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講師　小藤 智史

講師　小藤 智史

学歴

2003年（平成15年3月）東京大学薬学部卒業（堅田 利明 教授、薬剤師）
2008年（平成20年7月）東京大学大学院薬学系研究科　薬学博士

職歴

2005年（平成17年4月）日本学術振興会特別研究員（DC1）
2008年（平成20年4月）東京大学　薬学部　特任研究員
2008年（平成20年8月）秋田大学　医学部　特任助教
2014年（平成26年4月）米国オハイオ州シンシナティ大学　博士研究員
2017年（平成29年6月）広島大学大学院医歯薬保健学研究科　助教
2019年（令和元年12月）東京医科歯科大学難治疾患研究所　講師

受賞

2021年4月一般社団法人 海外日本人研究者ネットワーク UJA論文賞
"IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma"
https://cheironinitiative.wixsite.com/uja-award

英文原著

2023年

  • Jing Pu, Satoshi Kofuji*, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina* (2023) Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells accepted. (*Corresponding authors)
  • Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, and Shigeomi Shimizu (2023) Development of small fluorescent probes for the analysis of autophagy kinetics. iScience 26(7): 107218.

2022年

  • Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki (2022) Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Sci Rep. 12(1):7312.
  • Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Kofuji, Toshifumi Wakai, Hiroshi Nishina, Shuji Terai (2022) HBx and YAP Expression Could Promote Tumor Development and Progression in HBV-related Hepatocellular Carcinoma. Biochem. Biophys. Rep. 32, 101352.
  • Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui (2022) Collagen Type I mediated mechnotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and Regeneration 42(1):49.

2021年

  • Sachi Sunaga, Satoshi Kofuji* and Hiroshi Nishina* (2021) YAP drives cell competition by activating choline metabolism. Biochem. Biophys. Res. Commun. 572, 178-184. (*Corresponding authors)
  • Yikelamu Alifu#, Satoshi Kofuji#, Sachi Sunaga, Mizuki Kusaba, Jun Hirayama, and Hiroshi Nishina (2021) The light-inducible genes Per2, Cry1a, and Cry2a regulate oxidative status in zebrafish. Biological and Pharmaceutical Bulletin 44, 1160-1165. (#Contributed equally)
  • Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D. Marth, Josef M. Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji & Hiroshi Nishina (2021) MKK7-deficiency in mature neurons impairs parental behavior in mice. Genes to Cells 26(1):5-17. doi: 10.1111/gtc.12816.
  • Yoshiki Ikeda, Akiyoshi Hirayama, Satoshi Kofuji, Yoshihisa Hirota, Ryo Kamata, Natsuki Osaka, Yuki Fujii, Mika Sasaki, Satsuki Ikeda, Eric P Smith, Robert Bachoo, Tomoyoshi Soga, Atsuo T Sasaki. (2021) SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. J Biochem. doi: 10.1093/jb/mvab077.

2020年

  • Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki and Hiroshi Nishina (2020) Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes to Cells 25(3):197-214. doi: 10.1111/gtc.12750.

2019年

  • Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L Flanary, Annmarie Ramkissoon, Lionel M L Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric P Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric C Holland, William H Yong, Craig Horbinski, Ichiro Nakano, Ralph J DeBerardinis, Robert M Bachoo, Paul S Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff, Atsuo T Sasaki (2019) IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nat Cell Biol. 21(8):1003-1014.
  • Hirofumi Yoshino, Guowei Yin, Risa Kawaguchi, Konstantin I Popov, Brenda Temple, Mika Sasaki, Satoshi Kofuji, Kara Wolfe, Kaori Kofuji, Koichi Okumura, Jaskirat Randhawa, Akshiv Malhotra, Nazanin Majd, Yoshiki Ikeda, Hiroko Shimada, Emily Rose Kahoud, Sasson Haviv, Shigeki Iwase, John M Asara, Sharon L Campbell, Atsuo T Sasaki (2019) Identification of lysine methylation in the core GTPase domain by GoMADScan. PLoS One 14(8):e0219436
  • Shinya Takemasu, Kiyomi Nigorikawa, Miho Yamada, Go Tsurumi, Satoshi Kofuji, Shunsuke Takasuga, Kaoru Hazeki (2019) Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. J Biochem. 166(2):175-185.
  • Kara Wolfe, Satoshi Kofuji, Hirofumi Yoshino, Mika Sasaki, Koichi Okumura, Atsuo T Sasaki (2019) Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma. Biochem Biophys Res Commun. 516(1):50-56.
  • Kiyomi Nigorikawa, Takuma Matsumura, Hiromi Sakamoto, Shin Morioka, Satoshi Kofuji, Shunsuke Takasuga, Kaoru Hazeki (2019) Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages. Biol Pharm Bull. 42(6):923-928.
  • Shinya Takemasu, Masaaki Ito, Shin Morioka, Kiyomi Nigorikawa, Satoshi Kofuji, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Isao Matsuoka, Junko Sasaki, Takehiko Sasaki, Kaoru Hazeki (2019) Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes Cells. 24(5):366-376.
  • Yuri Isobe, Kiyomi Nigorikawa, Go Tsurumi, Shinya Takemasu, Shunsuke Takasuga, Satoshi Kofuji, Kaoru Hazeki (2019) PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. J Biochem. 165(1):75-84.

2018年

  • Shin Morioka, Kiyomi Nigorikawa, Eri Okada, Yoshimasa Tanaka, Yoshihiro Kasuu, Miho Yamada, Satoshi Kofuji, Shunsuke Takasuga, Hiroki Nakanishi, Takehiko Sasaki, Kaoru Hazeki (2018) TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. J Cell Sci. 131(5).

2017年

  • Hirofumi Yoshino, Nijiro Nohata, Kazutaka Miyamoto, Masaya Yonemori, Takashi Sakaguchi, Satoshi Sugita, Toshihiko Itesako, Satoshi Kofuji, Masayuki Nakagawa, Rajvir Dahiya, Hideki Enokida (2017) PHGDH as a key enzyme for serine biosynthesis in HIF2α-targeting therapy for renal cell carcinoma. Cancer Res. 15;77(22):6321-6329.
  • Daewoo Han, Mika Sasaki, Hirofumi Yoshino, Satoshi Kofuji, Atsuo T. Sasaki, Andrew J. Steckl (2017) In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells. J Drug Deliv Sci Tec 40:45-50.
  • Hongqi Liu, Xizhi Feng, Kelli N Ennis, Catherine A Behrmann, Pranjal Sarma, Tony T Jiang, Satoshi Kofuji, Liang Niu, Yiwen Stratton, Hala Elnakat Thomas, Sang-Oh Yoon, Atsuo T Sasaki, David R Plas (2017) Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Rep. 18(9):2088-2095.
  • Hirofumi Yoshino, Masaya Yonemori, Kazutaka Miyamoto, Syuichi Tatarano, Satoshi Kofuji, Nijiro Nohata, Masayuki Nakagawa, Hideki Enokida (2017) microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma. Oncotarget. 8(13):20881-20894. doi: 10.18632/oncotarget.14930.

2016年

  • Seong M Kim, Saurabh G Roy, Bin Chen, Tiffany M Nguyen, Ryan J McMonigle, Alison N McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T Finicle, Tricia T Nguyen, Archna Ravi, Manuel U Ramirez, Tim Wiher, Garret G Guenther, Mari Kono, Atsuo T Sasaki, Lois S Weisman, Eric O Potma, Bruce J Tromberg, Robert A Edwards, Stephen Hanessian, Aimee L Edinger (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 126(11):4088-4102.
  • Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M Emerling, John M Asara, Tetsuo Ishida, Jason W Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T Sasaki (2016) The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis. Mol Cell 61(2):187-98.

2015年

  • Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki (2015) INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 5(7):730-9. (*Spotlighted in Cancer Discov; 5(7); 697-700)
  • Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner (2015) Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 6(12):10548-62.

2013年

  • Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki (2013) Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 110(5):1726-31.

2010年

  • Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki (2010) Nature 465(7297):497-501.

2006年

  • Satoshi Kofuji, Takeshi Sakuno, Shinya Takahashi, Yasuhiro Araki, Yusuke Doi, Shin-ichi Hoshino, Toshiaki Katada (2006) The decapping enzyme Dcp1 participates in translation termination through its interaction with the release factor eRF3 in budding yeast. Biochem Biophys Res Commun. 344(2):547-53. (2006)

2004年

  • Takeshi Sakuno, Yasuhiro Araki, Yuriko Ohya, Satoshi Kofuji, Shinya Takahashi, Shin-ichi Hoshino, Toshiaki Katada (2004) Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human. J Biochem. 136(6):805-812.

英文総説

2020年

  • Satoshi Kofuji, Atsuo T Sasaki (2020) [review] GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism. J Biochem. 168(4):319-328. doi: 10.1093/jb/mvaa085.

2019年

  • Rand Naffouje, Punita Grover, Hongyang Yu, Arun Sendilnathan, Kara Wolfe, Nazanin Majd, Eric P Smith, Koh Takeuchi, Toshiya Senda, Satoshi Kofuji, Atsuo T Sasaki (2019) Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers (Basel). 2019 11(9). pii: E1346. doi: 10.3390/cancers11091346.

2016年

  • Koh Takeuchi, Miki Senda, Yu-Hua Lo, Satoshi Kofuji, Yoshiki Ikeda, Atsuo T Sasaki, Toshiya Senda (2016) Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells. FEBS J. 283(19):3556-3562.

2014年

  • Nazanin Majd, Kazutaka Sumita, Hirofumi Yoshino, Dillon Chen, Jumpei Terakawa, Takiko Daikoku, Satoshi Kofuji, Richard Curry, Trisha M. Wise-Draper, Ronald E. Warnick, Jessica Guarnaschelli, Atsuo T. Sasaki (2014) A Review of the Potential Utility of Mycophenolate Mofetil as a Cancer Therapeutic. J Cancer Res. 423401.

2009年

  • Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki (2009) Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res. 48(6):307-43.

和文総説

2021年

  • 小藤智史　がんにおける代謝変化　臨床免疫・アレルギー科 76(2) 190 - 195 (2021)

2020年

  • 小藤智史：核小体の活性と腫瘍形成を制御するGTP代謝リプログラミング：生化学 92：722-725 (2020)

2019年

  • 小藤智史、佐々木敦朗「GTP代謝リプログラミングによる核小体活性化とがん化メカニズム がん100年の謎 : 核小体異形成とGTP代謝のクロスロード」実験医学 37(16): 2743-2747. (2019)

2017年

  • 小藤智史, 池田幸樹, Kara Wolfe, Jaskirat Randhawa, 河口理紗, 島田裕子, 小藤香織, 佐々木美加, 奥村晃市, 竹内恒, 千田俊哉, 佐々木敦朗「GTP代謝」実験医学増刊号 35(10): 1633-1641. (2017)

2016年

  • 小藤智史、佐々木雄彦 「INPP4BはPTEN欠損による発がんへのフェイルセーフ機構を担う」実験医学 34 (3);450-453. (2016)

2013年

  • 木村洋貴、小藤智史、佐々木雄彦 「イノシトールリン脂質とイノシトールリン脂質代謝酵素」遺伝子医学MOOK 24;218-231. (2013)

2010年

  • 佐々木純子、小藤智史、佐々木雄彦 「ホスホイノシタイドホスファターゼの異常と病態」実験医学増刊号 28 (20);3358-3363. (2010)