 |
Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals. |
|
Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai T., Kodama T., Morio T., Geha, R.S., Kitamura, D., Kurosaki, T., Ellmeier W., Takayanagi, H.
Cell 132:794-806, 2008. In this Issue【PDF File】 |
|
Cathepsin K-Dependent Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis. |
|
Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa, K., Latz, E., Golenbock, DT., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono, K., Kato, S., Saftig, P., Takayanagi, H.
Science 319:624-627, 2008【PDF File】 |
|
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. |
|
Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J.
Cancer Research;68(7):2094-105. 2008【PDF File】 |
|
POU2AF1, an amplification target at 11q23, promotesgrowth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17 |
|
C Zhao, J Inoue, I Imoto, T Otsuki, S Iida, R Ueda and J Inazawa
Oncogene (2007), 1–13【PDF File】 |
|
Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma |
|
K Tanaka, I Imoto, J Inoue, K Kozaki, H Tsuda, Y Shimada, S Aiko, Y Yoshizumi, T Iwai, T Kawano and J Inazawa
Oncogene (2007) 26, 6456–6468 【PDF File】 |
|
Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas
|
|
Y Sugino, A Misawa, J Inoue, M Kitagawa, H Hosoi, T Sugimoto, I Imoto and J Inazawa
Oncogene (2007), 1–13【PDF File】 |
|
Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
|
|
Y Shinoda, K Kozaki, I Imoto, W Obara, H Tsuda, Y Mizutani, T Shuin, T Fujioka, T Miki and J Inazawa
Cancer Sci July 2007 vol. 98 no. 7 1078–1086【PDF File】 |
|
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
|
|
K Saigusa, I Imoto, C Tanikawa, M Aoyagi, K Ohno, Y Nakamura and J Inazawa
Oncogene (2007) 26, 1110–1121 【PDF File】 |
|
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation
|
|
E Suzuki, I Imoto, A Pimkhaokham, T Nakagawa1, N Kamata, K-i Kozaki, T Amagasa and J Inazawa
Oncogene (2007), 1–12【PDF File】 |
|
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma
|
|
Ken-ichi Kozaki, Issei Imoto, Atiphan Pimkhaokham, Shogo Hasegawa, Hitoshi Tsuda, Ken Omura and Johji Inazawa
Cancer Sci December 2006 vol. 97 no. 12 1351–1358 【PDF File】 |
|
Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer
|
|
Ryoko Kikuchi, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, and Issei Imoto
Cancer Res 2007; 67: (15).August 1, 2007【PDF File】 |
DY>
|
BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line
|
|
Tsutomu Kawasaki, Sana Yokoi, Hitoshi Tsuda, Hiroyuki Izumi, Ken-ichi Kozaki, Shinsuke Aida, Yuichi Ozeki, Yasuyuki Yoshizawa, Issei Imoto1, and Johji Inazawa
Cancer Sci July 2007vol. 98no. 7 1070–1077【PDF File】 |
|
Clinical and Molecular Cytogenetic Characterization of Two Patients With Non-Mutational Aberrations of the FMR2 Gene
|
|
Shozo Honda, Shin Hayashi, Mitsuhiro Kato, Yo Niida, Kiyoshi Hayasaka, Torayuki Okuyama, Issei Imoto, Shuki Mizutani, and Johji Inazawa
American Journal of Medical Genetics Part A 143A:687–693 (2007)【PDF File】 |
|
Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis |
|
Shin Hayashi, Shozo Honda, Maki Minaguchi, Yoshio Makita, Nobuhiko Okamoto, Rika Kosaki, Torayuki Okuyama, Issei Imoto, Shuki Mizutani, Johji Inazawa
Hum Genet (2007) 52:397–405【PDF File】 |
|
Fortuitous Detection of a Submicroscopic Deletion at 1q25 in a Girl With Cornelia-de Lange Syndrome Carrying t(5;13)(p13.1;q12.1) by Array-Based Comparative Genomic Hybridization |
|
Shin Hayashi, Masae Ono, Yoshio Makita, Issei Imoto, Shuki Mizutani, and Johji Inazawa
American Journal of Medical Genetics Part A 143A:1191–1197 (2007)【PDF File】 |
|
Prevention of Cartilage Destruction With Intraarticular Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in a Murine Model of Osteoarthritis |
|
Sadanori Shimizu, Yoshinori Asou, Soichiro Itoh, Ung-il Chung, Hiroshi Kawaguchi,
Kenichi Shinomiya, and Takeshi Muneta,
ARTHRITIS RHEUMATISM Vol. 56, No. 10, October 2007, pp 3358–3365【PDF File】 |
|
Central control of bone remodeling by neuromedin U |
|
Shingo Sato, Reiko Hanada, Ayako Kimura, Tomomi Abe, Takahiro Matsumoto, Makiko Iwasaki,Hiroyuki Inose, Takanori Ida, Michihiro Mieda, Yasuhiro Takeuchi, Seiji Fukumoto, Toshiro Fujita,Shigeaki Kato, Kenji Kangawa, Masayasu Kojima, Ken-ichi Shinomiya, Shu Takeda Nat Med 2007 Sep 16【PDF File】 |
|
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice. |
|
Hava Gil-Henn, Olivier Destaing, Natalie A. Sims, Kazuhiro Aoki, Neil Alles, Lynn Neff, Archana Sanjay, Angela Bruzzaniti, Pietro De Camilli, Roland Baron, and Joseph Schlessinger J Cell Biol. 2007 Sep 10;178(6):1053-64. 【PDF File】 |
|
A case report of hypertrophic pachymeningitis associated with systemic lupus erythematosus, showing a headache and hearing loss resembling intracranial hypotension |
|
Ochi S, Nanki T, Komano Y, Suzuki F, Ogawa J, Sugihara T, Nagasaka K, Nonomura Y, Hagiyama H, and Miyasaka N The Japan Societry for Clinical Immunology 55-60(2007)【PDF File】 |
|
Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis: a retrospective study |
|
Kazuki Takada • Jun Kishi • Nobuyuki Miyasaka Mod Rheumatol 123-130(2007)【PDF File】 |
|
Interaction between the immune system and bone metabolism: an emerging field of osteoimmunology. |
|
H Takayanagi. Proc Jpn Acad, Ser B 83, 136-143 (2007)【PDF File】 |
|
Runx2 is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in vivo |
|
R Salingcarnboriboon, K Tsuji, T Komori, K Nakashima, Y Ezura and M. Noda. Endocrinology 147(5):2296-2305, 2006 【PDF File】 |
|
The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein induced bone formation |
|
M. Morinobu, T. Nakamoto, K. Hino, K. Tsuji, Zhong-Jian Shen, K. Nakashima, A. Nifuji, H. Yamamoto, H. Hirai and M. Noda. JEM 201:(6), 961-970, 2005 【PDF File】 |
|
Leptin regulation of bone resorption by the sympathetic nervous system and CART |
|
F. Elefteriou, Jong Deok Ahn, S. Takeda, M. Starbuck, Xiangli Yang, Xiuyun Liu, H. Kondo, WG. Richards, TW. Bannon, M. Noda, K Clement,C. Vaisse, G. Karsenty. Nature 434:514-520, 2005【PDF File】 |
|
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis |
|
Usui M,Yoshida Y,Tsuji K,Oikawa K,Miyazono K,Ishikawa I,Yamamoto T,Nifuji A,Noda M. PNAS 101, 17:6653-6658, 2004. 【PDF File】 |
|
NARF, and Nemo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)
|
|
M Yamada, J Ohnishi, B Ohkawara, S Iemura, K Satoh, J Miura, K Kawachi, T Natsume and H Shibuya.
Journal of Biological Chemistry 281(30):20749-20760, 2006. 【PDF File】 |
|
WNK1 Regulates Phosphorylation of Cation-Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and PSR1
|
|
T Moriguchi, S Urushiyama, N Hisamoto, S Iemura, S Uchida, T Natsume, K Matsumoto and H Shibuya.
Journal of Biological Chemistry 280(52):42685-42693, 2005. 【PDF File】 |
|
Role of the TAK1-NLK-STAT3 pathway in TGF-B-mediated mesoderm induction
|
|
B Ohkawara, K Shirakabe, J Miura, R Matsuo, N Ueno, K Matsumoto and H Shibuya.
GENES and Development 18:381-386, 2004. 【PDF File】 |
|
MFB-1, an F-box-type ubiquitin ligase, regulates TGF-B signalling
|
|
U Aoyama, S Urushiyama, M Yamada, C Kato, H ide, S Higuchi, T Akiyama and H Shibuya. Genes to Cells 9:1093-1101, 2004. 【PDF File】 |
|
Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
|
|
Ohkawara B,Shirakabe K,Miura J,Matsuno R,Ueno N,Matsumoto K,Shibuya H. Gene Dev 18:381-386, 2004. 【PDF File】 |
|
An a-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients
|
|
N Satoh, A Shimatsu, K Yamada, M Abe, T Suganami, H Kuzuya and Y Ogawa.
Metabolism Clinical and Experimental 55:786-793, 2006. 【PDF File】 |
|
Attenuation of Diet-Induced Weight Gain and Adiposity through Increased Energy Expenditure in Mice Lacking Angiotensin Ⅱ Type 1a Receptor
|
|
R Kouyama, T Suganami, J Nishida, M Tanaka, T Toyoda, M Kiso, T Chiwata, Y Miyamoto, Y Yoshimasa, A Fukamizu, M Horiuchi, Y Hirata and Y Ogawa.
Endocrinology 146(8) :3481-3489, 2006. 【PDF File】 |
|
Leptin-to-Adiponectin Ratio as a Potential Atherogenic Index in Obese Type 2 Diabetic Patients
|
|
N Satoh, M Naruse, T Usui, T Tagami, T Suganami, K Yamada, H Kuzuya, A Shimatsu, Y Ogawa.
Diabetes Care 27(10) :2488-2490, 2004. 【PDF File】 |
|
Serum leptin level is a regulator of bone mass
|
|
Elefteriou F,Takeda S,Ebihara K,Magre J,Patano N,Kim C.Ae,Ogawa Y,Liu X,Ware S.M.,Craigen W.J.,Robert J.J.,Vinson C,Nakao K,Capeau J,Karsenty G. PNAS 101, 9:3258-3263, 2004. 【PDF File】 |
|
Mechanical properties and bond strength of dual-cure resin composites to root canal dentin |
|
J Aksornmuang, M Nakajima, RM Foxton and J Tagami. Dental Materials, 2006. 【PDF File】 |
|
Microtensile bond strength of a filled vs unfilled adhenseive to dentin using self-etch and total-etch technique |
|
EC Say, M Nakajima, P Senawongse, M Soyman, F Ozer, M Ogata and J Tagami. Journal of Dentistry 34:283-291, 2006. 【PDF File】 |
|
A synthetic enamel for rapid tooth repair |
|
K Yamagishi, K Onuma, T Suzuki, F Okada, J Tagami, M Otsuki, P Senawangse. Nature 433:819, 2005. 【PDF File】 |
|
Seven-year dentin bond strengths of a total- and self-etch system |
|
MF Burrow, N Harada, Y Kitasako, T Nikaido and J Tagami. European Journal of Oral Sciences 113:265-270, 2005. 【PDF File】 |
|
Effect of prolonged photo-irradiation time of three self-etch systems on the bonding to root canal dentine |
|
J Aksornmuang, M Nakajima, RM Foxton and J Tagami. Journal of Dentistry, 2005. 【PDF File】 |
|
Elemental Distributions and Microtensile Bond Strength of the Adhesive Interface to Normal and Caries-Affected Dentin |
|
M Nakajima, Y Kitasako, M Okuda, RM Foxton and J Tagami. EPMA Study OF Resin?Dentin Interface, 2004. 【PDF File】 |
|
Microtensile bond strength of a dual-cure resin core material to glass and quartz fibre posts |
|
J Aksornmuang, RM Foxton, M Nakajima and J Tagami. Journal of Dentistry 32:443-450, 2004. 【PDF File】 |
|
Gene expression analysis by cDNA microarray in oral squamous cell carcinoma
|
|
H Tomioka, K Morita, S Hasegawa and K Omura. Journal of Oral Pathol Med 35:206-211, 2006. 【PDF File】 |
|
In Vitro Chondrogenesis of Human Synovium-Derived Mesenchymal Stem Cells: Optimal Condition and Comparison with Bone Marrow-Derived Cells
|
|
S Shirasawa, I Sekiya, Y Sakaguchi, K Yagishita, S Ichinose and T Muneta. Journal of Cellular Biochemistry 97:84-97, 2006. 【PDF File】 |
|
In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel
|
|
A Yokoyama, I Sekiya, K Miyazaki, S Ichinose, Y Hata and T Muneta. Cell Tissue Res 1-10, 2005. 【PDF File】 |
|
The Effect of Hyaluronan on Tendon Healing in Rabbits
|
|
K Yagishita, I Sekiya, Y Sakaguchi, K Shinomiya and T Muneta. The Journal of Arthroscopic and Related Surgery 21(11); 1330-1336, 2005. 【PDF File】 |
|
Comparison of Human Stem Cells Derived From Various Mesenchymal Tissues
|
|
Y Sakaguchi, I Sekiya, K Yagishita and T Muneta. Arthritis and Rheumatism 52(8); 2521-2529, 2005. 【PDF File】 |
|
Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
|
|
Y Sakaguchi, I Sekiya, K Yagishita, S Ichinose, K Shinomiya and T Muneta. Blood 104(9); 2728-2735, 2004. 【PDF File】 |
|
Transforming growth factor-β stimulates IL-1β-induced monocyte chemoattractant protein-1 expression in human synovial cells via ERK/AP-1 pathway
|
|
H Yoshimura, K Nakahama, O Safronova, N Tanaka, T Muneta and I Morita. Inflammation Research 55: 1-7, 2006. 【PDF File】 |
|
Age- and cell cycle- dependent changes in EPC-1/PEDF promoter activity in human diploid fibroblast-like (HDF) cells
|
|
T Kojima, K Nakahama, K Yamamoto, H Uematsu and I Morita. Molecular and Cellular Biochemistry 2006. 【PDF File】 |
|
Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor
|
|
J Hosomichi, N Yasui, T Koide, K Soma and I Morita. Biochemical and Biophysical Research Communications. 335; 756-761, 2005. 【PDF File】 |
|
The potential role of amyloid β in the pathogenesis of age-related macular degeneration
|
|
T Yoshida, K Matsui, S Ichinose, T Sato, N Iwata, T Saido, T Hisatomi, M Mochizuki and I Morita. The Journal of Clinical Investigation. 115(10); 2793-2800, 2005.【PDF File】 |
|
Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients
|
|
M Onodera, Y Horiuchi, K Nakahama, T Muneta, Y Mano and I Morita. Inflammation Research 53; 217-222, 2004.【PDF File】 |
|
A three-dimensional cell-loading system using autologous plasma loaded into a porous β-tricalcium-phosphate block promotes bone formation at extraskeletal sites in rats
|
|
N Tajima, S Sotome, E Marukawa, K Omura and K Shinomiya. Materials Science and Engineering 2006.【PDF File】 |
|
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
|
|
Koga T,Inui M,Inoue K,Kim S,Suematsu A,Kobayashi E,Iwata T,Ohnishi H,Matozaki T,Kodama T,Taniguchi T,Takayanagi H,Takai T. Nature 428:758-763, 2004. 【PDF File】 |
