業績
 

2019

1

The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish.

Hirayama J, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y, Nakahama KI, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H

Scientific reports   9(1) 196   20191


2018 (H30)

1

Effect of gap junction-mediated intercellular communication on TGF-β induced epithelial-to-mesenchymal transition.

Fukuda S, Akiyama M, Harada H, Nakahama KI

Biochemical and biophysical research communications      201812

2

The improvement of calvarial bone healing by durable nanogel-crosslinked materials.

Charoenlarp P, Rajendran AK, Fujihara R, Kojima T, Nakahama KI, Sasaki Y, Akiyoshi K, Takechi M, Iseki S

Journal of biomaterials science. Polymer edition   1-19   201810 

3

Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells.

Manila NG, Kaida A, Nakahama KI, Miura M.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2977-2983. doi: 10.1016/j.bbrc.2018.08.080. Epub 2018 Aug 16.

PMID: 30119887

4

The improvement of calvarial bone healing by durable nanogel-crosslinked materials.

Charoenlarp P, Rajendran AK, Fujihara R, Kojima T, Nakahama KI, Sasaki Y, Akiyoshi K, Takechi M, Iseki S.

J Biomater Sci Polym Ed. 2018 Oct 3:1-19. doi: 10.1080/09205063.2018.1517403. [Epub ahead of print]

PMID: 30156966


2017 (H29)

1

Establishment of novel therapy to reduce progression of myopia in rats with experimental myopia by fibroblast transplantation on sclera.

Shinohara K, Yoshida T, Liu H, Ichinose S, Ishida T, Nakahama K, Nagaoka N, Moriyama M, Morita I, Ohno-Matsui K.

J Tissue Eng Regen Med. 2017 Apr 11. doi: 10.1002/term.2275. [Epub ahead of print]

PMID: 28401697

2

Potential role of sirtuin 1 in Müller glial cells in mice choroidal neovascularization.

Ishida T, Yoshida T, Shinohara K, Cao K, Nakahama KI, Morita I, Ohno-Matsui K.

PLoS One. 2017 Sep 8;12(9):e0183775. doi: 10.1371/journal.pone.0183775. eCollection 2017.

PMID: 28886036

3

A novel mode of stimulating platelet formation activity in megakaryocytes with peanut skin extract.

Sato T, Akiyama M, Nakahama KI, Seo S, Watanabe M, Tatsuzaki J, Morita I.

J Nat Med. 2017 Oct 10. doi: 10.1007/s11418-017-1135-0. [Epub ahead of print]

PMID: 29019067

4

Role of cAMP in phenotypic changes of osteoblasts.

Nishihara S, Ikeda M, Ozawa H, Akiyama M, Yamaguchi S, Nakahama KI.

Biochem Biophys Res Commun. 2017 Nov 21. pii: S0006-291X(17)32304-5. doi: 10.1016/j.bbrc.2017.11.125. [Epub ahead of print]

PMID: 29170126


2016 (H28)

1

Involvement of CX3CL1 in the Migration of Osteoclast Precursors Across Osteoblast Layer Stimulated by Interleukin-1ß.

Matsuura T, Ichinose S, Akiyama M, Kasahara Y, Tachikawa N, Nakahama K.

J Cell Physiol. 2017 Jul;232(7):1739-1745. doi: 10.1002/jcp.25577. Epub 2017 Feb 3. Accepted manuscript online in Wiley Online Library, (wileyonlinelibrary.com): 31 August 2016.


2015 (H27)

1

Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.

Okito A, Nakahama K, Akiyama M, Ono T, Morita I.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):435-40. doi: 10.1016/j.bbrc.2015.01.142. Epub 2015 Feb 7.


2014 (H26)

1

Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression.

Safronova OS, Nakahama K, Morita I.

Nucleic Acids Res. 2014 Aug;42(14):8954-69. doi: 10.1093/nar/gku611. Epub 2014 Jul 23.

PMID: 25056306 Free PMC Article


2

Tumor associated osteoclast-like giant cells promote tumor growth and lymphangiogenesis by secreting vascular endothelial growth factor-C.

Hatano Y, Nakahama K, Isobe M, Morita I.

Biochem Biophys Res Commun. 2014 Mar 28;446(1):149-54. doi: 10.1016/j.bbrc.2014.02.113. Epub 2014 Mar 4.


3

Communication-dependent mineralization of osteoblasts via gap junctions.

Hashida Y, Nakahama K, Shimizu K, Akiyama M, Harada K, Morita I.

Bone. 2014 Apr;61:19-26. doi: 10.1016/j.bone.2013.12.031. Epub 2014 Jan 2.


2013 (H25)


1

Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis.

Akiyama M, Nakahama K, Morita I.

Nutrients. 2013 Aug 13;5(8):3151-62. doi: 10.3390/nu5083151.

PMID: 23945674


2012 (H24)


1

Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering.

Fujioka-Kobayashi M, Ota MS, Shimoda A, Nakahama K, Akiyoshi K, Miyamoto Y, Iseki S.

Biomaterials. 2012 Oct;33(30):7613-20. doi: 10.1016/j.biomaterials.2012.06.075. Epub 2012 Jul 15.

PMID: 22800537


2

Role of intercellular adhesion molecule-2 in osteoclastogenesis.

Li X, Akiyama M, Nakahama K, Koshiishi T, Takeda S, Morita I.

Genes Cells. 2012 Jul;17(7):568-75. doi: 10.1111/j.1365-2443.2012.01608.x. Epub 2012 May 31.

PMID: 22646472 Free Article


3

The role of the Cx43 C-terminus in GJ plaque formation and internalization.

Wayakanon P, Bhattacharjee R, Nakahama K, Morita I.

Biochem Biophys Res Commun. 2012 Apr 6;420(2):456-61. doi: 10.1016/j.bbrc.2012.03.018. Epub 2012 Mar 10.

PMID: 22430144


2011 (H23)

1

Cell-printing and transfer technology applications for bone defects in mice.

Tsugawa J, Komaki M, Yoshida T, Nakahama K, Amagasa T, Morita I.

J Tissue Eng Regen Med. 2011 Oct;5(9):695-703. doi: 10.1002/term.366. Epub 2011 Jan 10.

PMID: 21953867


2

The involvement of DNA and histone methylation in the repression of IL-1β-induced MCP-1 production by hypoxia.

Aoi Y, Nakahama K, Morita I, Safronova O.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):252-8. doi: 10.1016/j.bbrc.2011.09.066. Epub 2011 Sep 17.

PMID: 21951854


3

Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine, which may be associated with development of choroidal neovascularization.

Wang J, Ohno-Matsui K, Nakahama K, Okamoto A, Yoshida T, Shimada N, Mochizuki M, Morita I.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):e11-8. doi: 10.1161/ATVBAHA.110.215517. Epub 2011 Apr 28.

PMID: 21527754 Free Article


2010 (H22)


1

Cellular communications in bone homeostasis and repair.

Nakahama K.

Cell Mol Life Sci. 2010 Dec;67(23):4001-9. doi: 10.1007/s00018-010-0479-3. Epub 2010 Aug 8. Review.

PMID: 20694737


2

The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro.

Yuan J, Akiyama M, Nakahama K, Sato T, Uematsu H, Morita I.

Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):85-90. doi: 10.1016/j.prostaglandins.2010.04.001. Epub 2010 Apr 13.

PMID: 20394833


3

Implantation of capillary structure engineered by optical lithography improves hind limb ischemia in mice.

Akahori T, Kobayashi A, Komaki M, Hattori H, Nakahama K, Ichinose S, Abe M, Takeda S, Morita I.

Tissue Eng Part A. 2010 Mar;16(3):953-9. doi: 10.1089/ten.tea.2009.0097.

PMID: 19947885


2009 (H21)

1

Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein.

Obitsu S, Ahmed N, Nishitsuji H, Hasegawa A, Nakahama K, Morita I, Nishigaki K, Hayashi T, Masuda T, Kannagi M.

Arch Virol. 2009;154(9):1457-64. doi: 10.1007/s00705-009-0472-z. Epub 2009 Aug 14.

PMID: 19685004

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2

Regulation of chemokine gene expression by hypoxia via cooperative activation of NF-kappaB and histone deacetylase.

Safronova O, Pluemsampant S, Nakahama K, Morita I.

Int J Biochem Cell Biol. 2009 Nov;41(11):2270-80. doi: 10.1016/j.biocel.2009.05.003. Epub 2009 May 13.

PMID: 19446037

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3

Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes.

Kaneda M, Nomura SM, Ichinose S, Kondo S, Nakahama K, Akiyoshi K, Morita I.

Biomaterials. 2009 Aug;30(23-24):3971-7. doi: 10.1016/j.biomaterials.2009.04.006. Epub 2009 May 6.

PMID: 19423159

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4

The steady-state expression of connexin43 is maintained by the PI3K/Akt in osteoblasts.

Bhattacharjee R, Kaneda M, Nakahama K, Morita I.

Biochem Biophys Res Commun. 2009 May 1;382(2):440-4. doi: 10.1016/j.bbrc.2009.03.044. Epub 2009 Mar 13.

PMID: 19285956

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5

The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor.

Tsuchiya T, Nakahama K, Asakawa Y, Maemura T, Tanaka M, Takeda S, Morita M, Morita I.

Gynecol Endocrinol. 2009 Feb;25(2):104-9. doi: 10.1080/09513590802549841.

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2008 (H20)


1.Pluemsampant S, Safronova O, Nakahama K, Morita I. Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. Int. J. Cancer. 122(2):333-41, 2008

2.Kojima A, Nakahama K, Ohno-Matsui K, Shimada N, Mori K, Iseki S, Sato T, Mochizuki M, Morita I. Connexin 43 contributes to differentiation of retinal pigment epithelial cells via AMP signaling. Biochem. Biophys. Res. Commun., 366(2):532-8,2008

3.Kaneda M, Zhang D, Bhattacharjee R, Nakahama KI, Arii S, Morita I. Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43. Cancer Lett., 263(1): 53-60, 2008

4.Wang J, Ohno-Matsui K, Yoshida T, Kojima A, shimada N, Nakahama K, Safronova O, Iwara N, Saido TC, Mochizuki M, and Morita I. Altered function of factor caused by amiloid β: Implication for pathogensis of age-related macular degeneration from drusen. The Journal of Immunology, COMPLEMENT FACTOR I DYSFUNCTION CAUSED BY Aβ:712-720, 2008

5.Hayashi H, Nakahama K, Sato T, Tuchiya T, Asakawab Y, Maemura T, Tanaka M, Morita M, Morita  I. The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-jB ligand. FEBS Letters 582 :3243–3248, 2008

6.Takehiko Tsuchiya, Ken-ichi Nakahama, Yasuyuki Asakawa, Toshimitu Maemura, Masanobu Tanaka, Satoru Takeda, Mineto Morita, & Ikuo Morita, The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor., Gynecological Endocrinology, 2008, in press.


2007H19


1.Zhang D, Kaneda M, Nakahama K, Arii S, Morita I. Connexin 43 expression malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communication. Cancer Letters, 252(2): 208-215, 2007

2.Chen BK, Huang CC, Chang WC, Chen YJ, Kikkawa U, Nakahama KI, Morita I, Chang WC. PP2B-mediated Dephosphorylation of c-Jun C-Terminus Regulates Phorbol Ester-induced c-Jun/Sp1 interaction in A431 Cells. Mol. Biol. 18(3): 1118-27, 2007

3.Kakehi S, Nakahama K, Morita I. Expression and possible role PVR/CD155/Necl-5 in osteoclastogenesis. Mol. Cell. Biochem., 301(1-2): 209-17, 2007

4.Xu JW, Morita I, Ikeda K, Miki T, Yamori Y. C-reactive protein suppresses insulin signaling in endothelial cells. Role of Syk tyrosine kinase . Mol Endocrinol., 21(2) : 564-73, 2007

5.Zhao C, Fujinaga R, Tanaka M, Yanai A, Nakahama K, Shinoda K. Region-specific expression and sex-steroidal regulation on aromatase and its mRNA in the male rat brain: Immunohistochemical and in situ hybridization analyses. The Journal of Comparative Neurology, 500:557-573, 2007

6.Techawattanawisal W, Nakahama K, Komaki M, Abe M, Takagi Y, Morita I. Isolation of multipotent stem cells from adult rat periodontal ligment by neurosphere-forming culture system. Biochem. Biophys. Res. Commun., 357(4):917-923, 2007

7.Kobayashi A, Miyake H, Hattori H, kuwana R, Hiruma Y, Nakahama K, Ichinose S, Ota M, Nakamura M, Takeda S and Morita I. In vitro formation of full capillary networks using optical lithographic techniques. Biochem. Biophys. Res. Commun., 358(3): 692-7, 2007

8.Mukai N, Akahori T, Komaki M, Li Q, Kanayasu-Toyoda T, Ishii-Watabe A, Kobayashi A, Yamaguchi T, Abe M, Amagasa T, Morita I. A Comparison of the tube forming potentials of early and late endothelial progenitor cells. Exp. Cell Res., 2007



2006H18


1.Kojima T, Nakahama K, Yamamoto K, Uematsu H and Morita I. Age- and cell cycle-dependent changes in EPC-1/PEDF promoter activity in human diploid fibroblast-like (HDF) cells. Mol.  Cell. Biochem., 293(1-2): 63-69, 2006

2.Hong J, Yokomakura A, Nakano Y, Ishihara K, Kaneda M, Onodera M, Nakahama K, Morita I, Miikura K, Ahn J-W, Zee OP and Ohuchi K. Inhibition of vascular-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosiss in RAW 264.7 cells. FEBS Lett., 580(11):2723-2730, 2006

3.Yoshimura H, Nakahama K, Safronova O, Tanaka N, Muneta T and Morita I. Transformation growth factor-b stimulates IL-1b-induced monocyte chemoattractant protein-1 in human synovial cells via the ERK/AP-1 pathway. Inflammation Res., 55(12): 543-549, 2006

4.Ohno-Matsui K, Mori K, Ichinose S, Sato T, Wang J, Shimada N, Kijima A, Mochizuki M and Morita I. In vitro and in vivo characterization of iris pigment epithelial cells cultured on amniotic membranes. Mol. Vis., 12:1022-32, 2006

5.Nakatomi

6.M, Morita I, Eto K, Ota MS. Sonic hedgehog signaling is involved in tooth root development. J. Dent. Res., 85(5): 427-31, 2006



2005H17


1.Kim Y, Sato K, Asagiri M, Morita I, Soma K and Takayanagi H. Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclastassociated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. J. Biol. Chem., 280(38):32905-32913, 2005

2.Kubota K, Kubota T, Kamei D, Murakami M, Kudo I, Aso T and Morita I. Change in prostaglandin E synthases on mPGES-1 knockout mice in prêterm delivery model. J.  Endocrinol., 187:339-345, 2005

3.Asagiri M, Sato K, Usami T, Ochi S, Nishida H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E & Takayanagi H. Autoamplification of NFATc1 determines its essential role in bone homeostasis. J. Exp. Med., 202(9):1261-1269, 2005

4.Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saudo T, Hisatomi T, Mochizuki M and Morita I. The Potential role of amyloid-β in the phatogenesis of age-related macular degeneration. J. Clin Invest., 115:2793-2800, 2005

5.Hosomichi J, Yasui N, Koide T, Soma K, Morita I. Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor. Biochem. Biophys. Res. Commun., 335:756-761, 2005

6.Ohno-Matusi K, Ichinose S, Nakahama K, Yoshida T, Kojima A, Mochizuki M, Morita I. The effects of amniotic membrane on retinal pigment epithelial cell differentiation. Mol Vis., 11:1-10, 2005

7.Nakamura M, Kobayashi A, Takagi F, Watanabe A, Hiruma Y, Ohuchi K, Iwasaki Y, Horie M, Morita I, Takatani S. Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Engineering 11(11/12); 1658-1666,2005



2004H16


1.Asami-Miyagishi R, Iseki S, Usui M, Uchida K, Kudo H, Morita I. Expression and function of PPARγ in rat placental development. Biochem.Biophys. Res.Commun., 315(2):497-501, 2004

2.Tanaka N, Sato T, Fujita H, Morita I. Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis. Arterioscler.Thromb.Vasc.Biol.,24(3): 607-612, 2004

3.Hiruma Y, Nakahama K, Fujita H, Morita I. Vitamin K2 and geranylgeraniol, its side component, inhibited osteoclast formation in a different manner. Biochem.Biophys.Res.Commun., 314(1): 24-30, 2004

4.Onodera M, Horiuchi Y, Nakahama K, Muneta T, Mano Y, Morita I. Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients. Inflamm Res. 53(6):217-22, 2004

5.Arikawa T, Omura K, Morita I. Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells. J.Cell.Physiol., 200:400-406,2004

6.Iwasaki T, Nakahama K, Nagano M, Fujioka A, Ohyanagi H, Shigeyoshi Y. A partial hepatectomy results in altered expression of clock-related and cyclic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) genes. Life Sci. 7;74(25):3093-102, 2004

7.Fujinaga R, Kawano J, Matsuzaki Y, Kamei K, Yanai A, Sheng Z, Tanaka M, Nakahama K, Nagano M, and Shinoda K. Neuroanatomical Distribution of Huntingtin-Associated Protein 1-mRNA in the Male Mouse Brain. The Journal of Comparative Neurologu, 478:88-109 2004



2003H15


1.Morishima S. Morita I. Tokushima T. Kawashima H. Miyasaka M. Omura K. Murota S. Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation. Journal of Endocrinology. 176:285-292, 2003

2.Zhang Y, Nakayama K, Nakayama K, Morita I. A novel route for Connexin 43 to inhibit cell proliferation: Negative regulation of S-phase kinase-associated protein. Cancer Research, 3: 1623-1630, 2003

3.Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T. The homeodomain proteins, MEIS1 and PBXs, regulate the lineage specific transcription of the platelet factor 4 gene. Blood, 68:337-342, 2003

4.Tsuji M, Murota S, Morita I. Docosapentaenoic acid (22:5,n-3) suppressed tube forming activity in endothelial cells induced by vascular endothelial growth factor. Prost. Leuko.Essent. Fatty Acid., 68:337-342, 2003

5.Miyagishi D, Amagasa T, Murota S, Morita I. Regulation of the expression of pigment pithelium-derived factor, an anti-angiogenic factor in human oral squamous cell carcinoma cell lines. Cancer Letter, 30;196(1):77-85, 2003

6.Ohno-Matsui K, Yoshida T, Uetama T, Mochizuki M, Morita I. Vascular endothelial growth factor upregulates pigment epithelium-derived factor expression via VEGFR-1 in human retinal pigment epithelial cells. Biochem.Biopys.Res.Commun., 1303:962-967, 2003

7.Yoshino H, Morita I, Murota S, Ishikawa I. Mechanical stress regulates production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J.Periodont.Res., 38:405-10, 2003

8.Sato T, Ono M, Fujita H, Tanaka N, Tomiyama N, Sakamoto Y, Takano Y, Murota S, Morita I. Development of a liquid culture system for megakaryocyte terminal differentiation: Fibrinogen promotes megakaryocytopoiesis but not thrombopoiesis. British J.Haematal., 121:315-323, 2003

9.Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I. Doi T. REP1, MEIS1 homolog protein, regulates PF4 gene expression.  Biochem.Biophys.Res.Commum., 305:155-159, 2003

10.Satoh S, Matsumura H, Nakajima T, Nakahama K, Kanbayashi T, Nishino S, Yoneda H and Shigeyoshi Y. Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons European Journal of Neuroscience, Vol. 17, pp.1635-1645

11.Masumoto K, Fujioka A, Nakahama K, Inouye ST and Shigeyoshi Y. Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription. Biochem.Biophys.Res.Commun., 306:781-785, 2003

12.Nagano M, Adachi A, Nakahama K, Nakamura T, Tamada M, Meyer-Bernstein E, Sehgal A, Shigeyoshi Y. An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. J Neurosci., 9;23(14):6141-51. 2003

13.Zhang YW, Kaneda M, Morita I. The gap junction-independent tumor suppressing effect of connexine43. J.Biol.Chem., 278:44852-44856, 2003

14.Yu T, Morita I, Shimokado K, Iwai T, Yoshida M. Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction. Hypertension. 42:329-334. 2003

15.Fujita H, Morita I, Takase H, Ohno-Matsui K, Mochizuki M. Prolonged exposure to high glucose impaired cellular behavior of normal human corneal epithelial cells. Current Eye Research. 27:197-203, 2003

16.Uetama T, Ohno-Matsui K, Nakahama K, Morita I, Mochizuki M. Phenotypic change regulates monocyte chemoattractant protein-1 (MCP-1) gene expression in human retinal pigment epithelial cells. J.Cell Physiol., 197:77-85, 2003

17.Ohno-Matsui K, Uetama T, Yoshida T, Hayano M, Itoh T, Morita I, Mochizuki M. Reduced retinal angiogenesis in MMP-2-deficient mice. Invest.Ophthalmol.Visual.Sci., 44:5370-5375, 2003

18.Safronova O, Nakahama K, Onodera M, Muneta T, Morita I. Effect of hypoxia on monocytic protein-1 (MCP-1) gene expression induced by IL-1b in human synovial fibroblast. Inflamm.Res., 52:480-486, 2003

19.Himi T, Ikeda M, Yasuhara T, Nishida M, Morita I. Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons. J.Neural transmission, 110(12):1337-1348, 2003



2002H14


1.Wang J, Morita I, Onodera M, Murota S. Induction of KDR expression in bovine arterial endothelial cells by thrombin: involvement of nitric oxide. J.Cell.Physiol., 190:238-259, 2002

2.Zhang Y.W, Yao X.S, Murota S, Morita I.  Inhibitory effects of eicosapentaenoic acid (EPA) on the hypoxia/reoxygenation- induced tyrosine kinase activation in cultured human umbilical vein endothelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2002

3.Nakahama K, Fujioka A, Nagano M, Satoh S, Furukawa K, Sasaki H, Shigeyoshi Y. A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes. Genes to Cells. 2002;27: 731-741

4.Ueda H, Chen W, Adachi A, Wakamatsu H, Hayashi S, Takasugi T, Nagano N, Nakahama K, Suzuki Y, Sugano S, Iino M, Shigeyoshi Y Hashimoto E. A transcription factor response element for gene expression during circadian night. Nature. 2002; 418: 534-539

5.Morita I. Distinct functions of COX-1 and COX-2. Prostaglandins other lipid mediat. 68-69:165-175, 2002

6.Fujita H, Morita I, Takase H, Ohno-Matsui K, Murota S, Mochizuki M. The effect of high glucose on proliferation. Adhesion and migration of normal human corneal epithelial cells. Invest.Ophth. Vis.Sci., 43: 1635 Suppl. 1 MAY 2002



2001H13


1.Xu J-W, Morita I, Murota S. Role of SERCA2b in mobilization of nuclear Ca2+ in Hela cells. J. Med.Dent.Sci., 48:51-59, 2001

2.Zhang L, Himi T, Morita I, Murota S. Inhibition of phosphatidylinositol-3 kinase / Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-α cytotoxicity. Cell Death and Differentiation, 8:528-536, 2001

3.Taniguchi Y, Morita I, Kubota T, Murota S, Aso T. Human uterine myometrial smooth muscle cell proliferation and vascular endothelial growth-factor production in response to platelet-derived growth factor. J.Endocrinol., 169:79-86, 2001

4.Zhang Y.W, Morita I, Ikeda M, Ma K, Murota S. Connexin43 suppresses proliferation of osteosarcoma U2OS cells through posttranscriptional regulation of p27. Abstracts of papers at the 2001 Salk Institute/EMBL meeting on “Oncogenes & Growthcontrol”, 2001;August 18-22

5.Sato T, Morita I, Fujita H, Ono M, Kinoshita A, Tomiyama J, Murota S. Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura. Platelet. 2001;12:156-162

6.Fujita H, Morita I, Murota S. Hydrogen peroxide induced apoptosis of endothelial cells concomitantly with cycloheximide. J.Atheroscler.Thromb., 2001;7:209-215

7.Sato T, Morita I. Development of a liquid culture system for megakaryocyte terminal differentiation : fibrinogen promotes megakaryocytopoiesis but not thrombopoiesis. British Journal of Haematology. in press

8.Ohno-Matsui K, Morita I, Tombran-Tink J, Mrazek D, Onodera M, Uetama T, Hayano M, Murota S, Mochizuki M. Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factor VEGF and PEDF. J.Cell.Physiol., 189:323-333, 2001