東京医科歯科大学　難治疾患研究所　分子遺伝分野

Publications

2017

  1. Takaoka M, Miki Y. BRCA1 gene: function and deficiency. Int J Clin Oncol. 2017
    doi: 10.1007/s10147-017-1182-2. Review.
  2. Sato K, Koyasu M, Nomura S, Sato Y, Kita M, Ashihara Y, Adachi Y, Ohno S, Iwase T, Kitagawa D, Nakashima E, Yoshida R, Miki Y, Arai M. Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations. Cancer Sci. 2017 Nov;108(11):2287-2294.
  3. Miki Y. Molecular Diagnosis and Treatment of HBOC Syndrome. Gan To Kagaku Ryoho. 2017 Feb;44(2):102-106. Japanese.
  4. Hosoya K, Matsusaka S, Kashiwada T, Suzuki K, Ureshino N, Sato A, Miki Y, Kitera K, Hirai M, Hatake K, Kimura S, Sueoka-Aragane N. Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients. Pathol Oncol Res. 2017 Oct;23(4):737-744.
  5. Takaoka M, Ito S, Miki Y, Nakanishi A. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Sci. 2017 Mar;108(3):380-389.
  6. Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J Oral Pathol Med. 2016 Nov;45(10):730-739.
  7. Nguyen CT, Okamura T, Morita KI, Yamaguchi S, Harada H, Miki Y, Izumo T, Kayamori K, Yamaguchi A, Sakamoto K. LAMC2 is a predictive marker for the malignant progression of leukoplakia. J Oral Pathol Med. 2017 Mar;46(3):223-231.

2016

  1. Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS One. 2016 Aug 11;11(8):e0161163.
  2. Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A.　BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016 Aug 17;15(16):2145-2156.
  3. Osumi H, Shinozaki E, Suenaga M, Matsusaka S, Konishi T, Akiyoshi T, Fujimoto Y, Nagayama S, Fukunaga Y, Ueno M, Mise Y, Ishizawa T, Inoue Y, Takahashi Y, Saiura A, Uehara H, Mun M, Okumura S, Mizunuma N, Miki Y, Yamaguchi T. RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy. Int J Cancer. 2016 Aug 15;139(4):803-11.
  4. Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M. Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Oncotarget. 2016 Feb 16;7(7):7701-14.

2015

  1. Nakamura S, Takahashi M, Tozaki M, Nakayama T, Nomizu T, Miki Y, Murakami Y, Aoki D, Iwase T, Nishimura S, Yamauchi H, Ohsumi S, Baba S, Shimizu T. Prevalence and differentiation of hereditary breast and ovarian cancers in japan. Breast Cancer 2015 Sep;22(5):462-8.

2014

  1. Ishiba T, Nagahara M, Nakagawa T, Sato T, Ishikawa T, Uetake H, Sugihara K, Miki Y, Nakanishi A. Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion. Sci Rep. 2014 Nov 17;4:7069.
  2. Kimura H, Miki Y, Nakanishi A. Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins. Cell Cycle. 13, 1928-1937 (2014)
  3. Takaoka M, Saito H, Takenaka K, Miki Y, Nakanishi A. BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res. 74, 1518-1528 (2014)
  4. Wali N, Hosokawa K, Malik S, Saito H, Miyaguchi K, Imajoh-Ohmi S, Miki Y, Nakanishi A. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP). Biochem Biophys Res Commun. 443, 1148-1154 (2014)
  5. Wada Y, Matsuura M, Sugawara M, Ushijima M, Miyata S, Nagasaki K, Noda T, Miki Y. Development of detection method for novel fusion gene using genechip exon array. J Clin Bioinforma 2014; 4(1): 3.
  6. Tan TZ, Miow QH, Miki Y, Noda T, Mori S, Huang RY, Thiery JP. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med 2014; 6(10): 1279-93.

2013

  1. Nakamura S, Takahashi M, Tozaki M, Nakayama T, Nomizu T, Miki Y, Murakami Y, Aoki D, Iwase T, Nishimura S, Yamauchi H, Ohsumi S, Baba S, Shimizu T. Prevalence and differentiation of hereditary breast and ovarian cancers in japan. Breast Cancer 2013.
  2. Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y*, Yoshida K. Dyrk2 controls the epithelial-mesenchymal transition in breast cancer by degrading snail. Cancer Lett 2013; 339(2): 214-25.
  3. Low SK, Takahashi A, Ashikawa K, Inazawa J, Miki Y, Kubo M, Nakamura Y, Katagiri T. Genome-wide association study of breast cancer in the japanese population. PLoS One 2013; 8(10): e76463.
  4. Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL, Mano H. Transforming mutations of rac guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A 2013; 110(8): 3029-34.

2012

  1. Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by mlh1 haploinsufficiency and complete deficiency. Genome Res 2012; 22(2): 208-19.
  2. Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y*, Yoshida K. Dyrk2 priming phosphorylation of c-jun and c-myc modulates cell cycle progression in human cancer cells. J Clin Invest 2012; 122(3): 859-72.
  3. Suzuki K, Dashzeveg N, Lu ZG, Taira N, Miki Y*, Yoshida K. Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci 2012; 103(10): 1788-94.
  4. Satoh Y, Sugai S, Uehara H, Mun M, Sakao Y, Okumura S, Nakagawa K, Ishikawa Y, Miki Y, Miyata S. Clinical impact of intraoperative detection of carcinoembryonic antigen mrna in pleural lavage specimens from nonsmall cell lung cancer patients. Thorac Cardiovasc Surg 2012; 60(8): 533-40.
  5. Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of notch1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 2012; 92(5): 688-702.
  6. Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K, Omura K, Miki Y, Yamaguchi A. Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol 2012; 27(7): 949-59.

2011

  1. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Wang, HF., Takenaka, K., Nakanishi, A. and Miki Y. Cancer Res. 71, 68-77 (2011)
  2. Sakamoto K, Aragaki T, Morita K, Kawachi H, Kayamori K, Nakanishi S, Omura K, Miki Y, Okada N, Katsube K, Takizawa T, Yamaguchi A. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: A clue for histopathogenesis. Histopathology 2011; 58(4): 531-42.
  3. Kimura J, Kudoh T, Miki Y*, Yoshida K. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int J Cancer 2011; 128(7): 1524-31.
  4. Ito Y, Nagasaki K, Miki Y, Iwase T, Akiyama F, Matsuura M, Horii R, Makita M, Tokudome N, Ushijima M, Yoshimoto M, Takahashi S, Noda T, Hatake K. Prospective randomized phase ii study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. Cancer Sci 2011; 102(1): 130-6.
  5. Hew HC, Liu H, Miki Y*, Yoshida K. Pkcdelta regulates mdm2 independently of p53 in the apoptotic response to DNA damage. Mol Carcinog 2011; 50(9): 719-31.
  6. Hew HC, Liu H, Lu ZG, Kimura J, Miki Y*, Yoshida K. Identification of evi-1 as a novel effector of pkcdelta in the apoptotic response to DNA damage. Biochim Biophys Acta 2011; 1809(7): 285-94.