Department of Biodesign, Institute of Biomaterial and Bioengineering, Tokyo Medical and Dental University



Surgical Manipulator System with Image-based Organ Motion Compensation

In the future, it is expected that tissue regenerative medicine will become an alternative to organ transplantation and artificial organs. In our project, we are developing supporting devices for the transplantation of “cell sheets” produced in a temperature-responsive polymer-grafted culture dish, developed by the Institute of Advanced Biomedical Engineering and Science (ABMES), Tokyo Women's Medical University.

Instructions:“Cell Sheet Engineering” (ABMES, TWMU)

However, a cell sheet is very weak tissue because it comprises only one layer of cells. It is quite difficult to fabricate, and complicated techniques are required to handle and transplant it into a patient. We are developing some devices and methodologies to support the safe and precise transplantation of a cell sheet. We focused on a device to handle a weak cell sheet fabricated in a temperature-responsive culture dish and transplant it to a patient and to measure the heart motion, and we are planning to develop a total manipulation system to transplant a myocardial cell sheet to the beating heart of a patient without any damage to both the patient and the cell sheet.

Fig. 4D Heart Motion Estimation for Cell Sheet Transplantation Manipulator

Fig. Surgical robot with a heart-surface-motion synchronization mechanism for myoblast cell sheet transplantation

Fig. Cell sheet handling device for heart regenerative therapy

Related publications

Kangyi Xu, Ryoichi Nakamura, A surgical robot with a heart-surface-motion synchronization mechanism for myoblast cell sheet transplantation, The 35th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC2013), Osaka, July 3-7, 2013, Proceedings pp.5690-5693

D. Hagihara, T. Takahashi, I. Sato, R. Nakamura, 3D Heart Surface Motion Measurement System Using Template Matching Method for Myocardial Cell Sheet Implantation, 27th International Congress on Computer Assisted Radiology and Surgery (CARS2013), Heidelberg, Germany, June 26-29, 2013, Int J of CARS, 8(suppl1):S116-117, 2013

D. Hagihara, I. Sato, R. Nakamura, Tracking of heart surface motion for myocardial cell sheet implantation, 26th International Congress on Computer Assisted Radiology and Surgery (CARS2012), Pisa, Italy, June 27-30, 2012, Int J of CARS, 7(suppl1):S386-7, 2012

Kentaro Nakajima, Kiyoshi Naemura, Ryoichi Nakamura, Tatsuya Shimizu, Teruo Okano, Preliminary study for transplantation-assist device of the myocardial cell sheets with hydrogel, The World Congress on Medical Physics and Biomedical Engineering WC2009, Munich, Germany, Sept 7-12, 2009