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Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals.

Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai T., Kodama T., Morio T., Geha, R.S., Kitamura, D., Kurosaki, T., Ellmeier W., Takayanagi, H.
Cell 132:794-806, 2008. In this Issue【PDF File】

Cathepsin K-Dependent Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis.

Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa, K., Latz, E., Golenbock, DT., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono, K., Kato, S., Saftig, P., Takayanagi, H.
Science 319:624-627, 2008【PDF File】

Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J.
Cancer Research;68(7):2094-105. 2008【PDF File】

POU2AF1, an amplification target at 11q23, promotesgrowth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17

C Zhao, J Inoue, I Imoto, T Otsuki, S Iida, R Ueda and J Inazawa
Oncogene (2007), 1–13【PDF File】

Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma

K Tanaka, I Imoto, J Inoue, K Kozaki, H Tsuda, Y Shimada, S Aiko, Y Yoshizumi, T Iwai, T Kawano and J Inazawa
Oncogene (2007) 26, 6456–6468 【PDF File】

Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas

Y Sugino, A Misawa, J Inoue, M Kitagawa, H Hosoi, T Sugimoto, I Imoto and J Inazawa
Oncogene (2007), 1–13【PDF File】

Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells

Y Shinoda, K Kozaki, I Imoto, W Obara, H Tsuda, Y Mizutani, T Shuin, T Fujioka, T Miki and J Inazawa
Cancer Sci July 2007 vol. 98 no. 7 1078–1086【PDF File】

RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

K Saigusa, I Imoto, C Tanikawa, M Aoyagi, K Ohno, Y Nakamura and J Inazawa
Oncogene (2007) 26, 1110–1121 【PDF File】

PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation

E Suzuki, I Imoto, A Pimkhaokham, T Nakagawa1, N Kamata, K-i Kozaki, T Amagasa and J Inazawa
Oncogene (2007), 1–12【PDF File】

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

Ken-ichi Kozaki, Issei Imoto, Atiphan Pimkhaokham, Shogo Hasegawa, Hitoshi Tsuda, Ken Omura and Johji Inazawa
Cancer Sci December 2006 vol. 97 no. 12 1351–1358 【PDF File】

Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer

Ryoko Kikuchi, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, and Issei Imoto
Cancer Res 2007; 67: (15).August 1, 2007【PDF File】

BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line

Tsutomu Kawasaki, Sana Yokoi, Hitoshi Tsuda, Hiroyuki Izumi, Ken-ichi Kozaki, Shinsuke Aida, Yuichi Ozeki, Yasuyuki Yoshizawa, Issei Imoto1, and Johji Inazawa
Cancer Sci July 2007vol. 98no. 7 1070–1077【PDF File】

Clinical and Molecular Cytogenetic Characterization of Two Patients With Non-Mutational Aberrations of the FMR2 Gene

Shozo Honda, Shin Hayashi, Mitsuhiro Kato, Yo Niida, Kiyoshi Hayasaka, Torayuki Okuyama, Issei Imoto, Shuki Mizutani, and Johji Inazawa
American Journal of Medical Genetics Part A 143A:687–693 (2007)【PDF File】

Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis

Shin Hayashi, Shozo Honda, Maki Minaguchi, Yoshio Makita, Nobuhiko Okamoto, Rika Kosaki, Torayuki Okuyama, Issei Imoto, Shuki Mizutani, Johji Inazawa
Hum Genet (2007) 52:397–405【PDF File】

Fortuitous Detection of a Submicroscopic Deletion at 1q25 in a Girl With Cornelia-de Lange Syndrome Carrying t(5;13)(p13.1;q12.1) by Array-Based Comparative Genomic Hybridization

Shin Hayashi, Masae Ono, Yoshio Makita, Issei Imoto, Shuki Mizutani, and Johji Inazawa
American Journal of Medical Genetics Part A 143A:1191–1197 (2007)【PDF File】
Prevention of Cartilage Destruction With Intraarticular Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in a Murine Model of Osteoarthritis
Sadanori Shimizu, Yoshinori Asou, Soichiro Itoh, Ung-il Chung, Hiroshi Kawaguchi, Kenichi Shinomiya, and Takeshi Muneta,
ARTHRITIS RHEUMATISM Vol. 56, No. 10, October 2007, pp 3358–3365【PDF File】
Central control of bone remodeling by neuromedin U
Shingo Sato, Reiko Hanada, Ayako Kimura, Tomomi Abe, Takahiro Matsumoto, Makiko Iwasaki,Hiroyuki Inose, Takanori Ida, Michihiro Mieda, Yasuhiro Takeuchi, Seiji Fukumoto, Toshiro Fujita,Shigeaki Kato, Kenji Kangawa, Masayasu Kojima, Ken-ichi Shinomiya, Shu Takeda Nat Med 2007 Sep 16【PDF File】
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice.
Hava Gil-Henn, Olivier Destaing, Natalie A. Sims, Kazuhiro Aoki, Neil Alles, Lynn Neff, Archana Sanjay, Angela Bruzzaniti, Pietro De Camilli, Roland Baron, and Joseph Schlessinger J Cell Biol. 2007 Sep 10;178(6):1053-64. 【PDF File】
A case report of hypertrophic pachymeningitis associated with systemic lupus erythematosus, showing a headache and hearing loss resembling intracranial hypotension
Ochi S, Nanki T, Komano Y, Suzuki F, Ogawa J, Sugihara T, Nagasaka K, Nonomura Y, Hagiyama H, and Miyasaka N The Japan Societry for Clinical Immunology 55-60(2007)【PDF File】
Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis: a retrospective study
Kazuki Takada • Jun Kishi • Nobuyuki Miyasaka Mod Rheumatol 123-130(2007)【PDF File】
Interaction between the immune system and bone metabolism: an emerging field of osteoimmunology.
H Takayanagi. Proc Jpn Acad, Ser B 83, 136-143 (2007)【PDF File】
Runx2 is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in vivo
R Salingcarnboriboon, K Tsuji, T Komori, K Nakashima, Y Ezura and M. Noda. Endocrinology 147(5):2296-2305, 2006 【PDF File】
The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein induced bone formation
M. Morinobu, T. Nakamoto, K. Hino, K. Tsuji, Zhong-Jian Shen, K. Nakashima, A. Nifuji, H. Yamamoto, H. Hirai and M. Noda. JEM 201:(6), 961-970, 2005 【PDF File】
Leptin regulation of bone resorption by the sympathetic nervous system and CART
F. Elefteriou, Jong Deok Ahn, S. Takeda, M. Starbuck, Xiangli Yang, Xiuyun Liu, H. Kondo, WG. Richards, TW. Bannon, M. Noda, K Clement,C. Vaisse, G. Karsenty. Nature 434:514-520, 2005【PDF File】
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis
Usui M,Yoshida Y,Tsuji K,Oikawa K,Miyazono K,Ishikawa I,Yamamoto T,Nifuji A,Noda M. PNAS 101, 17:6653-6658, 2004. 【PDF File】
NARF, and Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)
M Yamada, J Ohnishi, B Ohkawara, S Iemura, K Satoh, J Miura, K Kawachi, T Natsume and H Shibuya. Journal of Biological Chemistry 281(30):20749-20760, 2006. 【PDF File】
WNK1 Regulates Phosphorylation of Cation-Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and PSR1
T Moriguchi, S Urushiyama, N Hisamoto, S Iemura, S Uchida, T Natsume, K Matsumoto and H Shibuya. Journal of Biological Chemistry 280(52):42685-42693, 2005. 【PDF File】
Role of the TAK1-NLK-STAT3 pathway in TGF-B-mediated mesoderm induction
B Ohkawara, K Shirakabe, J Miura, R Matsuo, N Ueno, K Matsumoto and H Shibuya. GENES and Development 18:381-386, 2004. 【PDF File】
MFB-1, an F-box-type ubiquitin ligase, regulates TGF-B signalling
U Aoyama, S Urushiyama, M Yamada, C Kato, H ide, S Higuchi, T Akiyama and H Shibuya. Genes to Cells 9:1093-1101, 2004. 【PDF File】
Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
Ohkawara B,Shirakabe K,Miura J,Matsuno R,Ueno N,Matsumoto K,Shibuya H. Gene Dev 18:381-386, 2004. 【PDF File】
An a-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients
N Satoh, A Shimatsu, K Yamada, M Abe, T Suganami, H Kuzuya and Y Ogawa. Metabolism Clinical and Experimental 55:786-793, 2006. 【PDF File】
Attenuation of Diet-Induced Weight Gain and Adiposity through Increased Energy Expenditure in Mice Lacking Angiotensin Ⅱ Type 1a Receptor
R Kouyama, T Suganami, J Nishida, M Tanaka, T Toyoda, M Kiso, T Chiwata, Y Miyamoto, Y Yoshimasa, A Fukamizu, M Horiuchi, Y Hirata and Y Ogawa. Endocrinology 146(8) :3481-3489, 2006. 【PDF File】
Leptin-to-Adiponectin Ratio as a Potential Atherogenic Index in Obese Type 2 Diabetic Patients
N Satoh, M Naruse, T Usui, T Tagami, T Suganami, K Yamada, H Kuzuya, A Shimatsu, Y Ogawa. Diabetes Care 27(10) :2488-2490, 2004. 【PDF File】
Serum leptin level is a regulator of bone mass
Elefteriou F,Takeda S,Ebihara K,Magre J,Patano N,Kim C.Ae,Ogawa Y,Liu X,Ware S.M.,Craigen W.J.,Robert J.J.,Vinson C,Nakao K,Capeau J,Karsenty G. PNAS 101, 9:3258-3263, 2004. 【PDF File】
Mechanical properties and bond strength of dual-cure resin composites to root canal dentin
J Aksornmuang, M Nakajima, RM Foxton and J Tagami. Dental Materials, 2006. 【PDF File】
Microtensile bond strength of a filled vs unfilled adhenseive to dentin using self-etch and total-etch technique
EC Say, M Nakajima, P Senawongse, M Soyman, F Ozer, M Ogata and J Tagami. Journal of Dentistry 34:283-291, 2006. 【PDF File】
A synthetic enamel for rapid tooth repair
K Yamagishi, K Onuma, T Suzuki, F Okada, J Tagami, M Otsuki, P Senawangse. Nature 433:819, 2005. 【PDF File】
Seven-year dentin bond strengths of a total- and self-etch system
MF Burrow, N Harada, Y Kitasako, T Nikaido and J Tagami. European Journal of Oral Sciences 113:265-270, 2005. 【PDF File】
Effect of prolonged photo-irradiation time of three self-etch systems on the bonding to root canal dentine
J Aksornmuang, M Nakajima, RM Foxton and J Tagami. Journal of Dentistry, 2005. 【PDF File】
Elemental Distributions and Microtensile Bond Strength of the Adhesive Interface to Normal and Caries-Affected Dentin
M Nakajima, Y Kitasako, M Okuda, RM Foxton and J Tagami. EPMA Study OF Resin?Dentin Interface, 2004. 【PDF File】
Microtensile bond strength of a dual-cure resin core material to glass and quartz fibre posts
J Aksornmuang, RM Foxton, M Nakajima and J Tagami. Journal of Dentistry 32:443-450, 2004. 【PDF File】
Gene expression analysis by cDNA microarray in oral squamous cell carcinoma
H Tomioka, K Morita, S Hasegawa and K Omura. Journal of Oral Pathol Med 35:206-211, 2006. 【PDF File】
In Vitro Chondrogenesis of Human Synovium-Derived Mesenchymal Stem Cells: Optimal Condition and Comparison with Bone Marrow-Derived Cells
S Shirasawa, I Sekiya, Y Sakaguchi, K Yagishita, S Ichinose and T Muneta. Journal of Cellular Biochemistry 97:84-97, 2006. 【PDF File】
In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel
A Yokoyama, I Sekiya, K Miyazaki, S Ichinose, Y Hata and T Muneta. Cell Tissue Res 1-10, 2005. 【PDF File】
The Effect of Hyaluronan on Tendon Healing in Rabbits
K Yagishita, I Sekiya, Y Sakaguchi, K Shinomiya and T Muneta. The Journal of Arthroscopic and Related Surgery 21(11); 1330-1336, 2005. 【PDF File】
Comparison of Human Stem Cells Derived From Various Mesenchymal Tissues
Y Sakaguchi, I Sekiya, K Yagishita and T Muneta. Arthritis and Rheumatism 52(8); 2521-2529, 2005. 【PDF File】
Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
Y Sakaguchi, I Sekiya, K Yagishita, S Ichinose, K Shinomiya and T Muneta. Blood 104(9); 2728-2735, 2004. 【PDF File】
Transforming growth factor-β stimulates IL-1β-induced monocyte chemoattractant protein-1 expression in human synovial cells via ERK/AP-1 pathway
H Yoshimura, K Nakahama, O Safronova, N Tanaka, T Muneta and I Morita. Inflammation Research 55: 1-7, 2006. 【PDF File】
Age- and cell cycle- dependent changes in EPC-1/PEDF promoter activity in human diploid fibroblast-like (HDF) cells
T Kojima, K Nakahama, K Yamamoto, H Uematsu and I Morita. Molecular and Cellular Biochemistry 2006. 【PDF File】
Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor
J Hosomichi, N Yasui, T Koide, K Soma and I Morita. Biochemical and Biophysical Research Communications. 335; 756-761, 2005. 【PDF File】
The potential role of amyloid β in the pathogenesis of age-related macular degeneration
T Yoshida, K Matsui, S Ichinose, T Sato, N Iwata, T Saido, T Hisatomi, M Mochizuki and I Morita. The Journal of Clinical Investigation. 115(10); 2793-2800, 2005.【PDF File】
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients
M Onodera, Y Horiuchi, K Nakahama, T Muneta, Y Mano and I Morita. Inflammation Research 53; 217-222, 2004.【PDF File】
A three-dimensional cell-loading system using autologous plasma loaded into a porous β-tricalcium-phosphate block promotes bone formation at extraskeletal sites in rats
N Tajima, S Sotome, E Marukawa, K Omura and K Shinomiya. Materials Science and Engineering 2006.【PDF File】
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Koga T,Inui M,Inoue K,Kim S,Suematsu A,Kobayashi E,Iwata T,Ohnishi H,Matozaki T,Kodama T,Taniguchi T,Takayanagi H,Takai T. Nature 428:758-763, 2004. 【PDF File】