| この度、文部科学省科学研究費補助金特定領域研究(C)「ゲノム医科学」国際交流委員会および第７回アジアオセアニアHLA会議の共催により、下記の通り、国際シンポジウム「免疫と疾患におけるゲノム多様性」を開催することとなりました。 本シンポジウムでは、ヒトゲノムの多様性と免疫機構や疾患感受性における個体差について討議を行いますので、奮ってご参加ください。 |
| 日時 | ： | 平成１５年９月２２日（月） １０:００−１８:００ |
| 場所 | ： | 東京大学山上会館 （〒113-8654 文京区本郷7-3-1） |
| 地図 | ： | http://www.u-tokyo.ac.jp/jpn/campus/map/map01/e11-j.html |
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問い合わせ先： 東京医科歯科大学難治疾患研究所 分子病態分野 木村 彰方 Tel: 03-5280-8056 Fax: 03-5280-8055 Email: akitis@mri.tmd.ac.jp |
| 10:00 | Opening Remarks: A. Kimura | ||
| 10:10-12:10 | Session I: Genome Diversity in Immunity-1 MHC | ||
| (Chaired by J. Trowsdale, A. Kimura) | |||
| E. Albert; | The evolution of the MICA and HLA polymorphisms | ||
| H. Erlich; | HLA polymorphism and evolutionary inferences | ||
| H. Inoko; | Diversity and evolution of MHC and related gene families | ||
| S. Beck; | Diversity of immune loci: lessons from genome sequencing | ||
| A. Kimura; | Diversity and linkage disequilibrium among alleles of genes in the HLA loci and mapping of disease susceptibility genes | ||
| 12:10-13:10 | Lunch | ||
| 13:10-15:15 | Session II: Genome Diversity in Immunity-2 KIR | ||
| (Chaired by S. Bahram, K. Tokunaga) | |||
| B. Dupont; | Immunobiology of natural killer cells mediated by activating and inhibiting receptors | ||
| T. Yabe; | Diversity of NK receptor KIR genes and its clinical significance in bone marrow transplantation | ||
| D. Geraghty; | Genetic diversity and genomics of the immune response: identifying immune variation within the MHC and throughout the genome | ||
| P. Pahram; | Co-evolution of natural killer cell receptors and MHC class I molecules in higher primates | ||
| F. Christiansen; | NK receptor genes are predictors of HIV progression | ||
| 15:15-15:30 | Coffee Break | ||
| 15:30-18:00 | Session III: Genome Diversity in Disease | ||
| (Chaired by J. McCluskey, T. Sasazuki) | |||
| E. Thorsby; | Several different genes in the HLA complex predispose to autoimmune diseases | ||
| Y. Nishimura; | Manipulation of immune response by genetically modified dendritic cells derived from mouse ES cells | ||
| D. Charron; | MHC class II signaling in APC | ||
| J. Hansen; | Genetic variation and clinical outcome following allogeneic hematopoietic cell transplantation | ||
| K. Tokunaga; | Diversity of immune response genes and their associations with multifactorial immune disorders | ||
| J. McCluskey; | A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire and T cell recognition | ||
| 18:00 | Closing Remarks: K. Tokunaga | ||