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主要論文

英文原著

2011年
  • H. Nambu, M. Fukushima, H. Hikichi, T. Inoue, N. Nagano, Y. Tahara, T. Nambu, J. Ito, Y. Ogawa, S. Ozaki, and H. Ohta. Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor. Life Sci.89: 765-772, 2011.
  • [PubMed]
  • M. Itoh, T. Suganami, N. Nakagawa, M. Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, and Y. Ogawa. Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis. Am. J. Pathol.179: 2454-2463, 2011.
  • [PubMed]
  • L. Zhang, T. Sugiyama, N. Murabayashi, T. Umekawa, N. Ma, Y. Kamimoto, Y. Ogawa, and N. Sagawa. The inflammatory changes of adipose tissue in late pregnant mice. J. Mol. Endocrinol. 47: 157-165, 2011.
  • [PubMed]
  • M. Tanaka, T. Suganami, M. Kim-Saijo, C. Toda, M. Tsuiji, K. Ochi, Y. Kamei, Y. Minokoshi, and Y. Ogawa. Role of central leptin signaling in the starvation-induced alteration of B cell development. J. Neurosci. 31: 8373-8380, 2011.
  • [PubMed]
  • S. Sugita, Y. Kamei, F. Akaike, T. Suganami, S. Kanai, M. Hattori, Y. Manabe, N. Fujii, T. Takai-Igarashi, M. Tadaishi, J. Oka, H. Aburatani, T. Yamada, H. Katagiri, S. Kakehi, Y. Tamura, H. Kubo, K. Nishida, S. Miura, O. Ezaki, and Y. Ogawa. Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle. PLoS ONE 6: e20467, 2011.
  • [PubMed]
  • M. Ichioka, T. Suganami, N. Tsuda, I. Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, and Y. Ogawa. Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 60: 819-826, 2011.
  • [PubMed]
  • N. Satoh-Asahara, T. Suganami, T. Majima, K. Kotani, Y. Kato, R. Araki, K. Koyama, T. Okajima, M. Tanabe, M. Oishi, A. Himeno, S. Kono, A. Sugawara, M. Hattori, Y. Ogawa, and A. Shimatsu; the Japan Obesity Metabolic Syndrome Study (JOMS) Group. Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome. Clin. J. Am. Soc. Nephrol. 6: 265-273, 2011.
  • [PubMed]
2010年
  • A. Sato, H. Kawano, T. Notsu, M. Ohta, M. Nakakuki, K. Mizuguchi, M. Itoh, T. Suganami, and Y. Ogawa. Anti-obesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis. Diabetes 59: 2495-2504, 2010.
  • [PubMed]
  • Y. Okazaki, N. Ohshima, I. Yoshizawa, Y. Kamei, S. Mariggiò, K. Okamoto, M. Maeda, Y. Nogusa, Y. Fujioka, T. Izumi, Y. Ogawa, Y. Shiro, M. Wada, N. Kato, D. Corda, and N. Yanaka. A novel glycerophosphodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism. J. Biol. Chem. 285: 27652-27663, 2010.
  • [PubMed]
  • K. Yamashiro, T. Sasano, K. Tojo, I. Namekata, J. Kurokawa, N. Sawada, T. Suganami, Y. Kamei, H. Tanaka, N. Tajima, K. Utsunomiya, Y. Ogawa, and T. Furukawa. Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem. Biophys. Res. Commun. 398: 284-289, 2010.
  • [PubMed]
  • T. Yamamoto, T. Suganami, M. Kiso-Narita, P. A. Scherle, Y. Kamei, M. Isobe, S. Higashiyama, and Y. Ogawa. Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro: role of a disintegrin and metalloproteinase 17. Obesity 18: 1888-1894, 2010.
  • [PubMed]
  • Y. Kamei, T. Suganami, T. Ehara, S. Kanai, K. Hayashi, Y. Yamamoto, S. Miura, O. Ezaki, M. Okano, and Y. Ogawa. Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice. Obesity 18: 314-321, 2010.
  • [PubMed]
  • Y. Yamazaki, Y. Kamei, S. Sugita, F. Akaike, S. Kanai, S. Miura, Y. Hirata, B.R. Troen, T. Kitamura, I. Nishino, T. Suganami, O. Ezaki, and Y. Ogawa. The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle. Biochem. J. 427: 171-178, 2010.
  • [PubMed]
  • N. Satoh, A. Shimatsu, A. Himeno, Y. Sasaki, H. Yamakage, K. Yamada, T. Suganami, and Y. Ogawa. Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: effect of pioglitazone. Diabetes Care 33: e7, 2010.
  • [PubMed]
  • M. Tanaka, T. Suganami, S. Sugita, Y. Shimoda, M. Kasahara, S. Aoe, M. Takeya, S. Takeda, Y. Kamei, and Y. Ogawa. Role of central leptin signaling in renal macrophage infiltration under unilateral ureteral obstruction. Endocr. J. 57: 61-72, 2010.
  • [PubMed]
2009年
  • T. Suganami, X. Yuan, Y. Shimoda, K. Uchio-Yamada, N. Nakagawa, I. Shirakawa, T. Usami, T. Tsukahara, K. Nakayama, Y. Miyamoto, K. Yasuda, J. Matsuda, Y. Kamei, S. Kitajima, and Y. Ogawa. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ. Res. 105: 25-32, 2009.
  • [PubMed]
  • M. Kawamura, H. Itoh, S. Yura, H. Mogami, T. Fujii, H. Makino, Y. Miyamoto, Y. Yoshimasa, S. Aoe, Y. Ogawa, N. Sagawa, N. Kanayama, and I. Konishi. Isocaloric high-protein diet ameliorates systolic blood pressure increase and cardiac remodeling caused by maternal caloric restriction in adult mouse offspring. Endocr. J. 56: 679-689, 2009.
  • [PubMed]
  • T. Chiba, Y. Kamei, T. Shimizu, T. Shirasawa, A. Katsumata, L. Shiraishi, S. Sugita, Y. Ogawa, S. Miura, and O. Ezaki. Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice. Mech. Ageing Dev. 130: 420-428, 2009.
  • [PubMed]
  • N. Satoh, A. Shimatsu, K. Kotani, A. Himeno, H. Yamakage, T. Majima, K. Yamada, T. Suganami, and Y. Ogawa. Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decrease in serum amyloid A-LDL in metabolic syndrome. Hypertens. Res. 32: 1004-1008, 2009.
  • [PubMed]
  • H. Mogami, S. Yura, H. Itoh, M. Kawamura, T. Fujii, A. Suzuki, S. Aoe, Y. Ogawa, N. Sagawa, I. Konishi, and S. Fujii. Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth. Growth Hormone & IGF Res. 19: 478-485, 2009.
  • [PubMed]
2008年
  • H. Yamada, M. Yoshida, Y. Nakano, T. Suganami, N. Satoh, T. Mita, K. Azuma, M. Itoh, Y. Yamamoto, Y. Kamei, M. Horie, H. Watada, and Y. Ogawa. In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arterioscler. Thromb. Vasc. Biol. 28: 2173-2179, 2008.
  • [PubMed]
  • A. Ito, T. Suganami, A. Yamauchi, M. Degawa-Yamauchi, M. Tanaka, R. Kouyama, Y. Kobayashi, N. Nitta, K. Yasuda, Y. Hirata, W. A. Kuziel, M. Takeya, S. Kanegasaki, Y. Kamei, and Y. Ogawa. Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J. Biol. Chem. 283: 35715-35723, 2008.
  • [PubMed]
  • S. Yura, H. Itoh, N. Sagawa, H. Yamamoto, H. Masuzaki, K. Nakao, M. Kawamura, H. Mogami, Y. Ogawa, and S. Fujii. Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice. Obesity 16: 1289-1295, 2008.
  • [PubMed]
  • T. Toyoda, Y. Kamei, H. Kato, S. Sugita, M. Takeya, T. Suganami, and Y. Ogawa. Anti-inflammatory effect of peroxisome proliferator activated receptor α ligands in the interaction between adipocytes and macrophages in obese adipose tissue. Obesity 16: 1199-1207, 2008.
  • [PubMed]
  • Y. Kamei, S. Miura, T. Suganami, F. Akaike, S. Kanai, S. Sugita, A. Katsumata, H. Aburatani, T. G. Unterman, O. Ezaki, and Y. Ogawa. Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor. Endocrinology 149: 2293-2305, 2008.
  • [PubMed]
  • N. Satoh, A. Shimatsu, Y. Kato, R. Araki, K. Koyama, T. Okajima, M. Tanabe, M. Ooishi, K. Kotani, and Y. Ogawa for the Japan Obesity and Metabolic Syndrome Study (JOMS) Group. Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome. Hypertens. Res. 31: 1921-1930, 2008.
  • [PubMed]
2007年
  • Y. Kamei, T. Suganami, T. Kohda, F. Ishino, K. Yasuda, S. Miura, O. Ezaki, and Y. Ogawa Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett. 581: 91-96, 2007.
  • [PubMed]
  • T. Suganami, K. Tanimoto-Koyama, J. Nishida, M. Itoh, X. Yuan, S. Mizuarai, H. Kotani, S. Yamaoka, K. Miyake, S. Aoe, Y. Kamei, and Y. Ogawa. Role of the Toll-like receptor 4/NF-κB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27: 84-91, 2007.
  • [PubMed]
  • N. Satoh, A. Shimatsu, K. Kotani, N. Sakane, K. Yamada, T. Suganami, H. Kuzuya, and Y. Ogawa. Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome. Diabetes Care 30: 144-146, 2007.
  • [PubMed]
  • T. Suganami, T. Mieda, M. Itoh, Y. Shimoda, Y. Kamei, and Y. Ogawa. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem. Biophys. Res. Commun. 354: 45-49, 2007.
  • [PubMed]
  • K. Ebihara, T. Kusakabe, M. Hirata, H. Masuzaki, F. Miyanaga, N. Kobayashi, T. Tanaka, H. Chusho, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, A.M. Depaoli, M. Fukushima, and K. Nakao. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J. Clin. Endocrinol. Metab. 92: 532-541, 2007.
  • [PubMed]
  • L. Miyamoto, T. Toyoda, T. Hayashi, S. Yonemitsu, M. Nakano, S. Tanaka, K. Ebihara, H. Masuzaki, K. Hosoda, Y. Ogawa, G. Inoue, T. Fushiki, and K. Nakao. Effect of acute activation of 5’-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle. J. Appl. Physiol. 102: 1007-1013, 2007.
  • [PubMed]
  • H. Kobayashi, M. Kasahara, M. Hino, S. Takahara, K. Ikeda, C. Son, T. Iwakura, N. Matsuoka, A. Yoshimoto, N. Ogo, R. Kasai, T. Ishihara, and Y. Ogawa. A novel heterozygous splice-site mutation of LEM domain-containing 3 in a Japanese kindred with Buschke-Ollendorff syndrome. J. Endocrinol. Invest. 30: 263-265, 2007.
  • [PubMed]
  • S. Sugita, Y. Kamei, J. Oka, T. Suganami, and Y. Ogawa. Macrophage-colony stimulating factor in obese adipose tissue: studies with heterozygous op/+ mice. Obesity 15: 1988-1995, 2007.
  • [PubMed]
  • A. Ito, T. Suganami, Y. Miyamoto, Y. Yoshimasa, M. Takeya, Y. Kamei, and Y. Ogawa. Role of mitogen-activated protein kinase phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J. Biol. Chem. 282: 25445-25452, 2007.
  • [PubMed]
  • M. Itoh, T. Suganami, N. Satoh, K. Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano, S. Aoe, M. Takeya, A. Shimatsu, H. Kuzuya, Y. Kamei, and Y. Ogawa. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler. Thromb. Vasc. Biol. 27: 1918-1925, 2007.
  • [PubMed]
  • R. Hachiya, Y. Ohashi, Y. Kamei, T. Suganami, H. Mochizuki, N. Mitsui, M. Saitoh, M. Sakuragi, G. Nishimura, H. Ohashi, T. Hasegawa, and Y. Ogawa. Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development. J. Clin. Endocrinol. Metab. 92: 4009-4014, 2007.
  • [PubMed]
  • A. Yasui, H. Nishizawa, Y. Okuno, K. Morita, H. Kobayashi, K. Kawai, M. Matsuda, K. Kishida, S. Kihara, Y. Kamei, Y. Ogawa, T. Funahashi, and I. Shimomura. Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Biochem. Biophys. Res. Commun. 364: 358-365, 2007.
  • [PubMed]
2006年
  • M. Nakano, T. Hamada, T. Hayashi, S. Yonemitsu, L. Miyamoto, T. Toyoda, S. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, A. Otaka, T. Fushiki, and K. Nakao. α2 isoform-specific activation of 5’adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle. Metabolism 55: 300-308, 2006.
  • [PubMed]
  • H. Kobayashi, I. Fujisawa, K. Ikeda, C. Son, T. Iwakura, A. Yoshimoto, M. Kasahara, T. Ishihara, and Y. Ogawa. A novel heterozygous missense mutation in the vasopressin moiety is identified in a Japanese with neurohypophyseal diabetes insipidus. J. Endocrinol. Invest. 29: 252-256, 2006.
  • [PubMed]
  • N. Satoh, A. Shimatsu, K. Yamada, M. Aizawa-Abe, T. Suganami, H. Kuzuya, and Y. Ogawa. An α-glucosidase inhibitor voglibose reduces oxidative stress markers and soluble intercellular adhesion molecule-1 in obese type 2 diabetes. Metabolism 55: 786-793, 2006.
  • [PubMed]
  • H. Kobayashi, M. Kasahara, M. Hino, H. Yoshimura, S. Takahara, K. Ikeda, C. Son, T. Iwakura, A. Yoshimoto, T. Ishihara, and Y. Ogawa. A novel heterozygous deletion frameshift mutation of GATA3 in a Japanese kindred with the hypoparathyroidism, deafness, and renal dysplasia syndrome. J. Endocrinol. Invest. 29: 851-853, 2006.
  • [PubMed]
  • J. Park, S.S. Choe, A.H. Choi, K.H. Kim, M.J. Yoon, N. Houstis, E.D. Rogen, T. Suganami, Y. Ogawa, and J.B. Kim. Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signal. Diabetes 55: 2939-2949, 2006.
  • [PubMed]
  • H. Makino, M. Mukoyama, K. Mori, T. Suganami, M. Kasahara, K. Yahata, T. Nagae, H. Yokoi, K. Sawai, Y. Ogawa, S. Suga, Y. Yoshimasa, A. Sugawara, I. Tanaka, and K. Nakao. Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice. Diabetologia 49: 2514-2524, 2006.
  • [PubMed]
2005年
  • T. Suganami, M. Mukoyama, K. Mori, H. Yokoi, M. Koshikawa, K. Sawai, S. Hidaka, K. Ebihara, T. Tanaka, A. Sugawara, H. Kawachi, C. Vinson, Y. Ogawa, and K. Nakao. Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy. FASEB J. 19: 127-129, 2005.
  • [PubMed]
  • H. Kobayashi, M. Hino, T. Inoue, E. Nii, K. Ikeda, C. Son, T. Iwakura, T. Ishihara, and Y. Ogawa. GC79/TRPS1 and tumorigenesis in humans. Am. J. Med. Genet. 134A: 341-343, 2005.
  • [PubMed]
  • H. Iwakura, K. Hosoda, C. Son, J. Fujikura, T. Tomita, M. Noguchi, H. Ariyasu, K. Takaya, H. Masuzaki, Y. Ogawa, T. Hayashi, G. Inoue, T. Akamizu, H. Hosoda, M. Kojima, H. Itoh, S. Toyokuni, K. Kangawa, and K. Nakao. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. J. Biol. Chem. 280: 15247-15256, 2005.
  • [PubMed]
  • Y. Oike, M. Akao, K. Yasunaga, T. Yamauchi, T. Morisada, Y. Ito, T. Urano, Y. Kimura, Y. Kubota, H. Maekawa, T. Miyamoto, K. Miyata, S. Matsumoto, J. Sakai, N. Nakagata, M. Takeya, H. Koseki, Y. Ogawa, T. Kadowaki, and T. Suda. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med. 11: 400-408, 2005.
  • [PubMed]
  • S. Yura, H. Itoh, N. Sagawa, H. Yamamoto, H. Masuzaki, K. Nakao, M. Kawamura, M. Takemura, K. Kakui, Y. Ogawa, and S. Fujii. Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metabolism 1: 371-378, 2005.
  • [PubMed]
  • R. Kouyama, T. Suganami, J. Nishida, M. Tanaka, T. Toyoda, M. Kiso, T. Chiwata, Y. Miyamoto, Y. Yoshimasa, A. Fukamizu, M. Horiuchi, Y. Hirata, and Y. Ogawa. Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Endocrinology 146:3481-3489, 2005.
  • [PubMed]
  • T. Tanaka, S. Hidaka, H. Masuzaki, S. Yasue, Y. Minokoshi, K. Ebihara, H. Chusho, Y. Ogawa, T. Toyoda, K. Sato, F. Miyanaga, M. Fujimoto, T. Tomita, T. Kusakabe, N. Kobayashi, H. Tanioka, T. Hayashi, K. Hosoda, H. Yoshimatsu, T. Sakata, and K. Nakao. Skeletal muscle AMPK phosphorylation parallels metabolic phenotypes in leptin transgenic mice under dietary modification. Diabetes 54: 2365-2374, 2005.
  • [PubMed]
  • T. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, S. Yasue, H. Yukioka, H. Chusho, F. Miyanaga, T. Miyazawa, M. Fujimoto, T. Kusakabe, N. Kobayashi, T. Hayashi, K. Hosoda, and K. Nakao. Transgenic expression of mutant peroxisome proliferator-activated receptor (PPAR)γ in liver precipitates fasting induced steatosis but protects against high fat diet-induced steatosis in mice. Metabolism 54: 1490-1498, 2005.
  • [PubMed]
  • T. Suganami, J. Nishida, and Y. Ogawa. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α. Arterioscler. Thromb. Vasc. Biol. 25: 2062-2068, 2005.
  • [PubMed]
2004年
  • A. Yasoda, Y. Komatsu, H. Chusho, T. Miyazawa, A. Ozasa, M. Miura, T. Kurihara, T. Rogi, S. Tanaka, M. Suda, N. Tamura, Y. Ogawa, and K. Nakao. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Nat. Med. 10: 80-86, 2004.
  • [PubMed]
  • F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, S. M. Ware, W. J. Craigen, J. J. Robert, C. Vinson, K. Nakao, J. Capeau, and G. Karsenty. Serum leptin level is a regulator of bone mass. Proc. Natl. Acad. Sci. USA 101: 3258-3263, 2004.
  • [PubMed]
  • A. Takahashi-Yasuno, H. Masuzaki, T. Miyawaki, N. Matsuoka, Y. Ogawa, T. Hayashi, K. Hosoda, Y. Yoshimasa, G. Inoue, and K. Nakao. Association of Ob-R gene polymorphism and insulin resistance in Japanese men. Metabolism 53: 650-654, 2004.
  • [PubMed]
  • K. Ebihara, T. Kusakabe, H. Masuzaki, N. Kobayashi, T. Tanaka, H. Chusho, F. Miyanaga, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, and K. Nakao. Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese: a novel homozygous nonsense mutation in seipin gene. J. Clin. Endocrinol. Metab. 89: 2360-2364, 2004.
  • [PubMed]
  • E. Suganami, H. Takagi, H. Ohashi, K. Suzuma, I. Suzuma, H. Oh, D. Watanabe, T. Ojima, T. Suganami, Y. Fujio, K. Nakao, Y. Ogawa, and N. Yoshimura. Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. Diabetes 53: 2443-2448, 2004.
  • [PubMed]
  • N. Satoh, M. Naruse, T. Usui, T. Tagami, T. Suganami, K. Yamada, H. Kuzuya, A. Shimatsu, and Y. Ogawa. Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27: 2488-2490, 2004.
  • [PubMed]
  • R. Kawakami, Y. Saito, I. Kishimoto, M. Harada, K. Kuwahara, N. Takahashi, Y. Nakagawa, M. Nakanishi, K. Tanimoto, S. Usami, S. Yasuno, H. Kinoshita, H. Chusho, N. Tamura, Y. Ogawa, and K. Nakao. Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Circulation 110: 3306-3312, 2004.
  • [PubMed]
2003年
  • T. Nakagawa, Y. Ogawa, K. Ebihara, M. Yamanaka, A. Tsuchida, M. Taiji, H. Noguchi, and K. Nakao. Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. Int. J. Obes. 27: 557-565, 2003.
  • [PubMed]
  • K. Yamahara, H. Itoh, T.-H. Chun, Y. Ogawa, J. Yamashita, N. Sawada, Y. Fukunaga, M. Sone, T. Yurugi-Kobayashi, K. Miyashita, H. Tsujimoto, H. Kook, R. Feil, D. L. Garbers, F. Hofmann, and K. Nakao. Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration. Proc. Natl. Acad. Sci. USA 100: 3404-3409, 2003.
  • [PubMed]
  • K. Chin K, T. Nakamura, K. Takahashi, K. Sumi, Y. Ogawa, H. Masuzaki, S. Muro, N. Hattori, H. Matsumoto, A. Niimi, T. Chiba, K. Nakao, M. Mishima, M. Ohi, and T. Nakamura. Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am. J. Med. 114: 370-376, 2003.
  • [PubMed]
  • N. Takahashi, Y. Saito, K. Kuwahara, M. Harada, I. Kishimoto, Y. Ogawa, R. Kawakami, Y. Nakagawa, M. Nakanishi, and K. Nakao. Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation. Hypertens. Res. 26: 847-853, 2003.
  • [PubMed]
  • N. Satoh, Y. Ogawa, T. Usui, T. Tagami, S. Kohno, H. Uesugi, H. Sugiyama, A. Sugawara, K. Yamada, A. Shimatsu, H. Kuzuya, and K. Nakao. Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabetes Care 26: 2493-2499, 2003.
  • [PubMed]
  • F. Miyanaga, Y. Ogawa, K. Ebihara, S. Hidaka, T. Tanaka, S. Hayashi, H. Masuzaki, and K. Nakao. Leptin as an adjunct of insulin therapy in insulin-dependent diabetes. Diabetologia 46: 1329-1337, 2003.
  • A. Takahashi-Yasuno, H. Masuzaki, T. Miyawaki, Y. Ogawa, N. Matsuoka, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res. Clin. Pract. 62: 169-175, 2003.
  • [PubMed]
2002年
  • H. Kobayashi, Y. Ogawa, M. Shintani, K. Ebihara, M. Shimodahira, T. Iwakura, M. Hino, T. Ishihara, K. Ikekubo, H. Kurahachi, and K. Nakao. A novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity. Diabetes 51: 243-246, 2002.
  • [PubMed]
  • H. Kobayashi, M. Hino, M. Shimodahira, T. Iwakura, T. Ishihara, K. Ikekubo, Y. Ogawa, K. Nakao, and H. Kurahachi. Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III. Am. J. Med. Genet. 107: 26-29, 2002.
  • [PubMed]
  • Y. Ogawa, H. Masuzaki, K. Ebihara, M. Shintani, M. Aizawa-Abe, F. Miyanaga, and K. Nakao. Pathophysiogical role of leptin in lifestyle-related diseases: studies with transgenic skinny mice overexpressing leptin. J. Diabetes Complications 16: 119-122, 2002.
  • [PubMed]
  • Y. Fujita, M. Murakami, Y. Ogawa, H. Masuzaki, M. Tanaka, S. Ozaki, K. Nakao, and T. Mimori. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin. Exp. Immunol. 128: 21-26, 2002.
  • [PubMed]
  • K. Shimizu, K. Chin, T. Nakamura, H. Masuzaki, Y. Ogawa, R. Hosokawa, A. Niimi, N. Hattori, R Nohara, S. Sasayama, K. Nakao. M. Mishima, T. Nakamura, and M. Ohi. Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnea-hypopnea syndrome. Thorax 57: 429-434, 2002.
  • [PubMed]
  • T. Miyazawa, Y. Ogawa, H. Chusho, A. Yasoda, N. Tamura, Y. Komatsu, A. Pfeifer, F. Hofmann, and K. Nakao. cGMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification. Endocrinology 143: 3604-3610, 2002.
  • [PubMed]
  • H. Ariyasu, K. Takaya, H. Hosoda, H. Iwakura, K. Ebihara, K. Mori, Y. Ogawa, K. Hosoda, T. Akamizu, M. Kojima, K. Kangawa, and K. Nakao. Delayed short-term secretory regulation of ghrelin in obese animals: Evidenced by a specific radioimmunoassay for active form of ghrelin. Endocrinology 143: 3341-3350, 2002.
  • [PubMed]
  • M. Suda, K. Tanaka, A. Yasoda, Y. Komatsu, H. Chusho, M. Miura, N. Tamura, Y. Ogawa, and K. Nakao. C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line. J. Bone Miner. Metab. 20: 136-141, 2002.
  • [PubMed]
  • T. Miyawaki, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura, N. Azuma, A. Sugawara, I. Masuda, M. Murata, T. Matsuo, T. Hayashi, G. Inoue, Y. Yoshimasa, and K. Nakao. Clinical implications of leptin and its potential humoral regulators in long-term low-calorie diet therapy for obese humans. Eur. J. Clin. Nutr. 56: 593-600, 2002.
  • [PubMed]
2001年
  • T. Kuramoto, K. Kitada, T. Inui, Y. Sasaki, K. Ito, T. Hase, S. Kawaguchi, Y. Ogawa, K. Nakao, G. S. Barsh, M. Nagao, T. Ushijima, and T. Serikawa. Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Proc. Natl. Acad. Sci. USA 98: 559-564, 2001.
  • [PubMed]
  • M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, M. Kojima, K. Kangawa, and K. Nakao. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232, 2001.
  • [PubMed]
  • N. Matsuoka, Y. Ogawa, H. Masuzaki, K. Ebihara, M. Aizawa-Abe, N. Satoh, E. Ishikawa, Y. Fujisawa, A. Kosaki, K. Yamada, H. Kuzuya, and K. Nakao. Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin. Am. J. Physiol. 280: E334-E339, 2001.
  • [PubMed]
  • M. Nakagawa, I. Tanaka, M. Mukoyama, S. Suga, Y. Ogawa, N. Tamura, R. Ishibashi, M. Goto, O. Nakagawa, A. Sugawara, and K. Nakao. Monoclonal antibody against brain natriuretic peptide and characterization of brain natriuretic peptide-transgenic mice. J. Hypertens. 19: 475-483, 2001.
  • [PubMed]
  • H. Chusho, N. Tamura, Y. Ogawa, A. Yasoda, M. Suda, T. Miyazawa, K. Nakamura, K. Nakao, T. Kurihara, Y. Komatsu, H. Itoh, K. Tanaka, Y. Saito, M. Katsuki, and K. Nakao. Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc. Natl. Acad. Sci. USA 98: 4016-4021, 2001.
  • [PubMed]
  • S. Yonemitsu, H. Nishimura, M. Shintani, R. Inoue, Y. Yamamoto, H. Masuzaki, Y. Ogawa, T. Hayashi, K. Hosoda, G. Inoue, and K. Nakao. Troglitazone induces GLUT4 translocation in L6 myotubes. Diabetes 50: 1093-1101, 2001.
  • [PubMed]
  • K. Doi, T. Ikeda, H. Itoh, K. Ueyama, K. Hosoda, Y. Ogawa, J. Yamashita, T.-H. Chun, M. Inoue, K. Masatsugu, N. Sawada, Y. Fukunaga, T. Saito, M. Sone, K. Yamahara, H. Kook, M. Komeda, M. Ueda, and K. Nakao. C-type natriuretic peptide induces re-differentiation of vascular smooth muscle cells with accelerated re-endothelialization. Arterioscler. Thromb. Vasc. Biol. 21: 930-936, 2001.
  • [PubMed]
  • K. Ebihara, Y. Ogawa, H. Masuzaki, M. Shintani, F. Miyanaga, M. Aizawa-Abe, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, O. Gavrilova, M. L. Reitman, and K. Nakao. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes 50: 1440-1448, 2001.
  • [PubMed]
  • Y. Ogawa, N. Tamura, H. Chusho, and K. Nakao. Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart. Can. J. Pharmacol. Physiol. 79: 723-729, 2001.
  • [PubMed]
  • M. Shintani, H. Nishimura, S. Yonemitsu, Y. Ogawa, T. Hayashi, K. Hosoda, G. Inoue, and K. Nakao. Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes. Diabetes 50: 2296-2300, 2001.
  • [PubMed]
  • C. Son, K. Hosoda, J. Matsuda, J. Fujikura, S. Yonemitsu, H. Iwakura, H. Masuzaki, Y. Ogawa, T. Hayashi, H. Itoh, H. Nishimura, G. Inoue, Y. Yoshimasa, Y. Yamori, and K. Nakao. Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes. Endocrinology 142: 4189-94, 2001.
  • [PubMed]
  • H. Ariyasu, K. Takaya, T. Tagami, Y. Ogawa, K. Hosoda, T. Akamizu, M. Suda, T. Koh, K. Natsui, S. Toyooka, G. Shirakami, T. Usui, A. Shimatsu, K. Doi, H. Hosoda, M. Kojima, K. Kangawa, and K. Nakao. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 86: 4753-4758, 2001.
  • [PubMed]
  • T. Suganami, M. Mukoyama, A. Sugawara, K. Mori, T. Nagae, M. Kasahara, K. Yahata, H. Makino, Y. Fujinaga, Y. Ogawa, I. Tanaka, and K. Nakao. Overexpression of brain natriuretic peptide in transgenic mice ameliorates immune-mediated renal injury. J. Am. Soc. Nephrol. 12: 2652-2663, 2001.
  • [PubMed]
2000年
  • M. Shintani, H. Nishimura, S. Yonemitsu, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. Down-regulation of leptin by free fatty acids in rat adipocytes: Effects of triacsin C, palmitate and 2-bromopalmitate. Metabolism 49: 326-330, 2000.
  • [PubMed]
  • T.-H. Chun, H. Itoh, T. Saito, K. Yamahara, K. Doi, Y. Mori, Y. Ogawa, J. Yamashita, T. Tanaka, M Inoue, K. Masatsugu, N. Sawada, Y. Fukunaga, and K. Nakao. Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedulin. J. Hypertens. 18: 575-580, 2000.
  • [PubMed]
  • Y. Yamamoto, Y. Yoshimasa, M. Koh, J. Suga, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura, Y. Watanabe, G. Inoue, and K. Nakao. Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes. Diabetes 49: 332-339, 2000.
  • [PubMed]
  • S. Yura, Y. Ogawa, N. Sagawa, H. Masuzaki, H. Itoh, K. Ebihara, M. Aizawa-Abe, S. Fujii, and K. Nakao. Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. J. Clin. Invest. 105: 749-755, 2000.
  • [PubMed]
  • N. Tamura, Y. Ogawa, H. Chusho, K. Nakamura, K. Nakao, M. Suda, M. Kasahara, R. Hashimoto, G. Katsuura, M. Mukoyama, H. Itoh, Y. Saito, I. Tanaka, H. Otani, M. Katsuki, and K. Nakao. Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc. Natl. Acad. Sci. USA 97: 4239-4244, 2000.
  • [PubMed]
  • M. Aizawa-Abe, Y. Ogawa, H. Masuzaki, K. Ebihara, N. Satoh, H. Iwai, N. Matsuoka, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. Pathophysiological role of leptin in obesity-related hypertension. J. Clin. Invest. 105: 1243-1252, 2000.
  • [PubMed]
  • M. Kasahara, M. Mukoyama, A. Sugawara, H. Makino, T. Suganami, Y. Ogawa, M. Nakagawa, K. Yahata, M. Goto, R. Ishibashi, N. Tamura, I. Tanaka, and K. Nakao. Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation. J. Am. Soc. Nephrol. 11: 1691-1701, 2000.
  • [PubMed]
  • H. Chusho, Y. Ogawa, N. Tamura, M. Suda, A. Yasoda, T. Miyazawa, I. Kishimoto, Y. Komatsu, H. Itoh, K. Tanaka, Y. Saito, D.L. Garbers, and K. Nakao. Genetic models reveal that brain natriuretic peptide can signal through different tissue-specific receptor-mediated pathways. Endocrinology 141: 3807-3813, 2000.
  • [PubMed]
  • M. Nakayama, H. Yasue, M. Yoshimura, Y. Shimasaki, H. Ogawa, K. Kugiyama, Y. Mizuno, E. Harada, S. Nakamura, T. Ito, Y. Saito, Y. Miyamoto, Y. Ogawa, and K. Nakao. T-786→C mutation in the 5’-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. Am. J. Cardiol. 86: 628-634, 2000.
  • [PubMed]
  • M. Yoshimura, H. Yasue, M. Nakayama, Y. Shimasaki, H. Ogawa, K. Kugiyama, Y. Saito, Y.Miyamoto, Y. Ogawa, T. Kaneshige, H. Hiramatsu, T. Yoshioka, S. Kamitani, H. Teraoka, and K. Nakao. Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786→C and missense Glu298Asp variants. J. Investig. Med. 48: 367-374, 2000.
  • [PubMed]
  • K. Yahata, K. Mori, H. Arai, S. Koide, Y. Ogawa, M. Mukoyama, A. Sugawara, S. Ozaki, I. Tanaka, Y. Nabeshima, and K. Nakao. Molecular cloning and expression of a novel klotho-related protein. J. Mol. Med. 78: 384-394, 2000.
  • [PubMed]
  • M. Kotani, I. Tanaka, Y. Ogawa, T. Suganami, T. Matsumoto, S. Muro, Y. Yamamoto, A. Sugawara, Y. Yoshimasa, N. Sagawa, S. Narumiya, and K. Nakao. Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus. J. Clin. Endocrinol. Metab. 85: 4315-4322, 2000.
  • [PubMed]
  • K. Mori, K. Yahata, M. Mukoyama, T. Suganami, H. Makino, T. Nagae, H. Masuzaki, Y. Ogawa, A. Sugawara, Y. Nabeshima, and K. Nakao. Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem. Biophys. Res. Commun. 278: 665-670, 2000.
  • [PubMed]
  • K. Takaya, H. Ariyasu, N. Kanamoto, H. Iwakura, A. Yoshimoto, M. Harada, K. Mori, Y. Komatsu, T. Usui, A. Shimatsu, Y. Ogawa, K. Hosoda, T. Akamizu, M. Kojima, K. Kangawa, and K. Nakao. Ghrelin strongly stimulates growth hormone (GH) release in humans. J. Clin. Endocrinol. Metab. 85: 4908-4911, 2000.
  • [PubMed]
1999年
  • M. Nakayama, H. Yasue, M. Yoshimura, Y. Shimasaki, K. Kugiyama, H. Ogawa, T. Motoyama, Y. Saito, Y. Ogawa, Y. Miyamoto, and K. Nakao. T-786→C mutation in the 5’-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99: 2864-2870, 1999.
  • [PubMed]
  • K. Mori, Y. Ogawa, K. Ebihara, N. Tamura, K. Tashiro, T. Kuwahara, M. Mukoyama, A. Sugawara, S. Ozaki, I. Tanaka, and K. Nakao. Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J. Biol. Chem. 274: 15701-15705, 1999.
  • [PubMed]
  • K. Kuwahara, Y. Saito, O. Nakagawa, I. Kishimoto, M. Harada, E. Ogawa, Y. Miyamoto, I. Hamanaka, N. Kajiyama, N. Takahashi, T. Izumi, R. Kawakami, N. Tamura, Y. Ogawa, and K. Nakao. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes: possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett. 452: 314-318, 1999.
  • [PubMed]
  • K. Chin, K. Shimizu, T. Nakamura, N. Narai, H. Masuzaki, Y. Ogawa, M. Mishima, T. Nakamura, K. Nakao, and M. Ohi. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 100: 706-712, 1999.
  • [PubMed]
  • H. Masuzaki, Y. Ogawa, M. Aizawa-Abe, K. Hosoda, J. Suga, K. Ebihara, N. Satoh, H. Iwai, G. Inoue, H. Nishimura, Y. Yoshimasa, and K. Nakao. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes 48: 1615-1622, 1999.
  • [PubMed]
  • N. Satoh, Y. Ogawa, G. Katsuura, Y. Numata, T. Tsuji, M. Hayase, K. Ebihara, H. Masuzaki, K. Hosoda, Y. Yoshimasa, and K. Nakao. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes 48: 1787-1793, 1999.
  • [PubMed]
  • Y. Ogawa, H. Masuzaki, K. Hosoda, M. Aizawa-Abe, J. Suga, M. Suda, K. Ebihara, H. Iwai, N. Matsuoka, N. Satoh, H. Odaka, H. Kasuga, Y. Fujisawa, G. Inoue, H. Nishimura, Y. Yoshimasa, and K. Nakao. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 48: 1822-1829, 1999.
  • [PubMed]
  • K. Ebihara, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, N. Satoh, M. Tamaki, T. Yoshioka, M. Hayase, N. Matsuoka, M. Aizawa-Abe, Y. Yoshimasa, and K. Nakao. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48: 2028-2033, 1999.
  • [PubMed]
  • M. Suda, Y. Komatsu, K. Tanaka, A. Yasoda, Y. Sakuma, N. Tamura, Y. Ogawa, and K. Nakao. C-type natriuretic peptide/guanylate cyclase B system in rat osteogenic ROB-C26 cells and its down-regulation by dexamethazone. Calcif. Tissue Int. 65: 472-478, 1999.
  • [PubMed]
  • M. Shintani, H. Nishimura, T. Akamizu, S. Yonemitsu, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, and K. Nakao. Thyrotropin decreases leptin production in rat adipocytes. Metabolism 48: 1570-1574, 1999.
  • [PubMed]
  • K. Yahata, I. Tanaka, M. Kotani, M. Mukoyama, Y. Ogawa, M. Goto, M. Nakagawa, A. Sugawara, K. Tanaka, A. Shimatsu, and K. Nakao. Identification of a novel R642C mutation in Na/Cl cotransporter with Gitelman’ s syndrome. Am. J. Kidney Dis. 34: 845-853, 1999.
  • [PubMed]
1998年
  • S. Yura, N. Sagawa, H. Mise, T. Mori, H. Masuzaki, Y. Ogawa, and K. Nakao. A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth. Am. J. Obstet. Gynecol. 178: 926-930, 1998.
  • [PubMed]
  • M. Suda, Y. Ogawa, K. Tanaka, N. Tamura, A. Yasoda, T. Takigawa, M. Uehira, H. Nishimoto, H. Itoh, Y. Saito, K. Shiota, and K. Nakao. Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc. Natl. Acad. Sci. USA 95: 2337-2342, 1998.
  • [PubMed]
  • A. Yasoda, Y. Ogawa, M. Suda, N. Tamura, K. Mori, Y. Sakuma, H. Chusho, K. Shiota, K. Tanaka, and K. Nakao. Natriuretic peptide regulation of endochondral ossification: evidence for possible roles of C-type natriuretic peptide/guanylyl cyclase-B pathway. J. Biol. Chem. 273: 11695-11700, 1998.
  • [PubMed]
  • J. Yamashita, T. Yoshimasa, H. Arai, J. Hiraoka, K. Takaya, Y. Miyamoto, Y. Ogawa, H. Itoh, and K. Nakao. Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy. J. Biol. Chem. 273: 15993-15999, 1998.
  • [PubMed]
  • T. Igaki, H. Itoh, S. Suga, N. Hama, Y. Ogawa, Y. Komatsu, J. Yamashita, K. Doi, T. Chun, and K. Nakao. Effects of intravenously administered C-type natriuretic peptide in humans: comparison with atrial natriuretic peptide. Hypertens. Res. 21: 7-13, 1998.
  • [PubMed]
  • Y. Shimasaki, H. Yasue, M. Yoshimura, M. Nakayama, K. Kugiyama, H. Ogawa, E. Harada, T. Masuda, W. Koyama, Y. Saito, Y. Miyamoto, Y. Ogawa, and K. Nakao. Association of the missense Glu298Asp mutation of the endothelilal nitric oxide synthase gene with myocardial infarction. J. Am. Coll. Cardiol. 31: 1506-1510, 1998.
  • [PubMed]
  • N. Satoh, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, Y. Yoshimasa, and K. Nakao. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci. Lett. 249: 107-110, 1998.
  • [PubMed]
  • H. Mise, N. Sagawa, T. Matsumoto, S. Yura, H. Nanno, H. Itoh, T. Mori, H. Masuzaki, K. Hosoda, Y. Ogawa, and K. Nakao. Augmented placental production of leptin in preeclampsia: Possible involvement of placental hypoxia. J. Clin. Endocrinol. Metab. 83: 3225-3229, 1998.
  • [PubMed]
  • S. Yura, N. Sagawa, Y. Ogawa, H. Masuzaki, H. Mise, T. Matsumoto, K. Ebihara, S. Fujii, and K. Nakao. Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells. J. Clin. Endocrinol. Metab. 83: 3609-3614, 1998.
  • [PubMed]
  • M. Inoue, H. Itoh, M. Ueda, Y. Naruko, A. Kojima, R. Komatsu, K. Doi, Y. Ogawa, N. Tamura, K. Takaya, T. Igaki, J. Yamashita, T.-H. Chun, K. Masatsugu, A. E. Becker, and K. Nakao. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 98: 2108-2116, 1998.
  • [PubMed]
  • K. Imagawa, Y. Matsumoto, Y. Numata, A. Morita, S. Kikuoka, M. Tamaki, C. Higashikubo, T. Tsuji, K. Sasakura, H. Teraoka, H. Masuzaki, K. Hosoda, Y. Ogawa, and K. Nakao. Development of a sensitive ELISA for human leptin using monoclonal antibodies. Clin. Chem. 44: 2165-2171, 1998.
  • [PubMed]
  • M. Yoshimura, H. Yasue, M. Nakayama, Y. Shimasaki, H. Sumida, S. Sugiyama, K. Kugiyama, H. Ogawa, Y. Ogawa, Y. Saito, Y. Miyamoto, and K. Nakao. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum. Genet. 103: 65-69, 1998.
  • [PubMed]
  • K. Imagawa, Y. Numata, G. Katsuura, I. Sakaguchi, A. Morita, S. Kikuoka, Y. Matsumoto, T. Tsuji, M. Tamaki, K. Sasakura, H. Teraoka, K. Hosoda, Y. Ogawa, and K. Nakao. Structure-function studies of human leptin. J. Biol. Chem. 273: 35245-35249, 1998.
  • [PubMed]
1997年
  • H. Itoh, S. Suga, Y. Ogawa, Y. Komatsu, N. Tamura, T. Igaki, J. Yamashita, T. Ikeda, K. Doi, T. -H. Chun, M. Inoue, K. Matsuda, T. Yoshimasa, M. Ueda, T. Ban, and K. Nakao. Significance of vascular natriuretic peptide system in vascular remodeling in humans and its application to gene therapy. Ann. NY. Acad. Sci. 811: 533-541, 1997.
  • [PubMed]
  • N. Satoh, Y. Ogawa, G. Katsuura, T. Tsuji, H. Masuzaki, J. Hiraoka, T. Okazaki, M. Tamaki, M. Hayase, Y. Yoshimasa, S. Nishi, K. Hosoda, and K. Nakao. Pathophysiologic significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology 138: 947-954, 1997.
  • [PubMed]
  • K. Mori, Y. Ogawa, N. Tamura, K. Ebihara, T. Aoki, S. Muro, S. Ozaki, I. Tanaka, K. Tashiro, and K. Nakao. Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. FEBS Lett. 401: 218-222, 1997.
  • [PubMed]
  • M. Kotani, I. Tanaka, Y. Ogawa, T. Usui, N. Tamura, K. Mori, S. Narumiya, T. Yoshimi, and K. Nakao. Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). Genomics 40: 425-434, 1997.
  • [PubMed]
  • K. Yoshimine, M. Horiuchi, S. Suzuki, K. Kobayashi, J. M. Abdul, M. Masuda, M. Tomomura, Y. Ogawa, H. Itoh, K. Nakao, M. Osame, and T. Saheki. Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency. J. Mol. Cell. Cardiol. 29: 571-578, 1997.
  • [PubMed]
  • N. Satoh, Y. Ogawa, G. Katsuura, M. Hayase, T. Tsuji, K. Imagawa, Y. Yoshimasa, S. Nishi, K. Hosoda, and K. Nakao. The arcuate nucleus as a primary site of satiety effect of leptin in rats. Neurosci. Lett. 224: 149-152, 1997.
  • [PubMed]
  • J. Hiraoka, K. Hosoda, Y. Ogawa, K. Ikeda, Y. Nara, H. Masuzaki, K. Takaya, K. Nakagawa, T. Mashimo, M. Sawamura, R. J. Koletsky, Y. Yamori, and K. Nakao. Augmentation of obese (ob) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats). Biochem. Biophys. Res. Commun. 231: 582-585, 1997.
  • [PubMed]
  • T.-H. Chun, H. Itoh, Y. Ogawa, N. Tamura, K. Takaya, T. Igaki, J. Yamashita, K. Doi, M. Inoue, K. Masatsugu, R. Korenaga, J. Ando, and K. Nakao. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 29: 1296-1302, 1997.
  • [PubMed]
  • H. Masuzaki, Y. Ogawa, K. Hosoda, T. Miyawaki, I. Hanaoka, J. Hiraoka, A. Yasuno, H. Nishimura, Y. Yoshimasa, S. Nishi, and K. Nakao. Glucocorticoid regulation of leptin synthesis and secretion in humans: elevated plasma leptin levels in Cushing’s syndrome. J. Clin. Endocrinol. Metab. 82: 2542-2548, 1997.
  • [PubMed]
  • N. Matsuoka, Y. Ogawa, K. Hosoda, J. Matsuda, H. Masuzaki, T. Miyawaki, N. Azuma, K. Natsui, H. Nishimura, Y. Yoshimasa, S. Nishi, D. B. Thompson, and K. Nakao. Human leptin receptor gene in Japanese obese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia 40: 1204-1210, 1997.
  • [PubMed]
  • H. Masuzaki, Y. Ogawa, N. Sagawa, K. Hosoda, T. Matsumoto, H. Mise, H. Nishimura, Y. Yoshimasa, I. Tanaka, T. Mori, and K. Nakao. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3: 1029-1033, 1997.
  • [PubMed]
  • N. Sagawa, T. Mori, H. Masuzaki, Y. Ogawa, and K. Nakao. Leptin production by hydatidiform mole. Lancet 350: 1518-1519, 1997.
  • [PubMed]
  • K. Mori, Y. Ogawa, K. Ebihara, T. Aoki, N. Tamura, A. Sugawara, T. Kuwahara, S. Ozaki, M. Mukoyama, K. Tashiro, I. Tanaka, and K. Nakao. Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 417: 371-374, 1997.
  • [PubMed]
  • K. Doi, H. Itoh, T. Ikeda, K. Hosoda, Y. Ogawa, T. Igaki, J. Yamashita, T. Chun, M. Inoue, K. Masatsugu, K. Matsuda, K. Ohmori, and K. Nakao. Adenovirus-mediated gene transfer of C-type natriuretic peptide causes G1 growth inhibition of cultured vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 239: 889-894, 1997.
  • [PubMed]
  • M. Harada, H. Itoh, O. Nakagawa, Y. Ogawa, Y. Miyamoto, K. Kuwahara, E. Ogawa, T. Igaki, J. Yamashita, I. Masuda, T. Yoshimasa, I. Tanaka, Y. Saito, and K. Nakao. Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation 96: 3737-3744, 1997.
  • [PubMed]
  • K. Ebihara, Y. Ogawa, N. Isse, K. Mori, N. Tamura, H. Masuzaki, K. Kohno, S. Yura, K. Hosoda, N. Sagawa, and K. Nakao. Identification of the human leptin 5’-flanking sequences involved in the trophoblast-specific transcription. Biochem. Biophys. Res. Commun. 241: 658-663, 1997.
  • [PubMed]
  • M. Shigemoto, S. Nishi, Y. Ogawa, N. Isse, N. Matsuoka, T. Tanaka, N. Azuma, H. Masuzaki, H. Nishimura, Y. Yoshimasa, K. Hosoda, and K. Nakao. Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus. Eur. J. Endocrinol. 137: 511-513, 1997.
  • [PubMed]
1996年
  • H. Masuzaki, H. Jingami, N. Matsuoka, O. Nakagawa, Y. Ogawa, M. Mizuno,Y. Yoshimasa, T. Yamamoto, and K. Nakao. Regulation of very low density lipoprotein receptor in hypertrophic rat heart. Circ. Res. 78: 8-14, 1996.
  • [PubMed]
  • H. Masuzaki, K. Hosoda, Y. Ogawa, M. Shigemoto, N. Satoh, K. Mori, N. Tamura, S. Nishi, Y. Yoshimasa, Y. Yamori, and K. Nakao. Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats. FEBS Lett. 378: 267-271, 1996.
  • [PubMed]
  • Y. Miyamoto, T. Yoshimasa, H. Arai, K. Takaya, Y. Ogawa, H. Itoh, and K. Nakao. Alternative RNA splicing of human endothelin-A receptor generates multiple transcripts. Biochem. J. 313: 795-801, 1996.
  • [PubMed]
  • N. Tamura, H. Itoh, Y. Ogawa, O. Nakagawa, M. Harada, T. Chun, S. Suga, T. Yoshimasa, and K. Nakao. cDNA cloning and gene expression of human type I alpha cGMP-dependent protein kinase. Hypertension 27: 552-557, 1996.
  • [PubMed]
  • Y. Komatsu, H. Itoh, S. Suga, Y. Ogawa, N. Hama, I. Kishimoto, O. Nakagawa, T. Igaki, K. Doi, T. Yoshimasa, and K. Nakao. Regulation of endothelial production of C-type natriuretic peptide in coculture with vascular smooth muscle cells: the role of vascular natriuretic peptide system in vascular growth inhibition. Circ. Res. 78: 606-614, 1996.
  • [PubMed]
  • K. Hosoda, H. Masuzaki, Y. Ogawa, T. Miyawaki, J. Hiraoka, I. Hanaoka, A. Yasuno, T. Nomura, Y. Fujisawa, Y. Yoshimasa, S. Nishi, Y. Yamori, and K. Nakao. Development of radioimmunoassay for human leptin. Biochem. Biophys. Res. Commun. 221: 234-239, 1996.
  • [PubMed]
  • K. Mori, I. Tanaka, M. Kotani, F. Miyaoka, T. Sando, S. Muro, Y. Sasaki, O. Nakagawa, Y. Ogawa, T. Usui, S. Ozaki, A. Ichikawa, S. Narumiya, and K. Nakao. Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulations in monocytoid and lymphoid lineage cells by phorbol ester. J. Mol. Med. 74: 333-336, 1996.
  • [PubMed]
  • M. Suda, K. Tanaka, M. Fukushima, K. Natsui, A. Yasoda, Y. Komatsu, Y. Ogawa, H. Itoh, and　K. Nakao. C-type natriuretic peptide (CNP) as an autocrine/paracrine regulator of osteoblast: evidence for possible presence of bone natriuretic peptide system. Biochem. Biophys. Res. Commun. 223: 1-6, 1996.
  • [PubMed]
  • Y. Komatsu, H. Itoh, S. Suga, T. Igaki, Y. Ogawa, I. Kishimoto, O. Nakagawa, T. Yoshimasa and K. Nakao. Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells. Hypertension 14: 585-592, 1996.
  • [PubMed]
  • K. Takaya, Y. Ogawa, N. Isse, T. Okazaki, N. Satoh, H. Masuzaki, K. Mori, N. Tamura, K. Hosoda, and K. Nakao. Molecular cloning of rat leptin receptor isoform complementary DNAs: identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem. Biophys. Res. Commun. 225: 75-83, 1996.
  • [PubMed]
  • N. Tamura, Y. Ogawa, A. Yasoda, H. Itoh, Y. Saito, and K. Nakao. Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes. J. Mol. Cell. Cardiol. 28: 1811-1815, 1996.
  • [PubMed]
  • M. Hayase, Y. Ogawa, G. Katsuura, H. Shintaku, K. Hosoda, and K. Nakao. Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice. Am. J. Physiol. 271: E333-E339, 1996.
  • [PubMed]
  • K. Takaya, Y. Ogawa, J. Hiraoka, K. Hosoda, R. J. Koletsky, Y. Yamori, and K. Nakao. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat. Genet. 14: 130-131, 1996.
  • [PubMed]
  • T. Okazaki, Y. Ogawa, N. Tamura, K. Mori, N. Isse, T. Aoki, J. M. Rochelle, M.M. Taketo, M. F. Seldin, and K. Nakao. Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene. Genomics 37: 395-399, 1996.
  • [PubMed]
  • M. Hasegawa, N. Sagawa, H. Nanno, H. Itoh, K. Inamori, Y. Ihara, F. Kobayashi, T. Mori, J. Yano, G. Shirakami, S. Suga, Y. Ogawa, T. Yoshimasa, and K. Nakao. Endothelin-1-like immunoreactivity and endothelin receptors in the human placenta from normotensive and hypertensive pregnancies. J. Perinat. Med. 24: 451-460, 1996.
  • [PubMed]
  • K. Kikuta, H. Yasue, M. Yoshimura, E. Morita, H. Sumida, H. Kato, K. Kugiyama, H. Ogawa, K. Okumura, Y. Ogawa, and K. Nakao. Increased plasma levels of B-type natriuretic peptide in patients with unstable angina. Am. Heart J. 132: 101-107, 1996.
  • [PubMed]
1995年
  • H. Masuzaki, Y. Ogawa, M. Shigemoto, N. Satoh, K. Mori, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, and K. Nakao. Adipose tissue-specific expression of the obese (ob) gene in rats and its marked augmentation in genetically obese-hyperglycemic Wistar fatty rats. Proc. Jpn. Acad. Ser. B. 71: 148-152, 1995.
  • Y. Ogawa, I. Tanaka, M. Inoue, Y. Yoshitake, N. Isse, O. Nakagawa, T. Usui, H. Itoh, T. Yoshimasa, S. Narumiya, and K. Nakao. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics 27: 142-148, 1995.
  • [PubMed]
  • H. Masuzaki, Y. Ogawa, N. Isse, N. Satoh, T. Okazaki, M. Shigemoto, K. Mori, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, and K. Nakao. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44: 855-858, 1995.
  • [PubMed]
  • Nakagawa, Y. Ogawa, H. Itoh, S. Suga, Y. Komatsu, I. Kishimoto, K. Nishino, T. Yoshimasa, and K. Nakao. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy: Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J. Clin. Invest. 96: 1280-1287, 1995.
  • [PubMed]
  • Y. Ogawa, H. Masuzaki, N. Isse, T. Okazaki, K. Mori, M. Shigemoto, N. Satoh, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, and K. Nakao. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin. Invest. 96: 1647-1652, 1995.
  • [PubMed]
  • N. Hama, H. Itoh, G. Shirakami, O. Nakagawa, S. Suga, Y. Ogawa, I. Masuda, K. Nakanishi, T. Yoshimasa, Y. Hashimoto, M. Yamaguchi, R. Hori, H. Yasue, and K. Nakao. Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 92: 1558-1564, 1995.
  • [PubMed]
  • Y. Ogawa, H. Itoh, O. Nakagawa, G. Shirakami, N. Tamura, T. Yoshimasa, K. Nagata, N. Yoshida, and K. Nakao. Characterization of the 5’-flanking region and chromosomal assignment of the human brain natriuretic peptide gene. J. Mol. Med. 73: 457-463, 1995.
  • [PubMed]
  • N. Isse, Y. Ogawa, N. Tamura, H. Masuzaki, K. Mori, T. Okazaki, N. Satoh, M. Shigemoto, Y. Yoshimasa, S. Nishi, K. Hosoda, J. Inazawa, and K. Nakao. Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270: 27728-27733, 1995.
  • [PubMed]
  • M. Kotani, I. Tanaka, Y. Ogawa, T. Usui, K. Mori, A. Ichikawa, S. Narumiya, T. Yoshimi, and K. Nakao. Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distribution. Mol. Pharmacol. 48: 869-879, 1995.
  • [PubMed]
  • H. Masuzaki, Y. Ogawa, K. Hosoda, T. Kawada, T. Fushiki, and K. Nakao. Augmented Expression of the obese gene in the adipose tissue from rats fed high-fat diet. Biochem. Biophys. Res. Commun. 216: 355-358, 1995.
  • [PubMed]
  • M. Hasegawa, N. Sagawa, H. Itoh, K. Inamori, T. Mori, J. Yano, Y. Ogawa, T. Yoshimasa, and K. Nakao. Endothelin receptors in the human amnion, chorion laeve, decidua vera and placenta. Reprod. Fertil. Dev. 7: 1585-1589, 1995.
  • [PubMed]
1994年
  • Y. Ogawa, H. Itoh, N. Tamura, S. Suga, T. Yoshimasa, M. Uehira, S. Matsuda, S. Shiono, H. Nishimoto, and K. Nakao. Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene. J. Clin. Invest. 93: 1911-1921, 1994.
  • [PubMed]
  • N. Tamura, Y. Ogawa, H. Itoh, H. Arai, S. Suga, O. Nakagawa, Y. Komatsu, I. Kishimoto, K. Takaya, T. Yoshimasa, S. Shiono, and K. Nakao. Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs: cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides. J. Clin. Invest. 94: 1059-1068, 1994.
  • [PubMed]
  • I. Kishimoto, T. Yoshimasa, S. Suga, Y. Ogawa, Y. Komatsu, O. Nakagawa, H. Itoh, and K. Nakao. Natriuretic peptide clearance receptor is transcriptionally down-regulated by β2-adrenergic stimulation in vascular smooth muscle cells. J. Biol. Chem. 269: 28300-28308, 1994.
  • [PubMed]
  • Y. Ogawa, H. Itoh, Y. Yoshitake, M. Inoue, T. Yoshimasa, T. Serikawa, and K. Nakao.　Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide　(CNP) gene (Nppc): comparison with the human CNP gene (NPPC). Genomics 24: 383-387, 1994.
  • [PubMed]
1993年
  • H. Arai, K. Nakao, K. Takaya, K. Hosoda, Y. Ogawa, S. Nakanishi, and H. Imura. The human endothelin-B receptor gene: structural organization and chromosomal assignment. J. Biol. Chem. 268: 3463-3470, 1993.
  • [PubMed]
  • H. Itoh, N. Sagawa, M. Hasegawa, A. Okagaki, K. Inamori, Y. Ihara, T. Mori, Y. Ogawa, S. Suga, M. Mukoyama, K. Nakao, and H. Imura. Brain natriuretic peptide is present in the human amniotic fluid and is secreted from amnion cells. J. Clin. Endocrinol. Metab. 76: 907-911, 1993.
  • [PubMed]
  • S. Suga, H. Itoh, Y. Komatsu, Y. Ogawa, N. Hama, T. Yoshimasa, and K. Nakao. Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells: evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells. Endocrinology 133: 3038-3041, 1993.
  • [PubMed]
  • H. Imura, K. Nakao, A. Shimatsu, Y. Ogawa, T. Sando, I. Fujisawa, and H. Yamabe. Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus. N. Engl. J. Med. 329: 683-689, 1993.
  • [PubMed]
1992年
  • S. Suga, K. Nakao, K. Hosoda, M. Mukoyama, Y. Ogawa, G. Shirakami, H. Arai, Y. Saito, Y. Kambayashi, K. Inouye, and H. Imura. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide. Endocrinology 130: 229-239, 1992.
  • [PubMed]
  • Y. Ogawa, K. Nakao, O. Nakagawa, Y. Komatsu, K. Hosoda, S. Suga, H. Arai, K. Nagata, N. Yoshida, and H. Imura. Human C-type natriuretic peptide: characterization of the gene and peptide. Hypertension 19: 809-813, 1992.
  • [PubMed]
  • S. Suga, K. Nakao, M. Mukoyama, H. Arai, K. Hosoda, Y. Ogawa, and H. Imura. Characterization of natriuretic peptide receptors in cultured cells. Hypertension 19: 762-765, 1992.
  • [PubMed]
  • S. Suga, K. Nakao, I. Kishimoto, K. Hosoda, M. Mukoyama, H. Arai, G. Shirakami, Y. Ogawa, Y. Komatsu, O. Nakagawa, N. Hama, and H. Imura. Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells. Circ. Res. 71: 34-39, 1992.
  • [PubMed]
  • S. Suga, K. Nakao, H. Itoh, Y. Komatsu, Y. Ogawa, N. Hama, and H. Imura. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β: possible existence of “vascular natriuretic peptide system”. J. Clin. Invest. 90: 1145-1149, 1992.
  • [PubMed]
  • K. Hosoda, K. Nakao, N. Tamura, H. Arai, Y. Ogawa, S. Suga, S. Nakanishi, and H. Imura. Organization, structure, chromosomal assignment and expression of the gene encoding the human endothelin-A receptor. J. Biol. Chem. 267: 18797-18804, 1992.
  • [PubMed]
  • Y. Komatsu, K. Nakao, H. Itoh, S. Suga, Y. Ogawa, and H. Imura. Vascular natriuretic peptide. Lancet 340: 622, 1992.
  • Y. Komatsu, H. Itoh, S. Suga, T. Igaki, Y. Ogawa, I. Kishimoto, O. Nakagawa, T. Yoshimasa, and K. Nakao. Regulation of secretion and clearance of C-type natriuretic peptide in the interaction of vascular endothelial cells and smooth muscle cells. J. Hypertens. 14: 585-592, 1992.
  • [PubMed]
1991年
  • G. Shirakami, K. Nakao, Y. Saito, T. Magaribuchi, M. Jougasaki, M. Mukoyama, H. Arai, K. Hosoda, S. Suga, Y. Ogawa, T. Yamada, K. Mori, and H. Imura. Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats. Life Sci. 48: 969-976, 1991.
  • [PubMed]
  • M. Mukoyama, K. Nakao, K. Hosoda, S. Suga, Y. Saito, Y. Ogawa, G. Shirakami, M. Jougasaki, K. Obata, H. Yasue, Y. Kambayashi, K. Inouye, and H. Imura. Brain natriuretic peptide (BNP) as a novel cardiac hormone in humans: evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J. Clin. Invest. 87: 1402-1412, 1991.
  • [PubMed]
  • K. Hosoda, K. Nakao, M. Mukoyama, Y. Saito, M. Jougasaki, G. Shirakami, S. Suga, Y. Ogawa, H. Yasue, and H. Imura. Expression of brain natriuretic peptide gene in human heart: production in the ventricle. Hypertension 17: 1152-1155, 1991.
  • [PubMed]
  • K. Hosoda, K. Nakao, H. Arai, S. Suga, Y. Ogawa, M. Mukoyama, G. Shirakami, Y. Saito, S. Nakanishi, and H. Imura. Cloning and expression of human endothelin-1 receptor cDNA. FEBS Lett. 287: 23-26, 1991.
  • [PubMed]
  • Y. Ogawa, K. Nakao, M. Mukoyama, K. Hosoda, G. Shirakami, H. Arai, Y. Saito, S. Suga, M. Jougasaki, and H. Imura. Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats: the ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Circ. Res. 69: 491-500, 1991.
  • [PubMed]
  • Y. Ogawa, K. Nakao, H. Arai, O. Nakagawa, K. Hosoda, S. Suga, S. Nakanishi, and H. Imura. Molecular cloning of a non-isopeptide-selective human endothelin receptor. Biochem. Biophys. Res. Commun. 178: 248-255, 1991.
  • [PubMed]
  • Y. Komatsu, K. Nakao, S. Suga, Y. Ogawa, M. Mukoyama, H. Arai, G. Shirakami, K. Hosoda, O. Nakagawa, N. Hama, I. Kishimoto, and H. Imura. C-type natriuretic peptide (CNP) in rats and humans. Endocrinology 129: 1104-1106, 1991.
  • [PubMed]
  • M. Mukoyama, K. Nakao, K. Obata, M. Jougasaki, M. Yoshimura, E. Morita, K. Hosoda, S. Suga, Y. Ogawa, H. Yasue, and H. Imura. Augmented secretion of brain natriuretic peptide in acute myocardial infarction. Biochem. Biophys. Res. Commun. 180: 431-436, 1991.
  • [PubMed]
  • K. Nakao, M. Mukoyama, K. Hosoda, S. Suga, Y. Ogawa, Y. Saito, G. Shirakami, H. Arai, M. Jougasaki, and H. Imura. Biosynthesis, secretion and receptor selectivity of human brain natriuretic peptide. Can. J. Physiol. Pharmacol. 69: 1500-1506, 1991.
  • [PubMed]
  • K. Nakao, H. Arai, K. Hosoda, Y. Ogawa, O. Nakagawa, S. Suga, S. Nakanishi, and H. Imura. Molecular cloning of two subtypes of human endothelin receptor. J. Vasc. Med. Biol. 3: 303-307, 1991.
1990年
  • Y. Kambayashi, K. Nakao, M. Mukoyama, Y. Saito, Y. Ogawa, S. Shiono, K. Inoue, N. Yoshida, and H. Imura. Isolation and sequence determination of human brain natriuretic peptide in human atrium. FEBS Lett. 259: 341-345, 1990.
  • [PubMed]
  • Y. Saito, K. Nakao, M. Mukoyama, G. Shirakami, H. Itoh, T. Yamada, H. Arai, K. Hosoda, S. Suga, M. Jougasaki, Y. Ogawa, S. Nakajima, M. Ueda, and H. Imura. Application of monoclonal antibodies for endothelin to hypertensive research. Hypertension 15: 734-738, 1990.
  • [PubMed]
  • K. Nakao, H. Itoh, Y. Kambayashi, K. Hosoda, Y. Saito, T. Yamada, M. Mukoyama, H. Arai, G. Shirakami, S. Suga, M. Jougasaki, Y. Ogawa, K. Inoue, and H. Imura. Rat brain natriuretic peptide: isolation from rat heart and tissue distribution. Hypertension 15: 774-778, 1990.
  • [PubMed]
  • Y. Ogawa, K. Nakao, M. Mukoyama, G. Shirakami, H. Itoh, K. Hosoda, Y. Saito,H. Arai, S. Suga, M. Jougasaki, T. Yamada, Y. Kambayashi, K. Inoue, and H. Imura. Rat brain natriuretic peptide: tissue distribution and molecular form. Endocrinology 126: 2225-2227, 1990.
  • [PubMed]
  • M. Mukoyama, K. Nakao, Y. Saito, Y. Ogawa, K. Hosoda, S. Suga, G. Shirakami, M. Jougasaki, and H. Imura. Human brain natriuretic peptide, a novel cardiac hormone. Lancet 335: 801-802, 1990.
  • [PubMed]
  • M. Mukoyama, K. Nakao, Y. Saito, Y. Ogawa, K. Hosoda, S. Suga, G. Shirakami, M. Jougasaki, and H. Imura. Increased human brain natriuretic peptide in congestive heart failure. N. Engl. J. Med. 323: 757-758, 1990.
  • [PubMed]
1989年
  • Y. Kambayashi, K. Nakao, H. Itoh, K. Hosoda, Y. Saito, T. Yamada, M. Mukoyama, H. Arai, G. Shirakami, S. Suga, Y. Ogawa, M. Jougasaki, N. Minamino, K. Kangawa, H. Matsuo, K. Inouye, and H. Imura. Isolation and sequence determination of rat cardiac natriuretic peptide. Biochem. Biophys. Res. Commun. 163: 233-240, 1989.
  • [PubMed]
  • Y. Saito, K. Nakao, G. Shirakami, M. Jougasaki, T. Yamada, H. Itoh, M. Mukoyama, H. Arai, K. Hosoda, S. Suga, Y. Ogawa, and H. Imura. Detection and characterization of endothelin-1-like immunoreactivity in rat plasma. Biochem. Biophys. Res. Commun. 163: 1512-1516, 1989.
  • [PubMed]

英文総説

M. Itoh, T. Suganami, R. Hachiya, and Y. Ogawa. Adipose tissue remodeling as homeostatic inflammation. Int. J. Inflamm. 720926, 2011.[PubMed]

T. Suganami and Y. Ogawa. Adipose tissue macrophages: their role in adipose tissue remodeling. J. Leukoc. Biol. 88: 33-39, 2010.[PubMed]

Y. Ogawa, H. Masuzaki, and K. Nakao. Clinical implication of leptin, the obese gene product. Intern. Med. 38: 210-212, 1999.[PubMed]

K. Nakao, H. Itoh, Y. Saito, M. Mukoyama, and Y. Ogawa. The natriuretic peptide family. Curr. Opin. Cardiol. 5: 4-11, 1996.

Y. Ogawa, H. Itoh, and K. Nakao. Molecular biology and biochemistry of natriuretic peptide family. Clin. Exp. Pharmacol. Physiol. 22: 49-53, 1995.[PubMed]

K. Nakao, H. Itoh, S. Suga, Y. Ogawa, and H. Imura. The natriuretic peptide family. Curr. Opin. Nephrol. Hypertens. 2: 45-50, 1993.

K. Nakao, Y. Ogawa, S. Suga, and H. Imura. Molecular biology and biochemistry of the natriuretic peptide system II: natriuretic peptide receptors. J. Hypertens. 10: 1111-1114, 1992.[PubMed]

K. Nakao, Y. Ogawa, S. Suga, and H. Imura. Molecular biology and biochemistry of the natriuretic peptide system I: natriuretic peptides. J. Hypertens. 10: 907-912, 1992.[PubMed]

英文著書

Y. Ogawa. Leptin and the metabolic syndrome. In “Proceedings of the 3rd Asian-Oceania Conference on Obesity”, The Leader Book CO., LTD., pp. 23-30, 2005.

Y. Ogawa and K. Nakao. Pathophysiologic and therapeutic implication of leptin in obesity-related complications: lessons from transgenic skinny mice. In “Progress in Obesity Research: 9”, edited by G. Medeiros-Neto, A. Halpern, and C. Bouchard, John Libbey Eurotext Ltd, pp. 223-225, 2003.

H. Yasue, M. Yoshimura, M. Nakayama, Y. Shimasaki, K. Kugiyama, H. Ogawa, Y. Saito, Y. Ogawa, Y. Miyamoto, and K. Nakao. Genetic analysis of endothelial nitric oxide synthase in patients with coronary spasm. In “Common Diseases: Genetic and Pathogenic Aspects of Multifactorial Diseases”, edited by H. Imura, M. Kasuga, and K. Nakao, Elsevier Science B.V. pp.237-248, 1999.

K. Nakao, Y. Ogawa, H. Masuzaki, M. Aizawa-Abe, K. Ebihara, N. Mastuoka, N. Satoh, T. Hayashi, K. Hosoda, G. Inoue, and Y. Yoshimasa. Potential usefulness of leptin for the treatment of diabetes. In “Common Diseases: Genetic and Pathogenic Aspects of Multifactorial Diseases”, edited by H. Imura, M. Kasuga, and K. Nakao, Elsevier Science B.V. pp. 21-30, 1999.

Y. Ogawa, H. Masuzaki, N. Sagawa, and K. Nakao. Leptin as an adipocyte- and nonadipocyte-derived hormone. In “Pennington Center Nutrition Series: 9, Nutrition, Genetics, and Obesity”, edited by G.A. Bray & D.H. Ryan, Louisiana State University Press. pp. 147-155, 1999.

Y. Ogawa, N. Sagawa, H. Masuzaki, S. Yura, H. Mise, K. Ebihara, S. Fujii, and K. Nakao.　Leptin, a novel placenta-derived hormone in humans. In “Progress in Obesity Research: 8”, edited by G. Ailhaud & B. Guy-Grand, John Libbey & Company Ltd. pp. 71-75, 1999.

H. Itoh, S. Suga, Y. Ogawa, K. Komatsu, N. Tamura, T. Igaki, J. Yamashita, K. Doi, T.-H. Chun, M. Inoue, K. Masatsugu, T. Ikeda, G. Shirakami, K. Matsuda, G. Katsuura, M. Ueda, T. Ban, and K. Nakao. Cellular and molecular aspects of C-type natriuretic peptide (CNP). In “Contemporary Endocrinology: Natriuretic Peptides in Health and Disease” edited by W. K. Samson and E. R. Levin, Human Press Inc., Totowa, pp. 107-122, 1997.

K. Nakao, Y. Ogawa, S. Suga, and H. Imura. Molecular biology and biochemistry of the natriuretic peptide system. In “Molecular Reviews in Cardiovascular Medicine” edited by K. Lindpaintner & D. Ganten, Chapman & Hall, London, pp. 74-82, 1996.

Y. Ogawa, and K. Nakao. Brain natriuretic peptide as a cardiac hormone in cardiovascular disorders. In “Hypertension: Pathophysiology, Diagnosis and Management” 2nd Edition, edited by J. H. Laragh & B. M. Brenner. Raven Press, New York, pp. 833-840, 1995.

著書企画・編集

小川佳宏（編集）：「異所性脂肪：メタボリックシンドロームの新常識」　日本医事新報社

門脇　孝、小川佳宏（編集）：糖尿病カレントライブラリー⑦「脂肪細胞と脂肪組織」　文光堂

門脇　孝、小川佳宏、下村伊一郎（編集）：別冊・医学のあゆみ「糖尿病・代謝症候群－state of arts 2004-2006」　医歯薬出版株式会社

特集企画・編集

小川佳宏（編集）：アディポサイエンス　特集2011年3月「やせとアディポサイエンス」　フジメディカル出版

小川佳宏（編集）：実験医学　特集2010年7月「慢性炎症の分子プロセス」　羊土社

小川佳宏（編集）：Pharma Medica　特集2009年10月「やせの医学」　メディカルレビュー社

水島　昇、小川佳宏（編集）：細胞工学　特集2009年8月「栄養に応答する細胞シグナル：細胞生存、糖尿病、肥満，癌とのかかわり」　秀潤社

小川佳宏（編集）：アディポサイエンス　特集2008年3月「メタボリックシンドローム Update」　フジメディカル出版

小川佳宏（編集）：The Lipid 特集2009年7月「脂溶性シグナル分子と疾患」　メディカルレビュー社

小川佳宏（編集）：The Lipid 特集2008年10月「ω3高不飽和脂肪酸－最近の進歩－」　メディカルレビュー社