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ホーム  > 神経病理学分野  > Publications

Publications

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2018

Okazawa, H. (2018)
Bridging Multiple Dementias.
ACS Chem. Neurosci. 9 (4), 636–638. doi: 10.1021/acschemneuro.8b00119

Kawahori, K., Hashimoto, K., Yuan, X., Tsujimoto, K., Hanzawa, N., Hamaguchi, M., Kase, S., Fujita, K., Tagawa, K., Okazawa, H., Nakajima, Y., Shibusawa, N., Yamada, M. & Ogawa, Y. (2018)
Mild Maternal Hypothyroxinemia During Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring.
Thyroid 28, 395–406. doi: 10.1089/thy.2017.0331

Fujita, K., Chen, X., Homma, H., Tagawa, K., Amano, M., Saito, A., Imoto, S., Akatsu, H., Hashizume, Y., Kaibuchi, K., Miyano, S. & Okazawa, H. (2018)
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Nat. Commun. 9, 433. doi: 10.1038/s41467-018-02821-z

2017

Fujita, K., Mao, Y., Uchida, S., Chen, X., Shiwaku, H., Tamura, T., Ito, H., Watase, K., Homma, H., Tagawa, K., Sudol, M. & Okazawa, H. (2017)
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Nat. Commun. 8, 1864. doi: 10.1038/s41467-017-01790-z

Okazawa, H. (2017)
Ultra-Early Phase pathologies of Alzheimer’s disease and other neurodegenerative diseases.
Proc. Japan Acad. Ser. B, Physical and biological sciences 93(6), 361–377. doi: 10.2183/pjab.93.022

Okazawa, H. (2017)
PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases.
Neurochem. Int. S0197–0186(17)30213–9. doi: 10.1016/j.neuint.2017.06.005

Sato, K., Kerever, A., Kamagata, K., Tsuruta, K., Irie, R., Tagawa, K., Okazawa, H., Arikawa-Hirasawa, E., Nitta, N., Aoki, I. & Aoki, S. (2017)
Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain.
Acta Radiol. open 6(4), 2058460117703816. doi: 10.1177/2058460117703816

Yamanishi, E., Hasegawa, K., Fujita, K., Ichinose, S., Yagishita, S., Murata, M., Tagawa, K., Akashi, T., Eishi, Y. & Okazawa, H. (2017)
A novel form of necrosis, TRIAD, occurs in human Huntington’s disease.
Acta Neuropathol. Commun. 5, 19. doi: 10.1186/s40478-017-0420-1

2016

Imamura, T., Fujita, K., Tagawa, K., Ikura, T., Chen, X., Homma, H., Tamura, T., Mao, Y., Taniguchi, J. B., Motoki, K., Nakabayashi, M., Ito, N., Yamada, K., Tomii, K., Okano, H., Kaye, J., Finkbeiner, S. & Okazawa, H. (2016)
Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.
Sci. Rep. 6, 33861. doi: 10.1038/srep33861

Mao, Y., Chen, X., Xu, M., Fujita, K., Motoki, K., Sasabe, T., Homma, H., Murata, M., Tagawa, K., Tamura, T., Kaye, J., Finkbeiner, S., Blandino, G., Sudol, M. & Okazawa, H. (2016)
Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington’s disease pathology.
Hum. Mol. Genet. 25, 4749–4770. doi: 10.1093/hmg/ddw303

Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., Matsumi, C., Kajikawa, M., Saito, T., Saido, T., Sobue, G., Miyawaki, A. & Okazawa, H. (2016)
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease.
Sci. Rep. 6, 31895. doi: 10.1038/srep31895

Taniguchi, J. B., Kondo, K., Fujita, K., Chen, X., Homma, H., Sudo, T., Mao, Y., Watase, K., Tanaka, T., Tagawa, K., Tamura, T., Muramatsu, S.-I. & Okazawa, H. (2016)
RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair.
Hum. Mol. Genet. 25, 4432–4447. doi: 10.1093/hmg/ddw272

Mao, Y., Tamura, T., Yuki, Y., Abe, D., Tamada, Y., Imoto, S., Tanaka, H., Homma, H., Tagawa, K., Miyano, S. & Okazawa, H. (2016)
The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.
Cell Death Dis. 7, e2207. doi: 10.1038/cddis.2016.101

Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y. & Okazawa, H. (2016)
Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.
FEBS Lett. 590, 2221–2231. doi: 10.1002/1873-3468.12256

2015

Chen, X., Kondo, K., Motoki, K., Homma, H. & Okazawa, H. (2015)
Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta.
Sci. Rep. 5, 12115. doi: 10.1038/srep12115

Kamagata, K., Kerever, A., Yokosawa, S., Otake, Y., Ochi, H., Hori, M., Kamiya, K., Tsuruta, K., Tagawa, K., Okazawa, H., Aoki, S. & Arikawa-Hirasawa, E. (2016)
Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain.
Magn. Reson. Med. Sci. 15 (4), 416–421. doi: 10.2463/mrms.bc.2015-0148

Shiwaku, H. & Okazawa, H. (2015)
Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders.
Curr. Mol. Med. 15 (2), 119–128. 10.2174/1566524015666150303002556 (review)

Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S. & Okazawa, H. (2015)
Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer’s disease brain.
Hum. Mol. Genet. 24 (2), 540–558. doi: 10.1093/hmg/ddu475

2014

Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S. G. M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E. E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V. M. & Okazawa, H. (2015)
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
Mol. Psychiatry 20 (4), 459–471. doi: 10.1038/mp.2014.69

Mizuguchi, M., Obita, T., Serita, T., Kojima, R., Nabeshima, Y. & Okazawa, H. (2014)
Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD.
Nat. Commun. 5 (1), 3822. doi: 10.1038/ncomms4822

Nabeshima, Y., Mizuguchi, M., Kajiyama, A. & Okazawa, H. (2014)
Segmental isotope-labeling of the intrinsically disordered protein PQBP1.
FEBS Lett. 588 (24), 4583–4589. doi: 10.1016/j.febslet.2014.10.028

Ito, H., Fujita, K., Tagawa, K., Chen, X., Homma, H., Sasabe, T., Shimizu, J., Shimizu, S., Tamura, T., Muramatsu, S. & Okazawa, H. (2015)
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
EMBO Mol. Med. 7 (1), 78–101. doi: 10.15252/emmm.201404392

Shiraishi, R., Tamura, T., Sone, M. & Okazawa, H. (2014)
Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression.
PLoS One 9 (12), e116567. doi: 10.1371/journal.pone.0116567

2013

Fujita, K., Nakamura, Y., Oka, T., Ito, H., Tamura, T., Tagawa, K., Sasabe, T., Katsuta, A., Motoki, K., Shiwaku, H., Sone, M., Yoshida, C., Katsuno, M., Eishi, Y., Murata, M., Taylor, J. P., Wanker, E. E., Kono, K., Tashiro, S., Sobue, G., La Spada, A. R. & Okazawa, H. (2013)
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Nat. Commun. 4, 1816. doi: 10.1038/ncomms2828

Li, C., Ito, H., Fujita, K., Shiwaku, H., Qi, Y., Tagawa, K., Tamura, T. & Okazawa, H. (2013)
Sox2 Transcriptionally Regulates Pqbp1, an Intellectual Disability-Microcephaly Causative Gene, in Neural Stem Progenitor Cells.
PLoS One 8 (7), e68627. doi: 10.1371/journal.pone.0068627

Shiwaku, H., Yagishita, S., Eishi, Y. & Okazawa, H. (2013)
Bergmann glia are reduced in spinocerebellar ataxia type 1.
Neuroreport 24 (11), 620–625. doi: 10.1097/WNR.0b013e32836347b7

Ikeuchi, Y., de la Torre-Ubieta, L., Matsuda, T., Steen, H., Okazawa, H. & Bonni, A. (2013)
The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.
Cell Rep. 4 (5), 879–889. doi: 10.1016/j.celrep.2013.07.042

Barclay, S. S., Tamura, T., Ito, H., Fujita, K., Tagawa, K., Shimamura, T., Katsuta, A., Shiwaku, H., Sone, M., Imoto, S., Miyano, S. & Okazawa, H. (2014)
Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.
Hum. Mol. Genet. 23 (5), 1345–1364. doi: 10.1093/hmg/ddt524

Okazawa, H. (2013)
HD Research Around the World: Japan. Past, Present, Future.
HD Insights 4, 7–8. link

2012

Rees, M., Gorba, C., de Chiara, C., Bui, T. T. T., Garcia-Maya, M., Drake, A. F., Okazawa, H., Pastore, A., Svergun, D. & Chen, Y. W. (2012)
Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.
Biophys. J. 102 (7), 1608–1616. doi: 10.1016/j.bpj.2012.02.047

Tamura, T., Sone, M., Nakamura, Y., Shimamura, T., Imoto, S., Miyano, S. & Okazawa, H. (2013)
A restricted level of PQBP1 is needed for the best longevity of Drosophila.
Neurobiol. Aging 34 (1), 356.e11-20. doi: 10.1016/j.neurobiolaging.2012.07.015

2011

Oka, T., Tagawa, K., Ito, H. & Okazawa, H. (2011)
Dynamic changes of the phosphoproteome in postmortem mouse brains.
PLoS One 6 (6), e21405. doi: 10.1371/journal.pone.0021405

Tamura, T., Sone, M., Iwatsubo, T., Tagawa, K., Wanker, E. E. & Okazawa, H. (2011)
Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington’s Disease.
PLoS One 6 (11), e27408. doi: 10.1371/journal.pone.0027408

Nakamura, Y., Tagawa, K., Oka, T., Sasabe, T., Ito, H., Shiwaku, H., La Spada, A. R. & Okazawa, H. (2012)
Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network.
Hum. Mol. Genet. 21 (5), 1099–1110. doi: 10.1093/hmg/ddr539

Enokido, Y. & Okazawa, H. (2012)
DNA repair in the nervous system: A new research for neurological disorders.
DNA Repair New Res. 79–106. Edited by Kimura, S. and Shimizu, S. Nova Science. (ISBN: 978-1-62100-756-2)