１）Nifuji A., Kellerman O., Kuboki Y., Wozney J., and Noda M. Perturbation of BMP signaling in somitogenesis resulted in vertebral and rib malformation in the axial skeletal formation. Journal of Bone and Mineral Research 12: 332-342,1997.
２）Murakami S., Nifuji A. and Noda M. Expression of indian hedgehog in osteoblasts and its posttranscriptional regulation by transforming growth factor-b. Endocrinology 138: 1972-1978, 1997.
３）Matsue M., Kageyama R., Denhardt D. T. and Noda M. Helix-loop-helix type transcription factor, HES-1, is expressed in osteoblastic cells, suppressed by 1,25(OH)2 vitamin D3 and modulates 1,25(OH)2 vitamin D3 enhancement of osteopontin expression. Bone 20: 329-334, 1997.
４）Liu Y., Wozney J., Nifuji A., Olson E. and Noda M. Scleraxis is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2). Journal of Cellular Biochemistry 67: 1-9, 1997.
５）Liu Y., Watanabe H., Yamada, Y., Olson E., Nifuji A., and Noda M. Overexpression of a single helix-loop-helix type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. Journal of Biological Chemistry 272(47): 29880-29885,1997.
６）Ezura Y. Tournay O. Nifuji A. and Noda M. Identification of a novel suppressive vitamin D response sequence in the 5' flanking region of murine Id1 gene. Journal of Biological Chemistry, 272(47): 29865-29872, 1997.
７）Tsuji K., Ito Y. and Noda M. Expression of the PEBP2aA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22(2): 87-92, 1998.
８）Yamashita T., Nifuji A., Furuya K., Nabeshima Y. and Noda M. Elongation of the epiphyseal trabecular bone associated with precocious aging in transgenic mice carrying an insertional mutaiton in Klotho gene locus. Journal of Endocrinology 159:1-8,1998.
９）Rittling S., Matsumoto H.N., McKee M. , Novik K., An X.R., Nanci A., Denhardt D. and Noda M. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. Journal of Bone and Mineral Research 13: 1101-1111, 1998.
10）Kawauchi T., Nifuji A., Mataga N., Olson E.N., Bonaventure J., Shinomiya K., Liu Y. and Noda M. Fibriblast growth factor down-regulates expression of a basic helix-loop-helix type transcription factor, scleraxis, in chondrocyte-like cells, TC6. Journal of Cellular Biochemistry 70: 468-477, 1998.
11) Kawaguchi N. and Noda M. Osteoblastic cells regulate mi gene expression in cultured bone marrow cells. International Journal of Hematology 67: 275-281, 1998.
12)Li J., Tsuji K., Komori T., Miyazono K., Nifuji A., Wrana J. L., Ito Y. and Noda M. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. Journal of Biological Chemistry 273: 31009-31015, 1998.
13) Furuya K., Nifuji A., Rosen V. and Noda M. Effects of GDF7/BMP12 on proliferation and alkaline phosphatase expression in rat osteoblastic osteosarcoma ROS 17/2.8 cells. Journal of Cellular Biochemistry 72: 177-180, 1999.
14) Tamura M. and Noda M. Identification of DERMO-1 as a member of helix -llop-helix type transcription factors expressed in osteoblastic cells. Journal of Cellular Biochemistry 72: 167-176, 1999.
15) Nifuji A., and Noda M. Coordinated expression of noggin and BMPs during early skeletogenesis and induction of noggin expression by BMP7. Journal of Cellular Biochemistry 73:437-444, 1999.
16) Takazawa Y, Nifuji A, Mataga N, Noda M. Articular Cartilage Cells Immortalized by A Temperature Sensitive Mutant of SV40 Large T Antigen Survive and Form Cartilage Tissue in Articular Cartilage Environment, Journal of Cellular Biochemistry 74:338-345 1999.
17) Yoshitake Y, Rittling S.R., Denhardt D.T., Noda M. Osteopontin-deficient mice are resistant to ovariectomy-Induced bone resorption. Proceedings of the National Academy of Science U.S.A. 96:8156-8160, 1999.
18) Nifuji A., and Noda M. Coordinated expression of noggin and BMPs during early skeletogenesis and induction of noggin expression by BMP7. Journal of Bone and Mineral Research 14: 2057-66, 1999.
19) Yamashita T., Yo-ichi N., and Noda M. High-resolution uCT (micro-computed tomography) analyses of the abnormal trabecular bone structures in klotho gene mutant mice. Journal of Endocrinology 164:239-245, 2000.
20) Yamashita T., Yoshitake H.,Tsuji K., Kawaguchi N., Nabeshima Y., and Noda M. Retardation in bone resorption after bone marrow ablation in klotho mutant mice. Endocrinology 141: 438-445, 2000.
21) Murakami S. and Noda M. . Indian Hedgehog during Fracture Healing in Adult Rat Femora. Calcified Tissue International 66:272-276, 2000.
22) Takazawa Y., Tsuji K., Nifuji A., Kurosawa H., Ito Y., Noda M. An Osteogenesis-Related Transcription Factor, Cbfa1, Is Constitutively Expressed in Chondrocytic Cell Line, TC6, and its Expression Is Upregulated by BMP2. Journal of Endocrinology 164:239-579-586, 2000.
23) Sekiya I., Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M. SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Upregulated by Retinoic Acid in a Cartilage-Derived Cell Line, TC6. Journal Biological Chemistry 275: 10738-10744, 2000.
24) Tsuji K. and Noda M. Identification and Expression of a Novel 3'-Exon of Mouse Runx1/Pebp2αB/Cbfa2/AML1 Gene. Biochemical and Biophysical Research Communications 274:171-176,2000.
25) Kawaguchi N. and Noda M. Mitf Is Expressed in Osteoclast Progenitors in Vitro. Experimental Cell Research 260:284-291, 2000.
26) Furuya K., Nakamoto T., Shen Z. J., Tsuji K., Nifuji A., Hirai H. and Noda M. Overexpression of Cas-interactiong zinc finger protein (CIZ) Suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells. Experimental Cell Research 260:261:329-335, 2000.
27) Shiraki-Iida T, Iida A, Nabeshima Y, Anazawa H, Nishikawa S, Noda M, Kuro-o M, Nabeshima Y. Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. Journal of Gene Medicine 2(4):233-42, 2000.
28)Yoshida Y., Tanaka S., Umemori H., Minowa O., Usui M., Ikematsu N., Hosoda E., Imamura T., Kuno J., Yamasha T., Miyazono K., Noda M., Noda T., and Yamamoto T. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103:1085-1097, 2000.
29) Sekiya I., Koopman P, Tsuji K, Martin, S., Hrley, V., Yamada Y, Shinomiya K, Nifuji A, Noda M. Transcriptional Suppression of Sox9 Expression in Chondrocytes by Retinoic Acid Journal of Cellular Biochemistry (in press), 2001.
30) Kawaguchi N., Ono T., Mochii M. and Noda M. Spontaneous mutation in Mitf gene causes osteopetrosis in silver homozygote quail. Developmental Dynamics 220: 133-140, 2001.
31) Yamashita T., Sekiya I., Kawaguchi N., Nabeshma Y. and Noda M. Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy. Journalof Endocrinology 168(2):347-351, 2001.
32) Asou Y., Rittling S.R., Yoshitake H., Tsuji K., Shinomiya K., Nifuji A., Denhardt D.T., and Noda M. Osteopontin facilitates angiogenesis, accumulation of osteoclasts and resorption in ectopic bone. Endocrinology Endocrinology 142:1325-1332 , 2001
33) Nemoto H., Rittling S. R., Yoshitake H., Furuya K., Amagasa T., Tsuji K., Nifuji A., Denhardt D. T. and Noda M. Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. Journal of Bone and Mineral Research 16:652-659, 2001.
34)Hideyo Ihara, David T.Denhardt,Koichi Furuya,Teruhito Yamashita, Yukari Muguruma,Kunikazu Tsuji, Keith A.Hruska, Kanji Higashio, Shoji Enomoto,Akira Nifuji, Susan R.Rittling, and Masaki Noda. Parathyroid Hormone-Induced Bone Resorption does not Occur in the Absence of Osteopontin Journal of Biological Chemistry 276:13065-13071 , 2001.
35) Ishijima,M., Rittling,S.R., Yamashita,T. , Tsuji,K., Kurosawa,H., ,Nifuji,A., Denhardt, D.T., and Noda,M. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. Journal of Experimental Medicine 193(3):399-404, 2001.
36) YumotoK., Ishijima,M., Rittling,S.R., Tsuji,K., Tsuchiya, Y., Kon,S., Nifuji,A., Uede, T., Denhardt, D.T., and Noda,M., Osteopontin-Deficiency Protects Joints Against Destruction in Anti-Type II Collagen Antibody-Induced Arthritis in Mice. Proceedings of the National Academy of Sciences USA 99: 4556-4561,2002.
２．総説
１）骨の非コラーゲン蛋白について: 臨床整形外科３２巻 p79-81, 1997
２）TGF-βスーパーファミリーと骨形成: CLINICAL CALCIUM７巻 p59-61, 1997
３）骨芽細胞におけるhedgehogの発現とTGF-βによる制御: 整形外科４８巻 p1421, 1997
４）Hedgehog: 整形外科４８巻 p892, 1997
５）Paraxis: ノックアウトマウス・データブック p388-389, 1997
６） 河内敏行・四宮謙一・山浦伊裟吉・黒差義郎・野田政樹：脊柱靭帯骨化部由来細胞におけるTGFβsuperfamily ligand 受容体およびTSC-２２遺伝子の発現.
７) 野田政樹：急展開した骨代謝研究と骨粗鬆症の治療の未来. Molecular Medicine 35（4）：416-421,1998.
8) 野田政樹・山下照仁・二藤彰・古屋高一・鍋島陽一：個体老化モデルとしてのKlotho遺伝子変位をもつマウスの骨の形態学的異常. Molecular Medicine 35（4）：444-447,1998.
9) 辻邦和・関矢一郎・野田政樹：骨細胞の分化に関与するRunt型転写因子Cbfa1/Pebp2αAならびに骨軟骨形成におけるSox9の機能と骨形成異常. 実験医学16（11）：25-32,1998.
10) 村上俊一・野田政樹：インディアンヘッジホックと骨格形成. Molecular Medicine 35（4）：500-508,1998.
11) 野田政樹・二藤彰・辻邦和・古屋高一・関矢一郎・麻生義則・川口奈奈子・山口照仁：TRANSCRIPTION FACTORS AND OSTEOBLASTS. Frontiers in Bioscience 3 （8）：817-820,1998.
12) 野田政樹：Reverse Genetics で探る骨の代謝・形成の分子生物学：実験医学16（2）：100-101,1998.
13) 山下照仁・黒尾誠・鍋島陽一・野田政樹：早期老化（Klotho変異）マウスにおける骨の形態形成異常. 実験医学16（2）：131-135,1998.
14) 二藤彰・野田政樹：Indian hedgehog とnoggin の骨格形成への関与. 実験医学16（2）：114-119,1998.
15) 野田政樹・二藤彰・川口奈奈子・・古屋高一・山口照仁・辻邦和：骨基質蛋白と骨粗鬆症：現代医療 30 （12）：55-59,1998.
1６）. 野田政樹・二藤彰・山下照仁・川口奈奈子・辻邦和：骨の細胞の特異性を規定する転写因子群：CLINICAL CALCIUM 9 （4）、1999.
17) .野田政樹：骨再生と今後の展望。 第111回日本医学会シンポジウム記録集,1998.
18) 野田政樹・二藤彰・山下照仁・川口奈奈子・辻邦和：骨の細胞の特異性を規定する転写因子群：CLINICAL CALCIUM 9 （4）、1999.
19) 骨芽細胞の分化制御にかかわる分子群 野田政樹 辻邦和 高澤祐治 古屋高一 関矢一郎 儀武啓幸 ニ藤彰 最新医学 54(12): 96-102,1999
3. 国際学会発表
１）Ezura Y., Tournay O. and Noda M. A novel negative vitamin D response sequence in the promoter of Id1: An inhibitory transcription factor in osteoblastic differentiation. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 326.
２）Murakami S., McMahon A. P. and Noda M. Indian hedgehog gene is expressed in osteoblasts and is regulated by TGFb. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 327.
３）Kawa-uchi T., Olson E., Mataga N. and Noda M. A basic helix-loop-helix transcription factor, scleraxis, is expressed in chondrocytes and is suppressed by FGF. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 342.
４）Ezura Y. , Tournay O. and Noda M. Vitamin D suppression Id1 gene expression via A 57bp negative vitamin D response sequence which forms a novel nuclear protein-DNA complex. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
５）Tsuji K. , Ito Y. and Noda M. Overexpression of PEBP2aA/AML3/CBFA1 suppresses osteocalcin and type I collagen gene expression in osteoblastic cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
６）Li J. , Wrana J.L. , Ito Y. and Noda M. MADR2 Overexpression suppresses PEBP2aA/AML-3/CBFA1 gene expression and osteocalcin-promoter activity in osteoblast-like cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
７）Tamura M. and Noda M. Identification of DERMO-1 as a member of helix-loop-helix type transcription factors expressed in osteoblastic cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
８）Nifuji A., Kellermann O., Harland R. and Noda M. Noggin promotion of chondrogenic differentiation and enhancement of its expression by BMP4/7 in a pluripotent mesenchymal cell line, C1. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
９）Nifuji A., Harland R. and Noda M. Noggin modulates BMP actions during the development of somite. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
10）Rittling S., Matsumoto H.N., McKee M. , Novik K., An X.R., Nanci A., Denhardt D. and Noda M. Skeletal structure is normal while in vitro osteoclastogenesis is enhanced in mice deficient for osteopontin. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
11）Takazawa Y., Mataga M. and Noda M. A chondrogenic cell line, TC6, established from articular cartilage of transgenic mice harboring SV40 large T antigen gene, form cartilaginous tissue in the environment of articular cartilage but not in subcutaneous tissues.. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
12）Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via the promoter region containing a single HMG-box-sequence a chondrogenic cell line TC6. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
13）Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in Klotho gene locus.The 37th American Society for Cell Biology Annual Meeting, Washington, D.C., U.S.A. December 13-17, 1997. Molecular Biology of the Cell 8.
14）Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Rescue of severe hypercalcification associated with precocious aging in mice carrying insertional mutation in novel gene, Klotho, locus.The 37th American Society for Cell Biology Annual Meeting, Washington, D.C., U.S.A. December 13-17, 1997. Molecular Biology of the Cell 8.
15）Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in a novel klotho gene locus.The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
16）Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via its action on the promoter region containing a single HMG-box-sequence in a chondrogenic cell line, TC6. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
17）Takazawa Y., Mataga N. and Noda M. Articular cartilage environment supports the survival and differentiation of a condrogenic TC6 cells established from articular cartilage of transgenic mice harboring SV40 large T antigen. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
18）Aso Y., Nifuji A. and Noda M. Developmental regulation of a basic helix-loop-helix type transcription factor, scleraxis, gene expression in ligaments, tendons and insertions of muscles. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
17) Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in a novel klotho gene locus.The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
18) Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via its action on the promoter region containing a single HMG-box-sequence in a chondrogenic cell line, TC6. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
19) Takazawa Y., Mataga N. and Noda M. Articular cartilage environment supports the survival and differentiation of a condrogenic TC6 cells established from articular cartilage of transgenic mice harboring SV40 large T antigen. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
20) Aso Y., Nifuji A. and Noda M. Developmental regulation of a basic helix-loop-helix type transcription factor, scleraxis, gene expression in ligaments, tendons and insertions of muscles. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
21）Yoshitake H., Rittling S., Denhardt D.T. and Noda M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone loss. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
22）Yoshitake H., Rittling S., Tsuji K., Yamashta T., Wong B., Choi W., Denhardt D. and Noda M. Osteopontin-deficient mice reveal increase in osteoclast number, enhanced TRANCE/RANKL/ODF expression in bone but are resistant to bone resorption that follows bone formation after bone marrow ablation. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
23）Noda M., Rittling S., Muguruma Y., Asou Y., Yoshitake H., Tsuji K., and Denhardt D. Osteopontin-deficient(OD-) cells exhibit enhanced actin fiber formation and spreading while OD-osteoclasts are less efficient in remobing hydroxyapatite coated on glass and in recruitment to ectopically implanted bone matrix. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
24）Sekiya I., Tsuji K., Nifuji A., Wheatly S.W., Koopman P. and Noda M. Sox9, a chondrogenic transcriptin factor, is the target of retionic acid suppression of the phenotypic gene expression in chondrocytes. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
25）Nifuji A., Harland R.M. and Noda M. Noggin inhibition of cartilage development during skeletogenesis via its counteraction against BMP7 that upregulates noggin. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
26）Takazawa Y., Rittling S., Furuya K., Yoshake H., Yamasha T., Denhardt D. and Noda M. Interleukin-1 induced bone resorption does not occur in osteopontin-deficient mice. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
27)Yamashita T., Nabeshima Y. and Noda M. Lack of klotho gene product, a suppressor of a syndrome resembling aging and a novel regulator of bone metabolism, blocks bone resorption after bone marrow ablations. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
28）Tsuji K., Kraut N., Groudine M. and Noda M. A somite related transcription modulator, I-mfa (inhibitor of MyoD family A), is expressed in osteoblast-like cells and is upregulated by 1,25(OH)2 vitamin D3. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
29）Kawaguchi N., Yamashita T., TsujiK., Wong B., Nabeshima Y., Choi Y. and Noda M. Soluble TRANCE(RANKL, ODF) receptor blocks development of osteoclast-like cells in klotho mutant mice-derived bone marrow cells cultured in the presence of the mutant mice serum. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
30）Takazawa Y., Tsuji K., Ito Y., Nifuji A. and Noda M. CBFA1 is constitutively expressed in the chondrocytic cell line, TC6, and its expression is upregulated by BMP2. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
31) Tsuji K., Kraut N., Groudine M., and Noda M. A Transcription modulator, I-MFA (Inhibitor of Myod Family A), is expressed in osteoblast-like cells and is upregulated by 1,25-dihydroxyvitamin D3. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
32) Takazawa Y., Tsuji K., Nifuji A., Kurosawa H., Ito Y., and Noda M. CBFA1 is constitutively expressed in the chondrocytic cell line, TC6, and its expression is upregulated by BMP2. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
33) Sekiya I., Tsuji K., Nifuji A., Wheatly S.W., Shinomiya K., Koopman P., and Noda M. Retinoic acid reduces cartilage phenotype expression through suppression of Sox9 expression. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
34) Yoshitake H., Rittling S., Denhardt D.T., and Noda M. Osteopontin knock-out mice do not lose bone after ovariectomy. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
35) Takazawa Y., Rittling S., Furuya K., Yoshitake H., Yamashita T., Denhardt D., and Noda M. Interleukin-1-induced bone loss is blocked in osteopontin-knock-out mice. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
36) Sekiya I., Rittling S., Yoshitake H., Yamashita T., Denhardt D., and Noda M. Osteopontin knock-out mice are resistant to disuse osteoporosis. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
37) Yoshitake H., Rittling S., Tsuji K., Yamashita T., Denhardt D., and Noda M. Osteopontin knock-out mice are resistant to bone resorption after bone formation induced by bone marrow ablation. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
38) Asou Y., Rittling S., Yoshitake H., Denhardt D., and Noda M. Osteopntin-Dificient Bone Is Defective in Angiogenesis, Osteoclast-Recruitment and Ectopic Resorption. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
39) Nemoto H., Rittling S., Yoshitake S., Nifuji A., Denhardt D., and Noda M. Osteopontin (OPN) Promotes Tumor Cell Metastasis to Bone and Soft Tissues.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
40) Ishijima M., Rittling S., Yoshitake H., Yamashita T., Kurosawa H., Nifuji A., Denhardt D., and Noda M. Osteopontin-Deficiency Protects Bone against Osteopenia Induced by the Absence of Mechanical Stress.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
41) Tsuji K., Ito Y., and M. Noda. Basic FGF Down-regulates Cbfa1 Expression in Osteoblast-like Cells. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
42) Sekiya I., Tsuji K., Koopman P., Ito Y., Yamada Y., Shinomiya K., Nifuji A., and Noda M. Dexamethasone Promotes Chondrocyte ADifferentiation thorough Enhancement of Sox9 Expression.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
43) Yamashita T., Kawaguchi N., Nabeshima Y. and Noda M. Site-Specific Reduction of Osteoclast Number and Size in Klotho Mutant Mice That Exhibit a Syndrome Resembling Precocious Aging of Human. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
44) Kawaguchi N., Ono T., Kozuka D., Mochii M. and Noda M. A Novel Type of Double Mutation in Mitf, a bHLH-LZ-Type Transcription Factor in Silver Quail , Results in Osteopetrosis. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
45)Nifuji A., Miura N., Kellermann O. and Noda M. BMP Regulation of Forkhead/Winged Helix Transcription Factor, MFH1, in Murine Mesodermal Cell Line C1 and in Skeletal development. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
46)Ishijima M., Rittling, S. R., Yoshitake H., Yamashita T.,Kurosawa H., Nifuji A., Denhardt D. T., and Noda M. Osteopontin is required for bone loss induced by the absence of mechanical stress. 46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
47)Asou Y., Rittling S.R., Yoshitake H., Shinomiya K., Nifuji A., Denhardt D.T., and Noda M. Osteopontin in bone facilitates angiogenesis that is required for bone resorption. 46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
48) Asou Y., Yamashita T., Nifuji A., Shinomiya K., Nabeshima Y., and Noda M. Aberrant maturation of growth plate chondrobytes in klotho mutant mice.46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
49)Yamashita T., Higashio K., Nabeshima Y. and Noda M. Double Mutant Mice that Lack Both Klotho and OCIF/OPG Genes Reversed Osteopetrotic Klotho Phenotype in Cancellouse Bone to Normal. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
50) Furuya K., Nakamoto T., Shen Z., Rittling S., Nifuji A., Tsuji K., Denhardt D.T., Hirai H., and Noda M. Cas-Interacting Zinc Finger Protein (CAZ), A Shuttling Molecule Signaling from Attachment Complex to Nuclei, Regulates Type I Collagen Gene Expression and Proliferation in Osteoblast-like Cells. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
51) Usui M., Yoshida Y., Yamashita T., Nifuji A., Ishikawa I., Yamamoto T. and Noda M. Deficiency of a Gene Encoding Antiproliferative Protein, Tob, Enhances BMP-Induced Bone Formaiton in Knock-out Mice: Identification of a Novel Type Inhibitor of BMP. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
52) Takamoto M., Tsuji K., Yamashita T., Nifuji A., Komori T and Noda M. Hedgehog Signaling Activates Cbfa1 Gene Expression in Chondrocytes thorough a Responsive Region in the Promoter Identified by Deletion Analysis. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
114. Ishijima M., Rittling S. R., Tsuji K., Yamashita T., Nifuji A., Kurosawa H., Denhardt D. T. and Noda M. Disruption of Mechano-sensing Signals in Osteoblasts and Osteoclasts in Tail-suspended Osteopontin-knock-out Mice in vivo and their Cells Exposed to Flow Stimuli. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
53)Asou Y., Amizuka N., Yamashita T., Nabeshima Y., Ozawa H. and Noda M. Reduction in the Number of Chondrocyte Columns and in the Height of Prehypertrophic/ Hypertrophic Zone in Growth Plate Temporarily Associate with Bone Phenotypes in Klotho Mutant Mice. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
54)Ihara H., Rittling S.R., Furuya K., Yamashita T., Tsuji K. Hrsuka K. A., Enomoto S., Nifuji A., Denhardt D. T and Noda M. Osteopontin-Deficiency Suppresses PTH/RANKL-Induced Bone Resorption in Organ Cultures. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
55)Tsuji K., Ito Y. and Noda M. Identification of A Novel C-terminal Exon of Pebp2αB/Cbfa2/AML1 (Runx1). Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
56) Kawaguchi N. and Noda M. Mitf is Expressed in Osteoclast Progenitors In Vitro. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.