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Klionsky, D.J., Abdalla, F. C. Tsubata, T. et al. (2012): Guidelines for the use and
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interpretation of assays for monitoring autophagy. Autophagy 8: 1-100.
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Kishi, Y., Higuchi, T., Phoon, S., Kamiya, K., Riemekasten, G., Akiyoshi, K., Weigert, M.
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and Tsubata, T. (2012): Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein
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B cells. Proc. Natl. Acad. Sci. USA. 109(20) : 7811-6
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Tsubata T.(2012): Role Of Inhibitory Bcr Co-Receptors In Immunity. Infect Disord
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Tsubata, T. (2011): ЯПОНИЯ ПОСЛЕ ЗЕМЛЕТРЯСЕНИЯ, ЦУНАМИ И
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КАТАСТРОФЫ В ФУКУСИМЕ. РОССИЯ И ГЕРМАНИЯ 2:30-31.
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Megesh, S., Ando, H., Tsubata, T., Ishida, H., Kiso, M. (2011) High-Affinity Ligands of
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Siglec Receptors and their Therapeutic Potentials. Current Medicinal Chemistry 18:
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Poe, J. C., Smith , S. H., Haas, K. M., Yanabe, K., Tsubata, T., Matsushita, T. and
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Tedder, T. F. (2011) Amplified B lymphocyte CD40 signaling drives regulatory B10 cell
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expansion in mice. PLoS ONE 6: 22464
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Tsubata, T. (2011) Role of inhibitory BCR co-receptors in immunity. Infectious
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Disorders - Drug Targets (in press).
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Abdu-Allah, H. H. M, Watanabe, K., Kanie, O., Tsubata, T. Ishida, H. and Kiso, M.
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(2011). Design and synthesis of multivalent heterobifunctional CD22-ligand as a
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potential immunomodulator. Synthesis (in press).
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Watanabe, K., Tsuchiya, Y., Kawaguchi, Y., Sawada, S.-i., Ayame, H., Akiyoshi, K. and
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Tsubata, T. (2011): The use of cationic nanogels to deliver proteins to myeloma cells
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and primary T lymphocytes that poorly express heparan sulfate. Biomaterials. 32: 5900
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Abdu-Allah, H. H. M., Watanabe, K., Completo, G. C., Sadagopan, M., Hayashizaki, K.,
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Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Paulson, J.C., Tsubata, T.,
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Ando, H., Ishida, H. and Kiso, M. (2011): CD22-antagonists with nanomolar potency:
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The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.
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Bioorg. Med. Chem. 19: 1966-1971.
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Bolduc, A., Long, E., Stapler, D., Cascalho, M., Tsubata, T. Koni, P. A. and Shimoda,
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M. (2010): Constitutive CD40L expression on B cells prematurely terminates germinal
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center response and leads to augmented plasma cell production in T cell areas. J.
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Kishi, Y., Aiba, Y., Higuchi, T., Furukawa, K., Tokuhisa, T., Takemori, T. and Tsubata, T.
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(2010): Augmented antibody response with premature germinal center regression in
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CD40L-transgenic mice. J. Immunol. 185: 211-219.
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Ishiura, N., Nakashima, H., Watanabe, R., Kuwano, Y., Adachi, T., Takahashi, Y.,
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Tsubata, T., Okochi, H., Tamaki, K., Tedder, TF., Fujimoto M.(2010): Differential
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phosphorylation of functional tyrosines in CD19 modulates B lymphocyte activation.
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Eur J Immunol. 40: 1192-1204.
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Man, R.-Y., Onodera, T., Komatsu, E., Tsubata, T. (2010): Augmented B lymphocyte
|
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response to antigen in the absence of antigen-induced B lymphocyte signaling in an
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IgG-transgenic mouse line. Plos one. 5:8815.
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Abdu-Allah, H. H. M., Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T.,
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Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H. and Kiso, M. (2009): Potent small
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molecule mouse CD22 inhibitors: exploring the interaction of the residue at C-2 of
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sialic acid scaffold. Bioorg. Med. Chem. Lett. 19:5573-75.
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Abdu-Allah, H. H. M., Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H.,
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Kozutsumi, Y., Tsubata, T., Ishida, H. and Kiso, M (2009): Synthesis of biotinylated
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sialoside to probe CD22-ligand interactions. Tetrahedron Lett. 50:4488−91.
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Engels, N., Konig, L. M., Heemann, C., Lutz, J., Tsubata, T., Griep, S. and Wienands,
|
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J. (2009): The immunoglobulin tail tyrosine of surface IgG and IgE provides antigen
|
|
receptor-intrinsic costimulation to class-switched B cells. Nature Immunol.
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Yanaba, K., Bouaziz, J.-D., Matsushita, T., Tsubata, T., and Tedder, T. F. (2009): The
|
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development and function of regulatory B cells expressing IL-10 requires antigen
|
|
receptor diversity and TLR signals. J. Immunol. 182:7459-72.
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Watanabe, K and Tsubata, T. (2009): Autophagy connects antigen receptor signaling
|
|
to costimulatory signaling in B lymphocytes. Autophagy.5: 108-110.
|
|
Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T.,
|
|
Tsubata, T. and Nakada, H. (2009): Ligation of tumor-produced mucins to CD22
|
|
dramatically impairs splenic marginal zone B cells. Biochem J. 417:673-683.
|
|
Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S. and Tsubata, T.
|
|
(2009): The centromeric interval of chromosome 4 derived from C57BL/6 mice
|
|
accelerates type 1 diabetes in NOD.CD72b congenic mice. Biochem. Biophys. Res.
|
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Yan, B.-C., Adachi, T. and Tsubata, T.(2008): ER stress is involved in B cell antigen
|
|
receptor ligation-induced apoptosis. Biochem. Biophys. Res. Comm. 365:143-148.
|
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Onodera, T., Poe, J. C., Tedder, T. F. and Tsubata, T. (2008): CD22 regulates time
|
|
course of both B cell division and antibody response. J. Immunol. 180: 907-913.
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|
Zhu, C., Fujimoto, M., Sato, M., Yanagisawa, T. and Tsubata, T. (2008): Novel binding
|
|
site for SH2-containing protein tyrosine phosphatase-1 in CD22 activated by B
|
|
Lymphocyte stimulation with antigen. J. Biol. Chem. 283: 1653-1659.
|
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Watanabe, K., Ichinose, S., Hayashizaki, K. and Tsubata, T. (2008): Induction of
|
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autophagy by B cell antigen receptor stimulation and its inhibition by costimulation.
|
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Biochem. Biophys. Res. Comm. 374:274-281
|
|
Abdu-Allah, H. H. M., Tamanaka, T., Yu, J., Lu, Z., Sadagopan, M., Adachi. T.,
|
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Tsubata, T., Kelm, S., Ishida, H. and Kiso, M. (2008): Design, synthesis, and structure-
|
|
activity relationships of novel series of sialosides as CD22-specific inhibitors. J.
|
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Medicinal Chem. 51: 6665-6681.
|
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Tsubata, T. (2008): Siglec-2 is a key molecule for immune response. Experimental
|
|
Glycoscience, Glycobiology. Springer. p.167-170.
|
|
Adachi, T., Tsubata, T., (2008): FRET-based Ca2+ measurement in B lymphocyte by
|
|
flow cytometry and confocal microscopy. Biochem Biophys Res Commun. 367:377-82
|
|
Watanabe, K and Tsubata, T. (2008): Autophagy connects antigen receptor signaling
|
|
to costimulatory signaling in B lymphocytes. Autophagy.
|
|
Sato, M., Adachi, T. and Tsubata, T. (2007): Augmentation of signaling through BCR
|
|
containing IgE but not that containing IgA due to lack of CD22-mediated signal
|
|
regulation. J. Immunol. 178: 2901-2907.
|
|
Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso,
|
|
M. and Tsubata, T. (2007): Synthetic glycan ligand excludes CD22 from antigen
|
|
receptor-containing lipid rafts. Biochem. Biophys. Res. Comm. 360: 759-764
|
|
Adachi, T., Wienands, J., Tsubata, T. and Kurosaki, T. (2007): Interdomain A is
|
|
crucial for ITAM-dependent and -independent regulation of Syk. Biochem. Biophys.
|
|
Devi, S. S., Hagiyama, H., Adachi, T., Miyasaka, N. and Tsubata, T. (2006): The tumor
|
|
suppressor p53 is not required for antigen receptor-mediated apoptosis of B
|
|
lymphocytes. Signal Transduction 6: 54-61.
|
|
Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Kawai, Y., Ishino, K.,
|
|
Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T. and Uchida, K.
|
|
(2006): Bispecific antibodies against modified protein and DNA with oxidized lipids.
|
|
Proc. Natl. Acad. Sci. USA. 103: 6160-5.
|
|
Tsubata, T. (2006): B cell abnormality and systemic lupus erythematosus. APLAR
|
|
Tsubata, T. (2005): B cell abnormality and autoimmune disorders. Autoimmunity 38:
|
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Hirai, H., Adachi, T., and Tsubata, T. (2004): Involvement of cell cycle progression in
|
|
survival signaling through CD40 in B lymphocyte line WEHI-231. Cell Death Differ. 11:
|
|
Kawamura, T., Kanai, T., Dohi, T., Uraushihara, K., Totsuka, T., Iiyama, R., Taneda, C.,
|
|
Yamazaki, M., Nakamura, T., Higuchi, T., Aiba, Y., Tsubata, T. and Watanabe, M. (2004):
|
|
Ectopic CD40 ligand expression on B cells trigger intestinal inflammation. J. Immunol.
|
|
Nitschke, L. and Tsubata, T. (2004): Molecular interactions regulate BCR signal
|
|
inhibition by CD22 and CD72. Trends Immunol. 25: 543-550.
|
|
Suzuki, A, Kaisho, T., Ohishi, M., Tsukio-Yamaguchi, M., Tsubata, T., Koni, P. A.,
|
|
Sasaki, T., Mak, T. W., and Nakano, T. (2003): Critical roles of Pten in B cell
|
|
homeostasis and immunoglobulin class switch recombination. J. Exp. Med. 197: 657-667.
|
|
Hokazono, Y., Adachi, T., Wabl, M., Tada, N., Amagasa, T., and Tsubata, T. (2003):
|
|
Inhibitory co-receptors activated by antigens but not by anti-immunoglobulin heavy
|
|
chain antibodies install requirement of co-stimulation through CD40 for survival and
|
|
proliferation of B cells. J. Immunol. 171: 1835-1843.
|
2002年以前の業績
● Wakabayashi, C., Adachi,T., Wienands,J., Tsubata,T.A distinct signaling pathway used by
the IgG-containing B cell antigen receptorScience.(2002) 298:2392-2395
抗体には、免疫応答の初期に産生されるIgM型(クラス)抗体、感染防御能の高いIgGクラスの抗体、消化管免疫に
関係するIgAクラス,寄生虫感染やアレルギーに関係するIgEクラスがあります。今回の論文では、抗体産生細胞の活
性化制御機構が抗体のクラスによって異なることを世界に先駆けて明らかにしました。この機構には膜型レクチン分
子CD22/Siglec2が関与します。この機構を人為的に制御することができるようになれば、どのようなクラスの抗体が
産生されるかを制御することが可能になります。
● Higuchi, T., Aiba, Y., Nomura, T., Matsuda, J., Mochida, K., Suzuki, M., Kikutani, H., Honjo, T.,
Nishioka, K. and Tsubata T.Cutting Edge: Ectopic expression of CD40 ligand on B cells
induces lupus-like autoimmune disease. J. Immunol.(2002) 168:9-12.
●Tsubata, T.Molecular mechanisms for apoptosis induced by siganling through the B cell
antigen receptor.Int. Rev. Immunol.(2001) vol20, no.6, 675-678,791-803.
●Adachi, T., Wienands, J., Wakabayashi, C., Yakura, H., Reth, M. and Tsubata, T.SHP-1
requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated
phosphorylation of cellular substrates.J. Biol. Chem.276:26648-26655 (2001) .
●Suzuki, A., Tsukio-Yamaguchi, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R.,
Wakeham, A., Higuchi, T., Fukumoto, M., Tsubata, T., Ohashi, P., Koyasu, S., Penninger, J. M.,
Nakano, T. and Mak, T. W.T cell-specific loss of Pten leads to defects in central and
peripheral tolerance. Immunity 14: 523-534 (2001)
●Tsubata, T., Wakabayashi, C. and Adachi, T.Regulation of B cell antigen receptor signaling
by CD72.In メActivating and Inhibitory Immunoglobulin-like Receptorsモ(ed. by Max D. Cooper,
Toshiyuki Takai, and Jeffrey V. Ravetch) Sprnger-Verlag Tokyo p. 123-128 (2001)
●Nagaoka, H., Takahashi, Y., Hayashi, R., Nakamura, T., Ishii, K., Matsuda, J.-I., Ogura,A.,
Shirakata, Y., Karasuyama, H., Sudo, T., Nishikawa, S.-I., Tsubata, T., Mizuochi, T., Asano, T.,
Sakano, H., Takemori, T. Ras mediates effector pathways responsible for pre-B cell survival,
which is essential for the developmental progression to the the late pre-B cell stage.J. Exp.
Med. 192: 171-181(2000)
●Yoshida, T., Higuchi, T., Hagiyama, H., Strasser, A., Nishioka, K., and Tsubata, T. Rapid B
cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the
adapter protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/
+ and MRL-lpr/lpr mice. Int. Immunol. 12: 517-526 (2000)
●Tsubata, T., and Honjo, T. B cell tolerance and autoimmunity. Rev. Immunogenet. 2: 18-25
(2000)
●Adachi, T., Wakabayashi, C., Nakayama, T., Yakura, H., and Tsubata T. CD72 negatively
regulates signaling through the antigen receptor of B cells. J. Immunol. 164: 1223-1229
(2000)
●Tsubata, T. Co-receptors on B lymphocytes. Curr. Opin. Immunol. 11: 249-255 (1999)
●Hagiyama, H., Adachi, T., Yoshida, T., Nomura, T, Miyasaka, N., Honjo, T., and Tsubata, T.
Signaling through the antigen receptor of B lymphocytes activates a p53-independent
pathway of c-Myc-induced apoptosis. Oncogene 18: 4091-4098 (1999)
●Tsubata, T. Apoptosis of mature B cells. Int. Rev. Immunol. 18: 347-365 (1999)
●Takeuchi, Y., Nishimura, K., Aoki, N., Adachi, T.,Sato, C., Kitajima, K., and Matsuda, T. A 42-
kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family
glycoproteins in mammalian Zona pellucida. Its first identification, cDNA cloning and
granulosa cell-specific expression. Eur. J. Biochm. 260: 736-742 (1999)
●Hirayama, F., Aiba, Y., Ikebuchi, K., Sekiguchi, S., and Ogawa, M. Differentiation in culture
of murine primitive lymphohematopoietic progenitors toward T-cell lineage.Blood. 93: 4187-
4195 (1999)
●Sato, T., Laver, J.H., Aiba, Y., and Ogawa, M.NK cell colony formation from human fetal
thymus. Exp. Hematol. 27: 726-733 (1999)
● Adachi, T., Flaswinkel, H., Yakura, H., Reth, M., and Tsubata, T. The B cell surface protein
CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. In "
Proceedings of 10th International Congress of Immunology" (ed. by G.P.Talwar, I, Nath, N.K.
Ganguly, K.V.S.Rao) p.341-344. Monduzzi Editore S.p.A., Bologna. (1998)
●Adachi, T., Flaswinkel, H., Yakura, H., Reth, M., and Tsubata, T. The B cell surface protein
CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol.
160: 4662-4665 (1998)
●Watanabe N., Nomura, T., Takai, T., Chiba, T., Honjo, T. and Tsubata, T. Antigen receptor
cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces
rapid apoptosis of normal spleen B cells. Scand. J. Immunol. 47: 541-547 (1998)
●Oubihi, M., Kitajima, K., Kobayashi, K., Adachi, T., Aoki, N., and Matsuda, T.Development of
an enzyme-linked immunosorbent assay-based method for measuring galactosyltransferase
activity using a synthetic glycopolymer acceptor substrate.Anal. Biochem. 257: 169-175
(1998)
●Hotta, H., Aoki, N., Nakamura, R., Matsuda, T. and Adachi, T. Molecular analysis of a novel
protein kinase in maturing rice seed. Gene 212: 47-54 (1998)
1997年以前の主要論文
鍔 田 武 志 Takeshii Tsubata
●Han, H., Nomura, T., Honjo, T., and Tsubata, T.
Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via
the antigen receptor of B cells and positive signaling via CD40.
Eur. J. Immunol. 26: 2425-2432 (1996)
●Nomura, T., Han, H., Howard, M. C., Yagita, H., Yakura, H., Honjo, T., and Tsubata, T.
Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with
dextran sulfate and is defective in autoimmunity-prone mice.
Int. Immunol. 8: 867-875 (1996)
●Nisitani, S., Tsubata, T., Murakami, M., and Honjo, T.
Administration of interleukins 5 or 10 activates peritoneal B-1 cells and induces
autoimmune hemolytic anemia in anti-erythrocyte autoantibody transgenic mice.
Eur. J. Immunol. 25: 3047-3052 (1995)
●Murakami, M., Tsubata, T., Shinkura, R., Nisitani, S., Okamoto, M., Yoshioka, H., Usui, T.,
Miyawaki, S. and Honjo, T.
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and
lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic
mouse.
J. Exp. Med. 180: 111-121 (1994)
●Tsubata, T., Murakami, M. and Honjo, T.
Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not
autoimmunity-prone mice.
Curr. Biol. 4: 8-17 (1994)
●Nisitani, S., Tsubata, T., Murakami, M., Okamoto, M. and Honjo, T.
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the
periphery but not in the bone marrow.
J. Exp. Med. 178: 1247-1254 (1993)
●Tsubata, T., Wu, J. and Honjo, T.
B-cell apoptosis induced by antigen receptor crosslinking is blocked by T-cell signal through
CD40.
Nature 364: 645-648 (1993)
●Murakami, M., Tsubata, T., Okamoto, M., Shimizu, A., Kumagai, S., Imura, H. and Honjo, T.
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in
transgenic mice.
Nature 357: 77-80 (1992)
●Tsubata, T. and Nishikawa, S.-I.
Molecular and cellular aspects of early B-cell development.
Curr. Opin. Immunol. 3: 186-192 (1991)
●Tsubata, T. and Reth, M.
The products of pre-B specific genes (l5 and VpreB) and the immunoglobulin m chain form a
complex that is transported onto the cell surface.
J. Exp. Med. 172: 973-976 (1990)
●Hombach, J., Tsubata, T., Leclercq, L., Stappert, H. and Reth, M.
Molecular components of the B-cell antigen receptor complex of the IgM class.
Nature 343: 760-762 (1990)
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