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メディカル統計数理研究部門

生物統計学分野

Department of Biostatistics

生物統計学(Biostatistics)の視点から、医学・歯学・医療にフォーカスしたデータ分析のための方法論を開発し、さらに統計学の応用を通して実践的なＭ＆Ｄ領域研究を推進していきます。

メンバー

研究プロジェクト

M&D分野データ分析のための方法論開発

M&D分野のデータ分析のための生物統計学的な方法論の開発を行っています。特に地理・時間情報を利用した空間疫学研究、感染症サーベイランス・モニタリング、複雑かつ精緻でない医療リアルワールドデータ（RWD）分析、多元的なエビデンスやモデルの統合に向けたメタアナリシス、ダイナミックモデリングなどにおける問題解決のための新たな統計的方法の開発とともに、実践的な応用研究、普及に向けたソフトウェアの開発も進めています。

新型インフルエンザ発生時におけるNYC保健局サーベイランスデータ解析

新型インフルエンザ発生時におけるNYC保健局サーベイランスデータ解析

用量反応関係のメタアナリシス（コーヒー摂取量と大腸がんの関係）

用量反応関係のメタアナリシス
（コーヒー摂取量と大腸がんの関係）

実践的なＭ＆Ｄ領域研究の推進

医学・歯学・医療分野の専門家と協力し、M&D領域の研究の発展・さらなる向上を目指した共同研究を推進しています。臨床研究・試験、観察研究、基礎実験研究など様々な研究において、研究設計から統計解析まで協業し、実践していきます。さらにデータサイエンスとしての視点から、新たな横断的研究の提案と実践、健診・検査・診療データなど、Ｍ＆Ｄデータの有効的な活用研究の推進も目指しています。

最近の主な研究業績

2022

  1. Iwakawa H, Takigawa M, Goya M, Iwata T, Martin CA, Anzai T, Takahashi K, Amemiya M, Yamamoto T, Sekigawa M, Shirai Y, Tao S, Hayashi T, Takahashi Y, Watanabe H, Sasano T. Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: An ex vivo study. J Interv Card Electrophysiol. 2022; 63: 185-195.
  2. Takigawa M, Goya M, Iwakawa H, Marin CA, Anzai T, Takahashi K, Kamata T, Matsumura Y, Amemiya M, Yamamoto T, Hirao T, Sekigawa M, Shirai Y, Tao S, Takahashi Y, Sasano T. Impact of a formula combining local impedance and conventional parameters on lesion size prediction. J Interv Card Electrophysiol. 2022; 63: 389-398.
  3. Nakaya T, Takahashi K, Takahashi H, Yasumura S, Ohira T, Shimura H, Suzuki S, Suzuki S, Iwadate M, Yokoya S, Ohto H, Kamiya K. Revisiting the geographical distribution of thyroid cancer incidence in Fukushima Prefecture: analysis of the data from the second and third round ultrasound examinations of the Fukushima Health Management Survey. J Epidemiol. (in press)
  4. Ishikawa T, Fukui S, Fujita J, Fujikawa A, Iwahara Y, Takahashi K. Factors related to end-of-life care discussion among community-dwelling people in Japan. J Pain Symptom Manage. 2022; 63(4): 539-547.
  5. Sakakibara T, Shindo Y, Kobayashi D, Sano M, Okumura J, Murakami Y, Takahashi K, Matsui S, Yagi T, Saka H, Hasegawa Y. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study. BMC Pulm Med. 2022; 22: 34.
  6. Liu K, Kotani T, Nakamura K, Takai C, Morita Y, Ishii K, Fujizuka K, Daisetsu Y, Taniguchi D, Hamagami T, Shimojo N, Nitta M, Hongo T, Akieda K, Maeda A, Kaneko T, Sakuda Y, Andoh K, Nagatomi A, Tanaka Y, Irie Y, Kamijo H, Hanazawa M, Kasugai D, Matsuoka A, Oike K, Lefor AK, Takahashi K, Katsukawa H, Ogura T. Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicenter prospective observational cohort study in Japan. BMJ Open. 2022; 12: e054478.
  7. Sano M, Shindo Y, Takahashi K, Okumura J, Sakakibara T, Murakami Y, Iguchi M, Tagi T, Matsui S, Hasegawa Y. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia. J Infect Chemother. 2022; 28: 745-752.
  8. Yakuwa N, Takahashi K, Anzai T, Ito N, Goto M, Koinuma S, Uno C, Suzuki T, Watanabe O, Yamatani A, Murashima A. Pregnancy outcomes with exposure to second-generation antipsychotics during the first trimester. J Clin Psychiatry. 2022; 83(4):21m14081.
  9. Takahashi N, Matsuhisa T, Takahashi K, Ban N. Diversity of academic general medicine: A cross-sectional bibliometric study of original English-language research articles in general medicine and cardiology in Japan. Medicine. 2022; 101(11): e29072.
  10. Hatakeyama S, Goto M, Yamamoto A, Ogura J, Watanabe N, Tsutsumi S, Yakuwa N, Yamane R, Nagase S, Takahashi K, Kosaki R, Murashima A, Yamaguchi H. The safety of pranlukast and montelukast during the first trimester of pregnancy: a prospective, two-centered cohort study in Japan. Congenit Anom. 2022; 62(4): 161-168.
  11. Takahashi N, Matsuhisa T, Takahashi K, Aomatsu M, Mercer S, Ban N. A two-item version of the Japanese Consultation and Relational Empathy measure: A pilot study using secondary analysis of a cross-sectional survey in primary care. Fam Pract. (in press)
  12. Inose H, Hirai T, Yoshii T, Kimura A, Takeshita K, Inoue H, Maekawa A, Endo K, Miyamoto T, Furuya T, Nakamura A, Mori K, Kanbara S, Imagama S, Seki S, Matsunaga S, Takahashi K, Okawa A. Factors contributing to neck pain in patients with degenerative cervical myelopathy: a prospective multicenter study. J Orthop Surg. 2022; 30: 1-8.
  13. Liu K, Nakamura K, Kudchadkar S, Katsukawa H, Nydahl P, Wes E, Takahashi K, Inoue S, Nishida O. Mobilization and rehabilitation practice in ICUs during the COVID-19 pandemic. J Intensive Care Med. 2022; 37(9): 1256-1264.
  14. Amemiya M, Takigawa M, Goya M, Martin C, Anzai T, Takahashi K, Shimizu Y, Ikenouchi T, Kamata T, Yamamoto T, Nishimura T, Shirai Y, Tao S, Miyazaki S, Sasano T. Comparison of two catheters measuring local impedance: local impedance variation vs lesion characteristics and steam pops. J Interv Card Electrophysiol. (in press)
  15. Mitsumura T, Okamoto T, Tosaka M, Yamana T, Shimada S, Iijima Y, Sakakibara R, Shibata S, Honda T, Shirai T, Ishizuka M, Aiboshi J, Furusawa H, Tateishi T, Tamaoka M, Shigemitsu H, Arai H, Otomo Y, Tohda S, Anzai T, Takahashi K, Yasuda S, Miyazaki Y. SARS-CoV-2 RNA copy number is a factor associated with the mortality of COVID-19 and improves the predictive performance of mortality in severe cases. Jpn J Infect Dis. 2022; 75(5): 504-510.
  16. Liu K, Shibata J, Fukuchi K, Takahashi K, Sonoo T, Ogura T, Goto T. Optimal timing of introducing mobilization therapy for ICU patients with sepsis. J Intensive Care. 2022; 10: Article number 22.
  17. Inose H, Ariga A, Motoyoshi T, Fukushima K, Tomizawa S, Kato T, Takahashi K, Yoshii T, Okawa A. The real-world effect of 12 months of romosozumab treatment on patients with osteoporosis with a high risk of fracture and factors predicting the rate of bone mass increase: A multicenter retrospective study. JBMR Plus. 2022; 6(7): e10637.
  18. Shirahata T, Nishida Y, Sato H, Yogi S, Akagami T, Nagata M, Tanaka S, Nakamura H, Katsukawa F. Impact of non-exercise activity thermogenesis on physical activity in patients with COPD. Sci. Adv. 2022; 105(3): 368504221117064.
  19. Shirahata T, Sato H, Yogi S, Inoue K, Niitsu M, Miyazaki H, Akagami T, Soma M, Mio T, Nagata M, Nishida Y, Tanaka S, Katsukawa F, Nakamura H. Possible association of high-density lipoprotein cholesterol levels with trunk muscle deficits and decrease in energy expenditure in patients with or at risk for COPD: A pilot study. Respir Investig. 2022; 60(5): 720-724.
  20. Murakami Y, Shindo Y, Sano M, Okumura J, Kobayashi H, Sakakibara T, Iguchi M, Takahashi K, Yagi T, Matsui S, Hasegawa Y. Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia. Scientific Reports. 2022; 12: 14564.
  21. Wang Q, Edahiro Y, Namkoong H, Hasegawa T, et al. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nature Communications. 2022; 13: Article number 4830.
  22. Nishida K, Usami T, Matsumoto N, Nishikimi M, Takahashi K, Matsui S. The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department. Nagoya J. Med. Sci. 2022; 84: 621-629.
  23. Morita A, Takahashi Y, Takahashi K, Fujiwara T. Depressive symptoms homophily among community-dwelling older adults in Japan: A social networks analysis. Frontiers Public Health. 2022; 10: 965026.
  24. Namkoong H, Edahiro R, Takano T, Nishihara H, et al. DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature. 2022; 609: 754-760.
  25. Oi K, Arai H, Nagaoka E, Fujiwara T, Oishi K, Takeshita M, Anzai T, Mizuno T. Long-term outcomes of papillary muscle relocation anteriorly for functional mitral regurgitation. Interact Cardiovasc Thorac Surg. (in press)
  26. Endo A, Yamawaka K, Tagami T, Umemura Y, Takahashi K, Nagasawa H, Araki Y, Kojima M, Sera T, Yagi M, Yamamoto R, Takahashi J, Nakane M, Takeda C, Narita C, Kazuma S, Okura H, Takahashi H, Wada T, Tahara S, Matsuoka A, Masaki T, Shiraishi A, Shimoyama K, Yokokawa Y, Nakamura R, Sageshima H, Yanagida Y, Takahashi K, Otomo Y. Optimal target blood pressure in elderly with septic shock (OPTPRESS) trial: study protocol for a randomized controlled trial. Trials. 2022; 23: 799.
  27. Kikuchi K, Anzai T, Takahashi K. The unusual increase in suicides among women in Japan during the COVID-19 pandemic: A time-series analysis until October 2021. J Epidemiol. (in press)
  28. Anzai T, Kikuchi K, Fukui K, Ito Y, Takahashi K. Have restrictions on human mobility impacted suicide rates during the COVID-19 pandemic in Japan? Psychiatry Res. (in press)

2021

  1. Inose H, Kato T, Nakamura H, Hoshino M, Togawa D, Hirano T, Tokuhashi Y, Ohba T, Haro H, Tsuji T, Sato K, Sasao Y, Takahata M, Otani K, Momoshima S, Takahashi K, Yuasa M, Hirai T, Yoshii T, Okawa A. Predictors for quality of life improvement after acute osteoporotic vertebral fracture: Results of post hoc analysis of a prospective randomized study. Qual Life Res. 2021; 30 (1): 129-135.
  2. Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H. Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study. Mod Rheumatol. 2021; 31 (1): 42-52.
  3. Anzai T, Fukui K, Ito T, Ito Y, Takahashi K. Excess Mortality from suicide during the early COVID-19 pandemic period in Japan: A time-series modeling before the pandemic. J Epidemiol. 2021; 31 (2): 152-156.
  4. 高橋邦彦. 保健医療のための空間データサイエンス. 医学のあゆみ 2021; 276 (9): 843-848.
  5. Ito T, Sugasawa S. Improved confidence regions in meta-analysis of diagnostic test accuracy. Comp Stat Data Analysis. 2021; 153: 107068.
  6. Iijima Y, Okamoto T, Shirai T, Mitsumura T, Sakakibara R, Honda T, Ishizuka M, Tateishi T, Tamaoka M, Aiboshi J, Otomo Y, Anzai T, Takahashi K, Miyazaki Y. MuLBSTA score is a useful tool for predicting COVID-19 disease behavior. J Infect Chemother. 2021; 27 (2): 284-290.
  7. Mitsumura T, Okamoto T, Shirai T, Iijima Y, Sakakibara R, Honda T, Ishizuka M, Aiboshi J, Tateishi T, Tamaoka M, Shigemitsu H, Arai H, Otomo Y, Tohda S, Anzai T, Takahashi K, Yasuda S, Miyazaki Y. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia. J Infect Chemother. 2021; 27 (6): 857-863.
  8. Ito T, Kubokawa T. Corrected empirical Bayes confidence region in a multivariate Fay-Herriot model. J Stat Plan Inf. 2021; 211: 12-32.
  9. Fujimoto A, Anzai T, Fukuda T, Uchida N, Ohta T, Mori T, Sawa M, Yoshioka S, Miyamoto T, Uchiyama H, Katayama Y, Matsuoka K, Shiratori S, Nakazawa H, Kanda J, Ichinohe T, Atsuta Y, Fujita N, Kondo E, Suzuki R. Impact of event-free survival status after stem cell transplantation on subsequent survival of patients with lymphoma. Blood Adv. 2021; 5 (5): 1412-1424.
  10. Inose H, Hirai T, Yoshii T, Kimura A, Takeshita K, Inoue H, Maekawa A, Endo K, Furuya T, Nakamura A, Mori K, Kanbara S, Imagama S, Seki S, Matsunaga S, Takahashi K, Okawa A. Predictors associated with neurological recovery after anterior decompression with fusion for degenerative cervical myelopathy. BMC Surg. 2021; 21 (1): 144.
  11. Isumi A, Takahashi K, Fujiwara T. Prenatal sociodemographic factors predicting maltreatment of children up to 3 years old: A prospective cohort study using administrative data in Japan. Int J Environ Res Public Health. 2021; 18 (5): 2505.
  12. Liu K, Nakamura K, Katsukawa H, Elhadi M, Nydahl P, Ely E W, Kudchadkar S R, Takahashi K, Inoue S, Lefor A K, Kesecioglu J, Nishida O. ABCDEF bundle and supportive ICU practices for patients with coronavirus disease 2019 infection: An international point prevalence study. Crit Care Explor. 2021; 3 (3): e0353.
  13. Matsuhisa T, Takahashi N, Takahashi K, Yoshikawa Y, Aomatsu M, Sato J, Mercer S W, Ban N. Effect of physician attire on patient perceptions of empathy in Japan: A quasi-randomized controlled trial in primary care. BMC Fam Pract. 2021; 22 (1): 59.
  14. Ito T, Kubokawa T. Empirical best linear unbiased predictors in multivariate nested-error regression models. Commun Stat Theory Methods. 2021; 50(10): 2224-2249.
  15. Sato R, Hasegawa D, Hamahata N, Narala S, Nishida K, Takahashi K, Sempokuya T, Daoud G. The predictive value of airway occlusion pressure at 100 msec (P0.1) on successful weaning from mechanical ventilation: A systematic review and meta-analysis. J Crit Care. 2021; 63: 124-132.
  16. Inose H, Kato T, Ichimura S, Nakamura H, Hoshino M, Togawa D, Hirano T, Tokuhashi Y, Ohba T, Haro H, Tsuji T, Sato K, Sasao Y, Takahata M, Otani K, Momoshima S, Takahashi K,Yuasa M, Hirai T, Yoshii T, Okawa A. Risk factors for subsequent vertebral fracture after acute osteoporotic vertebral fractures. Eur Spine J. 2021; 30: 2698-2707.
  17. Inose H, Yoshii T, Kimura A, Takeshita K, Inoue H, Maekawa A, Endo K, Miyamoto T, Furuya T, Nakamura A, Mori K, Kanbara S, Imagama S, Seki S, Matsunaga S, Takahashi K, Okawa A. Predictors of falls in patients with degenerative cervical myelopathy: A prospective multi-institutional study. Spine (Phila Pa 1976). 2021; 46(15): 1007-1013.
  18. Morisawa J, Otani T, Nishino J, Emoto R, Takahashi K, Matsui S. Semi-parametric empirical Bayes factor for genome-wide association studies. Eur J Hum Genet. 2021; 29: 800-807.
  19. Hasegawa D, Sato R, Prasitlumkum N, Nishida K, Takahashi K, Yatabe T, Nishida O. Effect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation: A systematic review and meta-analysis of randomized controlled trials. Chest. 2021; 159(6): 2289-2300.
  20. Fukasawa T, Takahashi H, Takahashi K, Tanemura N, Amagai M, Urushihara H. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with anticonvulsants in a Japanese population: Matched case-control and cohort studies. Allergol Int. 2021; 70(3): 335-342.
  21. Hishinuma K, Yamane R, Yokoo I, Arimoto T, Takahashi K, Goto M, Saito Y, Nakajima K, Murashima A, Hayashi M. Pregnancy outcome after first trimester exposure to domperidone-an observational cohort study. J Obstet Gynaecol Res. 2021; 45(5): 1704-1710.
  22. Kohno C, Kaneko K, Takahashi K. Ohya Y, Nakajima H, Murashima A. Intrauterine exposure to immunosuppressantsinfluences the development of postnatal allergic diseases. Allergy. 2021; 76(9): 2890-2893.
  23. Otani T, Takahashi K. Flexible scan statistics for detecting spatial disease clusters: The rflexscan R package. J Stat Softw. 2021; 99(13): 1-29.
  24. Kasugai D, Ozaki M, Nishida K, Goto Y, Takahashi K, Matsui S, Matsuda N. Relative platelet reduction provides a better pathophysiologic signature of coagulopathy in sepsis than absolute platelet count: A large multicenter eICU database analysis. Sci Rep. 2021; 11(1): 14033.
  25. Anzai T, Yamauchi T, Ozawa M, Takahashi K. A generalized structural equation model approach to long working hours and near-misses among healthcare professionals in Japan. Int J Environ Res Public Health. 2021; 18(13): 7154.
  26. Ejima M, Okamoto T, Suzuki T, Anzai T, Takahashi K, Miyazaki Y. Efficacy of treatment with corticosteroids for fibrotic hypersensitivity pneumonitis: a propensity score-matched cohort analysis. BMC Pulm Med. 2021; 21(1): 243.
  27. Liu K, Nakamura K, Katsukawa H, Nydahl P, Ely EW, Kudchadkar S, Takahashi K, Elhadi M, Gurjar M, Leong BK, Chung CR, Balachandran J, Inoue S, Lefor A, Nishida O. Implementation of the ABCDEF bundle for critically ill ICU patients during the COVID-19 pandemic: A multi-national one-day point prevalence study. Front Med. 2021; 8, Article 735860: 1-13.
  28. Sato R, Hasegawa D, Nishida K, Takahashi K, Schleicher M, Chaisson N. Prevalence of pulmonary embolism in patients with acute exacerbations of COPD: A systematic review and meta-analysis. American J Emerg Med. 2021; 50: 606-617.
  29. 長谷川嵩矩, 安齋達彦, 高橋邦彦. AI・機械学習とデータサイエンス. 体育の科学 2021; 71(11): 764-768.
  30. Sato R, Hasegawa D, Prasitlumkum N, Ueoka M, Nishida K, Takahashi K, Nasu M, Dugar S. Effect of IV high-dose vitamin C on mortality in patients with sepsis: A systematic review and meta-analysis of randomized controlled trials. Crit Care Med. 2021; 49(12): 2121-2130.
  31. Fukui S, Ishikawa T, Iwahara Y, Fujikawa A, Fujita J, Takahashi K. Measuring well-being in older adults: identifying an appropriate single-item questionnaire. Geriatr Gerontol Int. 2021; 21(12): 1131-1137.
  32. Tanaka H, Lee H, Morita A, Namkoong H, Chubachi S, Kabata H, Kamata H, Ishii M, Hasegawa N, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Murakami K, Okada Y, Koike R, Kitagawa Y, Tokunaga K, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K, The Japan COVID-19 Task Force. Clinical characteristics of patients with coronavirus disease (COVID-19): Preliminary baseline report of Japan COVID-19 Task Force, a nationwide consortium to investigate host genetics of COVID-19. Int J Infect Dis. 2021; 113: 74-81.
  33. The COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature 2021; 600: 472-477.
  34. Shirahata T, Sato H, Yogi S, Inoue K, Niitsu M, Akagami T, Soma M, Mio T, Nagata M, Nakae S, Nishida Y, Tanaka S, Katsukawa F, Nakamura H. The product of trunk muscle area and density on the CT image is a good indicator of energy expenditure in patients with or at risk for COPD. Respir Res. 2021; 22(1): 18.
  35. Nishida Y, Nakamura H, Sasaki S, Shirahata T, Sato H, Yogi S, Yamada Y, Nakae S, Tanaka S, Katsukawa F. Evaluation of energy intake by brief-type self-administered diet history questionnaire among male patients with stable/at risk for chronic obstructive pulmonary disease. BMJ Open Respir Res. 2021; 8(1): e000807.
  36. Nishida Y, Tanaka S, Hatamoto Y, Hatanaka M, Ishikawa-Takata K, Abe T, Higaki Y, Katsukawa F. Impact of walking aids on estimating physical activity using a tri-axial accelerometer in frail older adults. BMJ Open Sport Exerc Med. 2021; 7(2): e001014.
  37. Sato H, Nakamura H, Nishida Y, Shirahata T, Yogi S, Akagami T, Soma M, Inoue K, Niitsu M, Mio T, Miyashita T, Nagata M, Nakae S, Yamada Y, Tanaka S, Katsukawa F. Energy expenditure and physical activity in COPD by doubly labelled water method and an accelerometer. ERJ Open Res. 2021; 7: 00407-2020.
  38. 西田優紀, 田中茂穂. 高齢者におけるエネルギー必要量の考え方と課題. 公衆衛生. 2021; 85: 513-518.

2020

  1. Takahashi K, Takahashi H, Nakaya T, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K. Factors influencing the proportion of non-examinees in the Fukushima Health Management Survey for childhood and adolescent thyroid cancer: Results from the baseline survey. J Epidemiol. 2020; 30(7): 301-308.
  2. Takahashi H. Yasumura S, Takahashi K, Ohira T, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Ishikawa T, Sakai A, Suzuki S, Yokoya S, Tanigawa K, Ohto H, Kamiya K. Nested matched case control study for the Japan Fukushima Health Management Survey's first full-scale (second-round) thyroid examination. Medicine. 2020; 99(27): e20440.
  3. Anzai T, Takahashi K, Watanabe M, Mochizuki M, Murashima A. Adverse event reports in patients taking psychiatric medication during pregnancy from spontaneous reports in Japan and the United States: an approach using latent class analysis. BMC Psychiatry. 2020; 20 (1): 118.
  4. Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial. Crit Care Explor. 2020; 2 (2): e0082.
  5. Yoshihara M, Kajiyama H, Tamauchi S, Iyoshi S, Yokoi A, Suzuki S, Kawai M, Nagasaka T, Takahashi K, Matsui S, Kikkawa F. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis. Jpn J Clin Oncol. 2020; 50 (2): 145-151.
  6. Takagi H, Hagiwara D, Handa T, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Iwama S, Goto M, Suga H, Banno R, Takahashi K, Matsui S, Arima H. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion. Endocr J. 2020; 67 (3): 267-274.
  7. Ito T, Kubokawa T. Robust estimation of mean squared error matrix of small area estimators in a multivariate Fay-Herriot model. Japanese Journal of Statistics and Data Science 2020; 3: 39-61.
  8. Takagishi M, Esaki N, Takahashi K, Takahashi M. Cytoplasmic dynein functions in planar polarization of basal bodies within ciliated cells. iScience. 2020; 23(6): 101213.
  9. Yoshihara M, Kajiyama H, Tamauchi S, Iyoshi S, Yokoi A, Suzuki S, Kawai M, Nagasaka T, Takahashi K, Matsui S, Kikkawa F. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis. Int J Gyn Obstetrics. 2020; 150(2): 177-183.
  10. Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. J Anesthesia. 2020; 34: 72-78.
  11. Ishimaru T, Fujino Y, Anzai T, Matsuda S, Tanaka Y. Validity and responsiveness of the Work Functioning Impairment Scale (WFun) in rheumatoid arthritis patients: A multicenter prospective study. Mod Rheumatol. 2020; 30(5): 821-827.
  12. Takahashi K, Shimadzu H. Detecting multiple spatial disease clusters: Information criterion and scan statistic approach. Int J Health Geogr. 2020; 19:33.
  13. Kasugai D, Hirakawa A, Ozaki M, Nishida K, Ikeda T, Takahashi K, Matsui S, Uenishi N. Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: a retrospective study. J Intensive Care Med. 2020; 35(11): 1285-1289.
  14. Yamauchi T, Takahashi K, Suka M, Sasaki T, Takahashi M, Yoshikawa T, Okoshi H, Umezaki S, Yanagisawa H. Longitudinal association between near-misses/minor injuries and moderate/severe injuries in industrial settings by presence/absence of depressive symptoms in a nationally representative sample of workers in Japan. Occup Environ Med. 2020; 77(22): 832-838.
  15. Emoto R, Kawaguchi A, Takahashi K, Matsui S. Effect-size estimation using semi-parametric hierarchical mixture models in disease-association studies with neuroimaging data. Comput Math Methods Med. 2020. Article ID 7482403.
  16. Isumi A, Doi S, Yamaoka Y, Takahashi K, Fujiwara T . Do suicide rates in children and adolescents change during school closure in Japan? The acute effect of the first wave of COVID-19 pandemic on child and adolescent mental health. Child Abuse Negl. 2020; 110 (Pt 2): 104680.
  17. Nishida Y, Tanaka S, Nakae S, Yamada Y, Shirato H, Hirano H, Sasaki S, Katsukawa F. Energy Gap between Doubly Labeled Water-Based Energy Expenditure and Calculated Energy Intake from Recipes and Plate Waste, and Subsequent Weight Changes in Elderly Residents in Japanese Long-Term Care Facilities: CLEVER Study. Nutrients. 2020; 12(9): 2677.
  18. Miyazawa I, Morino K, Fuse K, Kondo K, Ohi A, Nishida K, Kurihara M, Yasuhara S, Nakanishi N, Nishida Y, Nakae S, Yamada Y, Tanaka S, Ebine N, Sasaki S, Katsukawa F, Sasaki M, Ugi S, Maegawa H; CLEVER-DM Study Research Group. Impact of obesity on underreporting of energy intake in type 2 diabetic patients: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) study. Clin Nutr ESPEN. 2020; 39: 251-254.
  19. Nishida Y, Tanaka S, Nakae S, Yamada Y, Morino K, Kondo K, Nishida K, Ohi A, Kurihara M, Sasaki M, Ugi S, Maegawa H, Ebine N, Sasaki S, Katsukawa F. Validity of the Use of a Triaxial Accelerometer and a Physical Activity Questionnaire for Estimating Total Energy Expenditure and Physical Activity Level among Elderly Patients with Type 2 Diabetes Mellitus: CLEVER-DM Study. Ann Nutr Metab. 2020; 76(1): 62-72.

2019

  1. Anzai T, Takahashi K, Watanabe M. Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database. Psychiatry Clin. Neurosci.. 2019; 73 (1): 27-33.
  2. Okada E, Takahashi K, Nakamura K, Ukawa S, Takabayashi S, Nakamura M, Sasaki S, Tamakoshi A, Takimoto H. Dietary patterns and abnormal glucose tolerance among Japanese: findings from the National Health and Nutrition Survey, 2012. Public Health Nutr. 2019; 22 (13): 2460-2468.
  3. Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki S, Suzuki H, Nishikimi M, Komatsu M, Kawarai L, Mato M. A progressive early mobilization program is significantly associated with clinical and economic improvement: a single-center quality comparison study. Crit. Care Med.. 2019; 47 (9): e744-e752.
  4. Yamauchi T, Sasaki T, Takahashi K, Umezaki S, Takahashi M, Yoshikawa T, Suka M, Yanagisawa H. Long working hours, sleep-related problems, and near-misses/injuries in industrial settings using a nationally representative sample of workers in Japan. PLoS ONE. 2019; 14 (7): e0219657.
  5. Kawabata T, Emoto R, Nishino J, Takahashi K, Matsui S. Two-stage analysis for selecting fixed numbers of features in omics association studies. Stat Med. 2019; 38 (16): 2956-2971.
  6. Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation. 2019; 140 135-141.
  7. Nomura K, Hiyama T, Sakuta H, Matsuda T, Lin C, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M. [Na+] increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a. Neuron. 2019; 101 (1): 60-75.e6.
  8. Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Anaesthesia. 2019; 74 (12): 1558-1562.
  9. Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H. Steeper macular curvature in eyes with non-highly myopic retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci.. 2019; 60 (8): 3135-3141.
  10. Minakata Y, Motegi T, Ueki J, Gon Y, Nakamura S, Anzai T, Hirata K, Ichinose M. Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: post hoc analysis of the VESUTO study. Int J Chron Obstruct Pulmon Dis. 2019; 14: 1789-1801.
  11. Yoshihara M, Kajiyama H, Tamauchi S, Suzuki S, Takahashi K, Matsui S, Kikkawa F. Prognostic factors and effects of fertility-sparing surgery in woman of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis. Journal of Gynecologic Oncology 2018; 30(6): e102.
  12. Nishida Y, Kawai A, Toguchida J, Ogose A, Ae K, Kunisada T, Matsumoto Y, Matsunobu T, Takahashi K, Nishida K, Ozaki T. Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan. Int J Clin Oncol. 2019; 24: 1498-1505.
  13. Morino K, Kondo K, Tanaka S, Nishida Y, Nakae S, Yamada Y, Ugi S, Fuse K, Miyazawa I, Ohi A, Nishida K, Kurihara M, Sasaki M, Ebine N, Sasaki S, Katsukawa F, Maegawa H. Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study. BMJ Open Diabetes Res Care. 2019; 7(1): e000648.
  14. Nishida Y, Nakae S, Yamada Y, Kondo E, Yamaguchi M, Shirato H, Hirano H, Sasaki S, Tanaka S, Katsukawa F. Validity of One-Day Physical Activity Recall for Estimating Total Energy Expenditure in Elderly Residents at Long-Term Care Facilities: CLinical EValuation of Energy Requirements Study (CLEVER Study). J Nutr Sci Vitaminol. 2019; 65(2): 148-156.

2018

  1. 高橋邦彦. 薬剤使用の研究における統計的指標 臨床精神医学. 2018; 47 26-30.
  2. 高橋邦彦（翻訳, 編集委員）. 統計科学百科事典. 丸善出版. 2018.
  3. 高橋邦彦（分担執筆）. 新版医学統計学ハンドブック. 朝倉書店. 2018.
  4. Takahashi K, Shimadzu H. Multiple-cluster detection test for purely temporal disease clustering: Integration of scan statistics and generalized linear models. PLoS ONE. 2018; 13 (11): e0207821.
  5. Nakaya T, Takahashi K, Takahashi H, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K. Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture. Sci Rep. 2018; 8 (1): 17661.
  6. Kuriki S, Takahashi K, Hara H. Multiplicity adjustment for temporal and spatial scan statistics using Markov property Japanese Journal of Statistics and Data Science. 2018; 1 (1): 191-231.
  7. Igeta M, Takahashi K, Matsui S. Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Biometrics. 2018; 74 (4): 1459-1467.
  8. Horisaki K, Takahashi K, Ito H, Matsui S. A dose-response meta-analysis of coffee consumption and colorectal cancer risk in the Japanese population: application of a cubic-spline model. J Epidemiol. 2018; 28 (12): 503-509.
  9. Okada E, Takahashi K, Takimoto H, Takabayashi S, Kishi T, Kobayashi T, Nakamura K, Ukawa S, Nakamura M, Sasaki S, Tamakoshi A. Dietary patterns among Japanese adults: findings from the National Health and Nutrition Survey, 2012. Asia Pac J Clin Nutr. 2018; 27 (5): 1120-1130.
  10. Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki D, Suzuki H, Nishikimi M, Kawarai L, Mato T. The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study. J Intensive Care. 2018; 6 10.
  11. Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, Taniguchi H, Saka H, Matsui S, Hasegawa Y. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy. Respirology. 2018; 23 (5): 526-534.
  12. Fukamachi S, Hashiguchi M, Takahashi K, Mochizuki M. Exploratory evaluation of a commercially available Japanese medical record database as an external control for comparative clinical trials in new drug development: Amyotrophic lateral sclerosis Neurology and Clinical Neuroscience. 2018; 6 (4): 94-99.
  13. Matsuhisa T, Takahashi N, Aomatsu M, Takahashi K, Nishino J, Ban N, Stewart W Mercer. How many patients are required to provide a high level of reliability in the Japanese version of the CARE Measure? A secondary analysis. BMC Fam Pract. 2018; 19 (1): 138.
  14. Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H. Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naive rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study. Arthritis Res. Ther.. 2018; 20 (1): 151.
  15. Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K. Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity. Int J Chron Obstruct Pulmon Dis. 2018; 13 1407-1419.
  16. 遅野井健, 志岐甲介, 石田真大, 唯保祐介, 安齋達彦, 宮本悠希, 生島一平. 日本人健康成人男性を対象としたエンパグリフロジン・リナグリプチン配合錠のバイオアベイラビリティに対する食事の影響　ランダム化、単回投与、2群クロスオーバー試験 薬理と治療. 2018; 46 (3): 343-353.

連絡先

  • MAIL biostat.dsc@@tmd.ac.jp
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