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Advanced Technology Laboratory

Medical Research Institute Tokyo Medical and Dental University

Genome Laboratory

The genome laboratory supports the fundamental technique of genome analysis in the institute, including DNA sequencing, fragment analysis, and PCR analysis. We are committed to a class of Genome and Gene Expression Analyses, an education program of graduate School of Biomedical Sciences in the University, and also provide an activity of introducing advanced DNA technology to researchers.

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Laboratory of Cytometry and Proteome

Laboratory of Cytometry and Proteome has equipments such as a cell sorter and a mass spectrometer, and provides services of cellular and proteome analysis.

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Laboratory of Genome Editing for Biomedical Research

Genome editing is now essential for biomedical research, especially for elucidating pathogenesis of and developing new treatment for various diseases. Using the improved CRISPR/Cas9 technology that was developed by a research group in this institute, the Laboratory of Genome Editing for Biomedical Research provides technical help and facility for establishing and maintaining knock-out (KO), knock-in (KI), conditional KO (floxed) mice.

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Laboratory of Anatomy and Cell Function

Laboratory of anatomy and cell function manages and maintains necessary equipment, and provides services such as morphologyical analysis and cell function analysis for all laboratories at MRI.

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Bioresource Laboratory

Bioresource Lab. of Medical Research Institute was established in 2004, to support researchers and help postgraduates in cell culture. The center safely supplies domestically or internationally well-recognized cultured cell lines as research materials. All of the cell lines handled have been collected after exchanging MTA with original developers. EB-virus transformed cell lines are also established with B-lymphocytes from patients with intractable diseases including genomic disorders after written informed consent from each of the patients or their parents and also with approval of the Internal Review Board on ethical issues. Web Site

Laboratory for Structure Analysis

The Laboratory of Structural Analysis is a small member of the Facilities and equipped with a high-brilliancy X-ray generator and an image plate X-ray detector. The Laboratory is also equipped with a dynamic light scattering (DLS) instrument, enabling the measurements of the particle size (thus oligomeric state and aggregation) of protein molecules. Web Site

Stem Cell Laboratory

Stem Cell Laboratory was established as of December, 2009 to help the researchers working on stem cell-related subjects across Medical Research Institute. Now the Laboratory is equipped with basic and state-of-the-art research instruments, including high-speed cell sorters (MoFlo Legacy and MoFlo XDP), confocal laser scanning microscopes (FV10i-W for time-lapse images, and FV10i-DOC for one shotimages ). We provide service for the use of equipment as well as cell sorting service. Web Site