Department of Pathological Cell Biology

Achievements

2023

Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. M. Tsujioka, K. Miyazawa, M. Ohmuraya, Y. Nibe, T. Shirokawa, H. Hayasaka, T. Mizushima, T. Fukuma, S. Shimizu. Cell Death Dis. Apr 8;14(4):256, 2023

2022

Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. H. Matsuda, Y. Nibe-Shirakihara, A. Tamura, E. Aonuma, S. Arakawa, K. Otsubo, Y. Nemoto, T. Nagaishi, K. Tsuchiya, S. Shimizu. A. Ma, M. Watanabe, M. Uo, R. Okamoto. BBRC 592, 74-80, 2022

Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. T. Yanagi, H. Kikuchi, K. Susa, N. Takahashi, H. Bamba, T. Suzuki, Y. Nakano, T. Fujiki, Y. Mori ,F. Ando, S. Mandai, T. Mori, K. Takeuchi, S. Honda, S. Torii, S. Shimizu, T. Rai, S. Uchida, E. Sohara. Genes Cells. Nov 1, 2022

FLIP-based autophagy-detecting technique reveals closed autophagic compartments. H. Tajima Sakurai, S. Arakawa, S. Noguchi, S. Shimizu, Scientific Reports volume 12, Article number: 22452, 2022

2021

Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. S. Sato, S. Noda, S. Torii, T. Amo, A. Ikeda, M. Funayama, J. Yamaguchi, T. Fukuda, H. Kondo, N. Tada, S. Arakawa, M. Watanabe, Y. Uchiyama, S. Shimizu, N. Hattori. Human Molecular Genetics 30, 443-453, 2021

Oxidized phospholipids and neutrophil elastase coordinately play critical roles in NET formation. T. Tokuhiro, A. Ishikawa, H. Sato, S. Takita, A. Yoshikawa, R. Anzai, S. Sato, R. Aoyagi, M. Arita, Y. Aratani, S. Shimizu, M. Tanaka, S. Yotsumoto. Frontiers in Cell and Developmental Biology, 2021

Molecular mechanisms and biological roles of GOMED.
S. Noguchi, S. Shimizu. FEBS J., Nov 17, 2021

2020

The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Y. Kato, S. Arakawa, K. Terasawa, J.I. Inokuchi, T. Iwata, S. Shimizu, T. Watabe. Bioorg. Med. Chem. Lett. 30: 126891, 2020

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. H. Kato, K. Okabe, M. Miyake, K. Hattori, T. Fukaya, K. Tanimoto, S. Beini, M. Mizuguchi, S. Torii, S. Arakawa, M. Ono, Y. Saito, T. Sugiyama, T. Funatsu, K. Sato, S. Shimizu, S. Oyadomari, H. Ichijo, H. Kadowaki, H. Nishitoh. Life Science Alliance 3: 3, e201900576, 2020

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy.
S. Torii, H. Yamaguchi, A. Nakanishi, S. Arakawa, S. Honda, K. Moriwaki, H. Nakano, S. Shimizu. Nature Commun 11, Article number: 1754, 2020

Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.
A. Yasueda, H. Kayama, M. Murohashi, J. Nishimura, K. Wakame, K. Komatsu, T. Ogino, N. Miyoshi, H. Takahashi, M. Uemura, C. Matsuda, T. Kitagawa, K. Takeda, T. Ito, Y. Doki, H. Eguchi, S. Shimizu, T. Mizushima. Scientific Reports 10, Article number: 9972, 2020

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. H. Yamaguchi, S. Honda, S. Torii, K. Shimizu, K. Katoh, K. Miyake, N. Miyake, N. Fujikake, H. Sakurai, S. Arakawa, S. Shimizu. Nature Commun 11, Article number: 5311, 2020

Association between Atg5-independent alternative autophagy and neurodegenerative diseases. S. Honda, S. Arakawa, H. Yamaguchi, S. Torii, HT. Sakurai, M. Tsujioka, M. Murohashi, S. Shimizu. J. Mol. Biol. 432(8): 2622-2632, 2020

Mitochondrial E3 Ubiquitin Ligase Parkin:Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate-Involved Mouse Experimental Models. S. Torii, S. Kasai, T. Yoshida, K. Yasumoto, S. Shimizu. Int. J. Mol. Sci. 21, 1202, 2020

Involvement of phosphorylation of ULK1 in alternative autophagy. S. Torii, S. Shimizu. Autophagy 16, 1532-1533, 2020

Cancer Science Autophagy Involvement in Oncogenesis. S. Torii, S. Honda, M. Murohashi, H. Yamaguchi, S. Shimizu Cancer Science, 111, 3993-3999, 2020

Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells.
K. Otsubo, C. Maeyashiki, Y. Nibe, A. Tamura, E. Aonuma, H. Matsuda, M. Kobayashi,
M. Onizawa, Y. Nemoto, T. Nagaishi, R. Okamoto, K. Tsuchiya, T. Nakamura, S. Torii,
E. Itakura, M. Watanabe, S. Oshima. FEBS Letters, 594, 1586-1595, 2020

2019

Organelle zones in mitochondria. S. Shimizu. J. Biochem. 165, 101-107, 2019

Beclin 1 regulates recycling endosome and is required for skin development in mice. S. Noguchi, S. Honda, T. Saitoh, H. Matsumura, E. Nishimura, S. Akira, S. Shimizu. Communications Biology Honda, 2, Article No. 37, 2019.

Role of cyclooxygenase-2/prostaglandin E2/prostaglandin E receptor 4 signaling in cardiac reprogramming. N. Muraoka, K. Nara, F. Tamura, H. Kojima, H. Yamakawa, T. Sadahiro, K. Miyamoto, M. Isomi, S. Haginiwa, H. Tani, S. Kurotsu, R. Osakabe, S. Torii, S. Shimizu, H. Okano, Y. Sugimoto, K. Fukuda, M. Ieda. Nature Commun. 10, Article No. 674, 2019.

Prediction of intracellular targets of a small compound by analyzing peptides presented on MHCclass I. Y. Sugimoto, M. Murohashi, S. Arakawa, S. Honda, S. Shimizu. BBRC 508, 480-486, 2019.

2018

Association between autophagy and neurodegenerative diseases. N. Fujikake, M. Shin, S. Shimizu. Frontiers in Neuroscience. 12, 255, 2018

Biological Roles of AlternativeAutophagy. S. Shimizu. Mol Cells. 41, 50-54, 2018

Dram1 regulates DNA damage-induced alternative autophagy. M. Nagata, S. Arakawa, H. Yamaguchi, S. Torii, H. Endo, M. Tsujioka, S. Honda, Y. Nishida, A. Konishi, S. Shimizu. Cell Stress 2, 55-65, 2018.

Fluorescent small molecules for monitoring autophagic flux. H. Iwashita, H. Tajima Sakurai, N. Nagahora, M. Ishiyama, K. Shioji, K. Sasamoto, K. Okuma, S. Shimizu, Y. Ueno. FEBS let. 592, 559-567, 2018.

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. T. Yamaguchi, T. Suzuki, T. Sato, A. Takahashi, H. Watanabe, A. Kadowaki, M. Natsui, H. Inagaki,S. Arakawa, S.Nakaoka, Y. Koizumi, S. Seki, S. Adachi, A. Fukao, T. Fujiwara, T. Natsume, A. Kimura, M. Komatsu, S. Shimizu, H. Ito, Y. Suzuki, J. M. Penninger, T. Yamamoto, Y. Imai, K.Kuba. Scientific Signalling 11(516), pii: eaan3638, 2018.

2017

Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy S. Arakawa, S. Honda, H. Yamaguchi, S. Shimizu. Proceedings of the Japan Academy, Series B, 93 (6), 378-385, 2017

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. S. Yotsumoto, Y. Muroi, T. Chiba, R. Ohmura, M. Yoneyama, M. Magarisawa, K. Dodo, N.Terayama, M. Sodeoka, R. Aoyagi, M. Arita, S. Arakawa, S. Shimizu, M. Tanaka. Scientific Reports 7, Article number: 16026, 2017

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates. K. Kanemoto, Y. Sugimura, S. Shimizu, S. Yoshida, T. Hosoya. Chem. Commun. 53, 10640–10643, 2017.

Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule. H. Iwashita, S. Torii, N. Nagahora, M. Ishiyama, K. Shioji, K. Sasamoto, S. Shimizu, K. Okuma. ACS Chemical Biology 12, 2546-2551 2017

Autophagy controls centrosome number. S. Honda, S. Shimizu. OncoTargetCommentary 8, 14277-14278, 2017

Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration. J. Asano, T. Sato, S. Ichinose, M. Kajita, N. Onai, S. Shimizu, T. Ohteki. Cell reports 20 (5), 1017-1254. 2017

Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. S. Arakawa, M. Tsujioka, T. Yoshida, H. Tajima-Sakurai, Y. Nishida, Y. Matsuoka, I. Yoshino, Y. Tsujimoto, S. Shimizu Cell Death Differ 24 (9), 1598-1608. 2017

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. T. Kozaki, J. Komano, D. Kanbayashi, M. Takahama, T. Misawa, T. Satoh, O. Takeuchi, T. Kawai, S. Shimizu, Y. Matsuura, S. Akira, T. Saitoh. PNAS114 (10), 2681-2686. 2017

2016

Autophagy controls centrosome number by degrading Cep63. Y. Watanabe, S. Honda, A. Konishi, S. Arakawa, M. Murohashi, H. Yamaguchi, S. Torii, M. Tanabe, S. Tanaka, E. Warabi, S. Shimizu Nature Commun 7:13508, 2016

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. S. Torii, T. Yoshida, S. Arakawa, S. Honda, A. Nakanishi, S. Shimizu EMBO R 11:1552-1564, 2016

TRF2 Interacts with Core Histones to Stabilize Chromosome Ends. A. Konishi, T. Izumi, and S. Shimizu J. Biol. Chem. 291(39):20798-810, 2016

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Y. Nasu, A. Benke, S. Arakawa, G. Yoshida, G. Kawamura, S. Manley, S. Shimizu, and T. Ozawa Scientific Reports 6, Article number: 27505, 2016

Golgi membrane-associated degradation pathway in yeast and mammals. H. Yamaguchi, S. Arakawa, T. Kanaseki, T. Miyatsuka, Y. Fujitani, H. Watada, Y. Tsujimoto and S. Shimizu EMBO J 35:1991-2007, 2016

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF.T. Yoshida, M. Tsujioka, S. Honda, M. Tanaka, S. Shimizu OncoTarget 7:34420-9, 2016

Monitoring of Atg5-independent Mitophagy. S. Arakawa, S. Honda, S. Torii, M. Tsujioka, S. Shimizu. "Mitophagy" Volume in ‘Methods in Molecular Biology Springer Press, p1-8, 2016

Global analysis gene expression of the liver on metabolic syndrome mice model treated by low-molecular-weight lychee fruit polyphenol. H. Uchiyama, K. Uehara, T. Nagashima, A. Nakata, K. Sato, Y. Mihara, K. Komatsu, J. Takanari, S. Shimizu, K. Wakame. Anticancer Research ,36(7):3705-13,2016

PPM1D is an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. S. Torii, T. Yoshida, S. Arakawa, S. Honda, A. Nakanishi, S. Shimizu. EMBO R 17(11):1552-1564

2015

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates. S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama, T. Yano, S. Shimizu, T. Hosoya. Chemical Commun. 51:16613-16616, 2015

Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. S. Arakawa, I. Nakanomyo, Y. Kudo-Sakamoto, H. Akazawa, I. Komuro, S. Shimizu. Biochem. Biophys. Res. Commun. 467, 1006-1011, 2015

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation. S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa,
S. Shimizu
, K. Tomooka, T. Hosoya. J. Am. Chem. Soc. 137:14071–14074, 2015

Autophagic Cell Death and Cancer Chemotherapeutics. S. Shimizu ."Innovative Medicine : Basic Research and Development" Springer Press, 219-226, 2015

2014

Autophagic Cell Death and Cancer. S. Shimizu, T. Yoshida, M.Tsujioka, S. Arakawa. INT.J. Mol. Sci. 2014, 15(2), 3145-3153

Alternative macroautophagy and mitophagy. S.Shimizu, S.Honda,S.Arakawa,H.Yamaguchi. Int J Biochem Cell Biol. 2014 May ;50:64-6. doi: 10.1016/j.biocel.2014.02.016.

HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. H. Ito, K. Fujita, K. Tagawa, X. Chen, H. Homma, T. Sasabe, J. Shimizu, S. Shimizu, T. Tamura, S. Muramatsu, H. Okazawa. EMBO Mol. Med. 7, 78-101, 2014

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. S. Honda, S. Arakawa, Y. Nishida, H. Yamaguchi, E. Ishii, S. Shimizu. Nature Commun. 5, Article number:4004, 2014

2013

Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice. T.Mizushima, S.Arakawa, Y.Sanada,I.Yoshino, D.Miyazaki, H.Urushima, Y.Tsujimoto,T. Ito, S.Shimizu. Am J Pathol. 2013 Dec ;183(6) :1936-1944.

Mammalian Autophagy Can Occur Through an Atg5/Atg7-Independent Pathway.
S. Shimizu, S. Arakawa, Y. Nishida, H. Yamaguchi, T. Yoshida.AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection.Vol.2 (Edit MA Hayat) Academic Press, 49-59, 2013

2012

p53 Inhibits Vascular Endothelial Growth Factor Expression in Solid Tumor. Y.Yoshioka, S.Shimizu, T.Ito, M.Taniguchi, M.Nomura, T.Nishida, Y.Sawa.
J Surg Res. 174:291-297, 2012

Involvement of beclin 1 in engulfment of apoptotic cells. A.Konishi, S.Arakawa, Z.Yue , and S.Shimizu. J Biol Chem. 287(17): 13919-13929. 2012.

Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. M.Fukumatsu, M.Ogawa , S.Arakawa , M.Suzuki, K.Nakayama , S.Shimizu, M.Kim , H.Mimuro, C.Sasakawa.  Cell Host Microbe. 11(4):325-336. 2012

Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Y.Miyaoka, K.Ebato, H.Kato, S.Arakawa, S.Shimizu, A.Miyajima. Curr. Biol. 22:1166-75, 2012

Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine. I.Nakase, S.Okumura, S.Katayama, H.Hirose, S.Pujals, H.Yamaguchi, S.Arakawa, S.Shimizu, S.Futaki. Chemical Commun. 48:11097-99, 2012

Guidelines for the use and interpretation of assays for monitoring autophagy. DJ. Klionsky, et al. (include S. Shimizu) .Autophagy 8, 445-544, 2012

2011

Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice. H. Hikita, T. Takehara, T. Kodama, S. Shimizu, M. Shigekawa, A.Hosui, T. Miyagi, T. Tatsumi, H. Ishida, Li W, T. Kanto, N.Hiramatsu, S. Shimizu, Y. Tsujimoto, N. Hayashi. Hepatology 54:240-251, 2011.

Spatial coupling of mTOR and autophagy augments secretory phenotypes. M. Narita, A.R.J. Young, S.Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S.K. Hong, L.S. Berry, S. Reichelt, M. Ferreira, S. Tavare, K. Inoki, S. Shimizu, and M. Narita. Science 332: 966-970, 2011

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. T. Yamasaki, H. Kawasaki, S. Arakawa, K. Shimizu, S.Shimizu, O. Reiner, H. Okano, S. Nishina, N. Azuma, J.M. Penninger, T. Katada and H Nishina. Journal of Neuroscience. 31: 16872-16883, 2011

2010

The role of cyclophilin D in learning and memory. A.Mouri, Y.Noda, S.Shimizu, Y.Tsujimoto, T,Nabeshima. Hippocampus20, 293-304, 2010

Involvement of JNK in the regulation of autophagic cell death. S.Shigeomi, A.Konishi, Y.Nishida, T.Mizuta, H.Nishina, A.Yamamoto, Y.Tsujimoto. Oncogene 29, 2070-2082, 2010

xCT deficiency accelerates chemically induced tumorigenesis. A.Nabeyama, A.Kurita, K.Asano, Y.Miyake, T.Yasuda, I.Miura, G.Nishital, S.Arakawa, S.Shimizu, S.Wakame, H.Yoshida, M.Tanaka. Proc. Natl. Acad. Ssi. USA 107, 6436-6441, 2010

Cyclophilin D-dependent mitochondrial permeability transition is not involved in neurodegeneration in mnd2 mice. K.Ideguchi, S.Shimizu, M.Okumura, Y.Tsujimoto.Biochem. Biophys. Res. Commun. 393, 264-267, 2010.

Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method. K.Kamiya, K.Tsumoto, S.Arakawa, S.Shimizu, I.Morita, T.Yoshimura, K.Akiyoshi. Biotechnol. Bioeng. 107, 836-843, 2010

Neurodegeneration in mnd2 mutant mice is not prevented by parkin transgene.
T.Yoshida, T.Mizuta, S.Shimizu. Biochem. Biophys. Res. Commun. 402, 676-679, 2010.

Autophagy takes an alternative pathway. S.Shimizu, S.Arakawa, Y.Nishida. Autophagy 6.2, 290-291, 2010

2009

Discovery of Atg5/Atg7-independent alternative macroautophagy. Y. Nishida,S. Arakawa, K. Fujitani., H. Yamaguchi, T. Mizuta, T. Kanaseki, M. Komatsu, K. Otsu, Y. Tsujimoto, S. Shimizu. Nature 461, 654-658, 2009

Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax. H. Yamagata, S. Shimizu, Y. Nishida, Y. Watanabe, W.J. Craigen, Y. Tsujimoto. Oncogene 28, 3563-3572, 2009

Autophagy mediates the mitotic-senescence transition. M. Narita, M. Ferreira, K. Kirschner, M. Sadaie, J.F. Darot, S. Tavaré, S. Arakawa, S. Shimizu, F.M. Watt, M. Narita. A.R. Young, Genes Dev. 23, 798-803, 2009

The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging. M. Kato, M. Akao, M. Matsumoto-Ida, T. Makiyama, M. Iguchi, T. Takeda, S. Shimizu, T. Kita. Cardiovascular Research 83, 335-344, 2009

Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase. H. Shimada, K. Hirai, E. Simamura, T. Hatta, H. Iwakiri, K. Mizuki, T. Hatta, T. Sawasaki, S. Matsunaga, Y. Endo, S. Shimizu. J. Biol. Chem. 284, 28642-28649, 2009

2008

Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution. K.Kajitani , M.Fujihashi , Y.Kobayashi, S.Shimizu, Y.Tsujimoto, K.Miki. Proteins. 2008 Mar;70 (4):1635-9.

Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis. C.Suzuki, Y.Isaka, S.Shimizu, Y.Tsujimoto, Y.Takabatake, T.Ito, S.Takahara, E.Imai. Cell Transplant. 2008;17(1-2):223-9.

Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H. Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur J Neurosci. 2008 Jul;28(1):30-40.

2001

Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y.Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells.J Cell Biol. 2001 Jan 22;152(2):237-50.

Nakagawa H, Ohshima Y, Takusagawa M, Ikota N, Takahashi Y, Shimizu S, Ozawa T. Functional modification of cytochrome c by peroxynitrite in an electron transfer reaction. Chem. Pharm. Bull. 49, 1547-1554, 2001

2000

Shimizu S, Tsujimoto Y.Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):577-82.

Shimizu S, Konishi A, Kodama T, Tsujimoto Y.BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3100-5.

Shimizu S, Ide T, Yanagida T, Tsujimoto Y.Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem. 2000 Apr 21;275(16):12321-5.

Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N.Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem. 2000 May 19;275(20):15343-9.

Shimizu S, Shinohara Y, Tsujimoto Y.Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene. 2000 Sep 7;19(38):4309-18.

Kusano H, Shimizu S, Koya RC, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y.Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 2000 Oct 5;19(42):4807-14.

Tsujimoto Y, Shimizu S.Bcl-2 family: life-or-death switch. FEBS Lett. 2000 Jan 21;466(1):6-10.

Tsujimoto Y, Shimizu S.VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ. 2000 Dec;7(12):1174-81.

1996

Hasegawa J, Kamada S, Kamiike W, Shimizu S, Imazu T, Matsuda H, Tsujimoto Y.Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. Cancer Res. 1996 Apr 15;56(8):1713-8.

Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, Yamabe K, Otsuki Y, Matsuda H, Tsujimoto Y. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res. 1996 May 1;56(9):2161-6.

Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y.Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene. 1996 May 16;12(10):2045-50.

Shimizu S, Eguchi Y, Kamiike W, Matsuda H, Tsujimoto Y.Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene. 1996 Jun 6;12(11):2251-7.

Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y.Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene. 1996 Jul 4;13(1):21-9.

Shimizu S, Eguchi Y, Kamiike W, Akao Y, Kosaka H, Hasegawa J, Matsuda H, Tsujimoto Y. Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am J Physiol. 1996 Dec;271(6 Pt 1):G949-58.

Morimoto Y, Kamiike W, Nishida T, Hatanaka N, Shimizu S, Huang TP, Hamada E, Uchiyama Y, Yoshida Y, Furuya E, Matsuda H.Improvement of rat liver graft function by insulin administration to donor. Gastroenterology. 1996 Oct;111(4):1071-80.