Our group, the Department of Organic Biomaterials, are now exploring a new paradigm of emerging biomedical functions using our supramolecular biomaterials. We focus on designing a variety of polyrotaxanes, a representative of supramolecular biomaterials in our group, in which a many cyclic molecules are threaded onto a polymer chain capped both terminals with bulky end-groups. Outstanding features toward biomaterials functions will be derived from structural characteristics of mechanically locked structures between cyclic molecules and a linear polymer chain in the polyrotaxanes: it is easily imagined that freely mobile nature of the cyclic molecules may contribute much to enhancing multivalent interaction with receptor proteins on cell membranes. Recently, we have clarified that the molecular mobility in polyrotaxanes is much related to directing stem cell fate: osteogenesis and adipogeness of mesenchymal stem cells are well directed via the mobility on biomaterials surfaces. Also, we have proposed that introducing biodegradable linkages at the terminals of the polyrotaxanes could achieve new functions of biodegradable polymers in intracellular organelles: for instance, releasing beta-cyclodextrins in endolysosomes has been clarified to impair cholesterol accumulation and its related diseases such as autophagic dysfunctions. Our research activity mentioned above is based on three great benefits: the time of our University mission requested from our Society, the location of our Institute very close to two Schools of Medicine and Dentistry on the campus, and the gathering of young scientists sympathized with our research strategy. It is convincing that the design of new biomaterials and their application in medical and dental fields can be strongly supported by these three advantages in our group. It is a historical fact that the paradigm shift of human society has been accomplished by the innovation of materials in many fields, and we believe that advanced medicines and therapeutics will be only achieved by the design of new biomaterials. Understanding the basis of biomaterials already established in the decades and the remaining issues to be solved in the field will finally bring about the design of innovative biomaterials eventually contributing to our human society. You may know that there are the words of article in the ZEN: Keikyoku-Rinchu-Ichijo-No-Michi (you can certainly explore one road even in a thorny forest). If starting research in our group, you will face many unexpected difficulties and problems not to go. However, you will soon understand every facing issue in your research lead to a long and winding load to your success in the future. Please join our group to explore new world of biomaterials together.
Message from the Chair
Recruitment for Graduate Students
In our laboratory, we are recruiting international graduate students If you are interested in our researches, please feel free to contact us. →E-mail address: orgbiomaterial■gmail.com（change ■ to @） →Admission guide（Link to our university）