| 2006-2010 | 2001-2005 | |||
| 1996-2000 | 1991-1995 | 総説 (英文 / 和文) | ||
| [2001-2005] |
| Synthetic Retinoid
Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima
Formaiton by Inhibiting KLF5 Fujiu, K.; Manabe, I.; Ishihara, A.; Oishi, Y.; Iwata, H.; Nishimura, G.; Shindo, T.; Maemura, K.; Kagechika, H.; Shudo, K.; Nagai, R. Circulation Res.2005, 97, 1132-1141. |
| Retinoic acid via RAR
alpha inhibits the expression of 24-hydroxylase in human prostate stromal
cells Lou, Y.-R.; Miettinen, S.; Kagechika, H.; Gronemeyer, H.; Tuohima, P. Biochem. Biophys. Res. Commun.2005, 338, 1973-1981. |
| Selective allosteric
ligand activation of the retinoid X receptor heterodimers of NGFI-B and
Nurr 1 Morita, K.; Kawana, K.; Sodeyama, M.; Shimomura, I.; Kagechika, H.; Makishima, M. Biochem. Pharmacol.2005, 71, 98-107. |
| Upregulation of
Nitric Oxide Production in Vascular Endothelical Cells by All-trans
Retinoic Acid Through the Phosphoinositide 3-Kinase/Akt
Pathway Uruno, A.; Sugawara, A.; Kanatsuka, H.; Kagechika, H.; Sato, K.; Kudo, M.; Takeuchi, K.; Ito, S. Circulation 2005, 112, 727-736. |
| RXR Agonist Enhances
the Differentiation of Cardiomyocytes Derived from Embryonic Stem Cells in
Serum-Free Conditions Honda, T.; Hamazaki, T. S.; Komazaki, S.; Kagachika, H.; Shudo, K.; Asashima, M. Biochmem. Biophys. Res. Commun. 2005, 333, 1334-1340. |
| Differential
modulation of PI3-kinase/Akt pathway during all-trans retinoic
acid- and Am80-induced HL-60 cell differentiation revealed by DNA
microarray analysis Ishida, S.; Shigemoto-Mogami, Y.; Shinozaki, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K. Biochem. Pharmacol. 2004, 68, 2177-2186. |
| ASynthetic Retinoid
Am80 (Tamibarotene) Rescue the Memory Deficit Caused by Scopolamine in a
Passive Avoidance Paradigm Shudo, K.; Kagechika, H.; Yamazaki, N.; Igarashi, M.; Takeda, C. Biol. Pharm. Bull. 2004, 27, 1887-1889. |
| Retinoic Acid Imprintis Gut-Homing Specificity on T
cells Iwata, M.; Hirakiyama, A.; Eshima, Y.; Kagechika, H.; Kato, C.; Song S.-Y. Immunity 2004, 21, 527-538. |
| Docosahexaenoic Acid Reduces Haloperidol-Induced Dyskinesias in
Mice: Involvement of Nur77 and Retinoid
Receptors Ethier, I.; Kagechika, H.; Shudo, K.; Rouillard, C.; Levesque, D. Biol. Psychiatry 2004, 56, 522-526. |
| The
Endocrine Disrutors Nonylphenol and Octylphenol Exert Direct Effects on T
cells to Suppress Th1 Development and Enhance Th2
Development Iwata, M.; Eshima, Y.; Kagechika, H.; Miyaura, H. Immunol. Lett. 2004, 94, 135-139. |
| Novel Retinoid X Receptor (RXR) Antagonists Having a
Dicarba-closo-dodecaborane as a Hydrophobic
Moiety Ohta, K.; Iijima, I.; Kawachi, E.; Kagechika, H.; Endo, Y. Bioorg. Med. Chem. Lett. 2004, 14, 5913-5918. |
| Design and synthesis cyclic urea compounds: a pharmacological study
for retinoidal activity Kurihara, M.; Rouf, A. S. S.; Kansui, H.; Kagechika, H.; Okuda, H.; Miyata, N. Bioorg. Med. Chem. Lett. 2004, 14, 4131-4134. |
| A
Novel Melatonin Derivative Modulates Sleep-wake Cycle in
Rats Akanmu, M. A.; Songkram, C.; Kagechika, H.; Honda, K. Neurosci. Lett. 2004, 364, 199-202. |
| Utility of Boron Clusters
for Drug Design. Relation Between Estrogen Receptor Binding Affinity and
Hydrophobicity of Phenols Bearing Various Types of Carboranyl
Groups Endo, Y.; Yamamoto, K.; Kagechika, H. Bioorg. Med. Chem. Lett. 2003, 13, 4089-4092. |
| Absolute Helical Arrangement of
Sulfonamide in the Crystal Azumaya, I.; Kato, T.; Okamoto, I.: Yamasaki, R.; Tanatani, A.; Yamaguchi, K.; Kagechika, H.; Takayanagi, H. Org. Lett. 2003, 5, 3939-3942. |
| Cyclooxygenase Inhibitors Derived from
Thalidomide Suidu, M.; Muroya, Y.; Kakuta, H.; Kagechika, H.; Tanatani, A.; Nagasawa, K.; Hashimoto, Y. Chem. Pharm. Bull. 2003, 51, 1098-1102. |
| Retinoic Acids Exert Direct Effects on T
Cells to Suppress Th1 Development and Enhance Th2 Development via Retinoic
Acid Receptors Iwata, M.; Eshima, Y.; Kagechika, H. Int. Immunol. 2003, 15, 1017-1025. |
| Amide Conformational Switching induced by
Protonation of Aromatic Substituent Yamasaki, R.; Tanatani, A.; Azumaya, I.; Saito, S.; Yamaguchi, K.; Kagechika, H. Org. Lett. 2003, 5, 1265-1267. |
| A retinoic acid receptor-selective
agonist causes jaw deformity in the Japanese flounder, Paralichthys olivaceus Haga, Y.; Suzuki, T.; Kagechika, H.; Takeuchi, T. Aquaculture 2003, 221, 381-392. |
| Effects of Retinoid Ligands on RIP140:
Molecular Interaction with Retinoid Receptors and Biological
Activity Farooqui, M.; Franco, P. J.; Thompson, J.; Kagechika, H.; Chandraratna, R. A. S.; Banaszak, L.; Wei, L.-N. Biochemsitry 2003, 42, 971-979. |
| Clinically Potential Subclasses of
Retinoid Synergists Revealed by Gene Expression Profiling Ishida, S.; Shigemoto-Mogami, Y.; Kagechika, H.; Shudo, K.; Ozawa, S.; Sawada, J.; Ohno, Y.; Inoue, K. Molecular Cancer Therapeutics 2003, 2, 49-58. |
| Effect of Synthetic Retinoid, TAC-101, on
Experimental Autoimmune Disease Miyagawa, N.; Homma, T.; Kagechika, H.; Shudo, K.; Nagaia, H. Pharmacology 2003, 67, 21-31. |
|
Determination of Endogenous
Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients.
Possible Correlation with HbA1c Values |
| Molecular construction based on
icosahedral carboranes and aromatic N,N'-dimethylurea groups. Aromatic
layered molecules and a transition metal complex Endo, Y.; Songkram, C.; Yamasaki, R.; Tanatani, A.; Kagechika, H.; Takaishi, K.; Yamaguchi, K. J. Organomet. Chem. 2002, 657, 48-58. |
|
Krueppel-like
zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II
signaling and an essential regulator of cardiovascular
remodeling |
| Novel Retinoid X Receptor Antagonists:
Specific Inhibition of Retinoid Synersism in RXR-RAR Heterodimer
Actions Takahashi, B.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H. J. Med. Chem. 2002, 45, 3327-3330. |
| Effect of natural and synthetic retinoids
on the proliferation and differentiation of three canine melanoma cell
lines Ohashi, E.; Inoue, K.; Kagechika, H.; Hong, S.-H.; Nakagawa, T.; Takahashi, T.; Mochizuki, M.; Nishimura, R.; Sasaki, N. J. Vet. Med. Sci. 2002, 64, 169-172. |
| Inhibition of RXR and PPAR ameliorates
diet-induced obesity and type 2 diabetes Yamauchi, T.; Waki, H.; Kamon, J.; Murakami, K.; Motojima, K.; Komeda, K.; Miki, H.; Kubota, N.; Terauchi, Y.; Tsuchida, A.; Tsuboyama-Kasaoka, N.; Yamauchi, N.; Ide, T.; Hori, W.; Kato, S.; Fukayama, M.; Akanuma, Y.; Ezaki, O.; Itai, A.; Nagai, R.; Kimura, S.; Tobe, K.; Kagechika, H.; Shudo, K.; Kadowaki, T. J. Clin. Invest. 2001, 108, 1001-1013. |
| Structures of bis- and
tris(2-phenyl-o-carboran-1-yl)benzenes. construction of three-dimensional
structures converted from planar arylacetylenic arrays Songkram, C.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y. Tetrahedron Lett. 2001, 42, 6365-6368. |
| Replenishment of the fat-derived hormone
adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Yamauchi, T.; Kamon, J.; Waki, H.; Terauchi, Y.; Kubota, N.; Hara, K.; Mori, Y.; Abe, M.; Tanaka, J.; Ohsumi, J.; Ide, T.; Murakami, K.; Tsuboyama-Kasaoka, N.; Ezaki, O.; Akanuma, Y.; Gavrilova, O.; Vinson, C.; Reitman, M.; Kagechika, H.; Shudo, K.; Yoda, M.; Nakano, Y.; Tobe, K.; Nagai, R.; Kimura, S.; Tomita, M.; Froguel P.; Kadowaki, T. Nature Medicine 2001, 7, 941-946. |
| Molecular Construction Based on
Icosahedral Carboranes and Aromatic Urea Groups. A New Type of Carboracycles. Songkram, C.; Yamasaki, R.; Tanatani, A.; Takaishi, K.; Yamaguchi, K.; Kagechika, H.; Endo, Y. Tetrahedron Lett. 2001, 42, 5913-5916. |
| a-Glucosidase Inhibitors with a
4,5,6,7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or
Dicarba-closo-dodecaborane Group Sou, S.; Takahashi, H.; Yamasaki, R.; Kagechika, H.; Endo, Y.; Hashimoto, Y. Chem. Pharm. Bull. 2001, 49, 791-793. |
| Structure-Activity Study of Retinoid
Agonists Bearing Substituted Dicarba-closo-dodecaborane. Relation between
Retinoidal Activity and Conformation of Two Aromatic Nuclei Endo, Y.; Iijima, T.; Yaguchi, K.; Kawachi, E.; Inoue, N.; Kagechika, H.; Kubo, A.; Itai, A. Bioorg. Med. Chem. Lett. 2001, 11, 1307-1311. |
| Inhibition by retinoids of
antigen-induced IL-4 production in rat mast cell line RBL-2H3
Hirasawa, N.; Kagechika, H.; Shudo, K.; Ohuchi, K. Life Sci. 2001, 68, 1287-1294. |
| Novel Retinoidal Tropolone Derivatives.
Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in
Retinoid Structure Ebisawa, M.; Ohta, K.; Kawachi, E.; Fukasawa, H.; Hashimoto, Y.; Kagechika, H. Chem. Pharm. Bull. 2001, 49, 501-503. |
| Synergistic Potentiation of
Thiazolidinedione-Induced ST 13 Preadipocyte Differentiation by RAR
Synergists Sato, M.; Yajima, Y.; Kawashima, S.; Tanaka, K.; Kagechika, H. Biochem. Biophys. Res. Commun. 2001, 280, 646-651. |