Immunol. 179:3315-3324, 2007.
10. Sharma MD, Babam B, Chandler P, Hou D, Singh N, Yagita H, Azuma M, Blazar BR, Mellor AL, Munn DH. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest. 117: 2570-2582, 2007.
11. Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin H, Blazar BR, Rothstein DM, Sayegh MH, and Najafian N. PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection. J Immunol 179: 5204-5210, 2007.
12. Habicht A, Dada S, Jurewicz M, Yagita H, Azuma M, Sayegh MH, Guleria I. A link between PDL1 and T regulatory cells in fetomaternal tolerance. J Immunol. 179: 5211-5219, 2007.

[総説]

1. 橋口　昌章、東　みゆき　B7 ファミリーによる補助シグナルとその新規役割　臨床免疫・アレルギー科 47(6):696-701, 2007
2. 東　みゆき　口腔粘膜・歯の樹状細胞によってどのような免疫応答が誘導されるか？?歯髄樹状細胞の初期応答を中心にー　炎症と免疫 15:725-730, 2007
3. 東　みゆき　移植免疫研究の新展開　第IV部　第24章　免疫病態の解明に向けて　　The Frontiers in Medical Science 免疫応答と免疫病態の統合的分子理解に向けて　p229-240, 2007.11南山堂　

[その他]

1. 東　みゆき　オキナワモズク由来フコイダンの免疫賦活作用　ファイトケミカル研究要覧　 p120-128, 2007.3東洋医学舎

[学会発表]
（国際学会）

1. Hori J, Wang MC, Taniguchi H, Kitahara Y, Takahashi H, Oshima M, Sakaguchi S, Azuma M. Role of Glucocorticoid-induced TNF receptor ligand in immune privilege of corneal allografts. ARVO annual meeting 2007. Florida. 2007.5.6-10
2. Azuma M. Ritprajak P. Hashiguchi M. Successful inhibition in contact hypersensitivity by topical painting of CD86 siRNA oligo. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
3. Igarashi H, Piao J. Cao Y. Hashiguchi M. Azuma M. GITRL-mediated costimulation in CD25− conventional and CD25+ regulatory CD4 T cells. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
4. Ritprajak P. Hashiguchi M. Yagita H. Okumura K. Azuma M. Different anti-B7-DC monoclonal antibodies show differential functions in immune responses. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
5. Hashiguchi M. Kobori H. Ritprajak P. Piao J. Azuma M. B7-H3 co-stimulates T-cell immune responses via the B7-H3 receptor ligation. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
6. Piao J. Kamimura Y. Igarashi H. Iwai H. Hashiguchi M. Shimon S. Azuma M. Involvement of GITRL-GTIR costimulatory pathway in T cell-mediated immune responses in vivo. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
7. Suvas S. Joo H.M. Sehrawat S. Suvas P.K. Sangster M.Y. Yagita H. Azuma M. Kaech S.M. Funcional significance of PD-1 expression on aging T cells. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
8. Piao J .Takano R. Ikehara Y. Takeda S. Miyagi T. Azuma M. Immunological and antitumor effects of fucoidans from Cladosiphon okamuranus TOKIDA ?Composition of fukoidan and biological activities-. International Conference on Food Factors for Health Promotion. Kyoto. 2007.11.27-12.1

（国内学会）

1. 庄　雅之、野見武男、赤堀宇広、金廣裕道、東　みゆき、八木田秀雄、中島祥介　消化器癌におけるT細胞Negative Pathwayの重要性　第66回日本癌学会　横浜2007.10.3-5
2. 朴　今花、五十嵐　英、橋口昌章、東　みゆき　腫瘍上のGITRL発現はT細胞依存症に抗腫瘍免疫応答を増強する　第66回日本癌学会　横浜2007. 10.3-5
3. Hori J. Wang M. Taniguchi H. Kitahara Y. Sakaguchi S. Azuma M. GITR-ligand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts. 第37回日本免疫学会　品川　2007.11.20-22
4. Ritprajak P. Hashiguchi M. Calermsarp N. Azuma M. Transgenic expression of B7-H1 on keratinocytes regulates effector T cell responses. 第37回日本免疫学会　品川　2007.11.20-22

（講演）

1. 東　みゆき　歯にも免疫システムがある 免疫ふしぎ未来2007 日本科学未来館　東京　2007.5.3-4
2. 東　みゆき　口腔領域と免疫　?口腔免疫システムの特殊性と全身性免疫とのリンク-　第 27回　昭和歯学会総会　特別講演 昭和大学 東京 2007.6.30
3. Miyuki Azuma Modulation of anti-tumor host responses by co-inhibition and co-stimulation. The sixth Japan-China Joint Conference for Cancer Research Cancer-Host Interaction Phonix Toya Club, Toya, Hokkaidoh Japan 2007.10.6-7
4. Nakanishi J, Wada Y, Matsumoto K, Azuma M, Kikuchi K, Ueda S. Over expression of B7-H1 (PD-L1) significantly associated with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother 56: 1173-1182, 2007.
5. Tanaka K, Piao J, Omura K, Azuma M. Multipotency of CD11bhigh Gr-1+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice. Oral Oncology. 43:586-592, 2007.
6. Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H, Nakamura S, Enomoto K, Yagita H, Azuma M, Nakajima Y. Clinical significance and therapeutic potential of the Programmed Death-1 ligand /Programmed Death-1 pathway in human pancreatic cancer. Clin Cancer Res 13 (7): 2151-2157, 2007.
7. Yadav D, Fine C, Azuma M, Sarvetmick N. B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol. Immunol. 44:2616-2624, 2007.
8. Kitazawa Y, Fujino M, Wang Q, Kimura H, Azuma M, Kubo M, Abe R, Li X. Involvement of the PD-1/PD-L1 pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses. Transplantation. 83: 774-782, 2007.
9. Oikawa T, Takahashi H, Ishikawa T, Hokari A, Otuski N, Azuma M, Zeniya M, Tajiri H. Intrahepatic expression of the costimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol Int 57: 485-492, 2007.
10. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Nguyen L, Vadivel N, Trikudanathan S, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Mechanisms of PD-L1-mediated regulation of autoimmune diabetes. Clin Immunol. 2007.
11. Seko Y, Yagit H, Okumura K, Azuma M, Nagai R. Roles of programmed death-1 (PD-1) / PD-1 ligands pathway in the development of murine cute myocarditis caused by coxsackievirus B3. Cradiovasc Res 75: 158-167, 2007.
12. Kawano A, Shimoda S, Kamihira T, Ishikawa F, Niiro H, Soejima Y, Takemori A, Maehara Y, Nakamura M, Komori A. Migita K, Ishibashi H, Azuma M, Gershwin ME, Harada M. Perioheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis. J Immunol. 179:3315-3324, 2007.
13. Sharma MD, Babam B, Chandler P, Hou D, Singh N, Yagita H, Azuma M, Blazar BR, Mellor AL, Munn DH. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest. 117: 2570-2582, 2007.
14. Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin H, Blazar BR, Rothstein DM, Sayegh MH, and Najafian N. PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection. J Immunol 179: 5204-5210, 2007.
15. Habicht A, Dada S, Jurewicz M, Yagita H, Azuma M, Sayegh MH, Guleria I. A link between PDL1 and T regulatory cells in fetomaternal tolerance. J Immunol. 179: 5211-5219, 2007.

[総説]

1. 橋口　昌章、東　みゆき　B7 ファミリーによる補助シグナルとその新規役割　臨床免疫・アレルギー科 47(6):696-701, 2007
2. 東　みゆき　口腔粘膜・歯の樹状細胞によってどのような免疫応答が誘導されるか？?歯髄樹状細胞の初期応答を中心にー　炎症と免疫 15:725-730, 2007
3. 東　みゆき　移植免疫研究の新展開　第IV部　第24章　免疫病態の解明に向けて　　The Frontiers in Medical Science 免疫応答と免疫病態の統合的分子理解に向けて　p229-240, 2007.11南山堂　

[その他]

1. 東　みゆき　オキナワモズク由来フコイダンの免疫賦活作用　ファイトケミカル研究要覧　 p120-128, 2007.3東洋医学舎

[学会発表]
（国際学会）

1. Hori J, Wang MC, Taniguchi H, Kitahara Y, Takahashi H, Oshima M, Sakaguchi S, Azuma M. Role of Glucocorticoid-induced TNF receptor ligand in immune privilege of corneal allografts. ARVO annual meeting 2007. Florida. 2007.5.6-10
2. Azuma M. Ritprajak P. Hashiguchi M. Successful inhibition in contact hypersensitivity by topical painting of CD86 siRNA oligo. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
3. Igarashi H, Piao J. Cao Y. Hashiguchi M. Azuma M. GITRL-mediated costimulation in CD25− conventional and CD25+ regulatory CD4 T cells. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
4. Ritprajak P. Hashiguchi M. Yagita H. Okumura K. Azuma M. Different anti-B7-DC monoclonal antibodies show differential functions in immune responses. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
5. Hashiguchi M. Kobori H. Ritprajak P. Piao J. Azuma M. B7-H3 co-stimulates T-cell immune responses via the B7-H3 receptor ligation. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
6. Piao J. Kamimura Y. Igarashi H. Iwai H. Hashiguchi M. Shimon S. Azuma M. Involvement of GITRL-GTIR costimulatory pathway in T cell-mediated immune responses in vivo. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
7. Suvas S. Joo H.M. Sehrawat S. Suvas P.K. Sangster M.Y. Yagita H. Azuma M. Kaech S.M. Funcional significance of PD-1 expression on aging T cells. 94TH Annual Meeting of The American Association of Immunologists. Florida. 2007.5.18-22
8. Piao J .Takano R. Ikehara Y. Takeda S. Miyagi T. Azuma M. Immunological and antitumor effects of fucoidans from Cladosiphon okamuranus TOKIDA ?Composition of fukoidan and biological activities-. International Conference on Food Factors for Health Promotion. Kyoto. 2007.11.27-12.1

（国内学会）

1. 庄　雅之、野見武男、赤堀宇広、金廣裕道、東　みゆき、八木田秀雄、中島祥介　消化器癌におけるT細胞Negative Pathwayの重要性　第66回日本癌学会　横浜2007.10.3-5
2. 朴　今花、五十嵐　英、橋口昌章、東　みゆき　腫瘍上のGITRL発現はT細胞依存症に抗腫瘍免疫応答を増強する　第66回日本癌学会　横浜2007. 10.3-5
3. Hori J. Wang M. Taniguchi H. Kitahara Y. Sakaguchi S. Azuma M. GITR-ligand-induced regulatory T cells as a mechanism of immune privilege of corneal allografts. 第37回日本免疫学会　品川　2007.11.20-22
4. Ritprajak P. Hashiguchi M. Calermsarp N. Azuma M. Transgenic expression of B7-H1 on keratinocytes regulates effector T cell responses. 第37回日本免疫学会　品川　2007.11.20-22

（講演）

1. 東　みゆき　歯にも免疫システムがある 免疫ふしぎ未来2007 日本科学未来館　東京　2007.5.3-4
2. 東　みゆき　口腔領域と免疫　?口腔免疫システムの特殊性と全身性免疫とのリンク-　第 27回　昭和歯学会総会　特別講演 昭和大学 東京 2007.6.30
3. Miyuki Azuma Modulation of anti-tumor host responses by co-inhibition and co-stimulation. The sixth Japan-China Joint Conference for Cancer Research Cancer-Host Interaction Phonix Toya Club, Toya, Hokkaidoh Japan 2007.10.6-7