Special Funds for Education and Research

Special Funds for Education and Research

Path-Signaling Biology Research Program

Principal Investigator: Yoshio MIKI, MD, PhD (Professor, Medical Research Institute)

"A path-signaling biology research program" was initiated with the Special Funds for Education and Research of the Ministry of Education, Culture, Sports, Science and Technology. In this project, we define the signal abnormality in the body which is the beginning of pathological states as "pathogenic signaling" and it is abbreviated to pathsignaling. We promote a disease signal research for conquering intractable diseases in medical science.

We use nervous, cardiovascular and locomotory diseases and cancers as models, and consolidate the basic and clinical research groups of TMDU and develop the biomedical science (path-signaling biology) based on the information of genome, transcriptome and phosphoproteome to elucidate a disease process (the molecular mechanism from normal state of cells and tissues to abnormal state, and further to onset of disease in a systemic manner ).

We set up the new mass spectrometry with high performance, and collect information of phosphoproteins,and aim at the new disease understanding based on phosphoproteomics. This analysis system is installed in Advanced Technology Laboratory of Medical Research Institute and it is planned to have use for researchers of TMDU by employing a full-time engineer. In addition, we combine an intermolecular interaction analyzer with MS. It's very important for signal transduction research to observe changes comprehensively in binding-proteins due to a structural change,

In this program, we establish the experimental basis for biomedical science and the system to use this basis for researchers of TMDU. Using this system, the researchers may develop the biomedical study based on the signal information.

Establishment of the Brain and Vascular Regulation Center

Hidehiro MIZUSAWA, MD, PhD (Director, Center for Brain Integration Research)

In modern societies like Japan, there are huge demands for high quality of life as well as various problems in development of mind from children to adults. Advanced countries have been overcoming infections, gastroenterological diseases, irculatory diseases, and even cancers. However, there has been a little achievement to treat diseases of the brain and nervous system, which is the key system for affluent life and could never be replaced although the other organs could.

In Tokyo Medical and Dental University (TMDU),there has been a long tradition of brain and nervous system science as proved by receiving a 5 years grant the 21st century COE (center of excellence) program "brain integration and its disorders" (2003-2007). TMDU established Center for Brain Integration Research (CBIR) in 2007 to follow the great success of the COE program. The mission of CBIR is to overcome diseases of the brain and nervous system by integration of basic and clinical neurosciences.
In 2008, according to the request of TMDU the Ministry of Education, Science and Culture permitted to establisha new Department of Vascular Intervention and form the Brain and Vascular Regulation Center as the clinical section of CBIR, to which Department of Neurology, Department of Neurosurgery, Department of Psychiatry, Department of Anesthesiology (pain clinic) as well as Department of Vascular Intervention belong.

In the near future, Department of Psychosomatic Medicine, Department of Neuro-rehabilitation, Department of Pediatric Neurology, Stroke Care Unit will be prepared and join the Brain and Vascular Regulation Center. Finally, the CBIR would be a unique center not only in Japan but also in the world for researches, education and clinicals of brain and nervous system disorders.